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Removing newlines in FASTA file increases ZSTD compression ratio by 10x

https://log.bede.im/2025/09/12/zstandard-long-range-genomes.html
3•bede•1h ago

Comments

rini17•1h ago
This might in general be a good preprocessing step to check for punctuation repeating in fixed intervals and remove it, and restore after decompression.

The Mirror with No Reflection

https://simone.org/mirror/
1•smnrg•1m ago•0 comments

Use qwen code free tier with VSCode+Kilo Code

https://www.youtube.com/watch?v=G0uIVEt3aj4
1•indigodaddy•1m ago•0 comments

Neo Scored 34.2% SOTA on OpenAI MLE-Bench

https://github.com/openai/mle-bench
2•vijgaurav•2m ago•0 comments

Everything is speeding up [video]

https://www.youtube.com/watch?v=lyJJ17WIoWE
1•surprisetalk•4m ago•0 comments

EU Court Rules Nuclear Energy Is Clean Energy

https://www.weplanet.org/post/eu-court-rules-nuclear-energy-is-clean-energy
2•mpweiher•4m ago•0 comments

Governments ban self-custody crypto, require backdoors on all computers (2035)

1•EGreg•4m ago•0 comments

Find Good Problems

https://dontbreakprod.com/posts/find-good-problems
1•dorkrawk•5m ago•0 comments

Help My therapist is using ChatGPT

https://www.technologyreview.com/2025/09/09/1123386/help-my-therapist-is-secretly-using-chatgpt/
1•nis0s•6m ago•0 comments

Panic in the Ozarks – The Great Cobra Scare

https://mdcp.nwaonline.com/news/2022/apr/21/opinion-panic-in-the-ozarks-the-great-cobra-scare/
1•geox•6m ago•0 comments

Virtual Boy for Nintendo Switch 2

https://www.nintendo.com/us/store/products/virtual-boy-for-nintendo-switch-2-120829/
1•coloneltcb•6m ago•0 comments

Fclones – Efficient Duplicate File Finder

https://github.com/pkolaczk/fclones
1•mihau•7m ago•0 comments

An embarrassing failure of the US patent system: Nintendo's latest patents

https://www.pcgamer.com/gaming-industry/an-embarrassing-failure-of-the-us-patent-system-videogame...
4•rsecora•10m ago•0 comments

Total automation is a fantasy in real-world deployment: (Daniel Jeffries)

https://www.freethink.com/artificial-intelligence/ai-wont-take-all-the-jobs
2•ieuanking•11m ago•0 comments

Mentat: One Agent to Review and Author

https://mentat.ai/blog/mentat-one-agent-to-review-and-author
1•ja3k•13m ago•0 comments

An Introduction to Program Synthesis

https://mchav.github.io/an-introduction-to-program-synthesis/
1•thunderbong•14m ago•0 comments

Apache Software Foundation Unveils Its Branding Overhaul

https://www.phoronix.com/news/New-Apache-Software-Logo
1•sulkie•14m ago•0 comments

Sega Accused of Using Police Raid to Recover Nintendo Dev Kits

https://www.timeextension.com/news/2025/09/sega-accused-of-using-police-to-recover-nintendo-dev-k...
1•chiffre01•15m ago•0 comments

Ask HN: When you imagine, do you see the distance?

1•imvetri•15m ago•0 comments

Show HN: Open-Source to Containerize Dev Environments

https://github.com/chalet-dev/chalet
1•fedepochat•16m ago•0 comments

What people learn from punishment: A cognitive model

https://www.pnas.org/doi/10.1073/pnas.2500730122
1•PaulHoule•17m ago•0 comments

Binge Through Any URL

https://www.hopit.ai/stories?slug=httpswwwycombinatorcomlibrary8t-the-18-mistakes-that-kill-start...
7•Arkid•17m ago•1 comments

Nintendo is bringing back the Virtual Boy as a Switch and Switch 2 accessory

https://www.engadget.com/gaming/nintendo/nintendo-is-bringing-back-the-virtual-boy-as-a-switch-an...
2•GuinansEyebrows•18m ago•0 comments

Preview of LibrePCB 2.0's Next-Gen UI

https://librepcb.org/blog/2025-09-12_preview_of_next_gen_ui/
1•dbrgn•18m ago•0 comments

Many-worlds interpretation of Quantum Mechanics

https://en.wikipedia.org/wiki/Many-worlds_interpretation
1•pykello•21m ago•0 comments

Is 'The Pitt' an 'ER' Spinoff? Michael Crichton's Estate Says It Is

https://www.nytimes.com/2025/09/12/business/the-pitt-er-michael-crichton-lawsuit.html
2•ChrisArchitect•21m ago•1 comments

AT&T – 1993 "You Will" Ad Campaign [video]

https://www.youtube.com/watch?v=RvZ-667CEdo
1•keepamovin•21m ago•0 comments

What Happens After I'm Gone? The Future of the Online Me

https://btxx.org/posts/planning-ahead/
3•todsacerdoti•24m ago•0 comments

The productivity paradox of AI coding assistants

https://www.cerbos.dev/blog/productivity-paradox-of-ai-coding-assistants
2•knes•25m ago•0 comments

Albania puts AI-created 'minister' in charge of public procurement

https://www.theguardian.com/world/2025/sep/11/albania-diella-ai-minister-public-procurement
2•taubek•27m ago•0 comments

Reverse engineering SkyCards, a flight spotting game

https://blog.jonlu.ca/posts/skycards
1•jonluca•29m ago•0 comments