Just got to get it approved for anything and …. well everything will be the same. I’ve seen so many vendors selling professionally packed psilocybin. I’m like “this is like Lion’s Mane..?” Nope, just drugs!

But at least you can talk about it with your family and coworkers more casually

What "assisted dying" legislation is being introduced for. Start with "humane approach to suffering" end up with "right, you have no savings, and you have been taking your pension for way too long, we suggest a humane termination, here's your goodbye pill"

30 grams of pure psilocybin? that requires eating 3 kilograms of mushrooms, right? usually it's 1% (or less) of dried mass.

well, actually more "doable" than initially I have assumed, but it would quickly lead to vomiting and a pretty guaranteed bad trip, well before ingesting enough.

also interestingly LD50 is 280 mg/kg.

I’m not an expert so I’ll just ask questions but IIRC, there is no deadly dose of psylocybin.

I would imagine that at some point the effects would plateau. Of course you would be pretty far away in space in multiple dimensions at the same time.

I would be surprised, if this plateau exists, that nobody would have reached it.

In psychedelics space, it’s not unheard of people accidentally taking 100-1000x the expected dose and having the best (or worse) time of their life without further health issues.

Also it seems that set&setting is far more important for the experience than the actual dose.

In general mice need larger doses of most medication candidates. AFAIK this is because they have a faster metabolism compared to humans. In addition I don't think there is a overdose risk with psychedelics.

I have no personal experience with mushrooms, but I never understood why placebo trials aren't done while the patients are asleep.

Just choose research subjects that don't remember their dreams and who sleep a solid 8 hours

I think a trip is much shorter than 8 hours and by the time you wake up you wouldn't be able to tell the difference