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GPT-5.3-Codex System Card [pdf]

https://cdn.openai.com/pdf/23eca107-a9b1-4d2c-b156-7deb4fbc697c/GPT-5-3-Codex-System-Card-02.pdf
1•tosh•7m ago•0 comments

Atlas: Manage your database schema as code

https://github.com/ariga/atlas
1•quectophoton•10m ago•0 comments

Geist Pixel

https://vercel.com/blog/introducing-geist-pixel
1•helloplanets•12m ago•0 comments

Show HN: MCP to get latest dependency package and tool versions

https://github.com/MShekow/package-version-check-mcp
1•mshekow•20m ago•0 comments

The better you get at something, the harder it becomes to do

https://seekingtrust.substack.com/p/improving-at-writing-made-me-almost
2•FinnLobsien•22m ago•0 comments

Show HN: WP Float – Archive WordPress blogs to free static hosting

https://wpfloat.netlify.app/
1•zizoulegrande•23m ago•0 comments

Show HN: I Hacked My Family's Meal Planning with an App

https://mealjar.app
1•melvinzammit•24m ago•0 comments

Sony BMG copy protection rootkit scandal

https://en.wikipedia.org/wiki/Sony_BMG_copy_protection_rootkit_scandal
1•basilikum•26m ago•0 comments

The Future of Systems

https://novlabs.ai/mission/
2•tekbog•27m ago•1 comments

NASA now allowing astronauts to bring their smartphones on space missions

https://twitter.com/NASAAdmin/status/2019259382962307393
2•gbugniot•31m ago•0 comments

Claude Code Is the Inflection Point

https://newsletter.semianalysis.com/p/claude-code-is-the-inflection-point
3•throwaw12•33m ago•1 comments

Show HN: MicroClaw – Agentic AI Assistant for Telegram, Built in Rust

https://github.com/microclaw/microclaw
1•everettjf•33m ago•2 comments

Show HN: Omni-BLAS – 4x faster matrix multiplication via Monte Carlo sampling

https://github.com/AleatorAI/OMNI-BLAS
1•LowSpecEng•34m ago•1 comments

The AI-Ready Software Developer: Conclusion – Same Game, Different Dice

https://codemanship.wordpress.com/2026/01/05/the-ai-ready-software-developer-conclusion-same-game...
1•lifeisstillgood•36m ago•0 comments

AI Agent Automates Google Stock Analysis from Financial Reports

https://pardusai.org/view/54c6646b9e273bbe103b76256a91a7f30da624062a8a6eeb16febfe403efd078
1•JasonHEIN•39m ago•0 comments

Voxtral Realtime 4B Pure C Implementation

https://github.com/antirez/voxtral.c
2•andreabat•42m ago•1 comments

I Was Trapped in Chinese Mafia Crypto Slavery [video]

https://www.youtube.com/watch?v=zOcNaWmmn0A
2•mgh2•48m ago•0 comments

U.S. CBP Reported Employee Arrests (FY2020 – FYTD)

https://www.cbp.gov/newsroom/stats/reported-employee-arrests
1•ludicrousdispla•50m ago•0 comments

Show HN: I built a free UCP checker – see if AI agents can find your store

https://ucphub.ai/ucp-store-check/
2•vladeta•55m ago•1 comments

Show HN: SVGV – A Real-Time Vector Video Format for Budget Hardware

https://github.com/thealidev/VectorVision-SVGV
1•thealidev•56m ago•0 comments

Study of 150 developers shows AI generated code no harder to maintain long term

https://www.youtube.com/watch?v=b9EbCb5A408
1•lifeisstillgood•57m ago•0 comments

Spotify now requires premium accounts for developer mode API access

https://www.neowin.net/news/spotify-now-requires-premium-accounts-for-developer-mode-api-access/
1•bundie•59m ago•0 comments

When Albert Einstein Moved to Princeton

https://twitter.com/Math_files/status/2020017485815456224
1•keepamovin•1h ago•0 comments

Agents.md as a Dark Signal

https://joshmock.com/post/2026-agents-md-as-a-dark-signal/
2•birdculture•1h ago•0 comments

System time, clocks, and their syncing in macOS

https://eclecticlight.co/2025/05/21/system-time-clocks-and-their-syncing-in-macos/
1•fanf2•1h ago•0 comments

McCLIM and 7GUIs – Part 1: The Counter

https://turtleware.eu/posts/McCLIM-and-7GUIs---Part-1-The-Counter.html
2•ramenbytes•1h ago•0 comments

So whats the next word, then? Almost-no-math intro to transformer models

https://matthias-kainer.de/blog/posts/so-whats-the-next-word-then-/
1•oesimania•1h ago•0 comments

Ed Zitron: The Hater's Guide to Microsoft

https://bsky.app/profile/edzitron.com/post/3me7ibeym2c2n
2•vintagedave•1h ago•1 comments

UK infants ill after drinking contaminated baby formula of Nestle and Danone

https://www.bbc.com/news/articles/c931rxnwn3lo
1•__natty__•1h ago•0 comments

Show HN: Android-based audio player for seniors – Homer Audio Player

https://homeraudioplayer.app
3•cinusek•1h ago•2 comments
Open in hackernews

Efficient mRNA delivery to resting T cells to reverse HIV latency

https://www.nature.com/articles/s41467-025-60001-2
110•matthewmacleod•8mo ago

Comments

Jalad•8mo ago
Also discussed here https://news.ycombinator.com/item?id=44202664
Zigurd•8mo ago
MRNA therapies have such high potential, there really ought to be much more public education and outreach to prevent people falling down the quackery rabbit hole. I don't just say that to pile on to the quacks. It's so detrimental and costs so many lives that it's probably a target for influence by adversary nation actors.
therein•8mo ago
[flagged]
foota•8mo ago
Unsubstantiated skepticism is unhealthy.
briangriffinfan•8mo ago
One requires a better reason than simply because they were told that their skepticism is unsubstantiated.
the_real_cher•8mo ago
Lobotomy's were viewed to have so much high potential back in the day that they won the Nobel prize.

In true scientific fashion both sides would ideally just stick with the facts.

hobs•8mo ago
There's no "both sides" in science.
more_corn•8mo ago
I mean, there is the side that is backed by evidence and the one that is not. That’s two sides. I just don’t feel inclined to listen to the side that is not.
the_real_cher•8mo ago
I guess the side that give the Nobel prize to lobotomies wasnt backed by evidence?

Or were they backed by evidence?

And then stronger more compelling evidence came out later against?

Thats kind of how science works, its a process of discovery not a set in stone right/wrong.

Things arent as reductionist as you claim, it does people good when they open their world up to that fact.

sheepdestroyer•8mo ago
Not only in science. Even (or especially) in impartial journalism or public debate, there's no valid reason why any unfounded (thus illegitimate) opinions should get as much consideration as sound and researched arguments.
dpe82•8mo ago
If we hadn't had a pandemic in which lots of people lost their collective minds and an irresponsible political machine that took advantage of that, mRNA would be pretty universally hailed as the miracle it is.

That aside, yes. Education is important. Sadly at least in the US some of the people who lost their minds are now in charge of such education.

chasil•8mo ago
This article asserts that white blood cells are the target, but we also know that (within the brain) astrocytes and [iirc] microglia can bear latent infection.

Is such a carrier capable of addressing latent reservoirs inside the blood-brain barrier? Can it cross the barrier, pervade the cerebrospinal fluid, then penetrate all infected cells?

White blood cells are a fantastic achievement, but far from the whole story.

joemazerino•8mo ago
Part of the pushback was the use of censorship apparatus during COVID. Science is supposed to be open to dispute, and silencing opposing opinions only adds to the conspiracy fuel.
sroussey•8mo ago
I wonder if this can be used for other latent viruses that embed in cells like herpes and chickenpox/shingles.
XorNot•8mo ago
That would be interesting because both of those have links to various late-life neurological conditions aa well.
stephen_g•8mo ago
Yeah, latent EBV would be great too since it seems to be one of the main causes of MS.

I believe this is already being researched with mRNA now, it would be amazing if it works out and we could treat all of these.

amy214•8mo ago
Not just those but there are various other lesser known latent viruses such as JC virus and BK virus. Most of us are infected with these viruses latently. For most of us, they do nothing (that we know of!) for life. For the immunosuppressed (eg AIDS, organ transplants), because there is no immune system to keep these viruses "latent", they do actually reactivate and cause problems. For viruses which operate by embedding themselves in the DNA itself, such that for some time the virus may only exist as information encoded in some nucleotides and not a physical virus, to cure that would be a powerful achievement