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The next frontier in weight-loss drugs: one-time gene therapy

https://www.washingtonpost.com/health/2026/01/24/fractyl-glp1-gene-therapy/
1•bookofjoe•2m ago•1 comments

At Age 25, Wikipedia Refuses to Evolve

https://spectrum.ieee.org/wikipedia-at-25
1•asdefghyk•5m ago•2 comments

Show HN: ReviewReact – AI review responses inside Google Maps ($19/mo)

https://reviewreact.com
1•sara_builds•5m ago•0 comments

Why AlphaTensor Failed at 3x3 Matrix Multiplication: The Anchor Barrier

https://zenodo.org/records/18514533
1•DarenWatson•6m ago•0 comments

Ask HN: How much of your token use is fixing the bugs Claude Code causes?

1•laurex•10m ago•0 comments

Show HN: Agents – Sync MCP Configs Across Claude, Cursor, Codex Automatically

https://github.com/amtiYo/agents
1•amtiyo•10m ago•0 comments

Hello

1•otrebladih•12m ago•0 comments

FSD helped save my father's life during a heart attack

https://twitter.com/JJackBrandt/status/2019852423980875794
2•blacktulip•15m ago•0 comments

Show HN: Writtte – Draft and publish articles without reformatting, anywhere

https://writtte.xyz
1•lasgawe•16m ago•0 comments

Portuguese icon (FROM A CAN) makes a simple meal (Canned Fish Files) [video]

https://www.youtube.com/watch?v=e9FUdOfp8ME
1•zeristor•18m ago•0 comments

Brookhaven Lab's RHIC Concludes 25-Year Run with Final Collisions

https://www.hpcwire.com/off-the-wire/brookhaven-labs-rhic-concludes-25-year-run-with-final-collis...
2•gnufx•20m ago•0 comments

Transcribe your aunts post cards with Gemini 3 Pro

https://leserli.ch/ocr/
1•nielstron•24m ago•0 comments

.72% Variance Lance

1•mav5431•25m ago•0 comments

ReKindle – web-based operating system designed specifically for E-ink devices

https://rekindle.ink
1•JSLegendDev•27m ago•0 comments

Encrypt It

https://encryptitalready.org/
1•u1hcw9nx•27m ago•1 comments

NextMatch – 5-minute video speed dating to reduce ghosting

https://nextmatchdating.netlify.app/
1•Halinani8•28m ago•1 comments

Personalizing esketamine treatment in TRD and TRBD

https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1736114
1•PaulHoule•29m ago•0 comments

SpaceKit.xyz – a browser‑native VM for decentralized compute

https://spacekit.xyz
1•astorrivera•30m ago•0 comments

NotebookLM: The AI that only learns from you

https://byandrev.dev/en/blog/what-is-notebooklm
2•byandrev•30m ago•1 comments

Show HN: An open-source starter kit for developing with Postgres and ClickHouse

https://github.com/ClickHouse/postgres-clickhouse-stack
1•saisrirampur•31m ago•0 comments

Game Boy Advance d-pad capacitor measurements

https://gekkio.fi/blog/2026/game-boy-advance-d-pad-capacitor-measurements/
1•todsacerdoti•31m ago•0 comments

South Korean crypto firm accidentally sends $44B in bitcoins to users

https://www.reuters.com/world/asia-pacific/crypto-firm-accidentally-sends-44-billion-bitcoins-use...
2•layer8•32m ago•0 comments

Apache Poison Fountain

https://gist.github.com/jwakely/a511a5cab5eb36d088ecd1659fcee1d5
1•atomic128•34m ago•2 comments

Web.whatsapp.com appears to be having issues syncing and sending messages

http://web.whatsapp.com
1•sabujp•34m ago•2 comments

Google in Your Terminal

https://gogcli.sh/
1•johlo•36m ago•0 comments

Shannon: Claude Code for Pen Testing: #1 on Github today

https://github.com/KeygraphHQ/shannon
1•hendler•36m ago•0 comments

Anthropic: Latest Claude model finds more than 500 vulnerabilities

https://www.scworld.com/news/anthropic-latest-claude-model-finds-more-than-500-vulnerabilities
2•Bender•40m ago•0 comments

Brooklyn cemetery plans human composting option, stirring interest and debate

https://www.cbsnews.com/newyork/news/brooklyn-green-wood-cemetery-human-composting/
1•geox•40m ago•0 comments

Why the 'Strivers' Are Right

https://greyenlightenment.com/2026/02/03/the-strivers-were-right-all-along/
1•paulpauper•42m ago•0 comments

Brain Dumps as a Literary Form

https://davegriffith.substack.com/p/brain-dumps-as-a-literary-form
1•gmays•42m ago•0 comments
Open in hackernews

Newfound Mechanism Rewires Cellular Energy Processing for Drastic Weight Loss

https://nyulangone.org/news/newfound-mechanism-rewires-cellular-energy-processing-drastic-weight-loss
16•gnabgib•8mo ago

Comments

WithinReason•8mo ago
Reminds me of DNP: https://en.wikipedia.org/wiki/2,4-Dinitrophenol
kylehotchkiss•8mo ago
If you're submerged in ice for a few hours, maybe?
molticrystal•8mo ago
The actual paper: https://www.nature.com/articles/s41586-025-08996-y

The most important part, especially if somebody is wondering if they might wither away, weaken from massive weight loss, and have a good chance of organ harm:

>We did not observe significant differences in muscle (quadricep) histology across the four groups (Extended Data Fig. 2f,g). In the liver, there was no significant fat accumulation or apparent pathology (Extended Data Fig. 2h,i). These findings may explain the lack of any effects on movement and the ease with which Cse−/− mice on a no-Cys diet can recover.

Unfortunately, an easy (maybe the easiest and most accessible) way to avoid cysteine and its precursor methionine is to have a low protein diet(Fruits, Non-starchy low-sulfur Vegetables, Fats and Sugars) but without protein you may lose a lot of muscle mass and have other issues as well.

gnabgib•8mo ago
You'll note the authors of this article are also authors of the paper, "actual paper" is a bit strong (this isn't AI slurm).
kylehotchkiss•8mo ago
30% weight loss in a week sounds more like dying than a dietary adjustment. I'm sure the side effects of this will be unpleasant.

Enjoy drinking your Soylent Zero Cysteine, everybody!!