40% doesn't seem "microdose" to me. If 100% is very effective as it seems right now, 40% should be reasonably effective assuming a somewhat linear dose response curve.
Further blood pressure and weight loss can be easily measured, so I'm not sure why it would be so hard to control the dosage yourself, with the doctors setting a maximum dose instead. It doesn't seem unreasonable at all.
Compare for example to doctors prescribing insane amounts of stimulants to ADHD patients in the past, which they've now scaled back. It's maybe sometimes better to just start with less and see if your symptoms improve.
Antibiotics have to be exactly administered to avoid creating immune bacteria. Many other medications I don't see that danger. Actually it seems more dangerous to use a high dose right away that causes issues for many patients.
40% of the starter dose (40% of 2.5mg = 1mg) would be between 6-10% of the "maintenance dose" (betweeen 10-15mg).
https://www.kff.org/health-costs/poll-1-in-8-adults-say-they...
[0]: https://www.cdc.gov/nchs/fastats/obesity-overweight.htm
evulhotdog•5mo ago