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Loss of epigenetic information as a cause of mammalian aging

https://www.cell.com/cell/fulltext/S0092-8674(22)01570-7
1•andsoitis•6m ago•0 comments

Specsmaxxing – On overcoming AI psychosis, and why I write specs in YAML

https://acai.sh/blog/specsmaxxing
1•brendanmc6•12m ago•1 comments

The AI coding tool config problem is getting worse, not better

https://github.com/sampleXbro/agentsmesh
2•samplexBro•14m ago•0 comments

FDA Clearance of IND Application for ER-100 in Optic Neuropathies

https://www.lifebiosciences.com/life-biosciences-announces-fda-clearance-of-ind-application-for-e...
1•andsoitis•16m ago•0 comments

Show HN: Seeker – Career Routing Engine

https://www.seekerscore.com
1•danylchukllc•17m ago•1 comments

Evaluating ER-100 for Safety in People with Glaucoma or Optic Nerve Conditions

https://clinicaltrials.gov/study/NCT07290244
1•andsoitis•18m ago•0 comments

Tython – Just a Small Language

https://github.com/younissk/tython
1•modinfo•22m ago•1 comments

Artisan (YC W24) uses AI to rip off "This is Fine" artist for ad

https://bsky.app/profile/kcg.bsky.social/post/3mkwcpx45q223
1•starkparker•23m ago•0 comments

The Final Form of Software Development

https://blog.zksecurity.xyz/posts/end-coding/
2•ricochet11•23m ago•0 comments

Deep Dive into the OTel Normalizer groundcover Built for GenAI

https://www.groundcover.com/blog/otel-normalizer-genai-part-2
1•thebitofmyheart•26m ago•0 comments

MathStudio Android APK modernized for Android >= 7

https://github.com/woct0rdho/mathstudio-apk-modernized
1•woctordho•44m ago•1 comments

Unruly Play

https://www.unrulyplay.com/
3•bkudria•48m ago•0 comments

I Wrote Ultralearning. This Is What I'd Change Because of AI

https://www.scotthyoung.com/blog/2026/04/29/ultralearning-ai/
2•pullshark91•48m ago•0 comments

Show HN: UIGen – Runtime front end for any OpenAPI spec with AI skills

https://github.com/darula-hpp/uigen
3•ombedzi•49m ago•0 comments

Turning live heart rate data into a generative audio story

https://runnory.com/blog/heart-rate-writes-the-story
2•danultimateb•50m ago•1 comments

Engaging Essays in Cosmology [1971-2026]

https://archive.org/details/a.-tomilin-engaging-essays-in-cosmology-mir-titles-2026
3•the-mitr•54m ago•0 comments

Yann LeCun's Billion Dollar Bet [video]

https://www.youtube.com/watch?v=kYkIdXwW2AE
1•mfiguiere•57m ago•0 comments

Show HN: Stay Lean – Calorie Navigation

https://apps.apple.com/us/app/stay-lean-calorie-navigation/id6762153463
1•janpmz•58m ago•1 comments

Making Postman load 60% Faster

1•vedkribhu•1h ago•1 comments

Model Engines Manufacturable drawings/plans

https://outerzone.co.uk/plans.asp?cat=Engines&Xcardsperpage=48
1•pillars•1h ago•0 comments

I wrote a custom CUDA inference engine to run Qwen3.5-27B on $130 mining cards

https://news.ycombinator.com/submit
2•Haru-neo•1h ago•0 comments

Einstein's Big Idea Documentry(2005) - 1h 49M [video]

https://thinktv.pbslearningmedia.org/resource/nvfb-sci-einsteinsidea/wgbh-nova-einsteins-big-idea...
1•num42•1h ago•0 comments

Pgxbackup: Continuity Support for PgBackRest

https://thebuild.com/blog/2026/05/01/pgxbackup-continuity-support-for-pgbackrest/
1•thunderbong•1h ago•0 comments

Show HN: Keryx: TypeScript framework where one Action becomes HTTP, WS, CLI, MCP

https://www.keryxjs.com
1•evantahler•1h ago•1 comments

The Reality of Being a Man in Your 50s in South Korea

https://indignified.com/the-hidden-realities-of-midlife-masculinity-in-south-korea/
12•ZguideZ•1h ago•4 comments

Mouse Pointer as a Mere Mortal

https://unsung.aresluna.org/mouse-pointer-as-a-mere-mortal/
1•zdw•1h ago•0 comments

Quantum Machine Learning: A Pragmatic Guide for Classical ML Engineers

https://pawankjha.substack.com/p/quantum-machine-learning-the-pragmatic
2•pawanjha25•1h ago•0 comments

Redesigning Agent Skills – two missing parts

https://simianwords.bearblog.dev/what-agent-skills-misses-now/
1•simianwords•1h ago•0 comments

NodeMind – binary document index, 48× smaller than float32 RAG, no GPU required

https://github.com/QLNI/NodeMind
2•Nodemind•1h ago•0 comments

MX Script: a scripting language for one file web APIs

https://www.mxscript.com/
2•jlkdevelop•1h ago•0 comments
Open in hackernews

Claude Plays Pokemon – Starter Version

https://github.com/davidhershey/ClaudePlaysPokemonStarter
8•minimaxir•1y ago
This is released by the Anthropic engineer who developed Claude Plays Pokemon.

Comments

minimaxir•1y ago
This is released by the Anthropic engineer who developed Claude Plays Pokemon.
CSMastermind•1y ago
It's interesting to me that they're extracting game state from memory instead of just passing the video into the LLM.
_--__--__•1y ago
Every agent step takes both a visual snapshot and a memory read, the memory gives more consistent tileset and location parsing and also has some stuff like party state/status conditions that isn't usually visible.
CSMastermind•1y ago
Shouldn't the goal be to compare it against a human player that would need to menu for that information?
_--__--__•1y ago
that's probably fair but I imagine that without memory access Claude would have been opening and searching the (completely unordered!) bag to check for progress critical items like the pokeflute every 5 minutes