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Running the "Reflections on Trusting Trust" Compiler

https://spawn-queue.acm.org/doi/10.1145/3786614
1•devooops•50s ago•0 comments

Watermark API – $0.01/image, 10x cheaper than Cloudinary

https://api-production-caa8.up.railway.app/docs
1•lembergs•2m ago•1 comments

Now send your marketing campaigns directly from ChatGPT

https://www.mail-o-mail.com/
1•avallark•5m ago•1 comments

Queueing Theory v2: DORA metrics, queue-of-queues, chi-alpha-beta-sigma notation

https://github.com/joelparkerhenderson/queueing-theory
1•jph•17m ago•0 comments

Show HN: Hibana – choreography-first protocol safety for Rust

https://hibanaworks.dev/
5•o8vm•19m ago•0 comments

Haniri: A live autonomous world where AI agents survive or collapse

https://www.haniri.com
1•donangrey•20m ago•1 comments

GPT-5.3-Codex System Card [pdf]

https://cdn.openai.com/pdf/23eca107-a9b1-4d2c-b156-7deb4fbc697c/GPT-5-3-Codex-System-Card-02.pdf
1•tosh•33m ago•0 comments

Atlas: Manage your database schema as code

https://github.com/ariga/atlas
1•quectophoton•36m ago•0 comments

Geist Pixel

https://vercel.com/blog/introducing-geist-pixel
2•helloplanets•39m ago•0 comments

Show HN: MCP to get latest dependency package and tool versions

https://github.com/MShekow/package-version-check-mcp
1•mshekow•46m ago•0 comments

The better you get at something, the harder it becomes to do

https://seekingtrust.substack.com/p/improving-at-writing-made-me-almost
2•FinnLobsien•48m ago•0 comments

Show HN: WP Float – Archive WordPress blogs to free static hosting

https://wpfloat.netlify.app/
1•zizoulegrande•49m ago•0 comments

Show HN: I Hacked My Family's Meal Planning with an App

https://mealjar.app
1•melvinzammit•50m ago•0 comments

Sony BMG copy protection rootkit scandal

https://en.wikipedia.org/wiki/Sony_BMG_copy_protection_rootkit_scandal
1•basilikum•52m ago•0 comments

The Future of Systems

https://novlabs.ai/mission/
2•tekbog•53m ago•1 comments

NASA now allowing astronauts to bring their smartphones on space missions

https://twitter.com/NASAAdmin/status/2019259382962307393
2•gbugniot•58m ago•0 comments

Claude Code Is the Inflection Point

https://newsletter.semianalysis.com/p/claude-code-is-the-inflection-point
3•throwaw12•59m ago•1 comments

Show HN: MicroClaw – Agentic AI Assistant for Telegram, Built in Rust

https://github.com/microclaw/microclaw
1•everettjf•59m ago•2 comments

Show HN: Omni-BLAS – 4x faster matrix multiplication via Monte Carlo sampling

https://github.com/AleatorAI/OMNI-BLAS
1•LowSpecEng•1h ago•1 comments

The AI-Ready Software Developer: Conclusion – Same Game, Different Dice

https://codemanship.wordpress.com/2026/01/05/the-ai-ready-software-developer-conclusion-same-game...
1•lifeisstillgood•1h ago•0 comments

AI Agent Automates Google Stock Analysis from Financial Reports

https://pardusai.org/view/54c6646b9e273bbe103b76256a91a7f30da624062a8a6eeb16febfe403efd078
1•JasonHEIN•1h ago•0 comments

Voxtral Realtime 4B Pure C Implementation

https://github.com/antirez/voxtral.c
2•andreabat•1h ago•1 comments

I Was Trapped in Chinese Mafia Crypto Slavery [video]

https://www.youtube.com/watch?v=zOcNaWmmn0A
2•mgh2•1h ago•1 comments

U.S. CBP Reported Employee Arrests (FY2020 – FYTD)

https://www.cbp.gov/newsroom/stats/reported-employee-arrests
1•ludicrousdispla•1h ago•0 comments

Show HN: I built a free UCP checker – see if AI agents can find your store

https://ucphub.ai/ucp-store-check/
2•vladeta•1h ago•1 comments

Show HN: SVGV – A Real-Time Vector Video Format for Budget Hardware

https://github.com/thealidev/VectorVision-SVGV
1•thealidev•1h ago•0 comments

Study of 150 developers shows AI generated code no harder to maintain long term

https://www.youtube.com/watch?v=b9EbCb5A408
2•lifeisstillgood•1h ago•0 comments

Spotify now requires premium accounts for developer mode API access

https://www.neowin.net/news/spotify-now-requires-premium-accounts-for-developer-mode-api-access/
2•bundie•1h ago•0 comments

When Albert Einstein Moved to Princeton

https://twitter.com/Math_files/status/2020017485815456224
1•keepamovin•1h ago•0 comments

Agents.md as a Dark Signal

https://joshmock.com/post/2026-agents-md-as-a-dark-signal/
2•birdculture•1h ago•1 comments
Open in hackernews

Cysteine depletion triggers adipose tissue thermogenesis and weight loss

https://www.nature.com/articles/s42255-025-01297-8
97•bookofjoe•8mo ago

Comments

zajio1am•8mo ago
(In mice)
myst•8mo ago
(So far)
r2_pilot•8mo ago
(also observed to be lethal in cases)
mbil•8mo ago
This 2012 study in humans says

> Since this was also a noninterventional study, two possibilities for interpretation of the findings were either that a high cysteine somehow promotes obesity or that obesity influences cysteine turnover, thereby raising plasma tCys.

https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2011.93

nkmnz•8mo ago
In genetically modified mice.
jdnier•8mo ago
An overview of other studies investigating cysteine and glycine sources and effects (from 2023; video or transcript):

https://nutritionfacts.org/hnta-video/how-to-get-less-cystei...

profstasiak•8mo ago
so... basically limit proteins especially from meat?
jostmey•8mo ago
This should only act as a clue into driving weight loss. Depleting of cysteine is severe. It would be depriving a team from writing html and discovery the code runs faster… very drastic imposition
LPisGood•8mo ago
Cysteine is also an irreplaceable building block of vital proteins required to sustain life. It’s unclear if there is any potential benefit of applying these findings to the problem of human weight loss or fitness.
kens•8mo ago
Cysteine is not an essential amino acid. Humans can synthesize it from methionine.
bell-cot•8mo ago
Wikipedia's disclaimers on that: "Cysteine can usually be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available."
nkmnz•8mo ago
These mice were GMO’d to be incapable of synthesising cysteine.
gus_massa•8mo ago
I agree, for example Pepsin[1] that is the protein inside the stomach that split proteins has Cysteine [2]

> Pepsin forms three between the sulfur atoms of cysteine residues in the peptide chain which hold important roles in the folding of the protein and stabilizing the two domains

[1] https://en.wikipedia.org/wiki/Pepsin

[2] https://biology.kenyon.edu/BMB/jsmol2021/Cat_Marko/index.htm...

User23•8mo ago
I would make a stronger statement and say that this belongs squarely on the effect and not the cause side.

I could be wrong, but I doubt it. Amino acid depletion sounds way more likely to be due to some kind of disruption in homeostasis rather than dietary intake.

readthenotes1•8mo ago
"Systemic cysteine depletion in mice causes lethal weight loss"

I didn't read much after that

dr_kiszonka•8mo ago
Maybe you should have.
bilsbie•8mo ago
Is this the same as homocysteine?
poirot2•8mo ago
Funny because cysteinuria doesn’t do this (pee out cysteine)
RS-232•8mo ago
Cysteine protease inhibitors could be used to reduce free cysteine available to cells. Some natural sources of those are papaya, kiwi, pineapple, fig, apples, and rice.
meew0•8mo ago
Cysteine proteases are named after their reaction mechanism, which involves a key cysteine residue within the enzyme. It doesn't have anything to do with the amino acids in the cleaved proteins.
riknos314•8mo ago
The phrasing of the title and paper steer the interpretation towards reducing cysteine as a method for increasing weight loss, however I think that the much more interesting takeaway is this:

> Notably, restoration of up to 75% cystine levels in the diet of Cth−/− CysF mice that were undergoing weight loss was sufficient to completely rescue the body weight

This might indicate that cysteine depletion could be one mechanism present in some wasting diseases, and that strategic supplementation of cysteine may be beneficial in reducing excessive weight loss in such diseases. I would be quite interested to see future research in this area.

biomcgary•8mo ago
Cysteine plays a key role in redox metabolism and removing reactive oxygen species (ROS). During brown fat burning, high flux of electrons increases the NADH/NAD⁺ and FADH₂/FAD ratios — shifting redox state toward a more reduced environment, which is exactly what you would need if deprived of cysteine.
drob518•8mo ago
So, does taking NAC make me fat? If I stop taking NAC, will it help me lose weight?
nkmnz•8mo ago
According to the article, you’ll lose so much weight that you need euthanasia if you stop taking NAC - but only if you’re also a mice that also happens to be genetically modified to not produce any Cysteine biologically. Oh, and you shouldn’t eat anything containing cysteine naturally.
drob518•8mo ago
Gotcha. So basically I’m going to be fat no matter what, you’re saying.
derbOac•8mo ago
Another linked article suggests that NAC administration if anything causes weight loss, and has a lot of opposite effects as cysteine. I don't think they're interchangeable.
drob518•8mo ago
Interesting. I missed that.
burnt-resistor•8mo ago
If only there were NAC that doesn't stink opening the bottle.
dave333•8mo ago
It's difficult to reduce cysteine by diet since it occurs in a wide variety of foods plus reducing it may be harmful as it is used in beneficial ways as well. So more research needed.