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The protein denitrosylase SCoR2 regulates lipogenesis and fat storage [pdf]

https://www.science.org/doi/10.1126/scisignal.adv0660
1•thunderbong•1m ago•0 comments

Los Alamos Primer

https://blog.szczepan.org/blog/los-alamos-primer/
1•alkyon•4m ago•0 comments

NewASM Virtual Machine

https://github.com/bracesoftware/newasm
1•DEntisT_•6m ago•0 comments

Terminal-Bench 2.0 Leaderboard

https://www.tbench.ai/leaderboard/terminal-bench/2.0
1•tosh•6m ago•0 comments

I vibe coded a BBS bank with a real working ledger

https://mini-ledger.exe.xyz/
1•simonvc•7m ago•1 comments

The Path to Mojo 1.0

https://www.modular.com/blog/the-path-to-mojo-1-0
1•tosh•9m ago•0 comments

Show HN: I'm 75, building an OSS Virtual Protest Protocol for digital activism

https://github.com/voice-of-japan/Virtual-Protest-Protocol/blob/main/README.md
4•sakanakana00•13m ago•0 comments

Show HN: I built Divvy to split restaurant bills from a photo

https://divvyai.app/
3•pieterdy•15m ago•0 comments

Hot Reloading in Rust? Subsecond and Dioxus to the Rescue

https://codethoughts.io/posts/2026-02-07-rust-hot-reloading/
3•Tehnix•16m ago•1 comments

Skim – vibe review your PRs

https://github.com/Haizzz/skim
2•haizzz•17m ago•1 comments

Show HN: Open-source AI assistant for interview reasoning

https://github.com/evinjohnn/natively-cluely-ai-assistant
4•Nive11•17m ago•6 comments

Tech Edge: A Living Playbook for America's Technology Long Game

https://csis-website-prod.s3.amazonaws.com/s3fs-public/2026-01/260120_EST_Tech_Edge_0.pdf?Version...
2•hunglee2•21m ago•0 comments

Golden Cross vs. Death Cross: Crypto Trading Guide

https://chartscout.io/golden-cross-vs-death-cross-crypto-trading-guide
2•chartscout•24m ago•0 comments

Hoot: Scheme on WebAssembly

https://www.spritely.institute/hoot/
3•AlexeyBrin•26m ago•0 comments

What the longevity experts don't tell you

https://machielreyneke.com/blog/longevity-lessons/
2•machielrey•28m ago•1 comments

Monzo wrongly denied refunds to fraud and scam victims

https://www.theguardian.com/money/2026/feb/07/monzo-natwest-hsbc-refunds-fraud-scam-fos-ombudsman
3•tablets•32m ago•1 comments

They were drawn to Korea with dreams of K-pop stardom – but then let down

https://www.bbc.com/news/articles/cvgnq9rwyqno
2•breve•35m ago•0 comments

Show HN: AI-Powered Merchant Intelligence

https://nodee.co
1•jjkirsch•37m ago•0 comments

Bash parallel tasks and error handling

https://github.com/themattrix/bash-concurrent
2•pastage•37m ago•0 comments

Let's compile Quake like it's 1997

https://fabiensanglard.net/compile_like_1997/index.html
2•billiob•38m ago•0 comments

Reverse Engineering Medium.com's Editor: How Copy, Paste, and Images Work

https://app.writtte.com/read/gP0H6W5
2•birdculture•43m ago•0 comments

Go 1.22, SQLite, and Next.js: The "Boring" Back End

https://mohammedeabdelaziz.github.io/articles/go-next-pt-2
1•mohammede•49m ago•0 comments

Laibach the Whistleblowers [video]

https://www.youtube.com/watch?v=c6Mx2mxpaCY
1•KnuthIsGod•50m ago•1 comments

Slop News - The Front Page right now but it's only Slop

https://slop-news.pages.dev/slop-news
1•keepamovin•55m ago•1 comments

Economists vs. Technologists on AI

https://ideasindevelopment.substack.com/p/economists-vs-technologists-on-ai
1•econlmics•57m ago•0 comments

Life at the Edge

https://asadk.com/p/edge
4•tosh•1h ago•0 comments

RISC-V Vector Primer

https://github.com/simplex-micro/riscv-vector-primer/blob/main/index.md
4•oxxoxoxooo•1h ago•1 comments

Show HN: Invoxo – Invoicing with automatic EU VAT for cross-border services

2•InvoxoEU•1h ago•0 comments

A Tale of Two Standards, POSIX and Win32 (2005)

https://www.samba.org/samba/news/articles/low_point/tale_two_stds_os2.html
4•goranmoomin•1h ago•0 comments

Ask HN: Is the Downfall of SaaS Started?

4•throwaw12•1h ago•0 comments
Open in hackernews

Universal Antivenom May Grow Out of Man Who Let Snakes Bite Him 100s of Times

https://www.nytimes.com/2025/05/02/health/snakes-universal-antivenom-tim-friede.html
45•ceejayoz•9mo ago

Comments

arbuge•9mo ago
https://archive.ph/unVGB
kstrauser•9mo ago
No one's that purely altruistic. It's like people who eat hot chilis and claim it's for food testing or quality control purposes.

At some point, you've gotta come to grips with the fact that you like getting bit by snakes.

Edit: Sorry, I really did mean that to be funny. I don't care what his motivations are for letting himself get bitten so many times. Whatever the root cause, it looks like we might benefit tremendously from it, and for that, I'm sincerely grateful to him.

zahlman•9mo ago
I don't know that "likes getting bit" explains it. Perhaps, for example, it's a matter of feeling pride for surviving.
kstrauser•9mo ago
I don't know, either. Maybe it'd be my favorite thing ever, but I hope I never find out.

But get bit by one snake, you're unlucky. Get bit by 5 snakes, it's an occupational hazard. Get bit by 100 snakes, I think there's something else going on.

toomuchtodo•9mo ago
> No one's that purely altruistic.

"James Harrison, a prolific Australian blood donor famed for having saved the lives of more than two million babies, has died at age 88."

https://en.wikipedia.org/wiki/James_Harrison_(blood_donor)

https://www.cnn.com/2025/03/03/health/james-harrison-blood-d...

sidewndr46•9mo ago
It seems he likely appreciate the indirect fame it brought him, but it is actually personal sacrifice on his part. I commend his efforts.
Pet_Ant•9mo ago
I think if you really get down to it, there are only three motivations for people to do things:

1) they benefit from it somehow, even if it just flatters their sense of justice

2) they did it unquestioningly because someone told them to, it didn't occur to them that they even had a choice

3) they did something reflexively and may not even have realise they did anything.

So I find criticising people for "they did it because there was something in it for them" such a lacklustre criticism, because that applies to almost everything. It's what was in it for them and how much they gave up for it that makes it laudable or contemptible.

soupfordummies•9mo ago
And as the old adage goes "doing good is its own reward", it's kind of impossible NOT to do it because of personal rewards since they're sort of inherent in the good deed anyway.

Besides, why does it matter anyway? A good thing happened regardless of the motivation.

Pet_Ant•9mo ago
I mean it is one of the oldest areas of human study: https://en.wikipedia.org/wiki/Ethics
fc417fc802•9mo ago
> I find criticising people for "they did it because there was something in it for them" such a lacklustre criticism

Agreed! However.

> there are only three motivations for people to do things

Cooperative behavior arises on its own via evolution in otherwise fairly primitive species. The benefit to the individual in such cases is extremely indirect but the game theory on a collective level is clear enough.

Which is to say, you could just genuinely want to help others. I suppose one could argue that doing so benefits you emotionally but I feel that would be getting a bit reductionist.

kstrauser•9mo ago
Alright. Almost no one is that purely altruistic.
ASalazarMX•9mo ago
Altruism is a weird thing, because deeds matter more than words, but doing altruistic things for the wrong reasons is still a bitter win. As an individual, intentions matter as much as deeds.

I'm not saying this man was or wasn't purely altruistic, I have no way of knowing that. I'm just playing Devil's advocate to point out that altruism can be a fascinatingly deceptive gray zone, even if it does a net good.

klik99•9mo ago
I was gonna disagree with you, until I saw this line:

"Mr. Friede’s first snake encounter, a harmless bite by a garter snake at age 5, started a lifelong fascination. “If I only knew back then what was going to happen,” he recalled, laughing uproariously.

But he didn’t begin dabbling with snakes in earnest until he was married with children and working in construction."

"Dabbling with snakes" is just poetry

I mean, I think people can be that altruistic, but the people who really make a difference are those whose interests align with an altruistic outcome.

0cf8612b2e1e•9mo ago
I am reminded of one of my favorite segments of Dirty Jobs where Mike Rowe works with a snake researcher. I do not know why his misery is so entertaining to me.

Relevant clip https://m.youtube.com/watch?v=xu6huF9KE1Q

koolba•9mo ago
Why is not wearing gloves???
abeppu•9mo ago
> But antivenom is made much the same way it was 130 years ago when it was first produced. A small amount of venom is pumped into a horse, camel or sheep, and the antibodies produced in response are harvested. The antibodies tend to be specific to the type of venom injected, and do little to ease symptoms from other types of snakes.

Ok so this guy did some crazy self-experiments with venoms from a range of snakes over an extended period. And more institutional scientists are finding useful antibodies in his blood. But ... why have the institutional scientists not previously done the equivalent process with animals. I.e. if you inject a horse with increasing concentrations of venom from a range of snakes, can you produce a universal antivenom?

thereisnospork•9mo ago
Probably would have issues passing an ethics review. Aside from the other non technical (cost) and technical hurdles (would it work).
fc417fc802•9mo ago
I wish ethics were the issue but seeing some of the mouse studies that "pass" is quite depressing. I expect it's the cost, facilities, and logistics of keeping multiple horses for multiple decades. It would literally be proposing the equivalent of starting a long term small business with an up front cost in the low digit millions (you need to purchase a small farm).
soupfordummies•9mo ago
More of a meta comment I guess, but this is the sort of unexpected and totally fascinating story that keeps me coming back to HN. It almost seems like a parody headline but, well, there it is.
felineflock•9mo ago
Non-paywalled link: https://archive.ph/ngJc9