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Microbial metabolite repairs liver injury by restoring hepatic lipid metabolism

https://journals.asm.org/doi/10.1128/mbio.01718-25
62•PaulHoule•6h ago

Comments

searine•3h ago
Supported by grants from NIH/NIAID Grants and the University of California Davis.
DaveZale•56m ago
yeah Davis is agriculturally oriented. Because this microbe grows in cows stomachs it is added to silage (feed) - so dairy products have this metabolite.

Amazing finding. The statistics on liver damage from aflatoxins said to affect potentially 5 billion people. And of course in the US, with its high incidence of obesity has liver issues due to NAFLD. Then of course the heavy drinkers are all at risk.

mmmpetrichor•2h ago
I'll drink to that!
DaveZale•1h ago
kefir has that microbe. So drink some kefir

and eat a kraut dog. Or a Ruben. https://en.m.wikipedia.org/wiki/Lactiplantibacillus_plantaru...

ck2•34m ago
10-HSA is a fatty-acid metabolite produced by Lactobacillus bacteria

Lactobacillus Plantarum is a super common probiotic that produces 10-HSA and other important metabolites

its commercial name is also known as lp299v which has been studied for decades, tons of studies

for example: https://www.mdpi.com/2073-4344/10/2/154

lp299v is extreme safe and can be taken in mega-doses however it will not colonize in the GI so would have to be taken routinely

Vibing options for whoever you are

https://seroter.com/2025/08/28/vibing-options-for-whoever-you-are/
1•richards•56s ago•1 comments

Show HN: FunnelBro 3000 – An AI that generates hustle-bro strategies

https://chatgpt.com/g/g-68af324bea4481918e3f71c3d915985c-funnelbro-3000
1•adriana_tica•1m ago•0 comments

Anthropic Will Now Train Claude on Your Chats

https://www.macrumors.com/2025/08/28/anthropic-claude-chat-training/
1•tosh•2m ago•0 comments

Func Prog Podcast #9 with Hécate

https://discourse.haskell.org/t/func-prog-podcast-9-with-hecate/12854
1•Vosporos•3m ago•0 comments

Why Radiology AI Didn't Work and What Comes Next

https://www.outofpocket.health/p/why-radiology-ai-didnt-work-and-what-comes-next
1•nradov•4m ago•0 comments

A Snake Hunt in God's Country

https://www.theparisreview.org/blog/2025/08/25/a-snake-hunt-in-gods-country/
1•bookofjoe•6m ago•0 comments

A Federal Appellate Court Finds the NLRB to Be Unconstitutional

https://prospect.org/justice/2025-08-25-federal-appellate-court-finds-nlrb-unconstitutional/
3•Tadpole9181•7m ago•0 comments

Seeing infrared: contact lenses that grant 'super-vision'

https://www.theguardian.com/science/2025/may/22/infrared-contact-lenses-super-vision
3•colinprince•7m ago•0 comments

The biggest frogs build their own ponds

https://www.science.org/content/article/world-s-biggest-frogs-build-their-own-ponds
1•MaysonL•9m ago•0 comments

Skills You Need to Develop to Be a Better CTO (2017)

https://m.brianmcmanus.org/5-skills-you-need-to-develop-to-be-a-better-cto-528ad055706d
1•colinprince•10m ago•0 comments

The Anti-Autocracy Handbook: Scholars Guide to Navigating Democratic Backsliding

https://zenodo.org/records/15696097
2•nabla9•10m ago•0 comments

Benedict Evans: Why AI Isn't What You Think

https://fs.blog/knowledge-project-podcast/benedict-evans/
1•feross•11m ago•0 comments

Long context GPT-OSS fine-tuning

https://unsloth.ai/blog/gpt-oss-context
1•danielhanchen•12m ago•1 comments

Why AI Models Are Bad at Verifying Photos

https://www.cjr.org/tow_center/why-ai-models-are-bad-at-verifying-photos.php
1•giuliomagnifico•13m ago•0 comments

A Denisovan skull is upending the story of human evolution

https://www.newscientist.com/article/2492337-an-incredible-denisovan-skull-is-upending-the-story-...
2•Anon84•15m ago•0 comments

Show HN: DataCompose – PyJanitor-style dataframe cleaning for PySpark

https://github.com/datacompose/datacompose
1•tccole•16m ago•0 comments

Fasting may affect metabolism and immune response differently in the obese

https://linkinghub.elsevier.com/retrieve/pii/S2589004225011332
1•PaulHoule•17m ago•0 comments

Medicare Will Require Prior Approval for Certain Procedures

https://www.nytimes.com/2025/08/28/health/medicare-prior-approval-health-care.html
2•whack•17m ago•0 comments

Exoplan: Health-Driven Calendar

https://exoplan.io
1•exo_paul•18m ago•0 comments

Interactive Monty Hall Problem Simulator with Probability Visualization

https://montyhallsim.vercel.app/
1•ig1201•19m ago•1 comments

Show HN: I built the ATS YC said would never work

https://www.gethivemind.ai
2•BrainyZeiny•19m ago•0 comments

Building the Space Industry in Colombia

https://www.saganprog.com
1•felipediaz_•20m ago•1 comments

Reevaluating the revolution that fed the world

https://beyondimitation.substack.com/p/revisiting-the-revolution-that-fed
1•mellosouls•24m ago•0 comments

A conservative vision for AI alignment

https://www.lesswrong.com/posts/iJzDm6h5a2CK9etYZ/a-conservative-vision-for-ai-alignment
3•flypunk•24m ago•1 comments

The Economics of Envy

https://www.astralcodexten.com/p/the-economics-of-envy
2•feross•25m ago•0 comments

Health Effects of Cousin Marriage: Evidence from US Genealogical Records

https://www.aeaweb.org/articles?id=10.1257/aeri.20230544
3•speckx•31m ago•0 comments

Solana Consensus – From Forks to Finality

https://neodyme.io/en/blog/solana_consensus/
1•lawrenceyan•31m ago•0 comments

Affiliates Flock to 'Soulless' Scam Gambling Machine

https://krebsonsecurity.com/2025/08/affiliates-flock-to-soulless-scam-gambling-machine/
7•todsacerdoti•32m ago•0 comments

'Isn't Designed to Solve Privacy Concerns,' Grafana CTO on Bring Your Own Cloud

https://www.theregister.com/2025/08/28/grafanas_tom_wilkie_interview/
2•rntn•33m ago•0 comments

Show HN: A high-level search agent

https://www.gensee.ai/tooling.html
5•bobby_zhu•34m ago•0 comments