Methanol toxicity hits in the range of grams of methanol over a short period.
I have no idea how the bacteria are applied (oral rinse) but maybe enough got ingested to colonize the intestines? That could produce enough formate.
https://www.asbmb.org/asbmb-today/science/060924/brushing-w-...
I don’t intend to argue we should kept Vioxx around, just to point out that the calculus can get complicated. I would vastly rather protect my heart than get rid of the insignificant amount of pain I experience. Turn that dial up far enough and people could rationally make the other choice.
> Around that time, the patent they had for this bacterial strain expired. Aaron Silverbook, who founded a company called Lantern Bioworks, saw a way to rescue this technology from the regulatory red tape: what if it wasn’t filed as a drug but as a probiotic? He made a deal with Oragenics to acquire the recipe and aimed to get it approved by the FDA through its much less stringent probiotic pathway. He first sold it in Próspera, a libertarian charter city on a Central American island where any biotech product can be sold as long as the buyer signs a waiver, and now the product, renamed Lumina, is gaining hype on social media among cryptocurrency enthusiasts and DIY experimenters. You can even preorder the product for USD 250, to be shipped in June of this year.
from https://www.mcgill.ca/oss/article/medical-critical-thinking-...
That's addressed in the OP:
> And in case you were wondering, this wouldn’t have shown up in the original BCS3-L1 rodent toxicity studies either as most non-primate animals metabolize formate much more efficiently, including rats. This has led to difficulties creating a rodent model of methanol toxicity, in fact.
Although, it doesn't preclude some kind of uncommon impairment to formate metabolism, which would explain why it doesn't happen to other people.
The article is also from a blog that was only created 2 hours ago, and has this one post.
I'm not sure why this is all the way up the front page, but it seems very unwarranted.
> At best it seems that I’ll likely never see a bright light or vibrant color ever again for the rest of my life, unless we get an aligned AGI that can fix me (<1%) or we start funding the NIH again and the scientists actually come back (0%).
I understand they are upset because of the symptoms involved but the lack of logic and knowledge here is something else. They mentioned they have used Kratom, which can apparently cause eye issues. Have they used anything else?
I do agree that vendors of genetically modified bacteria need some kind of plan or kill-switch for getting rid of their living therapeutics from your body.
If you are desperate then the Streptococcus mutans should respond to oral antibiotics penicillin, amoxicillin, erythromycin, and cephalosporins.
trhway•3h ago
i'm yet to see an alcoholic whose regular "mouth washing" by ethanol leads to good teeth (despite ethanol being very powerful antiseptic) .
jostmey•3h ago
trhway•3h ago
3eb7988a1663•3h ago
jostmey•3h ago
floren•3h ago