RNAs so far have been very bad drug targets. That is to a large part inherent in their properties, they have fewer different components (4 bases compared to 20 amino acids) and the RNA backbone is strongly charged and interactions with something like that are generally unspecific. Odds are that RNA will remain a bad drug target for almost all cases.
Source: PhD in RNA modifications
the post is easy to read - and yet there's wealth of information together with citations of science papers info comes from
I love how author researched and discusses opinions opposite of his too
perhaps most surprising was to learn that vaccine RNA differs from normal U-A-C-G memorized in school. One more piece of knowledge I can come back with to my teachers one day :)
So it's very cool to see the progress that has been made since 2020.
nextworddev•4mo ago
abhishaike•4mo ago