Development of an ultrahigh affinity, trimeric ACE2 biologic as a universal SARS-CoV-2 antagonist

https://www.nature.com/articles/s42003-025-08819-w

This is in vitro (i.e. in a "petri dish," not in a lab animal or a human being).

It's a very very cool idea, but there's a lot of work left to be done to turn something like this into an efficate and safe drug. Plus, a biologic like this would only work if it's active in your body when you're being infected with the virus. So users would either have to take it prophylactically, or it might help to reduce infection severity in a paxlovid-type role.

Relevant xkcd: https://xkcd.com/1217/

What impact would this potential future antagonist have on existing drugs that tinker with ACE2 such as blood pressure drugs? I ask because a lot of people are on such drugs.