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Ask HN: AI Generated Diagrams

1•voidhorse•2m ago•0 comments

Microsoft Account bugs locked me out of Notepad – are Thin Clients ruining PCs?

https://www.windowscentral.com/microsoft/windows-11/windows-locked-me-out-of-notepad-is-the-thin-...
1•josephcsible•2m ago•0 comments

Show HN: A delightful Mac app to vibe code beautiful iOS apps

https://milq.ai/hacker-news
1•jdjuwadi•5m ago•1 comments

Show HN: Gemini Station – A local Chrome extension to organize AI chats

https://github.com/rajeshkumarblr/gemini_station
1•rajeshkumar_dev•5m ago•0 comments

Welfare states build financial markets through social policy design

https://theloop.ecpr.eu/its-not-finance-its-your-pensions/
2•kome•9m ago•0 comments

Market orientation and national homicide rates

https://onlinelibrary.wiley.com/doi/10.1111/1745-9125.70023
3•PaulHoule•9m ago•0 comments

California urges people avoid wild mushrooms after 4 deaths, 3 liver transplants

https://www.cbsnews.com/news/california-death-cap-mushrooms-poisonings-liver-transplants/
1•rolph•10m ago•0 comments

Matthew Shulman, co-creator of Intellisense, died 2019 March 22

https://www.capenews.net/falmouth/obituaries/matthew-a-shulman/article_33af6330-4f52-5f69-a9ff-58...
3•canucker2016•11m ago•1 comments

Show HN: SuperLocalMemory – AI memory that stays on your machine, forever free

https://github.com/varun369/SuperLocalMemoryV2
1•varunpratap369•12m ago•0 comments

Show HN: Pyrig – One command to set up a production-ready Python project

https://github.com/Winipedia/pyrig
1•Winipedia•14m ago•0 comments

Fast Response or Silence: Conversation Persistence in an AI-Agent Social Network [pdf]

https://github.com/AysajanE/moltbook-persistence/blob/main/paper/main.pdf
1•EagleEdge•14m ago•0 comments

C and C++ dependencies: don't dream it, be it

https://nibblestew.blogspot.com/2026/02/c-and-c-dependencies-dont-dream-it-be-it.html
1•ingve•14m ago•0 comments

Show HN: Vbuckets – Infinite virtual S3 buckets

https://github.com/danthegoodman1/vbuckets
1•dangoodmanUT•15m ago•0 comments

Open Molten Claw: Post-Eval as a Service

https://idiallo.com/blog/open-molten-claw
1•watchful_moose•15m ago•0 comments

New York Budget Bill Mandates File Scans for 3D Printers

https://reclaimthenet.org/new-york-3d-printer-law-mandates-firearm-file-blocking
2•bilsbie•16m ago•1 comments

The End of Software as a Business?

https://www.thatwastheweek.com/p/ai-is-growing-up-its-ceos-arent
1•kteare•17m ago•0 comments

Exploring 1,400 reusable skills for AI coding tools

https://ai-devkit.com/skills/
1•hoangnnguyen•18m ago•0 comments

Show HN: A unique twist on Tetris and block puzzle

https://playdropstack.com/
1•lastodyssey•21m ago•1 comments

The logs I never read

https://pydantic.dev/articles/the-logs-i-never-read
1•nojito•22m ago•0 comments

How to use AI with expressive writing without generating AI slop

https://idratherbewriting.com/blog/bakhtin-collapse-ai-expressive-writing
1•cnunciato•24m ago•0 comments

Show HN: LinkScope – Real-Time UART Analyzer Using ESP32-S3 and PC GUI

https://github.com/choihimchan/linkscope-bpu-uart-analyzer
1•octablock•24m ago•0 comments

Cppsp v1.4.5–custom pattern-driven, nested, namespace-scoped templates

https://github.com/user19870/cppsp
1•user19870•25m ago•1 comments

The next frontier in weight-loss drugs: one-time gene therapy

https://www.washingtonpost.com/health/2026/01/24/fractyl-glp1-gene-therapy/
2•bookofjoe•28m ago•1 comments

At Age 25, Wikipedia Refuses to Evolve

https://spectrum.ieee.org/wikipedia-at-25
2•asdefghyk•31m ago•4 comments

Show HN: ReviewReact – AI review responses inside Google Maps ($19/mo)

https://reviewreact.com
2•sara_builds•31m ago•1 comments

Why AlphaTensor Failed at 3x3 Matrix Multiplication: The Anchor Barrier

https://zenodo.org/records/18514533
1•DarenWatson•32m ago•0 comments

Ask HN: How much of your token use is fixing the bugs Claude Code causes?

1•laurex•36m ago•0 comments

Show HN: Agents – Sync MCP Configs Across Claude, Cursor, Codex Automatically

https://github.com/amtiYo/agents
1•amtiyo•37m ago•0 comments

Hello

2•otrebladih•38m ago•1 comments

FSD helped save my father's life during a heart attack

https://twitter.com/JJackBrandt/status/2019852423980875794
3•blacktulip•41m ago•0 comments
Open in hackernews

Building Personal Digital Twins for Health Optimisation and Drug Simulation

1•Melissa_bime•9mo ago
Hi HN,

We’re working on BioReplica, a platform that lets you create a digital replica of your own biology, based on your DNA, medical records, wearable data, and physiological metrics. Why? Right now, if you want to know how a supplement, diet, or exercise protocol will affect you, you usually have to experiment on yourself and hope for the best. No two bodies respond the same way, but personalization is still mostly guesswork. BioReplica is an early attempt to change that. We build a personal biological model, a simulation that lets you test "what if?" scenarios safely before trying them in real life.

Examples:

"If I start taking NMN, will my inflammation markers likely improve or worsen?"

"Would intermittent fasting affect my heart health risk, based on my baseline data?"

"Is this new nootropic likely to interact badly with my genetics or medications?"

Instead of generic advice, you can start seeing predictions based on you, your genome, your health history, your day-to-day physiology.

We’re very early. Right now the simulations are basic, focused mainly on lifestyle and supplement interventions. But over time, the idea is to make it richer, more data inputs, better modeling, higher accuracy.

Caveats:

Biology is still messy, and simulations are probabilistic, not certainties.

The platform isn't diagnostic or a substitute for real medicine (and shouldn’t be).

Getting the modeling right is hard, and we’re very upfront about that. The long term goal is for these replica's to be used for pharma simulations. In clinical trials today, most failures happen late, billions spent, and sometimes only then do we learn that a drug doesn’t work or has hidden risks.

Still, we believe even imperfect simulations, if used carefully, can help people make smarter decisions about their health.

If this idea resonates (or if you see flaws we should be thinking about), we’d love feedback. Learn more on https://bioreplica.ai/landing