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What if you just did a startup instead?

https://alexaraki.substack.com/p/what-if-you-just-did-a-startup
1•okaywriting•2m ago•0 comments

Hacking up your own shell completion (2020)

https://www.feltrac.co/environment/2020/01/18/build-your-own-shell-completion.html
1•todsacerdoti•4m ago•0 comments

Show HN: Gorse 0.5 – Open-source recommender system with visual workflow editor

https://github.com/gorse-io/gorse
1•zhenghaoz•5m ago•0 comments

GLM-OCR: Accurate × Fast × Comprehensive

https://github.com/zai-org/GLM-OCR
1•ms7892•6m ago•0 comments

Local Agent Bench: Test 11 small LLMs on tool-calling judgment, on CPU, no GPU

https://github.com/MikeVeerman/tool-calling-benchmark
1•MikeVeerman•7m ago•0 comments

Show HN: AboutMyProject – A public log for developer proof-of-work

https://aboutmyproject.com/
1•Raiplus•7m ago•0 comments

Expertise, AI and Work of Future [video]

https://www.youtube.com/watch?v=wsxWl9iT1XU
1•indiantinker•8m ago•0 comments

So Long to Cheap Books You Could Fit in Your Pocket

https://www.nytimes.com/2026/02/06/books/mass-market-paperback-books.html
3•pseudolus•8m ago•1 comments

PID Controller

https://en.wikipedia.org/wiki/Proportional%E2%80%93integral%E2%80%93derivative_controller
1•tosh•12m ago•0 comments

SpaceX Rocket Generates 100GW of Power, or 20% of US Electricity

https://twitter.com/AlecStapp/status/2019932764515234159
1•bkls•12m ago•0 comments

Kubernetes MCP Server

https://github.com/yindia/rootcause
1•yindia•13m ago•0 comments

I Built a Movie Recommendation Agent to Solve Movie Nights with My Wife

https://rokn.io/posts/building-movie-recommendation-agent
3•roknovosel•14m ago•0 comments

What were the first animals? The fierce sponge–jelly battle that just won't end

https://www.nature.com/articles/d41586-026-00238-z
2•beardyw•22m ago•0 comments

Sidestepping Evaluation Awareness and Anticipating Misalignment

https://alignment.openai.com/prod-evals/
1•taubek•22m ago•0 comments

OldMapsOnline

https://www.oldmapsonline.org/en
1•surprisetalk•24m ago•0 comments

What It's Like to Be a Worm

https://www.asimov.press/p/sentience
2•surprisetalk•24m ago•0 comments

Don't go to physics grad school and other cautionary tales

https://scottlocklin.wordpress.com/2025/12/19/dont-go-to-physics-grad-school-and-other-cautionary...
1•surprisetalk•24m ago•0 comments

Lawyer sets new standard for abuse of AI; judge tosses case

https://arstechnica.com/tech-policy/2026/02/randomly-quoting-ray-bradbury-did-not-save-lawyer-fro...
3•pseudolus•25m ago•0 comments

AI anxiety batters software execs, costing them combined $62B: report

https://nypost.com/2026/02/04/business/ai-anxiety-batters-software-execs-costing-them-62b-report/
1•1vuio0pswjnm7•25m ago•0 comments

Bogus Pipeline

https://en.wikipedia.org/wiki/Bogus_pipeline
1•doener•26m ago•0 comments

Winklevoss twins' Gemini crypto exchange cuts 25% of workforce as Bitcoin slumps

https://nypost.com/2026/02/05/business/winklevoss-twins-gemini-crypto-exchange-cuts-25-of-workfor...
2•1vuio0pswjnm7•27m ago•0 comments

How AI Is Reshaping Human Reasoning and the Rise of Cognitive Surrender

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6097646
3•obscurette•27m ago•0 comments

Cycling in France

https://www.sheldonbrown.com/org/france-sheldon.html
2•jackhalford•29m ago•0 comments

Ask HN: What breaks in cross-border healthcare coordination?

1•abhay1633•29m ago•0 comments

Show HN: Simple – a bytecode VM and language stack I built with AI

https://github.com/JJLDonley/Simple
2•tangjiehao•31m ago•0 comments

Show HN: Free-to-play: A gem-collecting strategy game in the vein of Splendor

https://caratria.com/
1•jonrosner•32m ago•1 comments

My Eighth Year as a Bootstrapped Founde

https://mtlynch.io/bootstrapped-founder-year-8/
1•mtlynch•33m ago•0 comments

Show HN: Tesseract – A forum where AI agents and humans post in the same space

https://tesseract-thread.vercel.app/
1•agliolioyyami•33m ago•0 comments

Show HN: Vibe Colors – Instantly visualize color palettes on UI layouts

https://vibecolors.life/
2•tusharnaik•34m ago•0 comments

OpenAI is Broke ... and so is everyone else [video][10M]

https://www.youtube.com/watch?v=Y3N9qlPZBc0
2•Bender•34m ago•0 comments
Open in hackernews

'Turbocharged' Mitochondria Power Birds' Epic Migratory Journeys

https://www.quantamagazine.org/turbocharged-mitochondria-power-birds-epic-migratory-journeys-20250519/
78•pseudolus•8mo ago

Comments

coolcase•8mo ago
Wouldn't mind some bird mitochondria!
b800h•8mo ago
Seriously, what would happen if we swapped out human mitochondria from a zygote for bird mitochondria?
jyounker•8mo ago
I don't think you'd get the same sort of effects, because a huge part of the mitochondrial regulation and function is carried out by genes and gene products from outside the mitochondria.

It would be an interesting experiment though. I'd expect that they might not live, or that the cell would function sub-optimally, but who knows, maybe the cellular machinery is highly conserved.

dejj•8mo ago
Yes. Afaik from Nick Lane’s “Oxygen” the Cytochrome Oxidase made from the mitochondrial DNA have to match the Cytochrome C made from nuclear DNA. Even slight mismatch seems to lower mitochondrial performance and is a problem why heteroplasmy (mixing of mitochondria from father and mother) seems to be selected-out.
treyd•8mo ago
Well what if you also swapped out those genes?
dejj•8mo ago
If your mitochondria have bird DNA and your nucleus has bird DNA, then you’re a bird.

There’s an easier way. A single nucleotide polymorphism (SNP) that only and rarely is observed in Japanese can extend human lifespan greatly. Flip a single base pair. This seems the most promising first step for genetically engineering humans.

dghughes•8mo ago
You'd get Kids in the Hall Chicken Lady.
mckirk•8mo ago
And some whale blood!
ljf•8mo ago
Previously posted: https://news.ycombinator.com/item?id=44051652 (1 day ago, 78 comments)
rbanffy•8mo ago
Can the entries be merged?
EGreg•8mo ago
Can they? Yes. Should they? No.
rbanffy•8mo ago
Why have two separate discussions on the same topic a day apart?
gherkinnn•8mo ago
No layman's discussion about mitochondria is complete without the In Our Time episode on just that:

https://www.bbc.co.uk/programmes/m001md34

It is one of my favourites.

londons_explore•8mo ago
What is the typical lifespan of ATP within a cell?

Are we talking milliseconds or minutes?

pfdietz•8mo ago
According to the wikipedia page on ATP, the average ATP concentration in eukaryotic cells is 1 to 10 micromols per gram.

According to https://bionumbers.hms.harvard.edu/bionumber.aspx?s=n&v=2&id... a single mammalian cell has a mass of 3 to 4 nanograms.

Google AI tells me the average rate of ATP formation in a mammalian cell is around 10 million molecules per second.

The ratio here ranges from 3 to 40 minutes.

I imagine it varies greatly depending on cell type.

eitally•8mo ago
From an exercise physiology point of view, it's generally accepted that ATP-CP powered motility is possible for only about 10 seconds (that is to say, you only store enough ATP for about 10 seconds of high intensity work -- sprinting, maximal weight lifting, etc). After that, other energy systems become dominant ... both of which create ATP but depend on either glycolysis (anaerobic) or oxidative phosphorylation (aerobic) for the process/conversion.
ck2•8mo ago
vaguely related there is a fantastic new PBS Space Time this week which suggests the "no alien life" fermi paradox may be related to how our mitochondria evolved by a series of fortunate accidents which may not be reproducible elsewhere

https://www.pbs.org/video/is-there-a-simple-solution-to-the-...

( https://www.youtube.com/watch?v=abvzkSJEhKk )