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Polylaminin, a drug considered capable of reversing spinal cord injury

https://www1.folha.uol.com.br/internacional/en/scienceandhealth/2025/09/groundbreaking-brazilian-drug-considered-capable-of-reversing-spinal-cord-injury-presented-in-sao-paulo.shtml
135•_aleph2c_•4mo ago

Comments

voxleone•4mo ago
Paper: https://journals.plos.org/plosone/article?id=10.1371/journal...
mmaia•4mo ago
Published: October 8, 2014

More recent work indexed in Google Scholar: https://scholar.google.com/citations?hl=en&user=TVozLNoAAAAJ...

giarc•4mo ago
That paper is an in vitro demonstration whereas the OP article seems to imply they tested on actual patients?
lucasqueiroz•4mo ago
Yes, it was tested on patients. @ bfdrummond on Instagram was the first one - he is now almost 100% recovered
heavyset_go•4mo ago
Do we know of other patients?

Sometimes drug and medical device companies will gag patients with non-disparagement agreements, while letting the success stories post freely on social media to promote their product/procedure/etc.

zipy124•4mo ago
I think it's actually this one, or perhaps a new one after it:

https://www.medrxiv.org/content/10.1101/2024.02.19.24301010v...

klipklop•4mo ago
I find this part most interesting: "Three participants (2, 7, 8) regained motor control. i.e., converted to AIS C or D, at the 1-month examination. Other three (4, 5, 6) converted to grade C after 3 months. In the present study we observed that, in contrast to the expected baseline conversion of 15%, 75% (6/8) of the participants regained voluntary motor control after polylaminin treatment. If we consider only those participants that reached discharge, the proportion increases to 100% (6/6)."
lucasqueiroz•4mo ago
More details: https://ensaiosclinicos.gov.br/news/331
OptionOfT•4mo ago
This is fantastic news.

A good friend of mine spent years doing research at Caltech in basically trying to bridge the severed part of the spinal column with electrodes. In mice that is.

The department got lots of $ from the Christopher & Dana Reeve Foundation to help them in said research.

ReKindle – web-based operating system designed specifically for E-ink devices

https://rekindle.ink
1•JSLegendDev•22s ago•0 comments

Encrypt It

https://encryptitalready.org/
1•u1hcw9nx•23s ago•0 comments

NextMatch – 5-minute video speed dating to reduce ghosting

https://nextmatchdating.netlify.app/
1•Halinani8•1m ago•1 comments

Personalizing esketamine treatment in TRD and TRBD

https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1736114
1•PaulHoule•2m ago•0 comments

SpaceKit.xyz – a browser‑native VM for decentralized compute

https://spacekit.xyz
1•astorrivera•3m ago•1 comments

NotebookLM: The AI that only learns from you

https://byandrev.dev/en/blog/what-is-notebooklm
1•byandrev•3m ago•1 comments

Show HN: An open-source starter kit for developing with Postgres and ClickHouse

https://github.com/ClickHouse/postgres-clickhouse-stack
1•saisrirampur•4m ago•0 comments

Game Boy Advance d-pad capacitor measurements

https://gekkio.fi/blog/2026/game-boy-advance-d-pad-capacitor-measurements/
1•todsacerdoti•4m ago•0 comments

South Korean crypto firm accidentally sends $44B in bitcoins to users

https://www.reuters.com/world/asia-pacific/crypto-firm-accidentally-sends-44-billion-bitcoins-use...
1•layer8•5m ago•0 comments

Apache Poison Fountain

https://gist.github.com/jwakely/a511a5cab5eb36d088ecd1659fcee1d5
1•atomic128•7m ago•1 comments

Web.whatsapp.com appears to be having issues syncing and sending messages

http://web.whatsapp.com
1•sabujp•7m ago•2 comments

Google in Your Terminal

https://gogcli.sh/
1•johlo•9m ago•0 comments

Shannon: Claude Code for Pen Testing: #1 on Github today

https://github.com/KeygraphHQ/shannon
1•hendler•9m ago•0 comments

Anthropic: Latest Claude model finds more than 500 vulnerabilities

https://www.scworld.com/news/anthropic-latest-claude-model-finds-more-than-500-vulnerabilities
2•Bender•13m ago•0 comments

Brooklyn cemetery plans human composting option, stirring interest and debate

https://www.cbsnews.com/newyork/news/brooklyn-green-wood-cemetery-human-composting/
1•geox•13m ago•0 comments

Why the 'Strivers' Are Right

https://greyenlightenment.com/2026/02/03/the-strivers-were-right-all-along/
1•paulpauper•15m ago•0 comments

Brain Dumps as a Literary Form

https://davegriffith.substack.com/p/brain-dumps-as-a-literary-form
1•gmays•15m ago•0 comments

Agentic Coding and the Problem of Oracles

https://epkconsulting.substack.com/p/agentic-coding-and-the-problem-of
1•qingsworkshop•16m ago•0 comments

Malicious packages for dYdX cryptocurrency exchange empties user wallets

https://arstechnica.com/security/2026/02/malicious-packages-for-dydx-cryptocurrency-exchange-empt...
1•Bender•16m ago•0 comments

Show HN: I built a <400ms latency voice agent that runs on a 4gb vram GTX 1650"

https://github.com/pheonix-delta/axiom-voice-agent
1•shubham-coder•17m ago•0 comments

Penisgate erupts at Olympics; scandal exposes risks of bulking your bulge

https://arstechnica.com/health/2026/02/penisgate-erupts-at-olympics-scandal-exposes-risks-of-bulk...
4•Bender•17m ago•0 comments

Arcan Explained: A browser for different webs

https://arcan-fe.com/2026/01/26/arcan-explained-a-browser-for-different-webs/
1•fanf2•19m ago•0 comments

What did we learn from the AI Village in 2025?

https://theaidigest.org/village/blog/what-we-learned-2025
1•mrkO99•19m ago•0 comments

An open replacement for the IBM 3174 Establishment Controller

https://github.com/lowobservable/oec
1•bri3d•21m ago•0 comments

The P in PGP isn't for pain: encrypting emails in the browser

https://ckardaris.github.io/blog/2026/02/07/encrypted-email.html
2•ckardaris•24m ago•0 comments

Show HN: Mirror Parliament where users vote on top of politicians and draft laws

https://github.com/fokdelafons/lustra
1•fokdelafons•24m ago•1 comments

Ask HN: Opus 4.6 ignoring instructions, how to use 4.5 in Claude Code instead?

1•Chance-Device•26m ago•0 comments

We Mourn Our Craft

https://nolanlawson.com/2026/02/07/we-mourn-our-craft/
1•ColinWright•28m ago•0 comments

Jim Fan calls pixels the ultimate motor controller

https://robotsandstartups.substack.com/p/humanoids-platform-urdf-kitchen-nvidias
1•robotlaunch•32m ago•0 comments

Exploring a Modern SMTPE 2110 Broadcast Truck with My Dad

https://www.jeffgeerling.com/blog/2026/exploring-a-modern-smpte-2110-broadcast-truck-with-my-dad/
1•HotGarbage•32m ago•0 comments