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Anthropic's team cut ad creation time from 30 minutes to 30 seconds

https://claude.com/blog/how-anthropic-uses-claude-marketing
1•Brajeshwar•3m ago•0 comments

Show HN: Elysia JIT "Compiler", why it's one of the fastest JavaScript framework

https://elysiajs.com/internal/jit-compiler
1•saltyaom•3m ago•0 comments

Cache Monet

https://cachemonet.com
1•keepamovin•4m ago•0 comments

Chinese Propaganda in Infomaniak's Euria, and a Reflection on Open Source AI

https://gagliardoni.net/#20260208_euria
1•tomgag•5m ago•1 comments

Show HN: A free, browser-only PDF tools collection built with Kimi k2.5

https://pdfuck.com
2•Justin3go•7m ago•0 comments

Curating a Show on My Ineffable Mother, Ursula K. Le Guin

https://hyperallergic.com/curating-a-show-on-my-ineffable-mother-ursula-k-le-guin/
2•bryanrasmussen•13m ago•0 comments

Show HN: HackerStack.dev – 49 Curated AI Tools for Indie Hackers

https://hackerstack.dev
1•pascalicchio•20m ago•0 comments

Pensions Are a Ponzi Scheme

https://poddley.com/?searchParams=segmentIds=b53ff41f-25c9-4f35-98d6-36616757d35b
1•onesandofgrain•26m ago•7 comments

Divvy.club – Splitwise alternative that makes sense

https://divvy.club
1•filepod•27m ago•0 comments

Betterment data breach exposes 1.4M customers

https://www.americanbanker.com/news/1-4-million-data-breach-betterment-shinyhunters-salesforce
1•NewCzech•27m ago•0 comments

MIT Technology Review has confirmed that posts on Moltbook were fake

https://www.technologyreview.com/2026/02/06/1132448/moltbook-was-peak-ai-theater/
2•helloplanets•27m ago•0 comments

Epstein Science: the people Epstein discussed scientific topics with

https://edge.dog/templates/cml9p8slu0009gdj2p0l8xf4r
2•castalian•28m ago•0 comments

Bambuddy – a free, self-hosted management system for Bambu Lab printers

https://bambuddy.cool
2•maziggy•32m ago•1 comments

Every Failed M4 Gun Replacement Attempt

https://www.youtube.com/watch?v=jrnAU67_EWg
3•tomaytotomato•33m ago•1 comments

China ramps up energy boom flagged by Musk as key to AI race

https://techxplore.com/news/2026-02-china-ramps-energy-boom-flagged.html
2•myk-e•33m ago•0 comments

Show HN: ClawBox – Dedicated OpenClaw Hardware (Jetson Orin Nano, 67 Tops, 20W)

https://openclawhardware.dev
2•superactro•36m ago•0 comments

Ask HN: AI never gets flustered, will that make us better as people or worse?

1•keepamovin•36m ago•0 comments

Show HN: HalalCodeCheck – Verify food ingredients offline

https://halalcodecheck.com/
3•pythonbase•38m ago•0 comments

Student makes cosmic dust in a lab, shining a light on the origin of life

https://www.cnn.com/2026/02/06/science/cosmic-dust-discovery-life-beginnings
1•Brajeshwar•41m ago•0 comments

In the Australian outback, we're listening for nuclear tests

https://www.abc.net.au/news/2026-02-08/australian-outback-nuclear-tests-listening-warramunga-faci...
6•defrost•41m ago•0 comments

'Hermès orange' iPhone sparks Apple comeback in China

https://www.ft.com/content/e2d78d04-7368-4b0c-abd5-591c03774c46
1•Brajeshwar•42m ago•0 comments

Show HN: Goxe 19k Logs/S on an I5

https://github.com/DumbNoxx/goxe
1•nxus_dev•42m ago•1 comments

The async builder pattern in Rust

https://blog.yoshuawuyts.com/async-finalizers/
2•fanf2•44m ago•0 comments

(Golang) Self referential functions and the design of options

https://commandcenter.blogspot.com/2014/01/self-referential-functions-and-design.html
1•hambes•44m ago•0 comments

Show HN: Model Training Memory Simulator

https://czheo.github.io/2026/02/08/model-training-memory-simulator/
1•czheo•47m ago•0 comments

Claude Code Controller

https://github.com/The-Vibe-Company/claude-code-controller
1•shidhincr•50m ago•0 comments

Software design is now cheap

https://dottedmag.net/blog/cheap-design/
1•dottedmag•50m ago•0 comments

Show HN: Are You Random? – A game that predicts your "random" choices

https://github.com/OvidijusParsiunas/are-you-random
1•ovisource•56m ago•1 comments

Poland to probe possible links between Epstein and Russia

https://www.reuters.com/world/poland-probe-possible-links-between-epstein-russia-pm-tusk-says-202...
2•doener•1h ago•0 comments

Effectiveness of AI detection tools in identifying AI-generated articles

https://www.ijoms.com/article/S0901-5027(26)00025-1/fulltext
3•XzetaU8•1h ago•0 comments
Open in hackernews

RNA structure prediction is hard. How much does that matter?

https://www.owlposting.com/p/rna-structure-prediction-is-hard
70•abhishaike•4mo ago

Comments

nextworddev•4mo ago
Alphafold3 never claimed to solve rna structure prediction though
abhishaike•4mo ago
oh yeah, I didn’t mean to say that they did claim that, that was just my (mis)conception
cing•4mo ago
Author made it clear this was an educational essay, but concluding the problem has very limited therapeutic applications comes across like a bit of a take down for Atomic AI's platform.
abhishaike•4mo ago
I think it has very limited therapeutic applications with what we know about RNA structure today! But there's a great deal of completely unknown RNA biology (some of which I touch on in the essay) that may greatly benefit from RNA structure. The bit I mention about Arrakis Therapeutics preclinical work in drugging the (structured) RNA version of the MYC protein points to that being a very real possibility. All interesting biotech startups are built on bets on where the future is going, and I'm very happy that someone (AtomicAI and others) is betting on this, because clearly the answer of 'is RNA structure useful' isn't super open-and-shut
fabian2k•4mo ago
RNA structures are really more of a basic research thing. Having better tools there would be useful to understand these parts better. That's not irrelevant, but it doesn't lead directly to therapeutic applications.

RNAs so far have been very bad drug targets. That is to a large part inherent in their properties, they have fewer different components (4 bases compared to 20 amino acids) and the RNA backbone is strongly charged and interactions with something like that are generally unspecific. Odds are that RNA will remain a bad drug target for almost all cases.

DrAwdeOccarim•4mo ago
I don’t disagree with your point, but I just would like to point out that there are over 100 known post-transcriptional modified RNA bases [1]. In fact, tRNA are more modified bases than canonical if taken as a whole. AND! the ribosome can’t function without all of its modifications. If I were to put money toward “targeting an RNA to make a drug” rRNA is where I’d aim…

Source: PhD in RNA modifications

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC9073955/

NooneAtAll3•4mo ago
wow, what an awesome biochemistry blog

the post is easy to read - and yet there's wealth of information together with citations of science papers info comes from

I love how author researched and discusses opinions opposite of his too

perhaps most surprising was to learn that vaccine RNA differs from normal U-A-C-G memorized in school. One more piece of knowledge I can come back with to my teachers one day :)

Cosi1125•4mo ago
OP, one small correction: the abbreviation of "long non-coding RNAs" is lncRNA (lowercase "L"), not "IncRNA".
abhishaike•4mo ago
Fixed!
Metacelsus•4mo ago
My rotation project in the Church lab was on structure prediction for bacterial T-box riboswitches (the goal was to classify which tRNA was recognized by the riboswitch; fortunately we only needed to predict the secondary structure for this goal). Even these were rather difficult to model. We looked into deep learning methods but ended up going with a HMM approach due to lack of structural data. And of course, these are ribo switches, which change structure upon ligand binding.

So it's very cool to see the progress that has been made since 2020.