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The next frontier in weight-loss drugs: one-time gene therapy

https://www.washingtonpost.com/health/2026/01/24/fractyl-glp1-gene-therapy/
1•bookofjoe•33s ago•1 comments

At Age 25, Wikipedia Refuses to Evolve

https://spectrum.ieee.org/wikipedia-at-25
1•asdefghyk•3m ago•1 comments

Show HN: ReviewReact – AI review responses inside Google Maps ($19/mo)

https://reviewreact.com
1•sara_builds•3m ago•0 comments

Why AlphaTensor Failed at 3x3 Matrix Multiplication: The Anchor Barrier

https://zenodo.org/records/18514533
1•DarenWatson•4m ago•0 comments

Ask HN: How much of your token use is fixing the bugs Claude Code causes?

1•laurex•8m ago•0 comments

Show HN: Agents – Sync MCP Configs Across Claude, Cursor, Codex Automatically

https://github.com/amtiYo/agents
1•amtiyo•9m ago•0 comments

Hello

1•otrebladih•10m ago•0 comments

FSD helped save my father's life during a heart attack

https://twitter.com/JJackBrandt/status/2019852423980875794
2•blacktulip•13m ago•0 comments

Show HN: Writtte – Draft and publish articles without reformatting, anywhere

https://writtte.xyz
1•lasgawe•15m ago•0 comments

Portuguese icon (FROM A CAN) makes a simple meal (Canned Fish Files) [video]

https://www.youtube.com/watch?v=e9FUdOfp8ME
1•zeristor•16m ago•0 comments

Brookhaven Lab's RHIC Concludes 25-Year Run with Final Collisions

https://www.hpcwire.com/off-the-wire/brookhaven-labs-rhic-concludes-25-year-run-with-final-collis...
2•gnufx•18m ago•0 comments

Transcribe your aunts post cards with Gemini 3 Pro

https://leserli.ch/ocr/
1•nielstron•22m ago•0 comments

.72% Variance Lance

1•mav5431•23m ago•0 comments

ReKindle – web-based operating system designed specifically for E-ink devices

https://rekindle.ink
1•JSLegendDev•25m ago•0 comments

Encrypt It

https://encryptitalready.org/
1•u1hcw9nx•25m ago•1 comments

NextMatch – 5-minute video speed dating to reduce ghosting

https://nextmatchdating.netlify.app/
1•Halinani8•26m ago•1 comments

Personalizing esketamine treatment in TRD and TRBD

https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1736114
1•PaulHoule•27m ago•0 comments

SpaceKit.xyz – a browser‑native VM for decentralized compute

https://spacekit.xyz
1•astorrivera•28m ago•0 comments

NotebookLM: The AI that only learns from you

https://byandrev.dev/en/blog/what-is-notebooklm
2•byandrev•28m ago•1 comments

Show HN: An open-source starter kit for developing with Postgres and ClickHouse

https://github.com/ClickHouse/postgres-clickhouse-stack
1•saisrirampur•29m ago•0 comments

Game Boy Advance d-pad capacitor measurements

https://gekkio.fi/blog/2026/game-boy-advance-d-pad-capacitor-measurements/
1•todsacerdoti•29m ago•0 comments

South Korean crypto firm accidentally sends $44B in bitcoins to users

https://www.reuters.com/world/asia-pacific/crypto-firm-accidentally-sends-44-billion-bitcoins-use...
2•layer8•30m ago•0 comments

Apache Poison Fountain

https://gist.github.com/jwakely/a511a5cab5eb36d088ecd1659fcee1d5
1•atomic128•32m ago•2 comments

Web.whatsapp.com appears to be having issues syncing and sending messages

http://web.whatsapp.com
1•sabujp•32m ago•2 comments

Google in Your Terminal

https://gogcli.sh/
1•johlo•34m ago•0 comments

Shannon: Claude Code for Pen Testing: #1 on Github today

https://github.com/KeygraphHQ/shannon
1•hendler•34m ago•0 comments

Anthropic: Latest Claude model finds more than 500 vulnerabilities

https://www.scworld.com/news/anthropic-latest-claude-model-finds-more-than-500-vulnerabilities
2•Bender•39m ago•0 comments

Brooklyn cemetery plans human composting option, stirring interest and debate

https://www.cbsnews.com/newyork/news/brooklyn-green-wood-cemetery-human-composting/
1•geox•39m ago•0 comments

Why the 'Strivers' Are Right

https://greyenlightenment.com/2026/02/03/the-strivers-were-right-all-along/
1•paulpauper•40m ago•0 comments

Brain Dumps as a Literary Form

https://davegriffith.substack.com/p/brain-dumps-as-a-literary-form
1•gmays•40m ago•0 comments
Open in hackernews

I created Pareto³, a method to find the ~1% of causes driving >50% of effects

https://github.com/adistan/pareto_cube
3•adistan•5mo ago

Comments

adistan•5mo ago
Hi HN, author here.

I've spent the last few months developing a structured thinking methodology to deal with complex problems where everything seems important, but not everything actually is. The result is the Pareto Cube (Pareto³), an open-source architecture for clarity.

The core idea is to recursively apply the 80/20 principle to drill down to the actionable core of any issue (~0.8% of causes driving >50% of the impact) and then apply the "5 Whys" to find the true root cause.

This is v1.1, a stable and usable version, but it's just the beginning. I've also published a Development Roadmap that outlines the future of Pareto³, including the integration of concepts like the Gini Coefficient and Causal Loop Diagrams to make it even more robust.

I'm posting it here because I believe this community is the best in the world at stress-testing, critiquing, and improving such frameworks. All feedback is welcome and will be considered for future versions.

What complex problem would you apply this to first?

GitHub (with all files & the Roadmap): https://github.com/adistan/pareto_cube

Zenodo (Permanent Archive & DOI): https://doi.org/10.5281/zenodo.16899115

Thank you for your time!