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Zen Tools

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1•Malfunction92•2m ago•0 comments

Is the Detachment in the Room? – Agents, Cruelty, and Empathy

https://hailey.at/posts/3mear2n7v3k2r
1•carnevalem•2m ago•0 comments

The purpose of Continuous Integration is to fail

https://blog.nix-ci.com/post/2026-02-05_the-purpose-of-ci-is-to-fail
1•zdw•4m ago•0 comments

Apfelstrudel: Live coding music environment with AI agent chat

https://github.com/rcarmo/apfelstrudel
1•rcarmo•5m ago•0 comments

What Is Stoicism?

https://stoacentral.com/guides/what-is-stoicism
3•0xmattf•6m ago•0 comments

What happens when a neighborhood is built around a farm

https://grist.org/cities/what-happens-when-a-neighborhood-is-built-around-a-farm/
1•Brajeshwar•6m ago•0 comments

Every major galaxy is speeding away from the Milky Way, except one

https://www.livescience.com/space/cosmology/every-major-galaxy-is-speeding-away-from-the-milky-wa...
2•Brajeshwar•6m ago•0 comments

Extreme Inequality Presages the Revolt Against It

https://www.noemamag.com/extreme-inequality-presages-the-revolt-against-it/
2•Brajeshwar•6m ago•0 comments

There's no such thing as "tech" (Ten years later)

1•dtjb•7m ago•0 comments

What Really Killed Flash Player: A Six-Year Campaign of Deliberate Platform Work

https://medium.com/@aglaforge/what-really-killed-flash-player-a-six-year-campaign-of-deliberate-p...
1•jbegley•7m ago•0 comments

Ask HN: Anyone orchestrating multiple AI coding agents in parallel?

1•buildingwdavid•9m ago•0 comments

Show HN: Knowledge-Bank

https://github.com/gabrywu-public/knowledge-bank
1•gabrywu•14m ago•0 comments

Show HN: The Codeverse Hub Linux

https://github.com/TheCodeVerseHub/CodeVerseLinuxDistro
3•sinisterMage•15m ago•2 comments

Take a trip to Japan's Dododo Land, the most irritating place on Earth

https://soranews24.com/2026/02/07/take-a-trip-to-japans-dododo-land-the-most-irritating-place-on-...
2•zdw•16m ago•0 comments

British drivers over 70 to face eye tests every three years

https://www.bbc.com/news/articles/c205nxy0p31o
17•bookofjoe•16m ago•4 comments

BookTalk: A Reading Companion That Captures Your Voice

https://github.com/bramses/BookTalk
1•_bramses•17m ago•0 comments

Is AI "good" yet? – tracking HN's sentiment on AI coding

https://www.is-ai-good-yet.com/#home
3•ilyaizen•18m ago•1 comments

Show HN: Amdb – Tree-sitter based memory for AI agents (Rust)

https://github.com/BETAER-08/amdb
1•try_betaer•18m ago•0 comments

OpenClaw Partners with VirusTotal for Skill Security

https://openclaw.ai/blog/virustotal-partnership
2•anhxuan•18m ago•0 comments

Show HN: Seedance 2.0 Release

https://seedancy2.com/
2•funnycoding•19m ago•0 comments

Leisure Suit Larry's Al Lowe on model trains, funny deaths and Disney

https://spillhistorie.no/2026/02/06/interview-with-sierra-veteran-al-lowe/
1•thelok•19m ago•0 comments

Towards Self-Driving Codebases

https://cursor.com/blog/self-driving-codebases
1•edwinarbus•19m ago•0 comments

VCF West: Whirlwind Software Restoration – Guy Fedorkow [video]

https://www.youtube.com/watch?v=YLoXodz1N9A
1•stmw•20m ago•1 comments

Show HN: COGext – A minimalist, open-source system monitor for Chrome (<550KB)

https://github.com/tchoa91/cog-ext
1•tchoa91•21m ago•1 comments

FOSDEM 26 – My Hallway Track Takeaways

https://sluongng.substack.com/p/fosdem-26-my-hallway-track-takeaways
1•birdculture•22m ago•0 comments

Show HN: Env-shelf – Open-source desktop app to manage .env files

https://env-shelf.vercel.app/
1•ivanglpz•25m ago•0 comments

Show HN: Almostnode – Run Node.js, Next.js, and Express in the Browser

https://almostnode.dev/
1•PetrBrzyBrzek•26m ago•0 comments

Dell support (and hardware) is so bad, I almost sued them

https://blog.joshattic.us/posts/2026-02-07-dell-support-lawsuit
1•radeeyate•26m ago•0 comments

Project Pterodactyl: Incremental Architecture

https://www.jonmsterling.com/01K7/
1•matt_d•27m ago•0 comments

Styling: Search-Text and Other Highlight-Y Pseudo-Elements

https://css-tricks.com/how-to-style-the-new-search-text-and-other-highlight-pseudo-elements/
1•blenderob•28m ago•0 comments
Open in hackernews

RNA structure prediction is hard. How much does that matter?

https://www.owlposting.com/p/rna-structure-prediction-is-hard
70•abhishaike•4mo ago

Comments

nextworddev•4mo ago
Alphafold3 never claimed to solve rna structure prediction though
abhishaike•4mo ago
oh yeah, I didn’t mean to say that they did claim that, that was just my (mis)conception
cing•4mo ago
Author made it clear this was an educational essay, but concluding the problem has very limited therapeutic applications comes across like a bit of a take down for Atomic AI's platform.
abhishaike•4mo ago
I think it has very limited therapeutic applications with what we know about RNA structure today! But there's a great deal of completely unknown RNA biology (some of which I touch on in the essay) that may greatly benefit from RNA structure. The bit I mention about Arrakis Therapeutics preclinical work in drugging the (structured) RNA version of the MYC protein points to that being a very real possibility. All interesting biotech startups are built on bets on where the future is going, and I'm very happy that someone (AtomicAI and others) is betting on this, because clearly the answer of 'is RNA structure useful' isn't super open-and-shut
fabian2k•4mo ago
RNA structures are really more of a basic research thing. Having better tools there would be useful to understand these parts better. That's not irrelevant, but it doesn't lead directly to therapeutic applications.

RNAs so far have been very bad drug targets. That is to a large part inherent in their properties, they have fewer different components (4 bases compared to 20 amino acids) and the RNA backbone is strongly charged and interactions with something like that are generally unspecific. Odds are that RNA will remain a bad drug target for almost all cases.

DrAwdeOccarim•4mo ago
I don’t disagree with your point, but I just would like to point out that there are over 100 known post-transcriptional modified RNA bases [1]. In fact, tRNA are more modified bases than canonical if taken as a whole. AND! the ribosome can’t function without all of its modifications. If I were to put money toward “targeting an RNA to make a drug” rRNA is where I’d aim…

Source: PhD in RNA modifications

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC9073955/

NooneAtAll3•4mo ago
wow, what an awesome biochemistry blog

the post is easy to read - and yet there's wealth of information together with citations of science papers info comes from

I love how author researched and discusses opinions opposite of his too

perhaps most surprising was to learn that vaccine RNA differs from normal U-A-C-G memorized in school. One more piece of knowledge I can come back with to my teachers one day :)

Cosi1125•4mo ago
OP, one small correction: the abbreviation of "long non-coding RNAs" is lncRNA (lowercase "L"), not "IncRNA".
abhishaike•4mo ago
Fixed!
Metacelsus•4mo ago
My rotation project in the Church lab was on structure prediction for bacterial T-box riboswitches (the goal was to classify which tRNA was recognized by the riboswitch; fortunately we only needed to predict the secondary structure for this goal). Even these were rather difficult to model. We looked into deep learning methods but ended up going with a HMM approach due to lack of structural data. And of course, these are ribo switches, which change structure upon ligand binding.

So it's very cool to see the progress that has been made since 2020.