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U.S. CBP Reported Employee Arrests (FY2020 – FYTD)

https://www.cbp.gov/newsroom/stats/reported-employee-arrests
1•ludicrousdispla•1m ago•0 comments

Show HN: I built a free UCP checker – see if AI agents can find your store

https://ucphub.ai/ucp-store-check/
1•vladeta•7m ago•1 comments

Show HN: SVGV – A Real-Time Vector Video Format for Budget Hardware

https://github.com/thealidev/VectorVision-SVGV
1•thealidev•8m ago•0 comments

Study of 150 developers shows AI generated code no harder to maintain long term

https://www.youtube.com/watch?v=b9EbCb5A408
1•lifeisstillgood•9m ago•0 comments

Spotify now requires premium accounts for developer mode API access

https://www.neowin.net/news/spotify-now-requires-premium-accounts-for-developer-mode-api-access/
1•bundie•11m ago•0 comments

When Albert Einstein Moved to Princeton

https://twitter.com/Math_files/status/2020017485815456224
1•keepamovin•13m ago•0 comments

Agents.md as a Dark Signal

https://joshmock.com/post/2026-agents-md-as-a-dark-signal/
1•birdculture•15m ago•0 comments

System time, clocks, and their syncing in macOS

https://eclecticlight.co/2025/05/21/system-time-clocks-and-their-syncing-in-macos/
1•fanf2•16m ago•0 comments

McCLIM and 7GUIs – Part 1: The Counter

https://turtleware.eu/posts/McCLIM-and-7GUIs---Part-1-The-Counter.html
1•ramenbytes•19m ago•0 comments

So whats the next word, then? Almost-no-math intro to transformer models

https://matthias-kainer.de/blog/posts/so-whats-the-next-word-then-/
1•oesimania•20m ago•0 comments

Ed Zitron: The Hater's Guide to Microsoft

https://bsky.app/profile/edzitron.com/post/3me7ibeym2c2n
2•vintagedave•23m ago•1 comments

UK infants ill after drinking contaminated baby formula of Nestle and Danone

https://www.bbc.com/news/articles/c931rxnwn3lo
1•__natty__•24m ago•0 comments

Show HN: Android-based audio player for seniors – Homer Audio Player

https://homeraudioplayer.app
2•cinusek•24m ago•0 comments

Starter Template for Ory Kratos

https://github.com/Samuelk0nrad/docker-ory
1•samuel_0xK•26m ago•0 comments

LLMs are powerful, but enterprises are deterministic by nature

2•prateekdalal•29m ago•0 comments

Make your iPad 3 a touchscreen for your computer

https://github.com/lemonjesus/ipad-touch-screen
2•0y•34m ago•1 comments

Internationalization and Localization in the Age of Agents

https://myblog.ru/internationalization-and-localization-in-the-age-of-agents
1•xenator•34m ago•0 comments

Building a Custom Clawdbot Workflow to Automate Website Creation

https://seedance2api.org/
1•pekingzcc•37m ago•1 comments

Why the "Taiwan Dome" won't survive a Chinese attack

https://www.lowyinstitute.org/the-interpreter/why-taiwan-dome-won-t-survive-chinese-attack
2•ryan_j_naughton•37m ago•0 comments

Xkcd: Game AIs

https://xkcd.com/1002/
1•ravenical•39m ago•0 comments

Windows 11 is finally killing off legacy printer drivers in 2026

https://www.windowscentral.com/microsoft/windows-11/windows-11-finally-pulls-the-plug-on-legacy-p...
1•ValdikSS•39m ago•0 comments

From Offloading to Engagement (Study on Generative AI)

https://www.mdpi.com/2306-5729/10/11/172
1•boshomi•41m ago•1 comments

AI for People

https://justsitandgrin.im/posts/ai-for-people/
1•dive•42m ago•0 comments

Rome is studded with cannon balls (2022)

https://essenceofrome.com/rome-is-studded-with-cannon-balls
1•thomassmith65•48m ago•0 comments

8-piece tablebase development on Lichess (op1 partial)

https://lichess.org/@/Lichess/blog/op1-partial-8-piece-tablebase-available/1ptPBDpC
2•somethingp•49m ago•0 comments

US to bankroll far-right think tanks in Europe against digital laws

https://www.brusselstimes.com/1957195/us-to-fund-far-right-forces-in-europe-tbtb
4•saubeidl•50m ago•0 comments

Ask HN: Have AI companies replaced their own SaaS usage with agents?

1•tuxpenguine•53m ago•0 comments

pi-nes

https://twitter.com/thomasmustier/status/2018362041506132205
1•tosh•55m ago•0 comments

Show HN: Crew – Multi-agent orchestration tool for AI-assisted development

https://github.com/garnetliu/crew
1•gl2334•55m ago•0 comments

New hire fixed a problem so fast, their boss left to become a yoga instructor

https://www.theregister.com/2026/02/06/on_call/
1•Brajeshwar•57m ago•0 comments
Open in hackernews

I managed to grow countable yeast colonies

https://chillphysicsenjoyer.substack.com/p/i-managed-to-grow-countable-yeast
32•crescit_eundo•3mo ago

Comments

rbartelme•3mo ago
Countable is a relative term in microbiology. I like that the author stuck to the phrase "countable colonies", since colony forming units are not really "countable as cells".

Allan Konopka does a good deep dive into "The Great Plate Count Anomaly" here: https://thinkmicrobe.substack.com/p/the-great-plate-count-an...

jszymborski•3mo ago
Ah, brings me back to the countless nights I spent counting plate after plate of HEK293 cells using a Haemocytometer [0], a light microscope, and a mechanical counter [1].

At least with HEK293 cells you could mostly tell if they were dead through the microscope (dead cells are darker).

[0] https://en.wikipedia.org/wiki/Hemocytometer

[1] https://en.wikipedia.org/wiki/Tally_counter

rbartelme•3mo ago
Sometimes I miss the benchwork, but moving into bioinformatics/data science full-time has been much better for my physical and mental health.
jszymborski•3mo ago
I've made the same transition and feel the same way. I miss the bench, but I don't miss the late hours, vending machine dinners, and Christmas day cell culture maintenance.
koeng•3mo ago
Very chill :)

I do this at an industrial scale. It gets really annoying as you scale up to hundreds / thousands of different strains, all of which need pickable colonies.

A serial dilution 3 or 4 times seems to always do the trick. Typically on a robotic workstation you have to aspirate 6.5uL, then slowly dispense 5.5uL above the Petri dish (sbs format) and then stab into the agarose. Makes lovely perfectly-sized and separated wells, so 96 cell lines fit on only 3 or 4 plates.

With better plate reading you can get that down to 1 or 2 plates but it’s less reliable

flipfluck•3mo ago
Nice. Could I use a petri dish to figure out what sort of organism spoiled my homebrew?
throwawaymaths•3mo ago
yeah, colony on this plate is likely aspergillus spp.
schwartzworld•3mo ago
Why would it be mold if the OP was culturing bakers yeast?
flobosg•3mo ago
The culture was contaminated with fungal spores.
throwawaymaths•3mo ago
look at the 1:10 plate. there's colonies that isn't yeast there. luckily, it got diluted out, or, maybe that plating was a bit more careless than the others.

i didnt mean to imply that all of the colonies aren't yeast.

throwawaymaths•3mo ago
1:100 is very countable using automated techniques.
bhickey•3mo ago
Reminds me of phage work.

For growing up phage you start by mixing different dilutions of phage with the host and a thin top agar, then plate it. On those plates with a countable number of plaques you work backwards to your plaque forming units (PFU) per mL. Once you know this you can produce "lacy plates." You add enough PFUs so that you expect the plaques to just touch. This produces a plate that has the appearance of lace. The web of surviving bacteria provide evidence that it actually grew, while delivering a high yield. Finally you scrape off the top agar, suspend it and run it through a filter. Good times.