frontpage.
newsnewestaskshowjobs

Made with ♥ by @iamnishanth

Open Source @Github

fp.

Open in hackernews

Three-Minute Take-Home Test May Identify Symptoms Linked to Alzheimer's Disease

https://www.smithsonianmag.com/smart-news/three-minute-take-home-test-may-identify-symptoms-linked-to-alzheimers-disease-years-before-a-traditional-diagnosis-180987281/
15•pseudolus•2h ago

Comments

tptacek•27m ago
The standard statistical caution for these kinds of screening tests is especially important here, because while Alzheimers drugs may be more effective earlier in the disease course, none of them are "effective" in the sense of meaningfully staving the disease off; the upside to early detection is not very strong.

Meanwhile: the big challenge for screening tests is base rate confounding: the test needs to be drastically more specific the lower the percentage of the cohort that truly has the condition is. Relatively low rates of false positives can pile up quickly against true positives for conditions that are rare in the population.

The bad thing here is: you get a test suggestive of early-onset Alzheimers. It could realistically be the case that the test positive indicates in reality a coin-flip chance you have it. But that doesn't matter, because it will take years for the diagnosis to settle, and your mental health is materially injured in the meantime.

Ask HN: Why not have shoes that are just as loud as sports cars?

1•amichail•2m ago•0 comments

Redford and Newman: A Screen Partnership That Defined an Era

https://www.nytimes.com/2025/09/16/movies/robert-redford-paul-newman.html
1•prismatic•3m ago•0 comments

.YE ccTLD – Formal Redelegation Request to ICANN/IANA

2•FreeTheDotYE•3m ago•0 comments

Downsizing Done Right: A Guide for Empty Nesters and Retirees

https://estimateproperty.blogspot.com/2025/09/downsizing-done-right-guide-for-empty.html
1•Rebeccaui•9m ago•0 comments

How Beli Ate Yelp

https://www.nytimes.com/2025/09/15/dining/beli-restaurant-app.html
1•JumpCrisscross•9m ago•0 comments

Ask HN: Has anyone else been unemployed for over two years?

4•ncarlson•12m ago•1 comments

OpenAI's video generator Sora can mimic Netflix, TikTok and Twitch

https://www.washingtonpost.com/technology/interactive/2025/openai-training-data-sora/
2•tysone•14m ago•0 comments

Show HN: PayDroid – AI agents can now accept payments

https://paydroid.ai/
1•freebzns•17m ago•0 comments

Meme Generator

https://sundus.fun/memes
1•Spark88•17m ago•0 comments

Reflection: C++'s Decade-Defining Rocket Engine – CppCon 2025 [video]

https://www.youtube.com/watch?v=7z9NNrRDHQU
2•pjmlp•19m ago•0 comments

SaaS Fees Are Everywhere – Why Don't We Catch Them

3•fee_hunter•23m ago•0 comments

Trump Card – Pathway to American Citizenship

https://trumpcard.gov/
6•trothamel•24m ago•1 comments

Ask HN: Are you getting the new iPhone 17 series?

3•amrrs•26m ago•3 comments

Morgan and Morgan Sues Disney to Use "Steamboat Willy" in Their Commercials

https://www.reuters.com/legal/litigation/disney-sued-by-law-firm-morgan-morgan-over-steamboat-wil...
5•cool_dude85•26m ago•3 comments

Apple used AI, heart study data for Watch blood pressure feature

https://www.reuters.com/business/healthcare-pharmaceuticals/apple-used-ai-uncover-new-blood-press...
2•dctoedt•27m ago•0 comments

Ask HN: So Google blocked non-JS browsers, workarounds?

4•lynx97•28m ago•0 comments

Soft Skills for the 21st Century

https://link.springer.com/book/10.1007/978-3-031-89557-9
2•rramadass•29m ago•0 comments

NASA Selects Blue Origin to Deliver Viper Rover to Moon's South Pole

https://www.nasa.gov/news-release/nasa-selects-blue-origin-to-deliver-viper-rover-to-moons-south-...
2•ironyman•29m ago•0 comments

What GPT-OSS Leaks About OpenAI's Training Data

https://fi-le.net/oss/
3•fi-le•30m ago•0 comments

Themis (European Reusable Rocket) is assembled on launch pad

https://phys.org/news/2025-09-themis-pad-fully.html
4•theamk•30m ago•0 comments

TypePulse: Detecting type confusion bugs in Rust programs

https://dl.acm.org/doi/10.5555/3766078.3766435
2•fanf2•32m ago•0 comments

Show HN: fill harmonics, a crossword-themed music machine

https://fillharmonics.com/?grid=___---_-----__----------_---------------_---_---KICKERS_HISS-----...
3•thisisparker•33m ago•0 comments

'Revolutionary surveillance': 90% of Nicaraguans feel spied upon

https://english.elpais.com/international/2025-09-08/revolutionary-surveillance-90-of-nicaraguans-...
5•PaulHoule•36m ago•0 comments

Show HN: PlantDiagrams – AI-powered PlantUML editor

https://www.plantdiagrams.com
2•ivonellis•39m ago•0 comments

Genocide in the Gaza Strip: Brazil files a declaration of intervention to ICJ [pdf]

https://www.icj-cij.org/sites/default/files/case-related/192/192-20250919-pre-01-00-en.pdf
15•hggh•41m ago•0 comments

A Backdoor Disguised as a Job Interview

https://twitter.com/farezv/status/1969136304802644396
2•dabit3•42m ago•0 comments

Shorting Bitcoin as the Perfect Hedge

https://greyenlightenment.com/2025/09/19/shorting-bitcoin-as-the-perfect-hedge/
2•paulpauper•43m ago•0 comments

Elenchus – A research tool for public discourse

https://elenchusapp.io/
2•trentirvin•43m ago•2 comments

China's Great Firewall suffers a leak – 500GB of source code is spilled online

https://www.tomshardware.com/tech-industry/chinas-great-firewall-springs-huge-leak
5•bndr•44m ago•0 comments

Well, it's over - a brief eulogy for the "trans rights" movement

https://shonfaye.substack.com/p/well-its-over
3•mallopian•45m ago•1 comments