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Antipsychotic-treated patients with schizophrenia see benefits from semaglutide

https://medicalxpress.com/news/2025-09-antipsychotic-patients-schizophrenia-benefits-semaglutide.html
1•PaulHoule•2h ago

Comments

ggm•1h ago
The antipsychotic drugs cause weight gain either by a biochemical pathway change or because of behavioural changes but no matter which, patients on these drugs get weight related problems.

I don't think semaglutide directly affects their mental states (although it may since there's suggestions it helps with other problems OCD perhaps) but reducing their weight related health issues would be massive.

The report said to me "with care, it's safe and beneficial" and that's great to know. Hopefully the research community is going down a list of different classes of people on (complex) drug regimen who might have drug interaction risks, doing a risk assessment, starting with the ones who get weight gain as a problem in their treatment.

(Not a doctor or epidemiologist, just fascinated by it)

Hulu is officially shutting down after 20 years

https://www.al.com/news/2025/10/hulu-is-officially-shutting-down-after-20-years-heres-why.html
1•avonmach•1m ago•0 comments

Give me a single reason why Sora2 should exist [video]

https://www.youtube.com/watch?v=Vz0oQ0v0W10
1•JumpCrisscross•1m ago•0 comments

Ask HN: What problem would you solve with unlimited resources? (October 2025)

1•hedayet•3m ago•0 comments

Power and Fab Capacity: Last Jigsaw Pieces in the Dash for Compute

https://myriadperspectives.com/p/power-and-fab-capacity-last-jigsaw
1•leecmjohnny•3m ago•0 comments

Doing Math with Embeddings for Better AI Ad Targeting

https://www.ethicalads.io/blog/2025/10/doing-math-with-embeddings-for-better-ai-ad-targeting/
2•davidfischer•9m ago•0 comments

EPA Moves to Roll Back Drinking Water Standards

https://www.newsweek.com/epa-drinking-water-pfas-standards-10839033
4•thelastgallon•13m ago•0 comments

A Competitor Crippled a $23.5M Bootcamp by Becoming a Reddit Moderator

https://larslofgren.com/codesmith-reddit-reputation-attack/
5•SilverElfin•15m ago•1 comments

Open-Source Encrypted P2P Chat (WebRTC and Military-Grade Security)

https://github.com/SecureBitChat/securebit-chat
2•SecureBitChat•15m ago•1 comments

If AI can create any scene from a selfie, what's left for photographers?

https://www.jasonstevens.photo/rise-of-the-machines/
1•fengjiabo2400•15m ago•1 comments

The Refragmentation

https://paulgraham.com/re.html
1•jameslk•19m ago•0 comments

The problem with agentic AI in 2025

https://platforms.substack.com/p/the-problem-with-agentic-ai-in-2025
2•arrowsmith•20m ago•0 comments

List of Lost Objects

https://en.wikipedia.org/wiki/Category:Lost_objects
1•slater•23m ago•0 comments

Winter 2025/2026 weather outlook

https://www.severe-weather.eu/long-range-2/winter-2025-2026-outlook-colder-season-forecast-for-un...
4•NKosmatos•28m ago•0 comments

Radio Garten

https://radio.garden/
2•joebig•29m ago•0 comments

Real Programmers Don't Use Pascal (1982)

https://www.ee.torontomu.ca/~elf/hack/realmen.html
1•eps•31m ago•0 comments

</> htmxxx – more explicit high power tools for HTML

https://github.com/bigguysoftware/htmxxx
3•htmxxx•31m ago•0 comments

Scientists catch a shark threesome on camera

https://arstechnica.com/science/2025/09/scientists-catch-a-shark-threesome-on-camera/
1•PaulHoule•33m ago•0 comments

Bluesky civil war shows free speech is harder than it looks

https://unherd.com/newsroom/bluesky-civil-war-shows-free-speech-is-harder-than-it-looks/
2•sbuttgereit•35m ago•0 comments

Global efficiency record set for large, triple-junction perovskite solar cell

https://techxplore.com/news/2025-10-global-efficiency-large-triple-junction.html
1•westurner•36m ago•0 comments

Show HN: HyprMCP – Open-Source Analytics, Logs and Auth Platform for MCP Servers

https://github.com/hyprmcp/jetski
2•pmig•36m ago•0 comments

Americans' love of billiards paved the way for synthetic plastics

https://invention.si.edu/invention-stories/imitation-ivory-and-power-play
2•geox•37m ago•0 comments

Man Charged with 'Maliciously' Starting January LA Palisades Fire

https://www.bloomberg.com/news/articles/2025-10-08/person-arrested-in-connection-with-january-los...
1•JumpCrisscross•38m ago•0 comments

Israel and Hamas 'both sign off' on first phase of Gaza peace plan

https://www.bbc.co.uk/news/live/cx2nzlj2j4kt
6•FridayoLeary•39m ago•0 comments

Revolutionary Tolerance

https://aeon.co/essays/sebastian-castellio-and-the-deep-roots-of-religious-tolerance
2•bikenaga•40m ago•0 comments

Migrate Your Next.js App from Vercel to Your Own Infrastructure

https://disco.cloud/blog/migrate-your-nextjs-app-from-vercel-to-your-own-infrastructure/
3•gregsadetsky•41m ago•3 comments

Uber Eats partners with fintech firm Pipe to offer capital to small businesses

https://pipe.com/resources/press-releases/pipe-announces-new-integration-with-uber-empowering-res...
1•ryan_j_naughton•42m ago•1 comments

Israel, Hamas agree on first phase of ceasefire, hostage release

https://www.reuters.com/world/gaza-live-trump-says-israel-hamas-agree-first-phase-plan-end-war-20...
9•elinear•42m ago•3 comments

Hugo Blox: A toolkit for technical and academic websites

https://docs.hugoblox.com/
1•gingerceo•43m ago•0 comments

Discord says 70k users may have had their government IDs leaked in breach

https://www.theverge.com/news/797051/discord-government-ids-leaked-data-breach
5•PaulKeeble•43m ago•1 comments

JPMorgan Was Billed $115M for Fraud Founders' Legal Defense

https://www.bloomberg.com/news/articles/2025-10-07/jpmorgan-was-billed-115-million-for-fraud-foun...
2•neom•46m ago•0 comments