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Psilocybin therapy for mood dysfunction in Parkinson's disease: open-label trial

https://www.nature.com/articles/s41386-025-02097-0
4•nick__m•3h ago

Comments

alganet•2h ago
You don't want to sell magic mushrooms. You want to go home and rethink your life.
nick__m•2h ago
I don't see how that is selling magic mushroom. After all, one of twelve patients did feel worse off and they excluded 105 candidates but the motors improvement are hard to ignore...
alganet•2h ago
The scientists can go on about their business.
nick__m•2h ago
The mood improvement was predictable but what surprised me is the motor improvement. But it's not a silver bullet, one patient reported feeling more anxious and felt a worsening of his motor symptoms even if no such decline was measured. Another reported wanting medically assisted suicide when I would not be able to care for himself but like the researchers I don't see that as an adverse effect since it wasn't immediate suicidal ideation but a long term plan for when the inevitable happens.

What async communication patterns lead to better outcomes for engineers?

https://rdel.substack.com/p/rdel-89-what-async-communication
1•lizziechka•8m ago•0 comments

The Conversations Doctors Are Having About Vaccination Now

https://www.theatlantic.com/health/archive/2025/07/vaccination-doctors-trump-rfk/683541/
3•scarface_74•12m ago•0 comments

Show HN: Summary, topic, bullet points, references for popular HN posts

https://extraakt.com/extraakts
1•guybedo•13m ago•0 comments

How to spot fake products on AliExpress

1•FakeFind_ai•15m ago•0 comments

Bun adds pnpm-style isolated installation mode

https://github.com/oven-sh/bun/pull/20440
2•nateb2022•16m ago•0 comments

Patient-Specific in Vivo Gene Editing to Treat a Rare Genetic Disease

https://www.nejm.org/doi/full/10.1056/NEJMoa2504747
2•richardboegli•18m ago•0 comments

First Patient Treated with Personalized CRISPR Gene Editing Therapy

https://www.chop.edu/news/worlds-first-patient-treated-personalized-crispr-gene-editing-therapy-childrens-hospital
2•richardboegli•20m ago•0 comments

Reddit users in the UK must now upload selfies to access NSFW subreddits

https://mashable.com/article/reddit-age-verification-check-uk-law-online-safety
4•echelon•26m ago•1 comments

The Seductions of A.I. For the Writer's Mind

https://www.nytimes.com/2025/07/18/opinion/ai-chatgpt-school.html
1•pseudolus•36m ago•1 comments

Mr Browser – Macintosh Repository file downloader that runs directly on 68k Macs

https://www.macintoshrepository.org/44146-mr-browser
4•zdw•39m ago•0 comments

Tokyo's retro shotengai arcades are falling victim to gentrification

https://www.theguardian.com/world/2025/jul/18/cult-of-convenience-how-tokyos-retro-shotengai-arcades-are-falling-victim-to-gentrification
2•pseudolus•42m ago•0 comments

Control issues and ditching involving RPA swarm of 500 Damoda Newton 2.2 RPA

https://www.atsb.gov.au/publications/investigation_reports/2025/report/ao-2023-033
1•oliverdunk•45m ago•0 comments

Intel Announces It's Shutting Down Clear Linux

https://www.phoronix.com/news/Intel-Ends-Clear-Linux
8•gpi•47m ago•1 comments

Microsoft to stop using engineers in China for tech support of US Military

https://www.reuters.com/world/us/microsoft-stop-using-engineers-china-tech-support-us-military-hegseth-orders-2025-07-18/
4•miles•48m ago•0 comments

Playing Online Nintendo 64 Games with a Flashcart [video]

https://www.youtube.com/watch?v=v9aVrBq0aiY
5•giovannibajo1•50m ago•0 comments

Debcraft – Easiest way to modify and build Debian packages

https://optimizedbyotto.com/post/debcraft-easy-debian-packaging/
5•pabs3•55m ago•0 comments

Were Americans ever really healthy?

https://www.bloomberg.com/news/features/2025-07-18/was-the-us-ever-healthy-what-maha-gets-wrong-about-nutrition-history
2•zinekeller•56m ago•0 comments

How to Write Great Prompts for String

https://pipedream.com/blog/how-to-write-great-prompts-for-string/
1•todsacerdoti•57m ago•0 comments

Reinventing the Python Wheel

https://lwn.net/Articles/1028299/
1•zahlman•1h ago•0 comments

Why don't I drink? How much time you got?

https://shaungallagher.pressbin.com/blog/drinking.html
3•jawns•1h ago•0 comments

"Far out, man": how Jimi Hendrix boosted the career of Sha Na Na (2024)

https://faroutmagazine.co.uk/how-jimi-hendrix-boosted-the-career-of-sha-na-na
2•thomassmith65•1h ago•0 comments

Build an AI Agent Web App with String and Lovable

https://pipedream.com/blog/build-an-ai-agent-with-string-lovable/
1•todsacerdoti•1h ago•0 comments

Cascading retrieval with multi-vector representations

https://www.pinecone.io/blog/cascading-retrieval-with-multi-vector-representations/
1•gk1•1h ago•0 comments

What a bumble bee chooses to eat may not match its ideal diet

https://phys.org/news/2025-07-bumble-bee-ideal-diet.html
2•PaulHoule•1h ago•0 comments

Shutting Down Clear Linux OS

https://community.clearlinux.org/t/all-good-things-come-to-an-end-shutting-down-clear-linux-os/10716
58•todsacerdoti•1h ago•36 comments

Nuxt Joins Vercel

https://vercel.com/blog/nuxtlabs-joins-vercel
1•rattray•1h ago•1 comments

The Kap Programming Language

https://kapdemo.dhsdevelopments.com/examples.html
3•thunderbong•1h ago•0 comments

A Software for One

https://www.jasonthorsness.com/30
2•jasonthorsness•1h ago•0 comments

Women Are Falling Behind in America's Return to the Office

https://www.wsj.com/lifestyle/careers/return-to-office-gender-gap-236392aa
5•bdev12345•1h ago•2 comments

Astronomer launches internal investigation after viral Coldplay video

https://www.cnn.com/2025/07/18/entertainment/coldplay-concert-kiss-cam-astronomer-investigation
3•bb88•1h ago•0 comments