* Memantine has NMDAr antagonism effects which will weaken depressive thoughts.
* Memantine has dopaminergic agonist activity (which builds very slowly), eventually improving mood.
* Telmisartan has PPAR gamma activation effects which synergizes with its ARB effect for potent neurological benefits.
* Intense exercise synergizes with all of the above, although it's less critical if the environmental trigger of depression is eliminated.
A reductive investigation will find that the individual components don't cure depression, and that's beside the point. It is only their combination that fully normalizes things.
Noticed a moderate improvement. I think NMDA is one of those targets that's flown under the radar, but now is being implicated with all sorts of cognitive processes.
Treatment for PCP is benzodiazepines/antipsychotics, not ketamine.
Phencyclidine became a reference molecule for many modern drugs currently used.
Benzos aren't used in cases wherein the ER staff suspect the patient is at risk of respiratory depression. Ketamine is effective in these cases, that's the point I was making, I could rephrase it though.
Memantine, at least for Alzheimer's, is basically like giving the patient water, I've never actually seen it change anyone's life significantly.
There's also all the stuff w/ NMDA-receptor encephalitis, a lot of it was written up by Josep Dalmau
FollowingTheDao•18h ago
You can see the K values for the receptors ketamine effects on wikipedia:
https://en.wikipedia.org/wiki/Ketamine#Pharmacology
He does not seem to know ketamine is a D2 receptor agonsit, the same as PCP, yet he mentions it for PCP!
Like most of the "nootropics" people I read they speak only in "vibes".
grillbert•14h ago
>This article is remarkable incomplete
True! There's other posts in this vein on the blog. Most recent posts have concerned the NMDA Receptor, i'm mainly using ketamine to tease out intracellular effects of different NMDAR currents.
>At higher doses it start effecting other receptors which is why a higher does has seemingly opposite effects.
Also true, but not sure if that necessarily conflicts with what I'm writing about here in comparing Ketamine to Memantine.
>He does not seem to know ketamine is a D2 receptor agonsit, the same as PCP, yet he mentions it for PCP!
Learned this halfway through writing, forgot to amend that section. Completely on me.