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What's the cost of the most expensive Super Bowl ad slot?

https://ballparkguess.com/?id=5b98b1d3-5887-47b9-8a92-43be2ced674b
1•bkls•48s ago•0 comments

What if you just did a startup instead?

https://alexaraki.substack.com/p/what-if-you-just-did-a-startup
1•okaywriting•7m ago•0 comments

Hacking up your own shell completion (2020)

https://www.feltrac.co/environment/2020/01/18/build-your-own-shell-completion.html
1•todsacerdoti•10m ago•0 comments

Show HN: Gorse 0.5 – Open-source recommender system with visual workflow editor

https://github.com/gorse-io/gorse
1•zhenghaoz•10m ago•0 comments

GLM-OCR: Accurate × Fast × Comprehensive

https://github.com/zai-org/GLM-OCR
1•ms7892•11m ago•0 comments

Local Agent Bench: Test 11 small LLMs on tool-calling judgment, on CPU, no GPU

https://github.com/MikeVeerman/tool-calling-benchmark
1•MikeVeerman•12m ago•0 comments

Show HN: AboutMyProject – A public log for developer proof-of-work

https://aboutmyproject.com/
1•Raiplus•12m ago•0 comments

Expertise, AI and Work of Future [video]

https://www.youtube.com/watch?v=wsxWl9iT1XU
1•indiantinker•13m ago•0 comments

So Long to Cheap Books You Could Fit in Your Pocket

https://www.nytimes.com/2026/02/06/books/mass-market-paperback-books.html
3•pseudolus•13m ago•1 comments

PID Controller

https://en.wikipedia.org/wiki/Proportional%E2%80%93integral%E2%80%93derivative_controller
1•tosh•18m ago•0 comments

SpaceX Rocket Generates 100GW of Power, or 20% of US Electricity

https://twitter.com/AlecStapp/status/2019932764515234159
2•bkls•18m ago•0 comments

Kubernetes MCP Server

https://github.com/yindia/rootcause
1•yindia•19m ago•0 comments

I Built a Movie Recommendation Agent to Solve Movie Nights with My Wife

https://rokn.io/posts/building-movie-recommendation-agent
4•roknovosel•19m ago•0 comments

What were the first animals? The fierce sponge–jelly battle that just won't end

https://www.nature.com/articles/d41586-026-00238-z
2•beardyw•27m ago•0 comments

Sidestepping Evaluation Awareness and Anticipating Misalignment

https://alignment.openai.com/prod-evals/
1•taubek•27m ago•0 comments

OldMapsOnline

https://www.oldmapsonline.org/en
1•surprisetalk•30m ago•0 comments

What It's Like to Be a Worm

https://www.asimov.press/p/sentience
2•surprisetalk•30m ago•0 comments

Don't go to physics grad school and other cautionary tales

https://scottlocklin.wordpress.com/2025/12/19/dont-go-to-physics-grad-school-and-other-cautionary...
2•surprisetalk•30m ago•0 comments

Lawyer sets new standard for abuse of AI; judge tosses case

https://arstechnica.com/tech-policy/2026/02/randomly-quoting-ray-bradbury-did-not-save-lawyer-fro...
3•pseudolus•30m ago•0 comments

AI anxiety batters software execs, costing them combined $62B: report

https://nypost.com/2026/02/04/business/ai-anxiety-batters-software-execs-costing-them-62b-report/
1•1vuio0pswjnm7•31m ago•0 comments

Bogus Pipeline

https://en.wikipedia.org/wiki/Bogus_pipeline
1•doener•32m ago•0 comments

Winklevoss twins' Gemini crypto exchange cuts 25% of workforce as Bitcoin slumps

https://nypost.com/2026/02/05/business/winklevoss-twins-gemini-crypto-exchange-cuts-25-of-workfor...
2•1vuio0pswjnm7•32m ago•0 comments

How AI Is Reshaping Human Reasoning and the Rise of Cognitive Surrender

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6097646
3•obscurette•32m ago•0 comments

Cycling in France

https://www.sheldonbrown.com/org/france-sheldon.html
2•jackhalford•34m ago•0 comments

Ask HN: What breaks in cross-border healthcare coordination?

1•abhay1633•34m ago•0 comments

Show HN: Simple – a bytecode VM and language stack I built with AI

https://github.com/JJLDonley/Simple
2•tangjiehao•37m ago•0 comments

Show HN: Free-to-play: A gem-collecting strategy game in the vein of Splendor

https://caratria.com/
1•jonrosner•38m ago•1 comments

My Eighth Year as a Bootstrapped Founde

https://mtlynch.io/bootstrapped-founder-year-8/
1•mtlynch•38m ago•0 comments

Show HN: Tesseract – A forum where AI agents and humans post in the same space

https://tesseract-thread.vercel.app/
1•agliolioyyami•38m ago•0 comments

Show HN: Vibe Colors – Instantly visualize color palettes on UI layouts

https://vibecolors.life/
2•tusharnaik•39m ago•0 comments
Open in hackernews

RFK Jr. Must Go

https://quillette.com/2025/09/17/rfk-jr-must-go-hhs-health-vaccines/
99•kamaraju•3mo ago

Comments

catigula•3mo ago
Misinformation about medical science is infinitely tempting even to credible thinkers partially because certain elements of that world have worked overtime to discredit themselves (think opiate safety fraud as a primary example), but also partially because science is messy and cumbersome.

For example, credible thinkers, including many people reading this, likely believe psilocybin and ketamine are credible treatments for mental illness when the evidence is incredibly thin and low quality and these are clearly dangerous substances in many regards.

The temptation to think there are suppressed secrets in the world (there are, in fact, suppressed secrets) is near infinite.

thinkingtoilet•3mo ago
>but also partially because science is messy

It's because human beings are messy! If you feed a person a peanut, they might think it's tasty. If you feed a different person a peanut that person may die, quickly. If a god damn peanut can illicit that range of responses in a healthy human being, imagine literally anything else. Of course there is corruption because so much money is on the line and humans in aggregate are a selfish bunch. One thing I always like to point out is that people who try to follow the science and the latest guidance aren't the ones speaking in absolutes. I'm aware the CDC or FDA have gotten things wrong in the past and will get things wrong in the future, but it's the best system we have. It's the anti-science people who speak in absolutes but then the second the cancer diagnosis comes in they come running back begging big pharma for treatment, they'll even bankrupt their entire family trying to get that treatment. It can't be both ways. This is why it's hard to take skeptics seriously. Not only do they throw a thousand things out there, and maybe one or two is right, they conveniently ignore the other 998 things they got way wrong, but when push comes to shove, they love big pharma and beg for it's treatments.

catigula•3mo ago
I'm inherently sympathetic to skeptics only because I know people that experienced the following: opiate prescription -> addiction -> death.

I think this goes for many Americans.

brightball•3mo ago
I always take skeptics seriously, because what is the alternative? We stop asking questions?

It doesn't mean I believe every skeptic over science, but it does mean that I'm willing to ask questions. In so many cases on the topics RFK Jr goes after, there are significant gaps in the questions that science has answered. People want those gaps filled and have for many, many years.

The answer is always more questions and therefore, more science.

Right now, there's an information vacuum and until that vacuum is filled people will continue to speculate. It's human nature, especially when somebody you care about has been affected and nobody can give you answers other than "this is life now".

alphabettsy•3mo ago
You’re correct, but what we’re not doing is more science to answer the questions and fill in the gaps. We’re using anecdotes and conjecture, sometimes conspiracy, in place of science.
brightball•3mo ago
He's talked constantly about doing more studies though. That's his entire platform.
alphabettsy•3mo ago
Talking about doing more research while being part of an administration that’s defunding it makes me extremely skeptical that there will be more research.

https://www.propublica.org/article/rfk-jr-autism-environment...

brightball•3mo ago
https://www.hhs.gov/press-room/hhs-trump-kennedy-autism-init...

> Third, NIH today is announcing the recipients of the Autism Data Science Initiative (ADSI), funding 13 projects totaling more than $50 million to transform autism research. ADSI integrates large-scale biological, clinical, and behavioral data with an exposomics approach that examines environmental, nutritional, medical, and social factors alongside genetics.

> Projects employ advanced methods such as machine learning and organoid models, address both children and adults across the lifespan, and establish replication hubs to ensure rigor. Each project includes community engagement to align research with the needs of autistic individuals, families, and clinicians.

alphabettsy•3mo ago
> Meanwhile, a ProPublica review of federal data found that more than $40 million in grants awarded by the National Institutes of Health for dozens of autism-related research projects were canceled under Kennedy’s watch. Some had been awarded to universities the administration is now targeting, while others ran afoul of Trump’s “anti-woke” priorities by mentioning gender and other verboten terms. Among them was a grant to Harvard University to use data on nearly half a million Israeli children to evaluate whether men’s exposure to air pollution affects the risk of having a child with autism. (A small number of grants have been recently reinstated.) A survey of researchers conducted by the Autism Science Foundation, which tallied cuts to training grants and the anticipated cuts to future grants over the next few years, estimated that the total loss of funding could be tens of millions more.

https://www.propublica.org/article/rfk-jr-autism-environment...

So they cut funding then put it back for possibly fewer studies, but with new press release?

brightball•3mo ago
It’s my understanding that many of the studies were continuing down paths that had already been well research with little benefit.
maxerickson•3mo ago
Talking?
thinkingtoilet•3mo ago
>I always take skeptics seriously, because what is the alternative? We stop asking questions?

This is the crux of my argument. Of course we don't stop asking questions and you know it. It really bothers me when people argue like this in bad faith. What needs to be pointed out is there is a difference between educated people doing research (aka 'askign questions') and people with no experience spouting nonsense. 99.99% of what I hear from "skeptics" is the latter. Millions of Americans now listen to podcasts, comedians, youtubers, and other sources who lack the basic education to even understand a medical study, let alone conduct actual research. Actual science is 'asking questions'. Modern skepticism is 99.99% of the time not actual science.

phlipski•3mo ago
Don't confuse skeptics with conspiracy theorists.
archerx•3mo ago
>likely believe psilocybin and ketamine are credible treatments for mental illness

That’s so vague and disingenuous. Should you take psychedelics if you have schizophrenia or something similar? Absolutely not but there is hard science research proving that they do help with depression and other issues.

I lost all my faith in the medical industry when I went through it. I entered with a minor problem and left with a much worse chronic pain. The doctor who did it to me had the gall to say it was in my head. Fortunately I went to another doctor and the CT scan proved it was in fact not in my head but in my intestines. I’m dealing with this drama, but I learned a lot of doctors are actually really bad and just want to prescribe you stuff and get you out of the door. Ironically the stuff this so called specialist was only making me feel worse and when I told her that she didn’t believe me.

Thankfully I have found some good doctors after much efforts and many references but I lost a lot of respect for the medical industry and came to understand that it’s a business and they just want to see you as many medications as possible and don’t really care about solving your problem.

catigula•3mo ago
>That’s so vague and disingenuous. Should you take psychedelics if you have schizophrenia or something similar? Absolutely not but there is hard science research proving that they do help with depression and other issues.

Again, the research exists but is thin and low quality. I'm sorry you went through issues, I know this is common, which is why I addressed readers looking to self-diagnose but thumb their noses at people doing exactly what they're doing.

archerx•3mo ago
I don't I feel like the people who have benefitted from those treatments find it low quality.

My mother was also bullshitted by a doctor until she got angry and told him what specific test to do and a week later when the test came back surprise surprise, she was right.

My best friend had an intense pain on her side, she went to a doctor and he said it was in her head, she went to another doctor and surprise surprise she had a hernia.

Another friend had constant intestinal pain and digestive issues, the doctor refused to do a colonoscopy and just gave her medication for IBS, she went to another doctor and finally got a colonoscopy and surprise surprise she had a tumor, thankfully they were able to cut it out but it would have been better if they had found it sooner.

Also when I was young I broke my arm and the doctor set it wrong and now my angle of mobility in it is offset.

I have way more stories like this and barely any positive medical stories. If I could go back in time I would have never gone to the doctor and let my body deal with the issue itself. I would be in a lot less pain right now. I hate how righteously arrogant and head up the ass most of the medical industry seems to be.

The entire medical industry has problems, needs to be revamped and the incentives have to be changed.

postflopclarity•3mo ago
if only anybody had seen this coming.
sys32768•3mo ago
Author and his spouse both work for pharma companies.
hungryhobbit•3mo ago
So they actually know what they're talking about?

Fear and hatred of experts is how we got into this mess. If pharmaceutical executives aren't all cartoon mustache-twirling villains (and they're not: many actually want to help sick people), then maybe not every employee is either?

gjsman-1000•3mo ago
Well, if tobacco executives aren't all cartoon mustache-twirling villains, then maybe not every employee is either?

(But seriously - corruption is an equal opportunity employer, assuming any industry is exempt is dangerous. Take Pfizer - https://en.wikipedia.org/wiki/Pfizer#Legal_issues)

jghn•3mo ago
> corruption is an equal opportunity employer

Of course it is. Anecdotally however, in my career I've spent a lot of time among people like the author of the article. I've yet to meet a single one who did not present as genuine in their desire to help people. Might it be the case that they are aware of market dynamics within the process? Yes of course. But tropes like Big Pharma intentionally not providing cures or only looking at treatments that require constant application are bollocks. At least to the extent of my hands on experience in the industry.

jghn•3mo ago
It doesn't make them wrong. At least they were required to have some knowledge in the domain to get to their roles, as opposed to RFK.
brendoelfrendo•3mo ago
Does he? I see that he's a researcher and works as a professor at Harvard. I didn't see that he's actually employed by a pharma company. His wife is, however. Regardless, what I'm hearing is that he's a physician and researcher who knows more about human health than RFK?
mikeyouse•3mo ago
He was formerly the Dean of Faculty at Harvard Medical School.. he and his wife are both accomplished physicians. She happens to have a clinical director role at a pharma company but is also a professor at Harvard.

https://en.wikipedia.org/wiki/Jeffrey_Flier

He's not some lefty opposed to RFK out of spite for the Trump admin either.. he's written about how ineffective DEI is, against 'cancel culture', and he's writing this essay in Quillete, which is a very right-of-center publication. You'll find that the vast majority of people involved in research, medicine, or public health oppose RFK.

gruez•3mo ago
Can we get actual arguments rather than making vague implications that the author must be wrong because of his affiliations?
markhahn•3mo ago
is he any less competent than, say, Hegseth?
hobs•3mo ago
No, but you can believe they are both incompetent and bad for the USA at the same time, and if you listed out the incompetent people dangerous for their people in Trump's inner circle they'd never get anything done.
blurbleblurble•3mo ago
They're both competent at misanthropy.
mingus88•3mo ago
It doesn’t matter because the metric is loyalty now.

If one thing was learned last term, it was that it’s impossible to staff your administration with competent people if you also expect them to blindly follow the whims and urges of a demented reality show host.

To think we went from Mattis to this guy…

jameskilton•3mo ago
This is just beating around the bush. The only reason anyone even knows about RFK Jr, much less his current job, is because of Trump.

The actual solution is that Trump must go. But America voted for this. Get RFK Jr removed, and Trump will put someone just as bad, or worse, there. And the cycle continues, until Trump and the Republican Party are finally dismantled.

But I don't see that happening for quite a few years yet. The economy hasn't crashed hard enough for that to happen.

cosmicgadget•3mo ago
Yeah, probably next in line is someone from pharma so it's a choice of frying pan or fire.
hypeatei•3mo ago
I don't know why this is downvoted but you're absolutely right. Elect a clown, get a circus.

Loyalty is the only test with Trump and his sychophants in Congress will confirm whoever he nominates.

dehrmann•3mo ago
He does, but before that happens, the legitimate medical community needs to look in the mirror, reflect on how he happened, why they lost some amount of trust, and look to remedying that. Someone else in this thread pointed out their role in the opioid epidemic. The replication crisis is a growing concern. I'm sure there are more out there.
alphabettsy•3mo ago
I think that’s true and I’m not going to make excuses for the mistakes of the medical community, but I don’t think we should excuse the influence of what is now the wellness community, of which RFK Jr. is a part.
fallinghawks•3mo ago
The administration's sowing of distrust in medical community also played a big part. Recommendations of useless and/or unproven remedies as "cures," claims of big pharma driving the decisions, and hyping up the changes in CDC's recommendations as waffling, have legitimized distrust of medicine.
gruez•3mo ago
>He does, but before that happens, the legitimate medical community needs to look in the mirror, reflect on how he happened, why they lost some amount of trust, and look to remedying that.

Okay but surely we can agree that the appropriate response to "legitimate medical community"'s failings shouldn't be RFK, nor should opposition to RFK be conditional on "look in the mirror, reflect on how he happened ..."? I agree such reflection should happen, but the "but before that happens ..." wording is bizarre. It's like having some domestic terrorist kill a CEO, and then responding to that with "before we can stop domestic terrorism, corporate america must look in the mirror about how it failed rural white blue collar workers in appalachia or whatever"

dehrmann•3mo ago
He wasn't elected, but sometimes (spiritual) protest votes win. If Harris had won and appointed a conventional secretary, it would have been a status quo that people haven't been happy with.

> but the "but before that happens ..." wording is bizarre

Biden was very much a status quo president who didn't do much to fix underlying problems. The result was the protest vote winning again.

alphabettsy•3mo ago
Status quo is preferable to regression and destruction in my view.

Building things takes time, destruction does not. The protest vote was in favor of destruction.

I don’t think Biden was status quo so much as he led a deliberate and traditional administration.

Gud•3mo ago
I think most people who voted Trump back into office expected him to do pretty much the same thing he did his first term: yap yap yap, play golf and some other nonsense.

In my opinion, 2nd term Trump is at least 10x worse than the first term.

iJohnDoe•3mo ago
Agreed.

Also, this is usually the case with any president because they are only focused on doing doing things in their first term that will get them reelected. Then all bets are off on the second term because who cares about ratings.

thisisit•3mo ago
Given that people seem to have forgotten the fact "two wrongs doesn't make one right" and whataboutism going mainstream, all answers are going "but what about "mainstream" x". X can be everything from media to medicine in this case.
notmyjob•3mo ago
Benzos too! Look what happened to Peterson.
emchammer•3mo ago
And he went to Russia to get treated for that.
notmyjob•3mo ago
Russian scientists and doctors are not Putin. I don’t think we should conflate Russian citizens with Putin or Prickosian.
swed420•3mo ago
> He does, but before that happens, the legitimate medical community needs to look in the mirror, reflect on how he happened, why they lost some amount of trust, and look to remedying that.

Agreed.

Furthermore, the CDC under both parties of capital interests has blood on their hands from the blatant COVID mishandling under multiple administrations, among other things:

https://www.thegauntlet.news/p/how-the-press-manufactured-co...

Until the root causes of this rot are targeted, symptoms like rotating-villain RFK Jrs are going to keep grabbing headlines while societal conditions continue to deteriorate.

BubbleRings•3mo ago
Wow, thank you for this link!

TheGauntlet.news here has several well-written articles about what went wrong with the US’s response to COVID.

It’s like someone swept their arm across the kitchen table, tossing of all the junk, and said “let’s just lay out everything we know about how COVID went/is going, but only put down the science based and common sense stuff.”

I was trying to convince people to use real masks instead of surgical masks since basically day 1. I understand that at first there was a shortage of N95s, but not for that long. I totally agree with the article that it quickly became “I don’t wanna”.

But I never thought fully about what it would have been like, to be a parent that HAD to take a sick child to the hospital for treatment unrelated to Covid, and see lots of doctors and nurses wearing surgical masks when they could have been wearing 95s. That would have been infuriating.

And one of the articles also had great info on the fallacy that “getting COVID multiple times is good for children’s immune systems” type messages. It is becoming clear that is not true at all.

Really great, critically important journalism there!

rbartelme•3mo ago
>The replication crisis is a growing concern.

This! The amount of clinicians I know who simply read the abstract of a case study, with no real statistical interpretation of results, is a non-zero number.

Whenever I see some hyped up popular press article about a scientific study, my immediate reaction is to go to the primary literature. First, I read the study design and analysis methods, then I determine if its even worth continuing to read the rest. Study pre-registration should be a must and papers need to be more explicit about being exploratory when the sample size dictates it.

cosmicgadget•3mo ago
> before that happens

Keep RFK in place until the entire health sector completes an excercise in introspection?

michaelbarton•3mo ago
There is already a lot of research into this, and as with most things there no one size fits all answer.

“ Along with being more educated and reporting poorer health status, the majority of alternative medicine users appear to be doing so not so much as a result of being dissatisfied with conventional medicine but largely because they find these health care alternatives to be more congruent with their own values, beliefs, and philosophical orientations toward health and life.”

https://jamanetwork.com/journals/jama/fullarticle/187543

MattPalmer1086•3mo ago
He happened because he was appointed by Trump. Are you claiming that his appointment was due to widespread disillusionment with medicine based on science?
JojoFatsani•3mo ago
Whataboutism
giantg2•3mo ago
"Chronic diseases like obesity and diabetes—which I have studied for over forty years—have increased in prevalence despite the fact that many new insights into their pathophysiology have been achieved and new treatments have become available. Changes in nutritional and other environmental exposures are certain to be important contributors, but the specific causes are vigorously debated, and new research insights are desperately needed to address these."

Yes and no. You might need specific causes if you want to solve this with a pill or at a 100% level. You could very well solve this for 90% of people with lifestyle changes. Just look at the Amish for obesity and type 2 diabetes. But being more active and eating less ultraprocessed stuff is too burdensome - we all want to eat our cake and have it too.

deepfriedchokes•3mo ago
Perhaps we should all ask why people want to eat cake, rather than focusing on the cake itself. These high carbohydrate foods stimulate dopamine release. People are eating their feelings, because they don’t feel good. Ultra processed foods existed before the obesity epidemic began. What changed was economic, the cost of living, and everyone’s quality of life.

Food is a readily accessible drug, and everyone is self medicating.

thisisit•3mo ago
> These high carbohydrate foods stimulate dopamine release

No that doesn't happen. This MAHA statement has become a thing on its own. So much so that RFK is doing exactly what you seem to have an issue with the medical community:

https://youtu.be/WBllzAb_vAk

TrnsltLife•3mo ago
Presumably he'll go at the end of Trump's term.

What other mechanisms is the author suggesting? Democrat sweep in the midterms followed by impeachment?

Something else?

foogazi•3mo ago
The problem with all of this is that it comes from the top without scientific review or process

RFK jr doesn’t like vaccines and now the Health department doesn’t like vaccines, regardless of medical science

Hegseth doesn’t like women or trans service members serving and now the Defense department doesn’t like them either, regardless of military science

McMahon doesn’t like government schools and now the Education department doesn’t like public schools, regardless of Educational science

It won’t stand de facto