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Show HN: Introducing Burla – The simplest way to scale Python

https://www.burla.dev
5•pancakeguy•1y ago
Hi HN! We're Jake, Jack, and Joe, and we're happy to share what we think is probably the simplest way to scale python code across thousands of computers in the cloud.

Coming from the Biotech world we were frustrated by how surprisingly slow and difficult it can be to iterate on large-scale batch processing pipelines, while contending with the security requirements imposed on us by the FDA. Simple small changes necessitated rebuilding docker containers, waiting for batch pipelines to redeploy, and waiting for vm's to cold boot, a >5minute per iteration dev cycle, all just so I can see what error my code throws this time, then do it all over again! Many other tools in the space were either too complicated for our bioinformaticians and data scientists to use, closed-source / managed only (a no-no with medical data), too difficult to setup and manage, or simply too expensive.

This is why we created Burla, an incredibly simple way to run python on thousands of computers, in any container, with any hardware.

It's open-source, can be setup with one command, and is simple enough for beginners to use.

Most importantly, Burla allows developers to iterate quickly on large scale pipelines, changes to code deploy in about 2 seconds, even with thousands of vm's running.

We believe that, in general, whether you're coding locally, or on a cluster of 1000 machines, infrastructure should update and react quickly, like under-a-second quickly. We should be able to iterate at the speed of thought, not at the speed my lambda function, batch workload, ETL-pipeline, or Kubernetes service takes to redeploy. We wrote more out long term goal here: https://docs.burla.dev/about

Github: https://github.com/Burla-Cloud/burla

More info: https://docs.burla.dev

Nondisruptive 3D profiling of combinations of epigenetic marks in single cells

https://www.nature.com/articles/s41592-026-03253-0
1•bookofjoe•22s ago•0 comments

Genetics and intelligence differences: five special findings

https://www.nature.com/articles/mp2014105
1•gmays•3m ago•0 comments

Show HN: Record, branch, and compare command runs in stdlib-only Python

https://github.com/Protention/ocura-oss
1•protention•4m ago•0 comments

Who do AI search engines name when buyers ask about 12 cold-email tools?

https://www.nextiqumai.com/insights/who-does-chatgpt-name-instead-of-you-12-tool-citation-audit
1•attiqbinkhalid•5m ago•0 comments

Nvidia CEO Jensen Huang admits affair, board to launch investigation

https://www.axios.com/2026/11/08/nvidia-ceo-jensen-huang-admits-affair-board-to-launch-investigation
1•FireBeyond•10m ago•1 comments

The great software IP writedown

https://martinalderson.com/posts/the-great-software-ip-writedown/
1•martinald•10m ago•0 comments

Project Detroit: From Foreign Libraries to Foreign Language Runtimes

https://inside.java/2026/11/04/devoxxbelgium-project-detroit/
1•ejboy•13m ago•0 comments

YouTube's dominance has Hollywood running scared

https://www.economist.com/business/2026/11/08/youtubes-dominance-has-hollywood-running-scared
1•andsoitis•15m ago•1 comments

The Overton Window: How Unthinkable Ideas Become the Norm

https://paulitaylor.com/2026/03/27/the-overton-window-how-unthinkable-ideas-become-the-norm/
1•andsoitis•16m ago•0 comments

Super Fast Linux Photo Viewer

https://licasa.pics/
2•UncleJo7•19m ago•0 comments

Compend, Everything Is Up for Review

https://gurlworld.com/on-compend-everything-is-up-for-review/
2•rdmuser•20m ago•0 comments

Show HN: Fireside Folio – free books, comics and news editions for reMarkable

https://firesidefolio.com/
1•hashfunction•23m ago•0 comments

The 'Silver Label' Commodore 64: The Beginning of a Legend

https://www.amigalove.com/viewtopic.php?t=3079
1•erickhill•24m ago•0 comments

'Starlog' Magazine Returns with First Cover in 17 Years

https://www.hollywoodreporter.com/business/business-news/starlog-magazine-returns-with-first-cove...
1•rdmuser•26m ago•0 comments

U.S. Cleared Nvidia Chips to Chinese Firms with Empty Offices and Troubling Ties

https://www.nytimes.com/2026/11/07/business/economy/nvidia-chips-chinese-firms.html
3•porridgeraisin•34m ago•0 comments

Show HN: SafeScript, a safe version of JavaScript for executing untrusted code

https://github.com/SafeScript/safescript
2•EGreg•36m ago•0 comments

Show HN: A kernel written in Rust that can boot Ubuntu with Plasma desktop

https://github.com/ozkl/ruxis
1•ozkl•36m ago•0 comments

Piezoelectric toothbrush reduces plaque

https://www.science.org/doi/10.1126/sciadv.aeg5744
1•Gaishan•37m ago•0 comments

Ask HN: What are you working on? (November 2026)

12•david927•42m ago•68 comments

Surnames

https://dogdogfish.com/blog/2026/11/08/surnames/
3•matthewsharpe3•45m ago•0 comments

Microseason.app

https://www.microseason.app
2•mfix22•46m ago•1 comments

Future startup ideas, excavated from science fiction

https://absurd.website/startup-archaeology/
3•thunderbong•48m ago•0 comments

Welcome to Boulder Ruby

https://boulder-ruby.org/
1•mooreds•48m ago•0 comments

Nvidia launches investigation into CEO's affair with suspected Chinese spy

https://www.bbc.co.uk/news/articles/c3dxw10rjn9no
9•haritha-j•52m ago•1 comments

There Is No Place in a Functional Society for Elon Musk

https://defector.com/there-is-no-place-in-a-functional-society-for-elon-musk
8•HotGarbage•56m ago•2 comments

UK Government 'looking seriously' at banning under-16s from Vinted and eBay

https://www.bbc.co.uk/news/articles/cmzxjvpqrjxro
4•Lio•56m ago•3 comments

Making profile-guided optimization reproducible

https://fzakaria.com/2026/11/07/making-profile-guided-optimization-reproducible
1•ingve•57m ago•0 comments

Mstein – Ich klau den RAM

https://www.youtube.com/watch?v=8kd67EQaieU
1•amai•59m ago•0 comments

Nvidia's Jensen Huang admits to affair with Chinese spy

https://www.ft.com/content/1397e2f4-d7f5-4cbb-a4d9-04ecf661d1aa
10•zaki_01•59m ago•1 comments

You can no longer (un-)star archived GitHub repositories

https://joshua.hu/github-cannot-star-archived-repository
2•mmsc•1h ago•0 comments