* It does not show human harm, only cellular disruption.
* It uses an unnatural exposure method.
* It builds on epidemiological correlations that may be reverse causality.
* It does not account for systemic factors, metabolism, or adaptive responses.
As you say I believe the correlation is reverse causality. It's much more likely that people who consume stuff with "artificial" sweetener are already at risk for stroke than the other way around.
If you don't have weight/cardio problems it is weird to consume "sugar-free" stuff and associated because they are almost always worse tasting than the real deal.
To have any importance they would need a big population sample and correct for already existing risks for stroke and I believe they would find that this stuff has very little impact, if any.
But as always, it doesn't cost much to limit consumption, so why not?
The German Wikipedia article says it appears naturally in cheese, funghi, plums, strawberries and pistachios. So maybe the lab experiment might be a bit artifial, or the dose much higher than from normal consumption if the above?
Its almost like these days people are desperately grasping for anything that will deliver weight loss, apart from changing their longterm unhealthy fucking eating habits. US is a long term champion but it has slowly crept into most cultures, just not at that scale yet.
Food portion size, its composition and breaking some sweat regularly works wonders but nobody ain't got time or willpower for that.
It's better to eat things in moderation and know what antinutrients are in what foods. There are tradeoffs.
Indigenous people processed acorns to remove tanins.
Kidney beans (and many other legumes to variably lesser degree) naturally contain phytohaemagglutinins (PHA-E) which cause red blood cells to clump together. These can be reduces several orders of magnitude by repeated cooking, washing, and draining.
Men shouldn't eat too much soy or chia seeds. Small amounts of chia seeds are fine.
Most adults are lactose intolerant unless they have lactase persistence genes.
Spinach, pepper (the spice kind), rhubarb, almonds, and more contain oxalate that can lead to kidney stone formation. Excess vitamin C does also. Increasing citrate intake helps prevent calcium kidney stone formation, but doesn't help with oxalate kidney stones as much.
The list of antinutrients is long. Don't overdo eating one "natural" ingredient or another because that's the greatest risk of becoming a Chubbyemu video subject.
https://www.samsclub.com/p/quest-protein-bar-variety-chocola...
For example erythritol itself occurs naturally in some fruit and fermented foods, making it a "normal sweetener".
Of course, a significant majority of Americans aren't all that healthy - I guess I'm not sure what your point is.
Link to actual study: https://journals.physiology.org/doi/full/10.1152/japplphysio...
It's not like erythritol is hard for a consumer to avoid. P(serious problems like brain cell damage) does not need to get very high for it to start to make sense to avoid it, and it seems to me that studies done on cell culture can raise P high enough.
Add milk, an alcoholic beverage, or some lemon juice and those cells are unlikely to survive. Meanwhile the standard path of consumption handles the situation just fine before your brain is ever involved in metabolism.
If you poured distilled water on cells in culture they'd also all die.
- All study subjects had a "high prevalence of CVD [cardiovascular disease] and risk factor burden"
- Erythritol occurs naturally in the body and and this was not accounted for
- The study subjects were already suffering from cardiovascular disease and were likely to be consuming more artificial sweeteners than a general population, but this was not recognized or accounted for
- Erythritol's presence after a cardiovascular incident could be from consumption or from natural production but only baseline was measured despite data showing dramatic fluctuations after consumption
Another one of the studies cited for evidence of human claims (Khafagy et al., 2024) directly contradicts them. It stated said "we did not find supportive evidence from MR that erythritol increases cardiometabolic disease".
There are two more human studies referenced but I didn't read them.
IcyWindows•4h ago
Would the whole drink amount really all be given to those cells?
abeyer•1h ago