> Surprising that having more AMPA receptors would lead to decreased cognition

The study only looked at one marker. It doesn't confirm that increased AMPA receptor density is the cause of decreased cognition. It only suggests that decreased cognition is correlated with increased AMPA receptor density.

There are many processes in the body where reduced activation of a receptor system results in an increased number of those receptors. So don't conclude that this is the reason why patients have brain fog. I would guess it's just more of a symptom than a cause until there's more research

Maybe it's an attempt by the body to compensate?

Just a shot in the dark here, I'm just some guy on the internet, not a microbiologist or doctor.

In biology, cause and effect do not work the way they work in other fields. Effect is highly context-specific and things often work in the opposite direction than you might assume.

I had the same thing with my caffeine sensitivity, but my nicotine sensitivity hasn’t gone back and it’s been over a year. I used nicotine lozenges daily for years but even after 12 months post-covid my body does not tolerate them.

Mine has never recovered. I have to drink decaf now! I feel a small amount of relief that I'm not alone.

Thank you for sharing. I have the same thing and it is from my first bout with Covid in 2021. I have now had Covid 4 times and the caffeine sensitivity remains along with PVCs and chest pain. Brain fog has been almost debilitating and overall the impact on my career performance is noticeable.

Thanks. I love this comments that spare time for everybody else. But honestly, anything biology/medicine related, you KNOW the title is exaggerated, right out of the bat

It'd be nice to find out if there's any overlap with the "brain fog" from fibromyalgia. My college years would have been far less torturous if I could have lived without that, even if I still had to deal with the pain.

It sounds like you’re reading too much into it.

It doesn’t say root cause, or drug target. It doesn’t say reverse or cure. It quite specifically doesn’t say “the basis”. The word basis doesn’t have to refer to one root cause. It could be something foundational, but there can be many elements of a foundation. It certainly isn’t the entire structure.

I’d argue it’s quite tame as academic press releases go.

What do you do for managing dependency / tolerance?

This does not surprise me, it does have many neuroprotective benefits after all.

I vape like a fiend and I'm probably never going to stop