> The real question here: how do we stop these shifts from happening?

Or what happens when we stop them? Perpetual adolescence seems mainstream now. But it would be nice to know if some of these changes should be brought up as well as pushed back.

When I look into my biohacker bubble, the answer might be: enough sleep, regular workout routine with HIIT, healthy whole foods, no alcohol, socializing

Possibly with a hyperbaric oxygen chamber.

strength training

Is it possible that scientists employed at Stanford will have also had this insight, and worked around it?

Are you at or over 40?

Anecdotally I feel I noticed a very fast ageing speed between 38 and 40. Suddenly got white hairs, feel more tired, more wrinkles, way harder to keep VO2max up (I run a lot), muscle sores after training suddenly lasting up to 3 days instead of 1, face looks older, etc.

I feel like that all happened real fast around this age.

Sounds like something someone < 40 would say. To anyone over, I feel like this study is pretty obvious. I'm in my early 40's and whatever change this is, has been discussed multiple times with my peers, active lifestyle or not, wealth or not, married or not, physical career or not. Everything starts to feel a little harder, whether it's exercise, problem solving, memory, sleep, sex drive, appetite, fuckin everything. Things change in your late 30s, for sure.

All young people think they are special and age is just a number. The rest of the population knows that isn't true. Spare me your weight lifting 80 year old, or "my grandpa worked the farm til he was 90" stuff, we all know those are extreme outliers.

Yep, both eventually link to https://www.nature.com/articles/s43587-024-00692-2 "Nonlinear dynamics of multi-omics profiles during human aging"

The study in the post agrees on 60, but mentions 44 as the (average? median?) age of another intense change.

> people also stop moving (exercising) significantly in their forties

Also likely that people who never experienced the negative outcomes of a sedentary or unhealthy life style start doing so due to the biomolecular changes. Drinking more likely to hurt your liver, soda more likely to cause diabetes, smoking more likely to cause cavities despite having done all that for 20 years without visible problems.

Regular whole body physical activity (not even gym level hard) is such a gem and a free one.

Without writing a book about it I'll just say that I think the most important thing is people shouldn't look at this info and conclude that their body's going to fall apart no matter what.

I'm in my mid 40s and in the best shape of my life, lots of energy, aches and pains from my late 30s have all disappeared, to get there it took diet and exercise changes that were surprisingly modest. For me it was mostly weights, a little bit of cardio, and cutting back on my worst episodes of caloric excess.

I have friends who didn't do any diet and exercise interventions, and are starting to look like hell and complain about the "inevitable" consequences of aging.

And then there are those jacked dudes in their 70s who are hitting the gym 5 times a week, I can only aspire to be as healthy as them at their age.

Use it (with proper care and feeding) or lose it.

> I read this as an indicator that at least significant parts of the transition in this age range for men - acknowledged for a long time now - are just as big as menopause

Men emerge from it with their fertility intact.

Sorry but your post as strong #notallmen vibes. The article itself mentions that part of those changes might just be explained by lifestyle changes at 40s. I quote:

> It's possible some of these changes could be tied to lifestyle or behavioral factors that cluster at these age groups, rather than being driven by biological factors, Snyder said.

Changes in women metabolism due to menopause are pretty known and proved, and men don't experience it. I'm a mid-40s male as well.