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Using Chrome AI to Summarize Comic Books

https://www.raymondcamden.com/2025/09/12/using-chrome-ai-to-summarize-comic-books
2•gsky•2m ago•0 comments

"The Second Coming" by W. B. Yeats (1920)

https://poets.org/poem/second-coming
1•danielam•6m ago•0 comments

FedCM: A New Proposed Identity Standard That Could Change How We Log In

https://www.infoq.com/articles/federated-credentials-management-w3c-proposal/
3•mooreds•8m ago•0 comments

Kirk suspect's transgender roommate "aghast," may be key to motive

https://www.axios.com/2025/09/13/kirk-suspect-transgender-roommate
2•donsupreme•9m ago•0 comments

Screen History MCP Server

https://newbry.bearblog.dev/screen-history-mcp-server/
1•joenewbry•19m ago•0 comments

Charlie Kirk Didn't Shy Away from Who He Was. We Shouldn't Either

https://www.nytimes.com/2025/09/13/opinion/charlie-kirk-assassination.html
7•maxerickson•21m ago•1 comments

Pass: Unix Password Manager

https://www.passwordstore.org/
1•Bogdanp•22m ago•0 comments

Show HN: TheBigBadMouse – A safe place to ask for anonymous help

https://thebigbadmouse.org/
1•iCeGaming•23m ago•0 comments

Carimbo now have a better stack trace and Sentry integration

https://nullonerror.org/2025/09/11/carimbo-now-have-a-better-stack-trace-and-sentry-integration/
2•delduca•25m ago•0 comments

Elysia generate OpenAPI from TypeScript type

https://elysiajs.com/blog/openapi-type-gen
1•saltyaom•26m ago•0 comments

ERP Therapy Sucks

https://taylor.town/try-erp
1•surprisetalk•33m ago•0 comments

McDonald's AI Chatbot Olivia

https://aidarwinawards.org/nominees/mcdonalds.html
2•planetdebut•33m ago•0 comments

38C3 – BlinkenCity: Radio-Controlling Street Lamps and Power Plants

https://www.youtube.com/watch?v=DAf-T3bFJFs
2•doener•36m ago•0 comments

Twitter's Open-Source Algorithm Analysis with Claude Code

https://nibzard.github.io/twitter-algorithm-tufte/
1•nkko•42m ago•0 comments

Show HN: Tool for automating Twitter posts with news content and scheduling

https://www.markix.com
1•canercbo•43m ago•0 comments

Google tests forced pagination on SERPs

https://www.demandsphere.com/blog/google-tests-forced-pagination-on-serps/
2•rgrieselhuber•44m ago•0 comments

Sleep disorders increase risk of dementia, Alzheimer's, and cognitive decline

https://link.springer.com/article/10.1007/s11357-025-01637-2
2•pedalpete•48m ago•1 comments

The growth of Myanmar scam centres that may hold 100k trafficked people

https://www.theguardian.com/global-development/2025/sep/08/myanmar-military-junta-scam-centres-tr...
1•jnord•48m ago•0 comments

HTTPS: //calming.tools/ – Some help for anxiety

https://calming.tools/
1•DavidCanHelp•53m ago•0 comments

The Indian cafes where you can pay in rubbish

https://www.bbc.com/future/article/20250818-the-indian-garbage-cafes-giving-out-food-in-exchange-...
3•giuliomagnifico•56m ago•0 comments

Billion-dollar coffins? New technology could make oceans transparent

https://www.theguardian.com/australia-news/2025/sep/14/aukus-australian-submarines-vulnerable-new...
2•breve•57m ago•0 comments

Show HN: Musrv – Minimal zero‑config music server written in Rust

https://github.com/smoqadam/musrv
1•smoqadam•1h ago•0 comments

The Graphing Calculator Story

https://www.pacifict.com/Story/
2•KolmogorovComp•1h ago•1 comments

Inboxfuscation: Because Rules Are Meant to Be Broken

https://permiso.io/blog/inboxfuscation-because-rules-are-meant-to-be-broken
3•campuscodi•1h ago•0 comments

Show HN: Freak.nvim, an nvim config for control freaks

https://codeberg.org/fd93/freak.nvim
1•fdavies93•1h ago•1 comments

More than half the people with see large change in 3 traits of big 5 over life

https://bsky.app/profile/soodoku.bsky.social/post/3lyqsmyombc22
2•neehao•1h ago•0 comments

When AI Sells You What You Want

https://kinduff.com/2025/05/28/when-ai-sells-you-what-you-want/
1•kinduff•1h ago•0 comments

Pilot union urges FAA to reject drone cloud-seeding plan

https://techcrunch.com/2025/09/13/pilot-union-urges-faa-to-reject-rainmakers-drone-cloud-seeding-...
1•geox•1h ago•1 comments

M25 – A background job library for Gleam and Postgres

https://github.com/Pevensie/m25
1•TheWiggles•1h ago•0 comments

The climate case for planting trees has been overhyped – but it's not too late

https://theconversation.com/the-climate-case-for-planting-trees-has-been-overhyped-but-its-not-to...
6•PaulHoule•1h ago•4 comments
Open in hackernews

Heart attacks may be triggered by bacteria

https://www.tuni.fi/en/news/myocardial-infarction-may-be-infectious-disease
76•DaveZale•1h ago

Comments

andy99•1h ago
The original title is "Myocardial infarction may be an infectious disease" which appears to be clickbait, with the title posted here being much more accurate.

Immune response to bacteria in arterial plaques can cause them to break up and cause the attack (my lay-interpretation) so the bacteria is a trigger, but "infectious disease" is a bit of hyperbole.

JumpCrisscross•49m ago
> bacteria in arterial plaques can cause them to break up and cause the attack

“Dormant bacteria within the biofilm remain[ing] shielded from both the patient’s immune system and antibiotics because they cannot penetrate the biofilm matrix” whose rupture “result[s] in thrombus formation and ultimately myocardial infarction” sounds like infection more than careless bacteria kicking up muck.

tbrownaw•1h ago
I assume this is a "here's another way this can happen" rather than "actually this is caused only by this and not by what we used to think"?
lostlogin•18m ago
Surely this? The number of ‘oh, it turned out to be more more complicated’ scenarios in medicine is high.
tialaramex•16m ago
Of course it depends on fractions. You can develop cervical cancer via some other route, but the vast, vast majority of cervical cancers are caused by HPV infection. So knowing that all the plans towards eliminating this disease focus on HPV.

On the other hand most people with "flu" in summer months are not infected with Influenza, so an improved influenza treatment isn't going to make a big difference for them unlike in winter. We know other reasons you might get those symptoms which are more likely in summer.

op00to•1h ago
This seems like a good explanation of how my father died. He had the flu, and died overnight from a massive heart attack.
DaveZale•55m ago
sure does. chain of events. The epidemiologists should be able to validate these claims.
awesome_dude•50m ago
https://www.health.harvard.edu/heart-health/what-does-the-fl...

How does flu affect the heart? The virus only rarely infects the heart directly. Instead, the adverse effects of the virus on the heart are due to atherosclerosis of the arteries of the heart. Many people over age 50 have atherosclerosis — and in some people it has not yet been diagnosed. Because atherosclerosis narrows the arteries and reduces the flow of blood, less oxygen reaches the heart muscle. When the effect of the flu on the lungs lowers the amount of oxygen in the blood, this further reduces the supply of oxygen to the heart. This can lead to a heart attack or cardiac arrest (sudden death).

Is this risk more than theoretical? Many careful studies have shown there is an increased risk of heart disease following a bout of flu. In one study of 80,000 adults with influenza, nearly 12% had a serious cardiac event, such as a heart attack, during or in the weeks after getting the flu.

brandonb•52m ago
This is a nicely-designed study. For decades, we've known that inflammation is a risk factor for heart attacks.

In this study, the researchers designed a custom antibody that binds to oral bacteria. Then they used histological staining to identify specific biofilm structures inside the atherosclerotic tissue. Bacteria released from the biofilm were observed in heart attack cases, which gives us evidence that when the body's immune system responded to these bacteria, it triggered inflammation which ruptured cholesterol-laden plaque. So now we have more insight into the mechanism behind why inflammation is associated with heart attack risk.

The "pantheon" of risk factors for heart disease are:

* hs-CRP (inflammation): the mechanism studied by this research. High inflammation roughly doubles your risk of heart disease.

* ApoB - 20% of people with normal cholesterol will have abnormal ApoB, and be at risk of heart disease (ApoB is a structural protein in lipoproteins which cause arterial plaque).

* Lp(a) - the strongest hereditary risk factor for heart disease (Lp(a) acts as a multiplier on ApoB, since it camouflages cholesterol particles from your liver)

* HbA1c - insulin resistance /diabetes is a risk factor for just about everything.

* eGFR - estimates the volume of liquid your kidneys can filter, and is an input to the latest heart disease risk models (PREVENT).

All of these risk factors can be measured with a blood test. Easy to order online: https://www.empirical.health/product/comprehensive-health-pa...

DaveZale•49m ago
are you a cardiologist? Excellent points, thanks
brandonb•40m ago
Not a cardiologist, but adjacent to this type of research. I'm an MLE but have published research in cardiology.
DaveZale•24m ago
thanks for your input on this
mitchbob•19m ago
TIL MLE = Machine Language Engineer. It wasn't listed in Google's AI overview, although I did get

Major League Eating (MLE): a professional organization focused on competitive eating contests.

Mister Leather Europe (MLE): an event within the European leather subculture.

OutOfHere•45m ago
For lipids, besides the named tests, HDL, LDL, and triglyceride tests are older but shouldn't be overlooked.

For measuring inflammation, besides hs-CRP, additional tests are relevant and overlooked: regular CRP, ESR, and homocysteine.

Additionally, a heart attack can result from parasite induced inflammation too, e.g. in chagas disease, which is becoming increasingly common in the US while being very undetected without explicit testing. It is also very difficult to treat, but the gist 4196f31d12a43a95756e792500ff516f has some info on treating it. Lyme disease too can harm the heart permanently. In both cases a pacemaker could help as applicable.

brandonb•21m ago
Can you expand more on why you'd want regular CRP over hs-CRP (specifically for cardiovascular risk)?

For homocysteine, one proxy is B12 or folate (which are more cost-effective to test). To my knowledge, ESR is used in certain rheumatologic conditions, and was used more often in the past, but isn't currently used for heart disease.

OutOfHere•11m ago
It is true that hs-CRP is more relevant for cardiovascular risk. CRP and ESR are more for broader inflammatory risk, for acute and chronic values respectively.
andy99•45m ago
Understanding this is a shameless plug, it's very cool this exists.
stavros•37m ago
You don't need to use this specific blood test, by the way. Any lab near you will test these biomarkers for you.
andy99•29m ago
I live in Canada, despite being free this would be way more complicated to get. I don't want to be political, but just paying for this would be very appealing.
stavros•27m ago
I live in Greece, I can go to a lab, order this, and pay for it. I actually did, the other day, though it was free because the government happens to be running a Lp(a) testing program right now.

Can you not get private labs in Canada?

andy99•23m ago
I've always thought you need a requisition from a doctor, you can't just go pay for something, that's the only way I've seen it done. At least I've never seen services like the OP advertised, that's why I was stricken by it.

(Happy to be corrected)

stavros•22m ago
Hm, over here you need a prescription for medication, but you can do whatever test you want to pay for. I don't know about Canada, though.
brandonb•19m ago
Interesting that you can do this in Greece. In the US, a doctor has the order the labs. (Direct-to-consumer lab testing technically exists, but is always ordered by a doctor.)
stavros•11m ago
To be fair, I don't think anyone actually does it, because who will do their own bloods, but you definitely can. Labs expect to see an order from the doctor, because that's what 99.9% of people have, but they're happy if you just pay out of pocket too.
cj•11m ago
Anyone can order labs via websites like https://directlabs.com/

If there is a doctor involved, it’s invisible to the consumer.

I believe there are 2-3 states where the rules are different (one being New York) where you can’t self-order tests, but every other state is unrestricted.

Even in New York where you can’t order via the typical websites, you can still go directly to Quest or Labcorp and buy your labs directly from them (without talking to a doctor).

Source: I regularly get blood panels without seeing doctors. I highly recommend direct labs, or Quest Direct if you live in NY.

Fun fact… my primary care provider ordered a Vitamin D and lipid panel for me last year. The cost of the labs after insurance was 3x more expensive than buying the labs myself without insurance. Insanity.

hollerith•33m ago
Do you happen to know how much that test costs? (Clicking a link to try to find out brought me to a page that asks for my zip code.)
brandonb•29m ago
That panel is $190.
DaveZale•26m ago
in the US? There was a question from Canada
brandonb•18m ago
Yes -- in the US. I'm not super familiar with the options in Canada, unfortunately!
giveita•24m ago
What do you do next if one is high? See your Doctor?
A_D_E_P_T•21m ago
Yeah. If you don't have obvious symptoms, they'd likely prescribe you a statin, metformin, or some sort of dietary intervention. But you'd want to discuss it with your doctor in any case...
brandonb•18m ago
This particular panel includes a consult with a doctor (who can advise on next steps, prescribe medication, and so on). Or you can take the results to your doctor.
neehao•42m ago
see https://pubmed.ncbi.nlm.nih.gov/17420199/
JumpCrisscross•41m ago
“Dormant bacteria within the biofilm remain[ing] shielded from both the patient’s immune system and antibiotics because they cannot penetrate the biofilm matrix…”

Phages can penetrate biofilms [1]. (They have practice.)

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC8875263/

jimbo808•32m ago
But you can't patent phages, so we'll just continue ignoring them
JumpCrisscross•31m ago
> you can't patent phages, so we'll just continue ignoring them

Nope. Plenty of governments fund this sort of research. And chances are there isn’t an off-the-shelf phage that ticks the boxes, which means you need some amount of genetic engineering, in which case Monsanto has your back.

A_D_E_P_T•23m ago
This raises two questions.

- Does this suggest that courses of antibiotics might reduce heart attack risk?

- Does this suggest that regular use of, e.g., Listerine might reduce heart attack risk? (While, perhaps, slightly increasing esophageal cancer risk.)

It would be interesting to run an epidemiological study to see if current interventions move the needle in a meaningful way.

syntaxing•15m ago
I probably should find sources first but I was always under the impression that the mouth biome is strongly correlated to gut biome which strongly correlated to immune system.
jimbo808•11m ago
This has been suspected for decades.

https://www.thelancet.com/journals/laninf/article/PIIS147330...

Hopefully it leads somewhere that brings us new preventative care.