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Transcribe your aunts post cards with Gemini 3 Pro

https://leserli.ch/ocr/
1•nielstron•1m ago•0 comments

.72% Variance Lance

1•mav5431•2m ago•0 comments

ReKindle – web-based operating system designed specifically for E-ink devices

https://rekindle.ink
1•JSLegendDev•4m ago•0 comments

Encrypt It

https://encryptitalready.org/
1•u1hcw9nx•4m ago•0 comments

NextMatch – 5-minute video speed dating to reduce ghosting

https://nextmatchdating.netlify.app/
1•Halinani8•5m ago•1 comments

Personalizing esketamine treatment in TRD and TRBD

https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1736114
1•PaulHoule•6m ago•0 comments

SpaceKit.xyz – a browser‑native VM for decentralized compute

https://spacekit.xyz
1•astorrivera•7m ago•1 comments

NotebookLM: The AI that only learns from you

https://byandrev.dev/en/blog/what-is-notebooklm
1•byandrev•7m ago•1 comments

Show HN: An open-source starter kit for developing with Postgres and ClickHouse

https://github.com/ClickHouse/postgres-clickhouse-stack
1•saisrirampur•8m ago•0 comments

Game Boy Advance d-pad capacitor measurements

https://gekkio.fi/blog/2026/game-boy-advance-d-pad-capacitor-measurements/
1•todsacerdoti•8m ago•0 comments

South Korean crypto firm accidentally sends $44B in bitcoins to users

https://www.reuters.com/world/asia-pacific/crypto-firm-accidentally-sends-44-billion-bitcoins-use...
2•layer8•9m ago•0 comments

Apache Poison Fountain

https://gist.github.com/jwakely/a511a5cab5eb36d088ecd1659fcee1d5
1•atomic128•11m ago•1 comments

Web.whatsapp.com appears to be having issues syncing and sending messages

http://web.whatsapp.com
1•sabujp•11m ago•2 comments

Google in Your Terminal

https://gogcli.sh/
1•johlo•13m ago•0 comments

Shannon: Claude Code for Pen Testing: #1 on Github today

https://github.com/KeygraphHQ/shannon
1•hendler•13m ago•0 comments

Anthropic: Latest Claude model finds more than 500 vulnerabilities

https://www.scworld.com/news/anthropic-latest-claude-model-finds-more-than-500-vulnerabilities
2•Bender•18m ago•0 comments

Brooklyn cemetery plans human composting option, stirring interest and debate

https://www.cbsnews.com/newyork/news/brooklyn-green-wood-cemetery-human-composting/
1•geox•18m ago•0 comments

Why the 'Strivers' Are Right

https://greyenlightenment.com/2026/02/03/the-strivers-were-right-all-along/
1•paulpauper•19m ago•0 comments

Brain Dumps as a Literary Form

https://davegriffith.substack.com/p/brain-dumps-as-a-literary-form
1•gmays•19m ago•0 comments

Agentic Coding and the Problem of Oracles

https://epkconsulting.substack.com/p/agentic-coding-and-the-problem-of
1•qingsworkshop•20m ago•0 comments

Malicious packages for dYdX cryptocurrency exchange empties user wallets

https://arstechnica.com/security/2026/02/malicious-packages-for-dydx-cryptocurrency-exchange-empt...
1•Bender•20m ago•0 comments

Show HN: I built a <400ms latency voice agent that runs on a 4gb vram GTX 1650"

https://github.com/pheonix-delta/axiom-voice-agent
1•shubham-coder•21m ago•0 comments

Penisgate erupts at Olympics; scandal exposes risks of bulking your bulge

https://arstechnica.com/health/2026/02/penisgate-erupts-at-olympics-scandal-exposes-risks-of-bulk...
4•Bender•21m ago•0 comments

Arcan Explained: A browser for different webs

https://arcan-fe.com/2026/01/26/arcan-explained-a-browser-for-different-webs/
1•fanf2•23m ago•0 comments

What did we learn from the AI Village in 2025?

https://theaidigest.org/village/blog/what-we-learned-2025
1•mrkO99•23m ago•0 comments

An open replacement for the IBM 3174 Establishment Controller

https://github.com/lowobservable/oec
1•bri3d•26m ago•0 comments

The P in PGP isn't for pain: encrypting emails in the browser

https://ckardaris.github.io/blog/2026/02/07/encrypted-email.html
2•ckardaris•28m ago•0 comments

Show HN: Mirror Parliament where users vote on top of politicians and draft laws

https://github.com/fokdelafons/lustra
1•fokdelafons•28m ago•1 comments

Ask HN: Opus 4.6 ignoring instructions, how to use 4.5 in Claude Code instead?

1•Chance-Device•30m ago•0 comments

We Mourn Our Craft

https://nolanlawson.com/2026/02/07/we-mourn-our-craft/
2•ColinWright•32m ago•0 comments
Open in hackernews

RNA structure prediction is hard. How much does that matter?

https://www.owlposting.com/p/rna-structure-prediction-is-hard
70•abhishaike•4mo ago

Comments

nextworddev•4mo ago
Alphafold3 never claimed to solve rna structure prediction though
abhishaike•4mo ago
oh yeah, I didn’t mean to say that they did claim that, that was just my (mis)conception
cing•4mo ago
Author made it clear this was an educational essay, but concluding the problem has very limited therapeutic applications comes across like a bit of a take down for Atomic AI's platform.
abhishaike•4mo ago
I think it has very limited therapeutic applications with what we know about RNA structure today! But there's a great deal of completely unknown RNA biology (some of which I touch on in the essay) that may greatly benefit from RNA structure. The bit I mention about Arrakis Therapeutics preclinical work in drugging the (structured) RNA version of the MYC protein points to that being a very real possibility. All interesting biotech startups are built on bets on where the future is going, and I'm very happy that someone (AtomicAI and others) is betting on this, because clearly the answer of 'is RNA structure useful' isn't super open-and-shut
fabian2k•4mo ago
RNA structures are really more of a basic research thing. Having better tools there would be useful to understand these parts better. That's not irrelevant, but it doesn't lead directly to therapeutic applications.

RNAs so far have been very bad drug targets. That is to a large part inherent in their properties, they have fewer different components (4 bases compared to 20 amino acids) and the RNA backbone is strongly charged and interactions with something like that are generally unspecific. Odds are that RNA will remain a bad drug target for almost all cases.

DrAwdeOccarim•4mo ago
I don’t disagree with your point, but I just would like to point out that there are over 100 known post-transcriptional modified RNA bases [1]. In fact, tRNA are more modified bases than canonical if taken as a whole. AND! the ribosome can’t function without all of its modifications. If I were to put money toward “targeting an RNA to make a drug” rRNA is where I’d aim…

Source: PhD in RNA modifications

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC9073955/

NooneAtAll3•4mo ago
wow, what an awesome biochemistry blog

the post is easy to read - and yet there's wealth of information together with citations of science papers info comes from

I love how author researched and discusses opinions opposite of his too

perhaps most surprising was to learn that vaccine RNA differs from normal U-A-C-G memorized in school. One more piece of knowledge I can come back with to my teachers one day :)

Cosi1125•4mo ago
OP, one small correction: the abbreviation of "long non-coding RNAs" is lncRNA (lowercase "L"), not "IncRNA".
abhishaike•4mo ago
Fixed!
Metacelsus•4mo ago
My rotation project in the Church lab was on structure prediction for bacterial T-box riboswitches (the goal was to classify which tRNA was recognized by the riboswitch; fortunately we only needed to predict the secondary structure for this goal). Even these were rather difficult to model. We looked into deep learning methods but ended up going with a HMM approach due to lack of structural data. And of course, these are ribo switches, which change structure upon ligand binding.

So it's very cool to see the progress that has been made since 2020.