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Engineers build first artificial neurons that can connect to living cells

https://idp.nature.com/authorize?response_type=cookie&client_id=grover&redirect_uri=https%3A%2F%2...
1•alexcos•10s ago•0 comments

Anthropic Will Use Claude Chats for Training Data

https://www.wired.com/story/anthropic-using-claude-chats-for-training-how-to-opt-out/
1•stefap2•1m ago•0 comments

Study finds ancient Parthian man shot by an arrow which was never removed

https://phys.org/news/2025-09-ancient-parthian-shot-arrow.html
1•bookofjoe•2m ago•0 comments

Bug That Saved the White House from a Disney Lawsuit

https://alec.is/posts/bug-that-saved-the-white-house-from-a-disney-lawsuit/
1•arm32•4m ago•0 comments

Marc Andreessen and Charlie Songhurst (Cheeky Pint)

https://twitter.com/collision/status/1973409570144899458
1•tosh•4m ago•0 comments

The Secret Weapon in America's Critical Minerals Strategy

https://www.firstbreakfast.com/p/the-secret-weapon-in-americas-critical
1•galenmarchetti•4m ago•0 comments

Show HN: FSST – Fast Static Symbol Table Compression Library in Go

https://github.com/axiomhq/fsst
7•seiflotfy•5m ago•2 comments

Gemini CLI tried to RF -RF / on my system

https://github.com/google-gemini/gemini-cli/issues/10246
1•AlphaWeaver•5m ago•0 comments

Matlab vs. Julia: Top Choice for Renewable Energy?

https://blog.glcs.io/matlab-vs-julia-renewable-energy
1•leephillips•5m ago•0 comments

Stop Trusting Nix Caches

https://garnix.io/blog/stop-trusting-nix-caches
1•todsacerdoti•6m ago•0 comments

A Pipeline Approach to Language Migrations

https://www.infoq.com/articles/pipeline-language-migrations/
1•ftomassetti•7m ago•0 comments

Metabolomic-Based Aging Clocks

https://www.nature.com/articles/s44324-025-00078-x
1•PaulHoule•10m ago•0 comments

Sora 2 makes convincing fake crime footage

https://bsky.app/profile/drewharwell.com/post/3m25dwdtac22h
3•m-hodges•11m ago•1 comments

Ask HN: Aside from code, what are practical ways you're using AI?

1•bmau5•12m ago•1 comments

RoboBees: Autonomous Flying Microrobots

https://wyss.harvard.edu/technology/robobees-autonomous-flying-microrobots/
1•delichon•12m ago•0 comments

Make it so: GenAI, OpenAPI and ZAP

https://beny23.github.io/posts/make_it_so_genai_and_zap/
1•beny23•12m ago•0 comments

NYC apartment building partially collapses, ripping massive hole in high rise

https://www.nbcnews.com/news/us-news/new-york-city-apartment-building-partially-collapses-ripping...
3•voxadam•13m ago•1 comments

Show HN: Privacy-First AI Document Chat for macOS (Offline RAG)

https://github.com/cydanix/deepfind
2•irqlevel•15m ago•0 comments

Samsung Pilots Making Its Smart Fridges Billboards After People Bought Them

https://www.techdirt.com/2025/09/29/samsung-pilots-making-its-smart-fridges-billboards-after-peop...
2•Mgtyalx•15m ago•1 comments

Raspberrypi compute module price increases

https://www.raspberrypi.com/news/5-10-price-increases-for-some-4gb-and-8gb-products/
1•matt-p•16m ago•0 comments

Are You Collecting a Pile of Underpants?

https://www.nerdfitness.com/blog/underpants-gnomes/
1•herbertl•18m ago•0 comments

Government issues new data demand for UK Apple users

https://www.bbc.co.uk/news/articles/c740r0m4mzjo
2•latein•19m ago•0 comments

Small Products That Improved My Life

https://moultano.wordpress.com/2024/09/22/small-products-that-improved-my-life/
2•jxmorris12•20m ago•0 comments

Making Antibodies as Ubiquitous as Aspirin

https://www.worksinprogress.news/p/the-antibody-factory
1•ortegaygasset•20m ago•0 comments

OpenSUSE Leap 16 out with safeguards against potential Y2K38 disaster

https://www.neowin.net/news/opensuse-leap-16-out-with-the-new-agama-installer-safeguards-against-...
1•bundie•22m ago•0 comments

Colorado investigators to review author Hunter S. Thompson's death

https://www.cnn.com/2025/09/30/us/hunter-s-thompson-death-review-colorado
2•pseudolus•23m ago•2 comments

Show HN: Marble – Learn new tech by building throwaway projects with AI

https://www.withmarble.ai/
3•miguelacevedo•26m ago•0 comments

Apriel-1.5-15B-Thinker

https://huggingface.co/ServiceNow-AI/Apriel-1.5-15b-Thinker
1•tosh•26m ago•0 comments

OpenStack in the pink with Flamingo release that escapes ancient Python grip

https://www.theregister.com/2025/10/01/openstack_flamingo_release/
1•rntn•27m ago•0 comments

Roland TR-1000 Rhythm Creator [video]

https://www.youtube.com/watch?v=6oDy4V8cn0k
2•gregsadetsky•27m ago•0 comments
Open in hackernews

Autism Simulator

https://autism-simulator.vercel.app/
54•joshcsimmons•1h ago

Comments

p_ing•54m ago
> Someone from the "People Team" appears at your desk with a bright smile and a clipboard.

THE WORST! Why can't we just work?! Do stuff, make money, get the f- out.

ge96•45m ago
let's put a pin in that, circle back
joshcsimmons•43m ago
We're a family here.
WASDAai•53m ago
Nice game this is all i can say
joshcsimmons•43m ago
Thank you so much!
steeleyespan•45m ago
What is the medication you're supposed to take? Ritalin or something?
joshcsimmons•43m ago
Autism is a super diverse condition so varies pretty wildly person-to-person.
stego-tech•21m ago
This. I have no medication as I built up immense resiliency and masking mechanisms over the course of my life. Others may take a cocktail of meds just to make it to lunch.

It’s a condition that exists on a spectrum, as does its treatments or coping mechanisms. That said, I’m the “take my assigned medication” type, so I always took the full dose in the game.

p_ing•38m ago
Xanax, Zolpidem, Belsomra, and a fifth of your favorite.
cratermoon•36m ago
Do you view autism as a pathology or a difference?
joshcsimmons•30m ago
I'm pretty strongly in the difference camp. It giveth and taketh away. I can't get through a full meal hearing people chew food without some background noise going but I also completed my PhD before I was 30 so it feels wrong to call it a pathology ya know?
beeflet•23m ago
Is it rare to complete a PhD before 30?
joshcsimmons•16m ago
I just looked it up - I guess it's not! As I said in another thread, paid the price, didn't receive the intelligence.
tux3•35m ago
The side-effects are vaguely evocative of antipsychotics or some sort of antidepressant.

There's no specific autism medication that I'm aware of, but psychiatric diseases often have plenty of comorbidity. There's some ADHD popup in the game that distracts you with Wikipedia, there's misophonia, it sounds like the character has a whole mix of different things.

Mistletoe•33m ago
A lot of times they take an SSRI to be able to manage their emotions better and not be triggered by daily life. That’s what I remember when I was trying to help an autistic friend deal with having autistic children that were having a lot of issues.

Edit: Just asked her and the final cocktail they have settled on is aripriprazole (Abilify, an atypical antipsychotic) and hydroxyzine (first-generation antihistamine with anxiolytic and sedative properties).

kraig911•16m ago
People are touting Leucavorin. (It doesn't work) There are a lot of different things people have tried.
alterom•15m ago
There's no medication for autism, nor there really is supposed to be any.
rasengan•37m ago
Cool game. That said, autism is a spectrum. You can’t just say “this iz wut autism like.”
joshcsimmons•34m ago
Thanks for playing and agreed! I have a disclaimer in the [About] modal

Autism is an extremely diverse and complex phenomenon. No two autistic people experience the world in the same way. This simulation is based on the experiences of a single autistic individual and is not representative of all autistic people, although, I suspect many autistic people will recognize some aspects of their own experience in this simulation.

athorax•33m ago
Thats a bit uncalled for. This is a game made by someone shaped by their perspective on the world. It can be appreciated as such without applying your own additional intent.
kraig911•14m ago
I think masking is pretty general across the board. Even severe Autism. My daughter acts completely different in different contexts. Some could say we all do but you'll know it when you see it esp when the mask is gone.
qwertytyyuu•37m ago
Wait sleeping doesn’t restore eneger to people who have autism wha?
joshcsimmons•35m ago
https://www.autism.org.uk/advice-and-guidance/topics/physica...
slaterbug•37m ago
I feel called out :)
joshcsimmons•36m ago
I see u
cgio•35m ago
Is it supposed to work. I am in the spectrum and I feel like while energy may go to zero, there is in reality a separate resilience masking, where you actually keep up for the rest of the day. Also cannot relate to medication. I don’t think that’s a necessary part of the experience.
nemo•23m ago
I don't really relate to a lot of it, it's mostly a crude caricature of my experience, though it's still funny.
mustaphah•33m ago
Autism may be the price of human intelligence [1]

[1] https://www.sciencedaily.com/releases/2025/09/250927031224.h...

bagful•26m ago
I dare say autism is the pride of human intelligence.
beeflet•24m ago
Or this could be another cope
joshcsimmons•24m ago
I paid the price. I still haven't received the intelligence.
moomoo11•12m ago
Anything but admitting environmental effects of pollution, plastics, and over medicating.
ajmurmann•33m ago
Is it possible to even make it through day 2?
joshcsimmons•28m ago
Maybe if you're very careful but probably not.

There are point diffs on your stats each turn. The positive diffs are always the same for the same choices regardless of day.

The negative choices have an additional 25% added to them each day, so -10 the first day for a choice would be -12 (floor) the second day, -15 the third day, etc.

skylurk•31m ago
What's it like for people not on the spectrum? Can someone share a "Normal Simulator"?
spicyusername•28m ago
This is one of those things where I think autism has become a tag for the shared experiences of things like awkwardness, feeling out of place, or running out of the desire to socialize. Everyone wants an answer for why they have unpleasant experiences that aren't, "That's just life".

There is no normal experience, only the kinds of experiences that people have. Some people have buckets of experience that are worse or more challenging than others, everyone has shared experiences that cross-sect.

These labels are useful insofar as grouping experiences together that tend to co-occur makes it easy to talk about certain categories of aggregate experiences or strategies for navigating life, but I think too many people relegate too much importance to these arbitrary labels, like "autism", derive too much of their identity from them, and too often use them as excuses to not deal with life's challenges and complexities head on.

JohnMakin•20m ago
Then there's actually people who live their entire existence and every waking moment on the spectrum, and compensating for it - which is what the topic of discussion is. You minimizing it or thinking it isn't real isn't entirely helpful to discussion and frankly is pretty insulting.
spicyusername•13m ago

    Every waking moment on the spectrum 
If it's a spectrum, everyone is on it somewhere.

    thinking it isn't real isn't entirely helpful 
I neither said the category of shared experiences we typically call "autism" wasn't real nor said it wasn't helpful to use labels like autism.
JohnMakin•7m ago
No, you're just heavily implying it and minimizing it. I'm telling you it's extremely insulting. You can take that for what it is or don't, I don't really care.
McGlockenshire•8m ago
Ah yes the good old "well everyone experiences symptom X sometimes" canard.

Yeah you might experience symptom X but for me symptom X is literally crippling. You can take your minimization of the autistic experience and go jump off a cliff with it.

spicyusername•1m ago
We are commenting on a post where someone created a game that presents normal challenges everyone faces as if it was an "Autism Simulator".

It is exactly this kind of generalization that I'm referring to in my comment.

If anything, we are both equally frustrated by the fact that everyone who has experiences they consider "autistic" to happily jump on the bandwagon, despite the fact that it is a relatively small percentage of the population whose has experiences that are sufficiently severe or unusual to warrant any kind of label at all.

ashu1461•21m ago
The burn out due to unproductive meetings would probably be at a similar scale
flatline•20m ago
The normal simulator is the negative space in this game. The people on the party committee. The networking event. Your mom who has called three times. Just imagine those activities boosting all of your stats.
joshcsimmons•19m ago
Cool take, well put.
unclad5968•11m ago
I can't speak for everyone, but for myself the scenarios in this simulator basically don't affect my life at all. Annoying radio ad, "That's annoying". People team requests my participation at some event, "No thanks". Don't want to go to work, "oh well". If someone suggested we get coffee I'd be excited. I've never even considered not taking meds I've been prescribed. Other things seem normal to me. I put on ANC headphones at my office job all the time.

While going through the simulator, I was shocked with the response to some choices and situations. I was not aware that these things were so disruptive to some people.

cratermoon•30m ago
The blinking Autism Simulator text, in black on yellow, in the upper left is very distracting.
beeflet•27m ago
Autism is as difficult as the oregon trail. Woe is me.
barrenko•27m ago
This may be incredibly offensive, but how big could a potential overlap be between ADHD and autism?
VPenkov•25m ago
One is impulsive, the other requires structure. The two are not mutually exclusive though, because both conditions are pretty diverse. AuDHD is a term used to describe people with both.
soulofmischief•17m ago
This is a massive oversimplification of both autism and ADHD which approaches uselessness. Impulsivity is one possible symptom of ADHD, but doesn't even begin to describe the experience, and by itself paints an incorrect picture of the experience. Same for autism and structure. I know plenty of people with autism who absolutely do not deal in structure.

I know it feels nice to be able to craft a simple narrative, but this narrative feels more harmful and misconstrued than useful.

joshcsimmons•24m ago
Not at all - the stat I've heard is that 30-50% of autistics also have ADHD
tux3•24m ago
I've seen Twitter use "AuDHD" for the intersection. It's big enough to have its own label and subgroup who identify with it.
alterom•17m ago
Pretty big. The key word is "comorbidity"; having one of them means you are more likely to have the other than a random person.

There's also an overlap in traits.

I'm AuDHD (autism + ADHD). You can read about my ADHD side if the experience (with memes!) here:

https://romankogan.net/adhd

barrenko•15m ago
Thank you for sharing, I am sure I have inklings of either one of them, or both.
nixonpjoshua•17m ago
The diagnostic criteria and symptoms have substantial overlap, ultimately everything in the DSM is a descriptive diagnosis not based on a mechanistic understanding of neurobiology so it's VERY likely that our categories don't map 1:1 to the underlying causes.
herculity275•16m ago
There seems to be a prevalent pop psych view that a bunch of these conditions (Autism, ADHD, Anxiety-Depression, OCD) are sort of clustered together and people who manifest one will often manifest symptoms of others. It gets muddier because a lot of these conditions are understood as spectrums and different people who identify with them may manifest them in vastly different ways. I'm still hesitant that "autism" these days may describe either someone who's completely nonverbal and living in assisted living, or someone who's a successful academic/engineer/entrepreneur.
gopalv•6m ago
> how big could a potential overlap be between ADHD and autism?

The lack of executive function is overlapping, but this particular post might be more of an ADHD simulator.

The very first "Follow the morning routine" or not is where this veers off my experience of the spectrum.

"Changing plans because of situations internal or external" is hard.

The option should've been "Spend 20 minutes making eggs again, because the yolks weren't the right kind of runny", miss the train, take a cab to work, but tell the driver that you've now got a system for eggs which you didn't have today (yeah, fun fact, the recipe was off because they don't refrigerate them over in France).

bitwize•4m ago
Significant enough that the DSM-iV recognized ADHD symptoms as symptoms of autism and didn't allow a comorbid diagnosis of both conditions because of this. (The DSM-V does recognize both as possibly occurring together.)
_fat_santa•26m ago
Question: are there any good resources out there for leading those that are neurodivergent? I haven't led anyone that's neurodiverent yet but it's something I think alot about.
marky1991•23m ago
I swear I went home from work but then got fired from my job for falling asleep at my desk. I don't understand what happened. (And even if I did fall asleep at my desk, who fires an employee for falling asleep once?)
joshcsimmons•18m ago
Bummer - this has been the hardest code I've ever had to write test coverage for. I'm using https://www.inklestudios.com/ink/ for the story routing with inkjs so I'm not surprised that there are some lingering weird-paths.
criddell•17m ago
> who fires an employee for falling asleep once?

Happened to my grandfather even though he was probably the best damned cab driver in all of Michigan.

ikerino•17m ago
Eh, this just feels like "software engineering simulator." I don't have autism but a good bit of this feels familiar (am I on the spectrum?) I'm an introvert and have struggled to cope with corporate work for a while.

What helps:

- Challenging the idea that you need to mask to be successful. If masking is a recipe for burnout, then it actually seems like it's a strategy that will lower your chance for success. How much of the need here is self-imposed?

- Owning your calendar and timing for meetings to better suit your energy.

- Regular therapy and reflection, honestly.

- Regular exercise, doesn't matter who you are or what form, this is essential.

I can respect that this "simulation" fosters empathy, but worry that it also awfulizes/catastrophizes solvable problems. Figuring out functional routines and managing burnout is just as big a part of the job as writing code. It's very much a personal responsibility, maybe not in the job description, maybe harder for some than others, but it is our responsibility.

baggachipz•14m ago
The reason it's called a "spectrum" is that everyone's on it. :)
stego-tech•15m ago
Solid slice of the more extreme side of the autism spectrum for those who can still function within “normal” society, albeit with some assistance and tolerance.

I’m lucky enough to be on the lower/moderate side of things, but man all of this stuff hit home in its own way. Annoying noises (for me it’s the whine of cheap electronics or the chaotic bass of some music genres/upstairs neighbors), the forceful imposition of others in my space (“cameras on!”, scented cleaners, voluntold activities), and the daily task micromanagement to get by (do I call a friend/family member since they’ve texted me three times today about a trivial matter, or do I watch comfort shows and work on a personal project?).

This shit is hard, and adding in the requirement to engage in political maneuvering to succeed and thrive makes it exponentially worse.

I just want to do a good job and go home to live the best life I can. I suspect most autists are the same.

mrjay42•15m ago
Whoever chose flashy colors for this is a motherfluffer :')
joshcsimmons•9m ago
Hey all, I built this. It’s not trying to capture every autistic experience (that’d be impossible). It’s based on my own lived experience as well as that of friends on the spectrum.

I'm trying to give people a feel for what masking, decision fatigue, and burnout can look like day-to-day. That’s hard to explain in words, but easier to show through choices and stats. I'm not trying to "define autism".

I’ve gotten good feedback here about resilience, meds, and difficulty tuning. I’ll keep tweaking it. If even a few people walk away thinking, "ah, maybe that’s why my coworker struggles in those situations," then it’s worth it.

Appreciate everyone who’s tried it and shared thoughts.

cookiengineer•2m ago
This is sooo well done. I can so relate to the struggles of the daily minefields of social interactions.

The bad part is: when HR forces you to take some time off because you're sick, you can't regenerate, really. And if you're sick you don't have the mental capacity left to dampen the noises.

I always explain the perception of life to others as it being like living and working next to a construction site. All the time, including when you try to sleep. The world is full of too many noises, and social interactions are noises, too.

I also would love to see NICU being in there, too. Maybe with appointments the next day putting you in waiting mode so you can't sleep and rest in the game?