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Kucha

https://en.wikipedia.org/wiki/Kucha
1•benbreen•1m ago•0 comments

Boiling Frog

https://en.wikipedia.org/wiki/Boiling_frog
1•thunderbong•2m ago•0 comments

Crypto Royale – A Play to Earn Ecosystem That Rewards You for Having Fun

1•CryptoRoyale•3m ago•0 comments

Sci-Hub has been blocked in India

https://sci-hub.se/sci-hub-blocked-india
1•the-mitr•4m ago•0 comments

Show HN: CivMD – CivitAI model downloader in your terminal

https://github.com/jackowfish/civitai-downloader
1•jackdecker•9m ago•0 comments

Origins of Life: Thioester RNA Aminoacylation Enables Peptide Synthesis

https://bioengineer.org/thioester-rna-aminoacylation-enables-peptide-synthesis/
1•jbotz•10m ago•0 comments

Scientists Spotted a 'Yellow Brick Road' at the Bottom of the Pacific Ocean (2022)

https://www.sciencealert.com/scientists-spotted-a-yellow-brick-road-at-the-bottom-of-the-pacific-...
2•samaysharma•11m ago•0 comments

The Deletion of Docker.io/Bitnami

https://community.broadcom.com/tanzu/blogs/beltran-rueda-borrego/2025/08/18/how-to-prepare-for-th...
2•zdkaster•14m ago•0 comments

Checkpoints for Claude Code

https://apps.apple.com/us/app/checkpoints-for-claude-code/id6751541546?mt=12
1•punnerud•14m ago•0 comments

Matter Is Finally Ready to Deliver the Smart Home It Promised

https://www.wired.com/story/matter-is-finally-on-track-to-deliver-the-smart-home-it-promised/
1•CharlesW•15m ago•0 comments

An Automated Lego Car Factory [video]

https://www.youtube.com/watch?v=XTyzfUEb9_s
1•pajtai•15m ago•0 comments

Classic Psion fan releases proof-of-concept language server for OPL

https://www.theregister.com/2025/08/27/vintage_computing_boffin_resurrects_opl/
1•idw•16m ago•0 comments

Listers: A glimpse into extreme bird watching

https://www.youtube.com/watch?v=zl-wAqplQAo
1•brudgers•20m ago•0 comments

Smart Attack on Elliptic Curves for Programmers

https://leetarxiv.substack.com/p/smart-attack-on-elliptic-curves-for
1•thunderbong•23m ago•0 comments

Origin and history of 'deprecate'

https://www.etymonline.com/word/deprecate
2•pash•31m ago•1 comments

PGlite – embeddable Postgres with real-time, reactive bindings

https://github.com/electric-sql/pglite
1•microflash•33m ago•0 comments

Some Pixels are bricked and Google apparently won't help revive them

https://www.androidauthority.com/google-pixel-phones-bricked-3591218/
2•josephcsible•35m ago•0 comments

There Is Thinking and There Is Thinking and There Is Thinking

https://aethermug.com/posts/there-is-thinking-and-there-is-thinking-and-there-is-thinking
3•zdw•37m ago•0 comments

Ask HN: Do you read your own PR?

1•bubblebeard•40m ago•1 comments

Last Man

https://en.wikipedia.org/wiki/Last_man
3•ofrzeta•40m ago•0 comments

Show HN: Stop paying for analytics. I built a Bring-Your-Own database platform

https://berrylog.app/
1•lakshikag•43m ago•0 comments

Show HN: AIKit

https://github.com/chinmaymk/aikit
1•_chinmaymk•1h ago•0 comments

With little to show from 10 years of work, WA suspends $292M IT rebuild

https://www.seattletimes.com/business/with-little-to-show-from-10-years-of-work-wa-suspends-292m-...
4•rwc9•1h ago•0 comments

Hola Que Tu Al

1•Idodbslb•1h ago•1 comments

Anthropick.com Redirects to ChatGPT

4•nerdcortex•1h ago•0 comments

Ready to build Alaska's next legendary lodge?

https://www.motherlodehatcherpass.com/submit-a-proposal
3•thoughtstheseus•1h ago•0 comments

A Dark Mode PDF Reader Competing with Adobe

https://www.shadowreader.io/
2•EbenZergaw•1h ago•1 comments

Nothing busted using professional photos as Phone 3 samples

https://www.theverge.com/report/766543/nothing-busted-using-fake-phone-3-photo-samples
2•Brajeshwar•1h ago•1 comments

Htm.sh – turn your code into a live website instantly from your shell

https://htm.sh/
2•viniciusbarreto•1h ago•0 comments

Why Did ChatGPT Hit a Wall? [video]

https://www.youtube.com/watch?v=emHCav2pxLA
2•slashnode•1h ago•0 comments
Open in hackernews

White House fires CDC director Monarez after she refuses to resign

https://www.cnbc.com/2025/08/27/cdc-director-susan-monarez-.html
82•donsupreme•2h ago

Comments

andrewflnr•2h ago
> Monarez, a longtime federal government scientist, was sworn in on July 31.

> President Donald Trump nominated Monarez after withdrawing his first pick to lead the CDC, former Republican congressman Dave Weldon, hours before his confirmation hearing.

Is this a record from confirmation to firing?

pfannkuchen•1h ago
The guy likes firing people, he had a whole tv show about it.
ivraatiems•1h ago
Anthony Scaramucci wasn't confirmed, but he was hired and fired in 11 days during Trump I.
tw04•1h ago
Is it more or less than one Scaramucci?

Also: he had no idea she was actually going to try doing her job. He was hoping for another yes-woman and got someone semi-competent. I doubt they'll make that mistake a second time, expect some reality-TV star to be the next nomination.

drewbug01•1h ago
Just shy of three Scaramuccis, in fact.
treetalker•1h ago
The Mooch!
dragonwriter•57m ago
> Is it more or less than one Scaramucci?

Scaramucci wasn't in a Senate-confirmed position, so while perhaps useful as a unit of longevity measure, he’s not a relevant confirmation–firing competitor.

abeppu•2h ago
Logistically / organizationally, what has to go wrong for the administration to nominate her, have her in place for less than a month, and then remove her? Like, before you send someone through confirmation, do you have a quick conversation to confirm, "I want to do X, I have expectations Y" etc and confirm that they're onboard? It sounds like Monarez wasn't willing to be a loyal obedient servant, and good for her -- but could the Trump administration really not determine that in advance?

Or was she put in that position for the purpose of being fired, just for the news story, and this is all going to plan?

altairprime•2h ago
In terms of a CFO in a business: one month after you’re hired, the CEO asks you to lie on this year’s financial reports. You refuse, having joined up on the pretense that you’d be given some leeway to do what’s right, and they fire you. The CEO gets to filter out all future candidates for yeslings, makes clear to the marketplace that they’re powerful ans unconcerned with being viewed as evil, and gets to create suffering and woe for someone who stood up to them. Triple win, especially if sociopathy, and it’s a very effective honeypot for well-intended individuals with a “change from within” mindset.

:(

protocolture•1h ago
I saw this happen once.

Old owners sell the business, become the C team with profit targets for a big payout.

Minutes after the payout the old C team resign to be with family/visit foreign country.

New C team comes on board.

New C team cant figure out how the numbers work.

New C team realises that the books arent as in the black as described.

New C team refuses to go down with the ship, resign to be with family etc.

Owner manages the business for a few months, sells it back to one of the original owners for pennies on the dollar.

maest•1h ago
Clawback clauses are a thing, both for company sellers and C-suite payouts.
altairprime•50m ago
So are the Seychelles.
nativeit•48m ago
You figure we'll get sold in pieces back to the UK, France, Russia, Spain, and/or Denmark? Or just picked up as one big colony for China?
garyfirestorm•1h ago
You’re giving too much credit to the admin. They’re a rag tag group of below average IQ wannabes. They can’t possibly be smart about everything all the time. They can only hope people will fall in line with implied threats.
changoplatanero•1h ago
I heard from someone high up in the administration that it’s really hard for some of the political appointments it’s been hard for them to find qualified people, who are willing to take the job, and who haven’t publicly criticized trump. For some of these positions they might not have many people to pick from
neuronexmachina•1h ago
Yep. He was forced to pull his first nominee for CDC director due to the nominee being an anti-vaxxer: https://www.politico.com/news/2025/03/13/dave-weldon-vaccine...

> Weldon, a Florida representative from 1995 until 2009, has been critical of the federal government’s oversight of vaccine safety. While in the House, he sponsored a bill that would have taken vaccine safety oversight from the CDC and created a separate “Agency for Vaccine Safety Evaluation” under HHS, and as recently as 2019 repeated the disproved claim that “some children can get an autism spectrum disorder from a vaccine” in an interview.

myvoiceismypass•36m ago
This doesn’t seem to match the reality i see where anyone can get confirmed - Fox News has an entire roster of current and ex hosts that capable of fulfilling Trump’s order. Career drunks (Hesgeth, Pirro) are actually in adult professional government positions. Wild. Is Kid Rock an ambassador yet?
gnerd00•1h ago
people with knowledge about this multi-billion dollar situation are not commenting here; meanwhile, the forum is filled with vapid speculations. hint- the wealthiest man in the world for 20 straight years, who had business empires under him that stretched around the world, became obsessed with this exact topic. Literally nothing written here so far has insight into the real, high-stakes worlds that this is overseeing. Do I add my own clueless, rorschack-test reactions to fill space? no. The dizzying amounts of money and administrative power, among so very very few groups, is clearly lost on this otherwise smart board. I attribute it directly to the phenomenon that "those that know, do not talk"
glaucon•1h ago
> hint- the wealthiest man in the world for 20 straight years

Your hint doesn't help me much because, as far as I can tell, no individual has been considered the wealthiest person in the world for a period of twenty consecutive years since John P Getty[1], and he's been dead for fifty years. It seems unlikely that he had views about vaccine policy in the USA which are relevant to today, so who are you referring to?

[1] https://www.madisontrust.com/information-center/visualizatio...

knowitnone2•52m ago
so you chimed in to say absolutely nothing
myvoiceismypass•13m ago
To quote the Talking Heads:

You’re talking a lot - but you’re not saying anything!

Can you maybe rewrite this in a way that doesn’t assume everyone that doesn’t know what you apparently know is clued in?

ivraatiems•1h ago
The physicians in my life - including my spouse - have essentially all abandoned the CDC and FDA as a source of decision-making on vaccines and pharmaceuticals, except for what is required by law.

Other sources of guidance, such as the American Academy of Pediatrics' immunization schedule[0] and the WHO recommendations[1] are gaining prominence instead.

If you are an opponent of vaccines or a supporter of "MAHA", who is happy with what the CDC/FDA is doing, you might want to consider that the way they're doing it has utterly failed to convince the vast majority of people who are responsible for actually executing their guidance, and therefore will have limited impact.

As I am neither of those things, I am just glad these other options exist.

[0] https://publications.aap.org/redbook/resources/15585/AAP-Imm... [1] https://www.who.int/teams/immunization-vaccines-and-biologic...

(And no, I am not looking to debate vaccines or whatever else with you. I'm making a point about how fringe movements who get into power then have to solve the same problems the powerful movements did originally.)

analog31•1h ago
A concern of mine is where the insurance companies will get their guidelines, i.e., who pays. Also, being willing to pay out of pocket is not a panacea, as you can still be turned down.
clumsysmurf•1h ago
Indeed,

"Nineteen states have laws or regulations that only let pharmacists administer vaccines recommended by ACIP, according to the American Pharmacists Association.

In those states, pharmacies may not be able to dole out shots even for people who fit the FDA’s narrowed range until the committee makes its recommendation."

https://apnews.com/article/covid-19-vaccine-insurance-covera...

SoftTalker•1h ago
I'd expect insurance companies realize that paying for vaccines is a lot cheaper than paying for measles, mumps, covid, and the flu. They are in business to make a profit, not to pinch pennies at the cost of pounds.

Not to mention that common vaccines are not very expensive, even if you're paying out of pocket.

wredcoll•42m ago
Not if you get to stop paying for treatments if they get sick!
ggm•1h ago
> The physicians in my life - including my spouse - have essentially all abandoned the CDC and FDA as a source of decision-making on vaccines and pharmaceuticals, except for what is required by law.

The risk in this implicitly will be that some vaccines may be declared illegal, or not permitted in some other licencing model, which means physicians will be at risk of their professional registration to make them available.

I could imagine a similar risk in the prescribing of Mifepristone/Misoprostol. Not to actually declare 'day after' pill illegal, but withdraw licence to use the drugs, and put doctors at risk if they go ahead.

mcswell•51m ago
I worry that the pharmaceutical companies won't have the funding to develop vaccines for new variants of existing diseases (like the yearly Covid-19 and flu variants), or even for "new" diseases (e.g. there's a dog vaccine for Lyme disease, but not one for humans). IIUC (please correct me if I'm wrong), vaccine development is expensive, and relies on government subsidies--which certainly won't be coming from the US in the near future. And even provision of existing vaccines depends on there being a market, where the US has been the most reliable such market--again, correct me if I'm wrong (I'm hoping I am!).
knowitnone2•49m ago
I, for one, will be happy to see Covid make a vigorous comeback in the US. Theories need to be tested.
userbinator•47m ago
We're probably past herd immunity at this point.
wredcoll•41m ago
Yeah, just like how no one gets other forms of the flu these days... herd immunity...
timr•46m ago
> Other sources of guidance, such as the American Academy of Pediatrics' immunization schedule[0] and the WHO recommendations[1] are gaining prominence instead.

Not for nothing, but the AAP immunization schedule is explicitly at odds with the WHO schedule regarding the Covid vaccine: AAP says it is recommended for 18 years or younger, and the WHO does not. [1]

In fact, the AAP recommendations include some extremely questionable vaccines for children in the USA, such as Mpox and Dengue. Filtering for duplicates, I count 19 recommended vaccines for children in the AAP document, vs. 10 for the WHO.

Point being: there's obviously a reasonable amount of disagreement here, and any physician who treats them interchangeably clearly hasn't read them.

[1] And there's good reason for this: the risk/benefit ratio for Covid vaccine in healthy children has never been shown to be positive. The AAP is advancing an entirely unscientific recommendation based on, as far as I can tell, US politics.

magicalist•33m ago
> In fact, the AAP recommendations include some extremely questionable vaccines for children in the USA, such as Mpox and Dengue

Let's see:

> The AAP recommends dengue vaccination for children between ages 9-16 who have had a previous dengue infection confirmed by a laboratory test and live in dengue endemic areas (eg. Puerto Rico, American Samoa, US Virgin Islands)

> There is a vaccine available to individuals < 18 years who have been exposed to mpox (ie, JYNNEOS vaccine for post-exposure prophylaxis,) under expanded use authorization issued by the Food and Drug Administration.

> Point being: there's obviously a reasonable amount of disagreement here.

Only if you misrepresent their recommendations!

timr•27m ago
> Only if you're dishonest about their recommendations!

I literally just went to the PDF guide the OP linked to, which presents it as a recommended vaccination (for a non-endemic disease in the USA):

https://downloads.aap.org/AAP/PDF/AAP-Immunization-Schedule....

But fine, you've touched on 1 out of the 9 differences. You still won't find it in the WHO guide, which is odd, considering that the WHO is recommending vaccines for a number of countries around the world where the disease actually is endemic.

magicalist•15m ago
> I literally just went to the PDF guide the OP linked to, which presents it as a recommended vaccination (for a non-endemic disease in the USA):

https://downloads.aap.org/AAP/PDF/AAP-Immunization-Schedule....

They have a 1-6 steps right on the first page. Step 1: "Determine recommended vaccine by age (Table 1)"

OK, turn to Table 1. Dengue:

> Seropositive in areas with endemic dengue (See Notes)

Mpox: 18+ "for certain high-risk groups or populations"

You can also turn to page 7 for the same notes for Dengue, and page 11 for what constitutes risk factors that would lead you to consider administering the mpox vaccine.

timr•13m ago
You can nit-pick if you want, but there are major differences between the two schedules, they're different for a reason, and my point is that there's actual scientific disagreement around many of these vaccines.

In the case of Mpox, it's because the disease isn't a risk for most children (especially not in the USA). In the case of Dengue, it's because you can actually kill someone by giving the vaccine before they get Dengue. It's not a great vaccine.

Rejecting one schedule because you read that it was "anti-science" is as non-sensical as accepting the AAP without knowing that it's actually very different than the WHO recommendations.

nxobject•23m ago
> In fact, the AAP recommendations include some extremely questionable vaccines for children in the USA, such as Mpox and Dengue. Filtering for duplicates, I count 19 recommended vaccines for children in the AAP document, vs. 10 for the WHO.

Having read the AAP's schedule: the recommendations are Mpox and Dengue are only for populations at risk, and not necessarily infants: e.g. Mpox is indicated for individuals 18+ and at risk; Dengue is indicated for ages 9-16 in areas with endemic Dengue and with history of prior infection.

timr•15m ago
Neither recommendation is in the WHO document for good reasons.

Mpox isn't endemic in the USA, and children under 18 were never a risk group here even during the outbreaks a year or two ago. This is purely political.

The Dengue vaccine is...not very good, and has serious interactions with the virus itself. Getting the Dengue vaccine before you get Dengue can put you in the hospital. Even suggesting that this should be on a document of "recommended" vaccinations is, quite frankly, stupid [1].

I recognize that the AAP puts asterisks on these things, but the point is that there are big differences between the schedules, and you can't just put blind faith in their recommendations because you've decided that the CDC is anti-science.

[1] https://www.cdc.gov/dengue/hcp/vaccine/eligibility.html

magicalist•10m ago
> Getting the Dengue vaccine before you get Dengue can put you in the hospital

They literally list a positive blood test for previous Dengue infections as one of the requirements for getting the vaccine, in the document you're looking at.

Please stop spouting bullshit while desperately searching for something to latch on to.

timr•7m ago
Nothing I wrote is incorrect.
nxobject•6m ago
> Mpox isn't endemic in the USA, and children under 18 were never a risk group

> The Dengue vaccine is...not very good, and has serious interactions with the virus itself. Getting the Dengue vaccine before you get Dengue can put you in the hospital.

The "asterisks" contradict what you're saying: one of the Dengue recommendation's conditions are people who have diagnostic confirmation of a previous Dengue infection (endemic areas include Puerto Rico and American territories in the Pacific); Mpox is recommended for people over 18 (minimum age) which meet a series of risk factors primarily concerning being men-having-sex-with-men plus other conditions.

Seemingly having found more in the recommendations than you have, it seems to me the AAP's recommendations are complementary, rather than contradictory, save the recommendation for COVID-19 vaccination.

ChrisArchitect•1h ago
More discussion: https://news.ycombinator.com/item?id=45047395
JustExAWS•1h ago
I am trying to figure out what this means for me as a very pro vax person who is healthy - until I get any type of respiratory viral infection and my immune system over reacts.

Covid vaccines seem like they are going to be more of a pain to get because I will have to go to a doctor instead of the pharmacist. Flu and pneumonia vaccines don’t seem to be affected yet.

I am paying more attention to other country’s health departments since you can no longer trust the US.

On the other hand, the US was one of the last countries to admit that the COVID vaccines - especially the non mRNA variants effectiveness wore off. I got a booster off label a couple of months before it was officially recommended in the US based on credible evidence from other country’s health departments

crooked-v•48m ago
If the Trump administration follows through and makes modern vaccines difficult to get, the simplest option for US citizens will be to take a brief trip over the border to Canada or Mexico and pay out of pocket for a dose. Generally vaccines are cheap enough, even the fancy ones, that the per-dose cost is negligible compared to the travel. You can even make it a short vacation and time the shot at the end, so the full impact and recovery time kicks in once you're back home.

There's some intense irony here that "vaccine tourism" used to be an active economic boost for the US (https://www.nbcnews.com/news/latino/covid-shot-tourism-latin...), and now it's going to be very much the other way around.

nativeit•41m ago
I'm very pro-vax and less than healthy, having multiple sclerosis, which is famously not great when immune system production spikes as novel new viruses appear on the scene. My best case scenario for proactive management of my disease involves staying current and getting routine vaccines for seasonal flu and COVID-19.

I could literally scream until my lungs bled over the credulousness and willful ignorance of the broader populace. I understand there will always be esoteric areas of science and technology that no layperson should be expected to meaningfully comprehend, but why doesn't that still induce the natural response of "Ask my doctor,"? The lack apparent lack of critical thinking skills is frankly appalling.

knowitnone2•55m ago
fires anyone who disagrees or does not fall in line. absolute tyrany
itake•51m ago
I'm probably going to be down voted... but if an organization (business or government) is full of people that refuse to sing the same song, how can such an organization accomplish anything?

In politics, we saw what happens when the republicans can't agree with each other and failed to elect a majority leader. We also designate 1 person to control a significant part of our government, not a committee people with opposite view points.

Inconsistent messaging from leadership creates distrust amount the workers/population and prevents people from accomplishing anything.

aaomidi•49m ago
By engaging positively and understanding rather than creating a cult.
itake•18m ago
What successful organization isn't cult-like, where everyone sings the same song?
rossjudson•46m ago
It really depends on the song, doesn't it?
magicalist•12m ago
> I'm probably going to be down voted... but if an organization (business or government) is full of people that refuse to sing the same song, how can such an organization accomplish anything?

If the purpose of the organization is based in science, what does it matter if you accomplish anything if you've fired all the scientists and all you have left are the politicians and spokespeople?

And if the acts of Congress that created your organization mandate that science be conducted, is it maybe time to do some soul searching about why no one wants to sing your terrible song?

dragonwriter•5m ago
> I'm probably going to be down voted... but if an organization (business or government) is full of people that refuse to sing the same song, how can such an organization accomplish anything?

How can an organization learn, recognize new facts, adapt to change, and synthesize knowledge if everyone is constrained to singing one song?