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The protein denitrosylase SCoR2 regulates lipogenesis and fat storage [pdf]

https://www.science.org/doi/10.1126/scisignal.adv0660
1•thunderbong•1m ago•0 comments

Los Alamos Primer

https://blog.szczepan.org/blog/los-alamos-primer/
1•alkyon•3m ago•0 comments

NewASM Virtual Machine

https://github.com/bracesoftware/newasm
1•DEntisT_•6m ago•0 comments

Terminal-Bench 2.0 Leaderboard

https://www.tbench.ai/leaderboard/terminal-bench/2.0
1•tosh•6m ago•0 comments

I vibe coded a BBS bank with a real working ledger

https://mini-ledger.exe.xyz/
1•simonvc•6m ago•1 comments

The Path to Mojo 1.0

https://www.modular.com/blog/the-path-to-mojo-1-0
1•tosh•9m ago•0 comments

Show HN: I'm 75, building an OSS Virtual Protest Protocol for digital activism

https://github.com/voice-of-japan/Virtual-Protest-Protocol/blob/main/README.md
4•sakanakana00•12m ago•0 comments

Show HN: I built Divvy to split restaurant bills from a photo

https://divvyai.app/
3•pieterdy•15m ago•0 comments

Hot Reloading in Rust? Subsecond and Dioxus to the Rescue

https://codethoughts.io/posts/2026-02-07-rust-hot-reloading/
3•Tehnix•15m ago•1 comments

Skim – vibe review your PRs

https://github.com/Haizzz/skim
2•haizzz•17m ago•1 comments

Show HN: Open-source AI assistant for interview reasoning

https://github.com/evinjohnn/natively-cluely-ai-assistant
4•Nive11•17m ago•6 comments

Tech Edge: A Living Playbook for America's Technology Long Game

https://csis-website-prod.s3.amazonaws.com/s3fs-public/2026-01/260120_EST_Tech_Edge_0.pdf?Version...
2•hunglee2•21m ago•0 comments

Golden Cross vs. Death Cross: Crypto Trading Guide

https://chartscout.io/golden-cross-vs-death-cross-crypto-trading-guide
2•chartscout•23m ago•0 comments

Hoot: Scheme on WebAssembly

https://www.spritely.institute/hoot/
3•AlexeyBrin•26m ago•0 comments

What the longevity experts don't tell you

https://machielreyneke.com/blog/longevity-lessons/
2•machielrey•27m ago•1 comments

Monzo wrongly denied refunds to fraud and scam victims

https://www.theguardian.com/money/2026/feb/07/monzo-natwest-hsbc-refunds-fraud-scam-fos-ombudsman
3•tablets•32m ago•1 comments

They were drawn to Korea with dreams of K-pop stardom – but then let down

https://www.bbc.com/news/articles/cvgnq9rwyqno
2•breve•34m ago•0 comments

Show HN: AI-Powered Merchant Intelligence

https://nodee.co
1•jjkirsch•37m ago•0 comments

Bash parallel tasks and error handling

https://github.com/themattrix/bash-concurrent
2•pastage•37m ago•0 comments

Let's compile Quake like it's 1997

https://fabiensanglard.net/compile_like_1997/index.html
2•billiob•38m ago•0 comments

Reverse Engineering Medium.com's Editor: How Copy, Paste, and Images Work

https://app.writtte.com/read/gP0H6W5
2•birdculture•43m ago•0 comments

Go 1.22, SQLite, and Next.js: The "Boring" Back End

https://mohammedeabdelaziz.github.io/articles/go-next-pt-2
1•mohammede•49m ago•0 comments

Laibach the Whistleblowers [video]

https://www.youtube.com/watch?v=c6Mx2mxpaCY
1•KnuthIsGod•50m ago•1 comments

Slop News - The Front Page right now but it's only Slop

https://slop-news.pages.dev/slop-news
1•keepamovin•55m ago•1 comments

Economists vs. Technologists on AI

https://ideasindevelopment.substack.com/p/economists-vs-technologists-on-ai
1•econlmics•57m ago•0 comments

Life at the Edge

https://asadk.com/p/edge
4•tosh•1h ago•0 comments

RISC-V Vector Primer

https://github.com/simplex-micro/riscv-vector-primer/blob/main/index.md
4•oxxoxoxooo•1h ago•1 comments

Show HN: Invoxo – Invoicing with automatic EU VAT for cross-border services

2•InvoxoEU•1h ago•0 comments

A Tale of Two Standards, POSIX and Win32 (2005)

https://www.samba.org/samba/news/articles/low_point/tale_two_stds_os2.html
4•goranmoomin•1h ago•0 comments

Ask HN: Is the Downfall of SaaS Started?

4•throwaw12•1h ago•0 comments
Open in hackernews

Trigger Crossbar

https://serd.es/2025/09/14/Trigger-crossbar.html
89•zdw•4mo ago

Comments

frainfreeze•4mo ago
The "root canal" side quest was definitely something. Kudos to author
isoprophlex•4mo ago

    > The only thing left to do was solder it up (not trivial, given that I’m trying to hit a 250 μm diameter target at the bottom of a 1.6mm deep hole).
Shiiiit, absolutely heroic skill level.
nine_k•4mo ago
Pretty epic. A very impressive case of building one's own tools, or, rather, a one-off tool that seems to do a simple thing. The most impressive aspect is, of course, handling various issues that normally would require making a new PCB, but the author never retreated.
kragen•4mo ago
I imagine he'll post the files, so they won't be a one-off.
stephen_g•4mo ago
They’re already linked from the article - https://github.com/azonenberg/triggercrossbar/
kragen•4mo ago
Thanks! I had missed that!
azonenberg•4mo ago
Yep. Although given all of the bugs, I don't recommend anyone try to build one without forking and making substantial design changes :)
a1o•4mo ago
This is super impressive. Additionally, I had never heard about ngscopeclient before. Amazingly cool software!
kragen•4mo ago
This is very impressive.
amluto•4mo ago
> My original plan had been to use their standard 1U folded sheet metal design, but I discovered too late, after boards were ordered, that it wasn’t going to work due to the 5mm corner mounting holes being inside the keepout area for the rear bend.

I wonder if a less annoying solution would have been to omit the mounting holes and then drill and tap them after the fact, possibly at a slight angle if the metal is out of plane there.

philipallstar•4mo ago
> Unfortunately, having all of the transceivers in a single quad was a bit limiting due to the 7 series clocking architecture: they share the same QPLL, which has to be at 10.3125 Gbps for 10Gbase-R operation. While the CPLLs can be configured freely, they have a lower Fmax which meant that the BERT / CDR trigger channels cannot operate at arbitrary frequencies above 6 Gbps (most notably, 8 Gbps operation for PCIe gen3 mode is not available).

I'm glad someone understands this.

stephen_g•4mo ago
This one is especially tricky since even if you know what a phased lock loop (PLL) is, the terms CPLL and QPLL are specific to the arrangement of transceivers in these specific Xilinx FPGAs (7 series being one family of FPGAs which came before the UltraScale and then UltraScale+ series). There are four transceivers in a ‘quad’ which can either run from their ‘Channel PLL’ (CPLL) or the shared ‘Quad PLL’ that can run much faster to do basically double the line rate.
azonenberg•4mo ago
Yeah it's always tricky to decide how much detail to include in these posts. If I had gone on a whole explanation of the full 7 series GTX clocking architecture the post would easily have been another few pages in length.
baq•4mo ago
Soldered an ESP32 together with a couple I2C sensors the other week. Didn’t work. Read post, jaw hit floor, maybe I’ll revisit the project soon. Amazing.
thomasjb•4mo ago
This is a really beautiful bit of kit, really like the case and the thought given to signing, but the analog side is really impressive too. Would it be viable to use the same hardware as a base for an NTP server?
azonenberg•4mo ago
You could build an NTP server with much less horsepower (and of course without all of the high speed I/O etc).

The ones from Leo Bodnar are decent.

Liftyee•4mo ago
Amazing levels of depth and detail here. I wonder what sort of choices I need to make to eventually acquire a lab like this.
thrtythreeforty•4mo ago
The author is Andrew Zonenberg. For those unfamiliar, this qualifies as a "medium complexity" (!) project for him. His stuff is always a great read.