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Sharing everything I could understand about gradient noise

https://blog.pkh.me/p/42-sharing-everything-i-could-understand-about-gradient-noise.html
1•signa11•5m ago•0 comments

Some CUDA code examples with READMEs

https://github.com/drkennetz/cuda_examples
2•tanelpoder•9m ago•0 comments

Some Thoughts on the C Standard

https://johnbreaksstuff.substack.com/p/some-thoughts-on-the-c-standard
1•stock1218•15m ago•0 comments

Larry Summers on Stanley Fischer

https://larrysummers.com/news-item/stan-fischer/
2•paulpauper•29m ago•0 comments

I podcast with Azeem Azhar on the speed of AI take-off

https://marginalrevolution.com/marginalrevolution/2025/06/i-podcast-with-azeem-azhar-on-the-speed-of-ai-take-off.html
2•paulpauper•29m ago•0 comments

Tesla Optimus robotics vice president Milan Kovac is leaving the company

https://www.cnbc.com/2025/06/06/tesla-optimus-robotics-vp-is-leaving-the-company.html
6•TheAlchemist•43m ago•1 comments

China's driverless lorries hope to expand

https://www.bbc.com/news/articles/c5ykel5dr62o
1•mastazi•45m ago•0 comments

Why You Should Move Your Site Away from Weebly (YC W07)

https://www.articulation.blog/p/why-you-should-move-your-site-away-from-weebly
2•dustywusty•57m ago•0 comments

Colorado kayakers rescue a dog that tumbled over 60-foot waterfall in Mexico

https://coloradosun.com/2025/06/03/kayakers-rescue-waterfall-trapped-dog/
3•mooreds•59m ago•0 comments

Portable device captures airborne molecules for noninvasive disease detection

https://phys.org/news/2025-05-portable-device-captures-airborne-molecules.html
1•PaulHoule•1h ago•0 comments

Why does C++ think my class is copy-constructible when it can't be?

https://devblogs.microsoft.com/oldnewthing/20250606-00/?p=111254
2•ibobev•1h ago•0 comments

Building a Modern Python API with Azure Cosmos DB: A 5-Part Video Series

https://devblogs.microsoft.com/cosmosdb/building-a-modern-python-api-with-azure-cosmos-db-a-5-part-video-series/
1•ibobev•1h ago•0 comments

Retro Game Sprites Generated in One Attempt with Ideogram's "V3 Quality" Model

https://gametorch.app/commons/image_models/ideogram-v3-quality
2•gametorch•1h ago•1 comments

Ask HN: What would you do if AGI were coming in 2-4 years?

1•atleastoptimal•1h ago•12 comments

Ask HN: Is synthetic data generation practical outside academia?

1•cpard•1h ago•0 comments

Palantir is nuts. When's the crash?

https://www.ft.com/content/747dd085-6c83-4c0b-a93e-e134a643f2dd
17•1vuio0pswjnm7•1h ago•2 comments

Apple Cash Management (2021)

https://www.treasurefi.com/blog/a-look-inside-apple-cash-management
2•walterbell•1h ago•0 comments

Subcontinental Genetic Variation in the All of Us Research Program

https://www.cell.com/ajhg/fulltext/S0002-9297(25)00173-9
1•bookofjoe•1h ago•0 comments

Show HN: SQLAlchemy just the core – a better way

https://github.com/sayanarijit/sqla-fancy-core
2•sayanarijit•1h ago•0 comments

Show HN: Automate any workflow with Osly and 10x your productivity

https://app.osly.ai/
2•hez2000•1h ago•0 comments

Anthropic releases custom AI chatbot for classified spy work

https://arstechnica.com/ai/2025/06/anthropic-releases-custom-ai-chatbot-for-classified-spy-work/
1•gametorch•1h ago•0 comments

A man rebuilding the last Inca rope bridge

https://www.atlasobscura.com/articles/last-inca-rope-bridge-qeswachaka-tradition
1•kaonwarb•1h ago•0 comments

NATS Comparison to Kafka, Rabbit, gRPC, and Others

https://docs.nats.io/nats-concepts/overview/compare-nats
1•teleforce•1h ago•0 comments

SchemaPin prevents "MCP Rug Pull" attacks

https://github.com/ThirdKeyAI/SchemaPin
2•smugglereal•1h ago•1 comments

Autocomp: LLM-Driven Code Optimization for Tensor Accelerators

https://charleshong3.github.io/blog/autocomp.html
1•matt_d•1h ago•0 comments

Jony Ive's LoveFrom helped design Rivian's first electric bike

https://techcrunch.com/2025/06/06/jony-ives-lovefrom-helped-design-rivians-first-electric-bike/
3•coloneltcb•1h ago•0 comments

Michigan triples waters with 'Do Not Eat' warning for PFAS in fish

https://www.mlive.com/environment/2025/06/michigan-triples-waters-with-do-not-eat-warning-for-pfas-in-fish.html
3•mahirsaid•1h ago•1 comments

Dear High Schoolers, Time Is Precious

https://byronsharman.com/blog/dear-high-schoolers
4•chilipepperhott•1h ago•0 comments

Show HN: Bridgit – In-Person-First Networking

https://www.bridgitsocial.com/
1•amfooladgar•1h ago•2 comments

Understanding MCP Evals: Why Evals Matter for MCP

https://huggingface.co/blog/mclenhard/mcp-evals
1•mooreds•1h ago•0 comments
Open in hackernews

Cysteine depletion triggers adipose tissue thermogenesis and weight loss

https://www.nature.com/articles/s42255-025-01297-8
94•bookofjoe•1d ago

Comments

zajio1am•1d ago
(In mice)
myst•1d ago
(So far)
r2_pilot•1d ago
(also observed to be lethal in cases)
mbil•1d ago
This 2012 study in humans says

> Since this was also a noninterventional study, two possibilities for interpretation of the findings were either that a high cysteine somehow promotes obesity or that obesity influences cysteine turnover, thereby raising plasma tCys.

https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2011.93

nkmnz•23h ago
In genetically modified mice.
jdnier•1d ago
An overview of other studies investigating cysteine and glycine sources and effects (from 2023; video or transcript):

https://nutritionfacts.org/hnta-video/how-to-get-less-cystei...

profstasiak•8h ago
so... basically limit proteins especially from meat?
jostmey•1d ago
This should only act as a clue into driving weight loss. Depleting of cysteine is severe. It would be depriving a team from writing html and discovery the code runs faster… very drastic imposition
LPisGood•1d ago
Cysteine is also an irreplaceable building block of vital proteins required to sustain life. It’s unclear if there is any potential benefit of applying these findings to the problem of human weight loss or fitness.
kens•1d ago
Cysteine is not an essential amino acid. Humans can synthesize it from methionine.
bell-cot•1d ago
Wikipedia's disclaimers on that: "Cysteine can usually be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available."
nkmnz•23h ago
These mice were GMO’d to be incapable of synthesising cysteine.
gus_massa•1d ago
I agree, for example Pepsin[1] that is the protein inside the stomach that split proteins has Cysteine [2]

> Pepsin forms three between the sulfur atoms of cysteine residues in the peptide chain which hold important roles in the folding of the protein and stabilizing the two domains

[1] https://en.wikipedia.org/wiki/Pepsin

[2] https://biology.kenyon.edu/BMB/jsmol2021/Cat_Marko/index.htm...

User23•1d ago
I would make a stronger statement and say that this belongs squarely on the effect and not the cause side.

I could be wrong, but I doubt it. Amino acid depletion sounds way more likely to be due to some kind of disruption in homeostasis rather than dietary intake.

readthenotes1•1d ago
"Systemic cysteine depletion in mice causes lethal weight loss"

I didn't read much after that

dr_kiszonka•1d ago
Maybe you should have.
bilsbie•1d ago
Is this the same as homocysteine?
poirot2•1d ago
Funny because cysteinuria doesn’t do this (pee out cysteine)
RS-232•1d ago
Cysteine protease inhibitors could be used to reduce free cysteine available to cells. Some natural sources of those are papaya, kiwi, pineapple, fig, apples, and rice.
meew0•1d ago
Cysteine proteases are named after their reaction mechanism, which involves a key cysteine residue within the enzyme. It doesn't have anything to do with the amino acids in the cleaved proteins.
riknos314•1d ago
The phrasing of the title and paper steer the interpretation towards reducing cysteine as a method for increasing weight loss, however I think that the much more interesting takeaway is this:

> Notably, restoration of up to 75% cystine levels in the diet of Cth−/− CysF mice that were undergoing weight loss was sufficient to completely rescue the body weight

This might indicate that cysteine depletion could be one mechanism present in some wasting diseases, and that strategic supplementation of cysteine may be beneficial in reducing excessive weight loss in such diseases. I would be quite interested to see future research in this area.

biomcgary•1d ago
Cysteine plays a key role in redox metabolism and removing reactive oxygen species (ROS). During brown fat burning, high flux of electrons increases the NADH/NAD⁺ and FADH₂/FAD ratios — shifting redox state toward a more reduced environment, which is exactly what you would need if deprived of cysteine.
drob518•23h ago
So, does taking NAC make me fat? If I stop taking NAC, will it help me lose weight?
nkmnz•23h ago
According to the article, you’ll lose so much weight that you need euthanasia if you stop taking NAC - but only if you’re also a mice that also happens to be genetically modified to not produce any Cysteine biologically. Oh, and you shouldn’t eat anything containing cysteine naturally.
drob518•21h ago
Gotcha. So basically I’m going to be fat no matter what, you’re saying.
derbOac•19h ago
Another linked article suggests that NAC administration if anything causes weight loss, and has a lot of opposite effects as cysteine. I don't think they're interchangeable.
drob518•11h ago
Interesting. I missed that.
burnt-resistor•14h ago
If only there were NAC that doesn't stink opening the bottle.
dave333•52m ago
It's difficult to reduce cysteine by diet since it occurs in a wide variety of foods plus reducing it may be harmful as it is used in beneficial ways as well. So more research needed.