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Maple Mono: Smooth your coding flow

https://font.subf.dev/en/
1•signa11•6m ago•0 comments

Sid Meier's System for Real-Time Music Composition and Synthesis

https://patents.google.com/patent/US5496962A/en
1•GaryBluto•13m ago•1 comments

Show HN: Slop News – HN front page now, but it's all slop

https://dosaygo-studio.github.io/hn-front-page-2035/slop-news
3•keepamovin•14m ago•1 comments

Show HN: Empusa – Visual debugger to catch and resume AI agent retry loops

https://github.com/justin55afdfdsf5ds45f4ds5f45ds4/EmpusaAI
1•justinlord•17m ago•0 comments

Show HN: Bitcoin wallet on NXP SE050 secure element, Tor-only open source

https://github.com/0xdeadbeefnetwork/sigil-web
2•sickthecat•19m ago•1 comments

White House Explores Opening Antitrust Probe on Homebuilders

https://www.bloomberg.com/news/articles/2026-02-06/white-house-explores-opening-antitrust-probe-i...
1•petethomas•19m ago•0 comments

Show HN: MindDraft – AI task app with smart actions and auto expense tracking

https://minddraft.ai
2•imthepk•24m ago•0 comments

How do you estimate AI app development costs accurately?

1•insights123•25m ago•0 comments

Going Through Snowden Documents, Part 5

https://libroot.org/posts/going-through-snowden-documents-part-5/
1•goto1•26m ago•0 comments

Show HN: MCP Server for TradeStation

https://github.com/theelderwand/tradestation-mcp
1•theelderwand•28m ago•0 comments

Canada unveils auto industry plan in latest pivot away from US

https://www.bbc.com/news/articles/cvgd2j80klmo
2•breve•29m ago•1 comments

The essential Reinhold Niebuhr: selected essays and addresses

https://archive.org/details/essentialreinhol0000nieb
1•baxtr•32m ago•0 comments

Rentahuman.ai Turns Humans into On-Demand Labor for AI Agents

https://www.forbes.com/sites/ronschmelzer/2026/02/05/when-ai-agents-start-hiring-humans-rentahuma...
1•tempodox•34m ago•0 comments

StovexGlobal – Compliance Gaps to Note

1•ReviewShield•37m ago•1 comments

Show HN: Afelyon – Turns Jira tickets into production-ready PRs (multi-repo)

https://afelyon.com/
1•AbduNebu•38m ago•0 comments

Trump says America should move on from Epstein – it may not be that easy

https://www.bbc.com/news/articles/cy4gj71z0m0o
6•tempodox•38m ago•2 comments

Tiny Clippy – A native Office Assistant built in Rust and egui

https://github.com/salva-imm/tiny-clippy
1•salvadorda656•43m ago•0 comments

LegalArgumentException: From Courtrooms to Clojure – Sen [video]

https://www.youtube.com/watch?v=cmMQbsOTX-o
1•adityaathalye•45m ago•0 comments

US moves to deport 5-year-old detained in Minnesota

https://www.reuters.com/legal/government/us-moves-deport-5-year-old-detained-minnesota-2026-02-06/
8•petethomas•49m ago•3 comments

If you lose your passport in Austria, head for McDonald's Golden Arches

https://www.cbsnews.com/news/us-embassy-mcdonalds-restaurants-austria-hotline-americans-consular-...
1•thunderbong•53m ago•0 comments

Show HN: Mermaid Formatter – CLI and library to auto-format Mermaid diagrams

https://github.com/chenyanchen/mermaid-formatter
1•astm•1h ago•0 comments

RFCs vs. READMEs: The Evolution of Protocols

https://h3manth.com/scribe/rfcs-vs-readmes/
3•init0•1h ago•1 comments

Kanchipuram Saris and Thinking Machines

https://altermag.com/articles/kanchipuram-saris-and-thinking-machines
1•trojanalert•1h ago•0 comments

Chinese chemical supplier causes global baby formula recall

https://www.reuters.com/business/healthcare-pharmaceuticals/nestle-widens-french-infant-formula-r...
2•fkdk•1h ago•0 comments

I've used AI to write 100% of my code for a year as an engineer

https://old.reddit.com/r/ClaudeCode/comments/1qxvobt/ive_used_ai_to_write_100_of_my_code_for_1_ye...
2•ukuina•1h ago•1 comments

Looking for 4 Autistic Co-Founders for AI Startup (Equity-Based)

1•au-ai-aisl•1h ago•1 comments

AI-native capabilities, a new API Catalog, and updated plans and pricing

https://blog.postman.com/new-capabilities-march-2026/
1•thunderbong•1h ago•0 comments

What changed in tech from 2010 to 2020?

https://www.tedsanders.com/what-changed-in-tech-from-2010-to-2020/
3•endorphine•1h ago•0 comments

From Human Ergonomics to Agent Ergonomics

https://wesmckinney.com/blog/agent-ergonomics/
1•Anon84•1h ago•0 comments

Advanced Inertial Reference Sphere

https://en.wikipedia.org/wiki/Advanced_Inertial_Reference_Sphere
1•cyanf•1h ago•0 comments
Open in hackernews

Efficient mRNA delivery to resting T cells to reverse HIV latency

https://www.nature.com/articles/s41467-025-60001-2
110•matthewmacleod•8mo ago

Comments

Jalad•8mo ago
Also discussed here https://news.ycombinator.com/item?id=44202664
Zigurd•8mo ago
MRNA therapies have such high potential, there really ought to be much more public education and outreach to prevent people falling down the quackery rabbit hole. I don't just say that to pile on to the quacks. It's so detrimental and costs so many lives that it's probably a target for influence by adversary nation actors.
therein•8mo ago
[flagged]
foota•8mo ago
Unsubstantiated skepticism is unhealthy.
briangriffinfan•8mo ago
One requires a better reason than simply because they were told that their skepticism is unsubstantiated.
the_real_cher•8mo ago
Lobotomy's were viewed to have so much high potential back in the day that they won the Nobel prize.

In true scientific fashion both sides would ideally just stick with the facts.

hobs•8mo ago
There's no "both sides" in science.
more_corn•8mo ago
I mean, there is the side that is backed by evidence and the one that is not. That’s two sides. I just don’t feel inclined to listen to the side that is not.
the_real_cher•8mo ago
I guess the side that give the Nobel prize to lobotomies wasnt backed by evidence?

Or were they backed by evidence?

And then stronger more compelling evidence came out later against?

Thats kind of how science works, its a process of discovery not a set in stone right/wrong.

Things arent as reductionist as you claim, it does people good when they open their world up to that fact.

sheepdestroyer•8mo ago
Not only in science. Even (or especially) in impartial journalism or public debate, there's no valid reason why any unfounded (thus illegitimate) opinions should get as much consideration as sound and researched arguments.
dpe82•8mo ago
If we hadn't had a pandemic in which lots of people lost their collective minds and an irresponsible political machine that took advantage of that, mRNA would be pretty universally hailed as the miracle it is.

That aside, yes. Education is important. Sadly at least in the US some of the people who lost their minds are now in charge of such education.

chasil•8mo ago
This article asserts that white blood cells are the target, but we also know that (within the brain) astrocytes and [iirc] microglia can bear latent infection.

Is such a carrier capable of addressing latent reservoirs inside the blood-brain barrier? Can it cross the barrier, pervade the cerebrospinal fluid, then penetrate all infected cells?

White blood cells are a fantastic achievement, but far from the whole story.

joemazerino•8mo ago
Part of the pushback was the use of censorship apparatus during COVID. Science is supposed to be open to dispute, and silencing opposing opinions only adds to the conspiracy fuel.
sroussey•8mo ago
I wonder if this can be used for other latent viruses that embed in cells like herpes and chickenpox/shingles.
XorNot•8mo ago
That would be interesting because both of those have links to various late-life neurological conditions aa well.
stephen_g•8mo ago
Yeah, latent EBV would be great too since it seems to be one of the main causes of MS.

I believe this is already being researched with mRNA now, it would be amazing if it works out and we could treat all of these.

amy214•8mo ago
Not just those but there are various other lesser known latent viruses such as JC virus and BK virus. Most of us are infected with these viruses latently. For most of us, they do nothing (that we know of!) for life. For the immunosuppressed (eg AIDS, organ transplants), because there is no immune system to keep these viruses "latent", they do actually reactivate and cause problems. For viruses which operate by embedding themselves in the DNA itself, such that for some time the virus may only exist as information encoded in some nucleotides and not a physical virus, to cure that would be a powerful achievement