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Sebastian Galiani on the Marginal Revolution

https://marginalrevolution.com/marginalrevolution/2026/02/sebastian-galiani-on-the-marginal-revol...
1•paulpauper•1m ago•0 comments

Ask HN: Are we at the point where software can improve itself?

1•ManuelKiessling•1m ago•0 comments

Binance Gives Trump Family's Crypto Firm a Leg Up

https://www.nytimes.com/2026/02/07/business/binance-trump-crypto.html
1•paulpauper•1m ago•0 comments

Reverse engineering Chinese 'shit-program' for absolute glory: R/ClaudeCode

https://old.reddit.com/r/ClaudeCode/comments/1qy5l0n/reverse_engineering_chinese_shitprogram_for/
1•edward•1m ago•0 comments

Indian Culture

https://indianculture.gov.in/
1•saikatsg•4m ago•0 comments

Show HN: Maravel-Framework 10.61 prevents circular dependency

https://marius-ciclistu.medium.com/maravel-framework-10-61-0-prevents-circular-dependency-cdb5d25...
1•marius-ciclistu•4m ago•0 comments

The age of a treacherous, falling dollar

https://www.economist.com/leaders/2026/02/05/the-age-of-a-treacherous-falling-dollar
2•stopbulying•5m ago•0 comments

Ask HN: AI Generated Diagrams

1•voidhorse•7m ago•0 comments

Microsoft Account bugs locked me out of Notepad – are Thin Clients ruining PCs?

https://www.windowscentral.com/microsoft/windows-11/windows-locked-me-out-of-notepad-is-the-thin-...
2•josephcsible•8m ago•0 comments

Show HN: A delightful Mac app to vibe code beautiful iOS apps

https://milq.ai/hacker-news
2•jdjuwadi•11m ago•1 comments

Show HN: Gemini Station – A local Chrome extension to organize AI chats

https://github.com/rajeshkumarblr/gemini_station
1•rajeshkumar_dev•11m ago•0 comments

Welfare states build financial markets through social policy design

https://theloop.ecpr.eu/its-not-finance-its-your-pensions/
2•kome•14m ago•0 comments

Market orientation and national homicide rates

https://onlinelibrary.wiley.com/doi/10.1111/1745-9125.70023
3•PaulHoule•15m ago•0 comments

California urges people avoid wild mushrooms after 4 deaths, 3 liver transplants

https://www.cbsnews.com/news/california-death-cap-mushrooms-poisonings-liver-transplants/
1•rolph•15m ago•0 comments

Matthew Shulman, co-creator of Intellisense, died 2019 March 22

https://www.capenews.net/falmouth/obituaries/matthew-a-shulman/article_33af6330-4f52-5f69-a9ff-58...
3•canucker2016•16m ago•1 comments

Show HN: SuperLocalMemory – AI memory that stays on your machine, forever free

https://github.com/varun369/SuperLocalMemoryV2
1•varunpratap369•17m ago•0 comments

Show HN: Pyrig – One command to set up a production-ready Python project

https://github.com/Winipedia/pyrig
1•Winipedia•20m ago•0 comments

Fast Response or Silence: Conversation Persistence in an AI-Agent Social Network [pdf]

https://github.com/AysajanE/moltbook-persistence/blob/main/paper/main.pdf
1•EagleEdge•20m ago•0 comments

C and C++ dependencies: don't dream it, be it

https://nibblestew.blogspot.com/2026/02/c-and-c-dependencies-dont-dream-it-be-it.html
1•ingve•20m ago•0 comments

Show HN: Vbuckets – Infinite virtual S3 buckets

https://github.com/danthegoodman1/vbuckets
1•dangoodmanUT•20m ago•0 comments

Open Molten Claw: Post-Eval as a Service

https://idiallo.com/blog/open-molten-claw
1•watchful_moose•21m ago•0 comments

New York Budget Bill Mandates File Scans for 3D Printers

https://reclaimthenet.org/new-york-3d-printer-law-mandates-firearm-file-blocking
2•bilsbie•22m ago•1 comments

The End of Software as a Business?

https://www.thatwastheweek.com/p/ai-is-growing-up-its-ceos-arent
1•kteare•23m ago•0 comments

Exploring 1,400 reusable skills for AI coding tools

https://ai-devkit.com/skills/
1•hoangnnguyen•24m ago•0 comments

Show HN: A unique twist on Tetris and block puzzle

https://playdropstack.com/
1•lastodyssey•27m ago•1 comments

The logs I never read

https://pydantic.dev/articles/the-logs-i-never-read
1•nojito•28m ago•0 comments

How to use AI with expressive writing without generating AI slop

https://idratherbewriting.com/blog/bakhtin-collapse-ai-expressive-writing
1•cnunciato•29m ago•0 comments

Show HN: LinkScope – Real-Time UART Analyzer Using ESP32-S3 and PC GUI

https://github.com/choihimchan/linkscope-bpu-uart-analyzer
1•octablock•30m ago•0 comments

Cppsp v1.4.5–custom pattern-driven, nested, namespace-scoped templates

https://github.com/user19870/cppsp
1•user19870•31m ago•1 comments

The next frontier in weight-loss drugs: one-time gene therapy

https://www.washingtonpost.com/health/2026/01/24/fractyl-glp1-gene-therapy/
2•bookofjoe•34m ago•1 comments
Open in hackernews

Cysteine depletion triggers adipose tissue thermogenesis and weight loss

https://www.nature.com/articles/s42255-025-01297-8
97•bookofjoe•8mo ago

Comments

zajio1am•8mo ago
(In mice)
myst•8mo ago
(So far)
r2_pilot•8mo ago
(also observed to be lethal in cases)
mbil•8mo ago
This 2012 study in humans says

> Since this was also a noninterventional study, two possibilities for interpretation of the findings were either that a high cysteine somehow promotes obesity or that obesity influences cysteine turnover, thereby raising plasma tCys.

https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2011.93

nkmnz•8mo ago
In genetically modified mice.
jdnier•8mo ago
An overview of other studies investigating cysteine and glycine sources and effects (from 2023; video or transcript):

https://nutritionfacts.org/hnta-video/how-to-get-less-cystei...

profstasiak•8mo ago
so... basically limit proteins especially from meat?
jostmey•8mo ago
This should only act as a clue into driving weight loss. Depleting of cysteine is severe. It would be depriving a team from writing html and discovery the code runs faster… very drastic imposition
LPisGood•8mo ago
Cysteine is also an irreplaceable building block of vital proteins required to sustain life. It’s unclear if there is any potential benefit of applying these findings to the problem of human weight loss or fitness.
kens•8mo ago
Cysteine is not an essential amino acid. Humans can synthesize it from methionine.
bell-cot•8mo ago
Wikipedia's disclaimers on that: "Cysteine can usually be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available."
nkmnz•8mo ago
These mice were GMO’d to be incapable of synthesising cysteine.
gus_massa•8mo ago
I agree, for example Pepsin[1] that is the protein inside the stomach that split proteins has Cysteine [2]

> Pepsin forms three between the sulfur atoms of cysteine residues in the peptide chain which hold important roles in the folding of the protein and stabilizing the two domains

[1] https://en.wikipedia.org/wiki/Pepsin

[2] https://biology.kenyon.edu/BMB/jsmol2021/Cat_Marko/index.htm...

User23•8mo ago
I would make a stronger statement and say that this belongs squarely on the effect and not the cause side.

I could be wrong, but I doubt it. Amino acid depletion sounds way more likely to be due to some kind of disruption in homeostasis rather than dietary intake.

readthenotes1•8mo ago
"Systemic cysteine depletion in mice causes lethal weight loss"

I didn't read much after that

dr_kiszonka•8mo ago
Maybe you should have.
bilsbie•8mo ago
Is this the same as homocysteine?
poirot2•8mo ago
Funny because cysteinuria doesn’t do this (pee out cysteine)
RS-232•8mo ago
Cysteine protease inhibitors could be used to reduce free cysteine available to cells. Some natural sources of those are papaya, kiwi, pineapple, fig, apples, and rice.
meew0•8mo ago
Cysteine proteases are named after their reaction mechanism, which involves a key cysteine residue within the enzyme. It doesn't have anything to do with the amino acids in the cleaved proteins.
riknos314•8mo ago
The phrasing of the title and paper steer the interpretation towards reducing cysteine as a method for increasing weight loss, however I think that the much more interesting takeaway is this:

> Notably, restoration of up to 75% cystine levels in the diet of Cth−/− CysF mice that were undergoing weight loss was sufficient to completely rescue the body weight

This might indicate that cysteine depletion could be one mechanism present in some wasting diseases, and that strategic supplementation of cysteine may be beneficial in reducing excessive weight loss in such diseases. I would be quite interested to see future research in this area.

biomcgary•8mo ago
Cysteine plays a key role in redox metabolism and removing reactive oxygen species (ROS). During brown fat burning, high flux of electrons increases the NADH/NAD⁺ and FADH₂/FAD ratios — shifting redox state toward a more reduced environment, which is exactly what you would need if deprived of cysteine.
drob518•8mo ago
So, does taking NAC make me fat? If I stop taking NAC, will it help me lose weight?
nkmnz•8mo ago
According to the article, you’ll lose so much weight that you need euthanasia if you stop taking NAC - but only if you’re also a mice that also happens to be genetically modified to not produce any Cysteine biologically. Oh, and you shouldn’t eat anything containing cysteine naturally.
drob518•8mo ago
Gotcha. So basically I’m going to be fat no matter what, you’re saying.
derbOac•8mo ago
Another linked article suggests that NAC administration if anything causes weight loss, and has a lot of opposite effects as cysteine. I don't think they're interchangeable.
drob518•8mo ago
Interesting. I missed that.
burnt-resistor•8mo ago
If only there were NAC that doesn't stink opening the bottle.
dave333•8mo ago
It's difficult to reduce cysteine by diet since it occurs in a wide variety of foods plus reducing it may be harmful as it is used in beneficial ways as well. So more research needed.