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Newfound Mechanism Rewires Cellular Energy Processing for Drastic Weight Loss

https://nyulangone.org/news/newfound-mechanism-rewires-cellular-energy-processing-drastic-weight-loss
14•gnabgib•1d ago

Comments

WithinReason•1d ago
Reminds me of DNP: https://en.wikipedia.org/wiki/2,4-Dinitrophenol
kylehotchkiss•1d ago
If you're submerged in ice for a few hours, maybe?
molticrystal•1d ago
The actual paper: https://www.nature.com/articles/s41586-025-08996-y

The most important part, especially if somebody is wondering if they might wither away, weaken from massive weight loss, and have a good chance of organ harm:

>We did not observe significant differences in muscle (quadricep) histology across the four groups (Extended Data Fig. 2f,g). In the liver, there was no significant fat accumulation or apparent pathology (Extended Data Fig. 2h,i). These findings may explain the lack of any effects on movement and the ease with which Cse−/− mice on a no-Cys diet can recover.

Unfortunately, an easy (maybe the easiest and most accessible) way to avoid cysteine and its precursor methionine is to have a low protein diet(Fruits, Non-starchy low-sulfur Vegetables, Fats and Sugars) but without protein you may lose a lot of muscle mass and have other issues as well.

gnabgib•1d ago
You'll note the authors of this article are also authors of the paper, "actual paper" is a bit strong (this isn't AI slurm).
kylehotchkiss•1d ago
30% weight loss in a week sounds more like dying than a dietary adjustment. I'm sure the side effects of this will be unpleasant.

Enjoy drinking your Soylent Zero Cysteine, everybody!!

Former McKinsey partner jailed for deleting emails on US opioid work

https://www.ft.com/content/5e769fdf-8e80-4686-8118-53ac0b1a6f58
1•haltingproblem•3m ago•0 comments

SDR-RDMA: Software-Defined Reliability Architecture for Planetary Scale RDMA

https://arxiv.org/abs/2505.05366
1•tanelpoder•3m ago•0 comments

Like Lovable but can make apps with gen-AI powered back ends

https://getcreatr.com/
2•JonanJ•4m ago•0 comments

Do chatbots have free speech? Judge rejects claim in suit over teen's death

https://www.washingtonpost.com/nation/2025/05/22/sewell-setzer-suicide-ai-character-court-lawsuit/
1•jonny_eh•5m ago•0 comments

Twitter down as users of Elon Musk's X app report major issues

https://www.mirror.co.uk/news/uk-news/breaking-twitter-down-users-elon-35273712
1•andrewfromx•6m ago•0 comments

The Linux Memory Manager

https://linuxmemory.org/
1•teleforce•7m ago•0 comments

Gaming Out a Sudden Stop

https://paulkrugman.substack.com/p/gaming-out-a-sudden-stop
1•imichael•12m ago•0 comments

Spack: Flexible package manager supporting multi versions, configs and compilers

https://spack.io/
1•teleforce•13m ago•0 comments

Bajaj to Acquire KTM

https://www.motorcycle.com/bikes/news/bajaj-to-acquire-ktm-44622745
2•lwo32k•15m ago•0 comments

The Israel Embassy Shooter Manifesto

https://www.kenklippenstein.com/p/the-israel-embassy-shooter-manifesto
1•mhga•17m ago•0 comments

Five – A minimalist, to-do list and calendar

https://apps.apple.com/us/app/five-todo-list-calendar/id6740851007
1•gokbek•21m ago•0 comments

Unexplained electronics found in imported equipment for Denmark's supply network

https://www.reuters.com/sustainability/boards-policy-regulation/unexplained-components-found-denmarks-energy-equipment-imports-industry-group-2025-05-21/
3•namanyayg•24m ago•0 comments

Philosopher Alasdair MacIntyre has died

https://en.wikipedia.org/wiki/Alasdair_MacIntyre
2•keiferski•26m ago•1 comments

Show HN: Cardog – AI car companion for transparent ownership

https://cardog.app/waitlist
2•samsullivan•31m ago•0 comments

Show HN: KelpsGet – Modern download manager built in Rust

https://github.com/davimf721/KelpsGet
1•Ghoulmf7221•32m ago•0 comments

Some US banks explore venturing into crypto with joint stablecoin, WSJ reports

https://www.reuters.com/business/finance/some-us-banks-explore-venturing-into-crypto-with-joint-stablecoin-wsj-reports-2025-05-23/
5•cempaka•42m ago•1 comments

CRDTs #2: Turtles All the Way Down

https://jhellerstein.github.io/blog/crdt-turtles/
2•pfarago•50m ago•0 comments

Silly job interview questions in Haskell

https://chrispenner.ca/posts/interview
3•behnamoh•52m ago•0 comments

STS-61

https://en.wikipedia.org/wiki/STS-61
1•sarego•58m ago•0 comments

Show HN: I made a zero-setup back end API to launch apps without coding back end

https://github.com/broadwayinc/skapi-js
1•skapi_api•1h ago•0 comments

Mistral Document AI

https://mistral.ai/solutions/document-ai
2•ianhawes•1h ago•0 comments

Banana Pi BPI-Forge1 Is a Low-Cost RK3506J-Based SBC Compatible with RT-Thread

https://linuxgizmos.com/banana-pi-bpi-forge1-is-a-low-cost-rk3506j-based-sbc-compatible-with-rt-thread/
3•PixelN0va•1h ago•0 comments

Our Problem with Backlogs

https://www.octomind.dev/blog/our-problem-with-backlogs
1•thunderbong•1h ago•0 comments

Tariff Exemptions Are Terrible News for Electronics Repairability

https://www.ifixit.com/News/110121/tariff-exemptions-are-terrible-news-for-electronics-repairability
4•gnabgib•1h ago•0 comments

Ask HN: How do you feel about using AI tools on your phone? Privacy vs. Utility

1•fallinditch•1h ago•1 comments

Good Performance for Bad Days

https://brooker.co.za/blog/2025/05/20/icpe.html
1•SchwKatze•1h ago•0 comments

Kling 2.0: ready to turn your ideas into motion

https://twitter.com/wavespeed_ai/status/1925049015126970378
1•sylm•1h ago•0 comments

Bodybuilding star Nikita Tkachuk dead at 35

https://www.the-sun.com/sport/14296862/bodybuilding-star-nikita-tkachuk-dead-muscle-growth-injections/
3•wslh•1h ago•0 comments

US Treasury to stop producing pennies next year

https://www.bbc.com/news/articles/cx2j07858lno
6•DarkContinent•1h ago•0 comments

Show HN: I created a tool intro.new – Make your intro page in seconds

https://intro.new/
1•hellohacker007•1h ago•0 comments