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CRISPR-like tools that finally can edit mitochondria DNA

https://www.nature.com/articles/d41586-025-03307-x
70•ck2•3h ago

Comments

Miaourt•2h ago
A nice soul have a non-paywalled version to share ?
byrantech•2h ago
https://www.nature.com/articles/d41586-025-03307-x.pdf

this should work?

Miaourt•1h ago
Maybe I'm just stupid, but I'm seeing the typical "fade-out" at the bottom of the article, followed by a subscription-wall, suggesting more of the content is behind this gate. Tho, maybe the "Making the edit" infographic is really the bottom of the article...
bil7•1h ago
the only current archive on archive.is also has that. Watch this space for a complete archive, hopefully:

https://archive.is/https://www.nature.com/articles/d41586-02...

varispeed•1h ago
Imagine the future - vibe coding own DNA.

"Hey ChatGPT, I need third ear. Make it grow in two months."

Iolaum•1h ago
Now we "just" need a CRISPR-MCP server :p
mountainriver•52m ago
On the public internet
CSMastermind•45m ago
I've been reading a lot about biochemistry lately and it's actually insane how complicated all of life is. The idea that we can edit genes at all is a miracle and I think most software engineers significantly underestimate how hard it would be to make meaningful changes to our bodies through gene editing.
lanfeust6•19m ago
Recently have been reading the Gene by Mukherjee. I'm amazed at what had been accomplished in the mid 20th Century. A lot of what still seems crazy now was done already albeit in small scale.
fragmede•16m ago
Growing new appendages is clearly much more involved, but a Youtuber was able to give themselves lactose tolerance for a couple of months (they were lactose intolerant before). Assuming it wasn't faked for views, and that we are what we eat, that suggests other modifications to gut bateria aren't inconceivably far off.
toasterlovin•13m ago
Unfortunately biology only does spaghetti code.
thwarted•9m ago
This reminded me of the 1995 The Outer Limits episode "The New Breed".

Mapping the Social Graph of R/Indonesia's Daily Chat Thread

https://rtnf.substack.com/p/mapping-the-social-graph-of-rindonesias
1•altilunium•1m ago•0 comments

Ask HN: Open framework for generating thumbnails on untrusted files?

1•dafelst•1m ago•0 comments

Myanmar scam cities booming despite crackdown–using Musk's Starlink

https://techxplore.com/news/2025-10-myanmar-scam-cities-booming-crackdown.html
1•EA-3167•1m ago•0 comments

King vs. Rich: The Founder's Dilemma

https://thevcedge.substack.com/p/king-vs-rich-the-founders-dilemma
1•herbertl•2m ago•0 comments

Show HN: Replicas – Workspace VMs for your coding agents

https://www.replicas.dev/
1•connortbot•6m ago•0 comments

Tree Walk Format (TWF): a flat file format to describe your family tree

https://github.com/romforth/twf
1•romforth•6m ago•1 comments

A Tiny Typo May Explain Centuries-Old Mystery Bout Chaucer's 'Canterbury Tales'

https://www.smithsonianmag.com/smart-news/a-tiny-typo-may-explain-a-centuries-old-mystery-about-c...
1•keepamovin•6m ago•0 comments

Our Claude Code Cheatsheet

https://neon.com/blog/our-claude-code-cheatsheet
1•emschwartz•7m ago•0 comments

OpenAI Keeps Doing Deals

https://www.bloomberg.com/opinion/newsletters/2025-10-13/openai-keeps-doing-deals
1•feross•8m ago•0 comments

Poet.py: Fixing Substack Markdown formatting on paste with pynput

https://github.com/danielfalbo/poet
1•danielfalbo•8m ago•0 comments

Security firms dispute credit for overlapping CVE reports

https://www.bleepingcomputer.com/news/security/security-firms-dispute-credit-for-overlapping-cve-...
1•pepperfritz•9m ago•0 comments

Mycophagy in Primates of the Issa Valley, Tanzania

https://onlinelibrary.wiley.com/doi/10.1002/ece3.72000
1•PaulHoule•12m ago•0 comments

Frank Herbert: New World or No World

https://oceanofpdf.com/authors/frank-herbert/pdf-epub-new-world-or-no-world-download/
2•daly•12m ago•2 comments

Complex Life May Have Evolved Multiple Times

https://www.scientificamerican.com/article/complex-life-may-have-evolved-multiple-times/
1•beardyw•12m ago•0 comments

Ideas on Glitching in Rust

https://tritium.legal/blog/glitch
1•piker•13m ago•0 comments

ASM calls on UK to rethink customs strategy after Single Trade Window collapse

https://www.asm.org.uk/en/news-updates/comments-articles/asm-calls-on-uk-government-to-rethink-cu...
1•mooreds•14m ago•0 comments

JavaScript Temporal – Is It Here?

https://bryntum.com/blog/javascript-temporal-is-it-finally-here/
2•ritzaco•14m ago•0 comments

Chinese gang used ArcGIS as a backdoor for a year – and no one noticed

https://www.theregister.com/2025/10/14/chinese_hackers_arcgis_backdoor/
1•rntn•15m ago•0 comments

Radxa Orion O6n: smaller and cheaper version of the O6

https://www.cnx-software.com/2025/10/14/radxa-orion-o6n-smaller-cheaper-12-core-armv9-nano-itx-sb...
1•sunshine-o•15m ago•0 comments

Prefix sum: 20 GB/s (2.6x baseline)

https://github.com/ashtonsix/perf-portfolio/tree/main/delta
2•ashtonsix•15m ago•0 comments

Show HN: Get a PMF score for your website, based on simulated user data

https://semilattice.ai/demos/pmf-report
2•jtewright•16m ago•0 comments

From hand-tuned Go to self-optimizing code: Building BitsEvolve

https://www.datadoghq.com/blog/engineering/self-optimizing-system/
1•MrBuddyCasino•16m ago•0 comments

Streaming Patterns with DuckDB

https://duckdb.org/2025/10/13/duckdb-streaming-patterns.html
1•tanelpoder•16m ago•0 comments

The Free Software Foundation considers large language models

https://lwn.net/SubscriberLink/1040888/a263daa95171fc50/
2•chmaynard•16m ago•0 comments

The Payment Bible – a.k.a. Payments 101: A Beginner's Guide to Payments

https://thepaymentbible.com
2•pstadler•17m ago•0 comments

Job Satisfaction

https://digitalsociety.coop/posts/job-satisfaction/
1•mooreds•17m ago•0 comments

The EU must find a regulatory reverse gear

https://www.ft.com/content/6519cf91-e61c-43ea-ae80-fb616d37141b
1•hedgeho•17m ago•0 comments

AI for coding is still playing Go, not StarCraft

https://quesma.com/blog/coding-is-starcraft-not-go/
1•aamederen•17m ago•0 comments

Google has patched 'Pixnapping' attack in Android

https://9to5google.com/2025/10/14/google-patched-pixnapping-attack-further-fix-december-update/
1•saikatsg•17m ago•0 comments

Can anything knock China off its mountain?

https://www.noahpinion.blog/p/can-anything-knock-china-off-its
1•mooreds•18m ago•0 comments