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New bacteria, and two potential antibiotics, discovered in soil

https://www.rockefeller.edu/news/38239-hundreds-of-new-bacteria-and-two-potential-antibiotics-found-in-soil/
38•PaulHoule•2h ago

Comments

rogerrogerr•2h ago
> hundreds of complete bacterial genomes never seen before

Welllll that doesn’t sound like a great idea

PaulHoule•1h ago
Just because you don't know they are there doesn't mean they aren't there!
kulahan•1h ago
Meh, they came from the soil. It's always been here, just never seen by human eyes. That's true of lots and lots of bacteria though - we find new species pretty much every single time we take a stomach sample from someone, let alone random forest soil.
PaulHoule•43m ago
Many bacteria have commensal lifestyles —- scientists don’t feel in control if they can’t culture bacteria in isolation but in nature many bacteria aren’t metabolically complete and son’s live in isolation.
w10-1•43m ago
This should be re-titled something like: with 200x longer sequences and making products without culturing, dirt can make antibiotic gold.

The two prospects:

Erutacidin, disrupts bacterial membranes through an uncommon interaction with the lipid cardiolipin and is effective against even the most challenging drug-resistant bacteria.

trigintamicin, acts on a protein-unfolding motor known as ClpX, a rare antibacterial target

The difficulty with bacterial DNA is that they have common elements and actively share DNA to boot. Sequencing only short sections make genome assembly unreliable. 200x longer sequences makes much more accurate genomes.

Then even if you find genes, we can't usually culture enough bacteria to make the product (typically instead injecting the sequences into bacteria we can culture). So being able to make the product without culturing the organism is key.

Uber Launched a Women-Only Service. Will It Work?

https://knowledge.wharton.upenn.edu/article/uber-launched-a-women-only-service-will-it-work/
1•herecomethefuzz•4m ago•1 comments

The Hysteresis of Vibe Coding

https://the-nerve-blog.ghost.io/the-hysteresis-of-vibe-coding/
1•mprast•4m ago•0 comments

The Origins of Gaff Taxidermy as Historical Oddities

https://lethbridgenewsnow.com/2017/09/20/the-origins-of-gaff-taxidermy-as-historical-oddities/
1•speckx•5m ago•0 comments

Major study used to support affirmative action in med schools was faked – PNAS

https://www.pnas.org/doi/10.1073/pnas.2409264121
1•janandonly•6m ago•0 comments

We did a DB migration without logical replication – with zero downtime

https://reducto.ai/blog/reducto-database-migration-zero-downtime
2•raunakchowdhuri•6m ago•0 comments

There Was a RadioShack Ponzi

https://www.bloomberg.com/opinion/newsletters/2025-09-24/there-was-a-radioshack-ponzi
2•ioblomov•7m ago•1 comments

This link will send you to a random Web 1.0 website

https://wiby.me/surprise/
2•pfexec•8m ago•0 comments

Depictions of Celestial Objects Spanning Nearly a Millennium (2014)

https://publicdomainreview.org/collection/flowers-of-the-sky/
1•NaOH•11m ago•0 comments

Pathword, a neat new puzzle from The Daily Baffle

https://dailybaffle.com/pathword/
1•skywardacoustic•11m ago•1 comments

GPU Implementation of Second-Order Linear and Nonlinear Programming Solvers

https://arxiv.org/abs/2508.16094
1•adgjlsfhk1•12m ago•0 comments

Ask HN: Looking for a Book

2•phoenixhaber•13m ago•3 comments

Full Self Driving Cars

https://dan.bulwinkle.net/blog/full-self-driving-cars/
1•pilingual•14m ago•1 comments

To become a good C programmer (2011)

https://fabiensanglard.net/c/
2•pykello•16m ago•0 comments

Gen Z are eating dinner at 6pm – and it's because they're losers

https://www.standard.co.uk/comment/gen-z-eating-early-dining-alcohol-b1241442.html
4•mathattack•21m ago•3 comments

Broken Trust: Fixed Supermicro BMC Bug Gains New Life in Two New Vulnerabilities

https://www.binarly.io/blog/broken-trust-fixed-supermicro-bmc-bug-gains-a-new-life-in-two-new-vul...
2•gnabgib•22m ago•0 comments

A Guide to Fluent Bit Processors for Conditional Log Processing

https://thenewstack.io/a-guide-to-fluent-bit-processors-for-conditional-log-processing/
1•k8tgreenley•23m ago•0 comments

Show HN: I send you weekly insights from your bookmarks

https://tryeyeball.com/
1•quinto_quarto•25m ago•0 comments

Tether CEO confirms major capital raise at a reported $500B valuation

https://www.cnbc.com/2025/09/23/tether-reportedly-seeks-lofty-500-billion-valuation-in-capital-ra...
1•arvindh-manian•26m ago•2 comments

Unitree R1: A Next-Generation Humanoid Robot Platform for Real-World Use

https://www.dronesplusrobotics.com/post/unitree-r1-a-next-generation-humanoid-robot-platform-for-...
1•DPRobotics•27m ago•0 comments

Emmett Shear and Patrick McKenzie on AI Alignment

https://www.complexsystemspodcast.com/episodes/ai-alignment-with-emmett-shear/
2•surprisetalk•27m ago•0 comments

Drones Plus Robotics – Industrial Enterprise Robotics and Drone Solutions

https://www.dronesplusrobotics.com
1•DPRobotics•28m ago•0 comments

JRuby and JDK 25: Startup Time with AOTCache

https://blog.headius.com/2025/09/jruby-jdk25-startup-time-with-aotcache.html
1•todsacerdoti•30m ago•0 comments

Bluffing in Scrabble

https://arxiv.org/abs/2509.10471
3•fanf2•31m ago•0 comments

Microsoft microfluidic channels cool GPU 65%, outperform cold plates by up to 3x

https://www.tomshardware.com/pc-components/liquid-cooling/microsoft-develops-breakthrough-chip-co...
1•westurner•32m ago•2 comments

NFS at 40

https://nfs40.online/
1•fjarlq•33m ago•0 comments

Can Liberalism Be Saved?

https://www.newyorker.com/news/q-and-a/can-liberalism-be-saved
3•paulpauper•36m ago•1 comments

Do Soil Methanotrophs Remove About 5% of Atmospheric Methane?

https://www.mdpi.com/2073-445X/14/9/1864
1•PaulHoule•36m ago•0 comments

GitHub MCP Registry

https://github.com/mcp/
2•saikatsg•36m ago•0 comments

Build a Bear Success

https://www.washingtonpost.com/business/2025/09/22/build-a-bear-success-tariffs/
1•paulpauper•37m ago•0 comments

We should not auction off all H1B visas

https://marginalrevolution.com/marginalrevolution/2025/09/why-we-should-not-auction-off-all-h1-b-...
2•paulpauper•38m ago•0 comments