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New York Budget Bill Mandates File Scans for 3D Printers

https://reclaimthenet.org/new-york-3d-printer-law-mandates-firearm-file-blocking
1•bilsbie•37s ago•0 comments

The End of Software as a Business?

https://www.thatwastheweek.com/p/ai-is-growing-up-its-ceos-arent
1•kteare•1m ago•0 comments

Exploring 1,400 reusable skills for AI coding tools

https://ai-devkit.com/skills/
1•hoangnnguyen•2m ago•0 comments

Show HN: A unique twist on Tetris and block puzzle

https://playdropstack.com/
1•lastodyssey•5m ago•0 comments

The logs I never read

https://pydantic.dev/articles/the-logs-i-never-read
1•nojito•6m ago•0 comments

How to use AI with expressive writing without generating AI slop

https://idratherbewriting.com/blog/bakhtin-collapse-ai-expressive-writing
1•cnunciato•8m ago•0 comments

Show HN: LinkScope – Real-Time UART Analyzer Using ESP32-S3 and PC GUI

https://github.com/choihimchan/linkscope-bpu-uart-analyzer
1•octablock•8m ago•0 comments

Cppsp v1.4.5–custom pattern-driven, nested, namespace-scoped templates

https://github.com/user19870/cppsp
1•user19870•9m ago•1 comments

The next frontier in weight-loss drugs: one-time gene therapy

https://www.washingtonpost.com/health/2026/01/24/fractyl-glp1-gene-therapy/
1•bookofjoe•12m ago•1 comments

At Age 25, Wikipedia Refuses to Evolve

https://spectrum.ieee.org/wikipedia-at-25
1•asdefghyk•15m ago•3 comments

Show HN: ReviewReact – AI review responses inside Google Maps ($19/mo)

https://reviewreact.com
2•sara_builds•15m ago•1 comments

Why AlphaTensor Failed at 3x3 Matrix Multiplication: The Anchor Barrier

https://zenodo.org/records/18514533
1•DarenWatson•16m ago•0 comments

Ask HN: How much of your token use is fixing the bugs Claude Code causes?

1•laurex•20m ago•0 comments

Show HN: Agents – Sync MCP Configs Across Claude, Cursor, Codex Automatically

https://github.com/amtiYo/agents
1•amtiyo•21m ago•0 comments

Hello

1•otrebladih•22m ago•1 comments

FSD helped save my father's life during a heart attack

https://twitter.com/JJackBrandt/status/2019852423980875794
2•blacktulip•25m ago•0 comments

Show HN: Writtte – Draft and publish articles without reformatting, anywhere

https://writtte.xyz
1•lasgawe•27m ago•0 comments

Portuguese icon (FROM A CAN) makes a simple meal (Canned Fish Files) [video]

https://www.youtube.com/watch?v=e9FUdOfp8ME
1•zeristor•28m ago•0 comments

Brookhaven Lab's RHIC Concludes 25-Year Run with Final Collisions

https://www.hpcwire.com/off-the-wire/brookhaven-labs-rhic-concludes-25-year-run-with-final-collis...
2•gnufx•30m ago•0 comments

Transcribe your aunts post cards with Gemini 3 Pro

https://leserli.ch/ocr/
1•nielstron•34m ago•0 comments

.72% Variance Lance

1•mav5431•35m ago•0 comments

ReKindle – web-based operating system designed specifically for E-ink devices

https://rekindle.ink
1•JSLegendDev•37m ago•0 comments

Encrypt It

https://encryptitalready.org/
1•u1hcw9nx•37m ago•1 comments

NextMatch – 5-minute video speed dating to reduce ghosting

https://nextmatchdating.netlify.app/
1•Halinani8•38m ago•1 comments

Personalizing esketamine treatment in TRD and TRBD

https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1736114
1•PaulHoule•39m ago•0 comments

SpaceKit.xyz – a browser‑native VM for decentralized compute

https://spacekit.xyz
1•astorrivera•40m ago•0 comments

NotebookLM: The AI that only learns from you

https://byandrev.dev/en/blog/what-is-notebooklm
2•byandrev•40m ago•2 comments

Show HN: An open-source starter kit for developing with Postgres and ClickHouse

https://github.com/ClickHouse/postgres-clickhouse-stack
1•saisrirampur•41m ago•0 comments

Game Boy Advance d-pad capacitor measurements

https://gekkio.fi/blog/2026/game-boy-advance-d-pad-capacitor-measurements/
1•todsacerdoti•41m ago•0 comments

South Korean crypto firm accidentally sends $44B in bitcoins to users

https://www.reuters.com/world/asia-pacific/crypto-firm-accidentally-sends-44-billion-bitcoins-use...
2•layer8•42m ago•0 comments
Open in hackernews

Building Personal Digital Twins for Personal Health Optimisation

3•Melissa_bime•9mo ago
Hi HN, We’re working on BioReplica, a platform that lets you create a digital replica of your own biology, based on your DNA, medical records, wearable data, and physiological metrics. Why? Right now, if you want to know how a supplement, diet, or exercise protocol will affect you, you usually have to experiment on yourself and hope for the best. No two bodies respond the same way, but personalization is still mostly guesswork. BioReplica is an early attempt to change that. We build a personal biological model, a simulation that lets you test "what if?" scenarios safely before trying them in real life.

Examples:

"If I start taking NMN, will my inflammation markers likely improve or worsen?"

"Would intermittent fasting affect my heart health risk, based on my baseline data?"

"Is this new nootropic likely to interact badly with my genetics or medications?"

Instead of generic advice, you can start seeing predictions based on you, your genome, your health history, your day-to-day physiology.

We’re very early. Right now the simulations are basic, focused mainly on lifestyle and supplement interventions. But over time, the idea is to make it richer, more data inputs, better modeling, higher accuracy.

Caveats:

Biology is still messy, and simulations are probabilistic, not certainties.

The platform isn't diagnostic or a substitute for real medicine (and shouldn’t be).

Getting the modeling right is hard, and we’re very upfront about that. The long term goal is for these replica's to be used for pharma simulations. In clinical trials today, most failures happen late, billions spent, and sometimes only then do we learn that a drug doesn’t work or has hidden risks.

Still, we believe even imperfect simulations, if used carefully, can help people make smarter decisions about their health.

If this idea resonates (or if you see flaws we should be thinking about), we’d love feedback.