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First evidence of 'nearly universal' pharmacological chaperone for rare disease

https://medicalxpress.com/news/2025-09-drug-evidence-universal-pharmacological-chaperone.html
4•geox•1h ago

Risks in turning AI chatbots into AI agents

https://privacyinternational.org/long-read/5672/risks-turning-ai-chatbots-ai-agents-and-using-mcp
1•eustoria•39s ago•0 comments

How AI Is Impacting Engineering Leadership [video]

https://www.youtube.com/watch?v=aoyGUDL4jZU
1•GarethX•2m ago•0 comments

Bonkers CDC vaccine meeting ends with vote to keep Covid shot access

https://arstechnica.com/health/2025/09/bonkers-cdc-vaccine-meeting-ends-with-vote-to-keep-covid-s...
1•voxadam•2m ago•0 comments

Laws of order: expensive synchronization in concurrent algorithms cannot be elim [pdf]

https://files.sri.inf.ethz.ch/website/papers/popl168gf-attiya.pdf
1•fanf2•2m ago•0 comments

RIP "Browsers"

https://blog.jim-nielsen.com/2025/rip-browsers/
1•freediver•3m ago•0 comments

The Struggle to Visualize Zettelkasten Notes and How I Solved It

https://wasi0013.com/2025/09/22/data-visualization-challenge-the-struggle-to-visualize-thousands-...
2•pyprism•4m ago•0 comments

A staff revolt rocked the fintech powerhouse FNZ

https://www.thetimes.com/business-money/companies/article/how-a-staff-revolt-rocked-the-fintech-p...
1•gadders•5m ago•0 comments

The Right to Your Feed: A Simple Fix for Social Media

https://rosslazer.com/posts/right-to-feed/
1•rosslazer•6m ago•0 comments

Moody's raises Big Red over flag Oracle's mega AI DC buildout blueprint

https://www.theregister.com/2025/09/22/moodys_raises_questions_over_oracles/
1•rntn•7m ago•0 comments

Crystal v0.3: Codex support in Git Worktrees

https://github.com/stravu/crystal
2•jbentley1•8m ago•1 comments

Vertech Academy

https://www.vertechacademy.ca/
1•Hamid213•9m ago•1 comments

Dear GitHub: no YAML anchors, please

https://blog.yossarian.net/2025/09/22/dear-github-no-yaml-anchors
4•woodruffw•10m ago•0 comments

Show HN: T3 Chat for Image Models

https://frames.so
1•moschetti1•11m ago•0 comments

How to Make Sense of Any Mess

https://www.howtomakesenseofanymess.com
1•surprisetalk•13m ago•0 comments

WebKit Features in Safari 26.0

https://webkit.org/blog/17333/webkit-features-in-safari-26-0/
1•ksec•13m ago•0 comments

Future Fonts: where type designers sell fonts in progress

https://www.futurefonts.com/
1•surprisetalk•13m ago•0 comments

What is algebraic about algebraic effects?

https://interjectedfuture.com/what-is-algebraic-about-algebraic-effects/
2•iamwil•14m ago•0 comments

Oracle appoints insiders Clay Magouyrk, Mike Sicilia as co-CEOs in surprise move

https://finance.yahoo.com/news/oracle-appoints-insiders-clay-magouyrk-121559145.html
2•nixgeek•15m ago•0 comments

Show HN: Personalized offers via models trained on visitor actions

https://aiprice.me
1•aubmedia•16m ago•1 comments

Cloudflare's goal to hire 1,111 interns in 2026

https://blog.cloudflare.com/cloudflare-1111-intern-program/
3•pavel_lishin•16m ago•0 comments

Cryptocurrencies Sink as $1.5B in Bullish Bets Wiped Out

https://www.bloomberg.com/news/articles/2025-09-22/cryptocurrencies-sink-as-1-5-billion-in-bullis...
3•wslh•17m ago•1 comments

Nonplussed by "Nonplussed"

https://www.bookofjoe.com/2025/09/my-entry-29-2.html
1•surprisetalk•17m ago•0 comments

Underappreciated Subcultural Details

https://justismills.substack.com/p/underappreciated-subcultural-details
1•surprisetalk•17m ago•0 comments

Free access to Cloudflare developer features for students

https://blog.cloudflare.com/workers-for-students/
1•frasermarlow•18m ago•0 comments

I want a cross-platform tiling window manager

https://lgug2z.com/articles/i-want-a-cross-platform-tiling-window-manager/
3•bsnnkv•18m ago•0 comments

Private toll roads are supposed to save taxpayers' money, but have hidden costs

https://theconversation.com/private-toll-roads-are-supposed-to-save-taxpayers-money-but-can-have-...
3•PaulHoule•19m ago•0 comments

Anthropic Economic Index: Tracking AI's Role in the US and Global Economy

https://www.anthropic.com/research/economic-index-geography
1•myth_drannon•21m ago•0 comments

US and Indian VCs just formed a $1B+ alliance to fund India's deep tech startups

https://techcrunch.com/2025/09/01/u-s-and-indian-vcs-just-formed-a-1b-alliance-to-fund-indias-dee...
1•koolhead17•22m ago•0 comments

The Big Gotcha With starting-style

https://www.joshwcomeau.com/css/starting-style/
1•joshwcomeau•22m ago•0 comments

The Death of the Corporate Job

https://thestillwandering.substack.com/p/the-death-of-the-corporate-job
1•trevin•23m ago•0 comments