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Dabous Giraffes

https://en.wikipedia.org/wiki/Dabous_Giraffes
1•gametorch•3m ago•0 comments

NTSB – Hull Failure and Implosion of Submersible Titan [pdf]

https://www.ntsb.gov/investigations/AccidentReports/Reports/MIR2536.pdf
1•twalichiewicz•5m ago•0 comments

What Does George Orwell's '1984' Mean in 2024?

https://www.smithsonianmag.com/history/what-does-george-orwells-1984-mean-in-2024-180984468/
5•KnuthIsGod•12m ago•0 comments

KH3: A Frugal Trajectory Indexing System

https://ieeexplore.ieee.org/abstract/document/11104509
1•teleforce•14m ago•0 comments

The State of PHP in 2025

https://blog.jetbrains.com/phpstorm/2025/10/state-of-php-2025/
2•brentroose•14m ago•0 comments

Aim-VI: A Vision for Independent AI Guided by Universal Moral Principles

https://github.com/Bongikk/AIM-VI
2•bongik•19m ago•1 comments

Printing Money: Paxos Mints, Then Burns $300T in PayPal Stablecoins

https://decrypt.co/344463/printing-money-paxos-mints-burns-300-trillion-paypal-stablecoins
1•shscs911•23m ago•0 comments

Computerized Cognitive Training Improved Acetylcholine Transporter Levels

https://games.jmir.org/2025/1/e75161
1•jbotz•26m ago•0 comments

Many developers leave GZDoom due to leader conflicts and fork it into UZDoom

https://www.gamingonlinux.com/2025/10/many-developers-leave-gzdoom-due-to-leader-conflicts-and-fo...
2•MallocVoidstar•30m ago•0 comments

D'Angelo's Genius Was Pure, and Rare

https://www.newyorker.com/culture/postscript/dangelos-genius-was-pure-and-rare
2•tintinnabula•31m ago•0 comments

Nvidia Sued for Scraping YouTube

https://www.404media.co/nvidia-sued-for-scraping-youtube-after-404-media-investigation/
2•JumpCrisscross•32m ago•0 comments

Extracting Physical and Technical Structured Info from Natural Language Document

https://ieeexplore.ieee.org/document/10803712
1•teleforce•35m ago•0 comments

Australian wet rainforests may be switching from absorbing carbon to emitting it

https://www.abc.net.au/news/science/2025-10-16/australian-rainforest-trees-carbon-storage-produce...
3•nreece•36m ago•0 comments

Sanitized SQL

https://ardentperf.com/2025/10/15/sanitized-sql/
2•qianli_cs•36m ago•0 comments

Do we still have the spark gap in our rearview mirror?

https://www.amateurradio.com/do-we-still-have-the-spark-gap-in-our-rearview-mirror/
1•iamhamm•49m ago•0 comments

Ollama Rolls Out Experimental Vulkan Support for AMD and Intel

https://www.phoronix.com/news/ollama-Experimental-Vulkan
3•geerlingguy•50m ago•0 comments

New Relic's compute based pricing creates unpredictable costs

https://signoz.io/blog/new-relic-ccu-pricing-unpredictable-costs/
1•ak_builds•52m ago•0 comments

OpenAI Build Hour: Responses API [video]

https://www.youtube.com/watch?v=hNr5EebepYs
1•handfuloflight•54m ago•0 comments

Household upgrades can meet 100 percent of data center demand growth

https://www.rewiringamerica.org/research/homegrown-energy-report-ai-data-center-demand
4•zekrioca•56m ago•5 comments

Phases of Fitness

https://medium.com/@prashantgupta24/phases-of-fitness-8984c1c06f37
2•prashantgupta24•57m ago•2 comments

Deconstructing Functional Programming (2013)

https://www.infoq.com/presentations/functional-pros-cons/
2•teleforce•59m ago•0 comments

Inside the Trump Administration's Assault on Higher Education

https://www.newyorker.com/magazine/2025/10/20/inside-the-trump-administrations-assault-on-higher-...
5•mitchbob•1h ago•1 comments

Ad-X2: When US Politicians Took on Science

https://www.historytoday.com/archive/history-matters/ad-x2-when-us-politicians-took-science
1•samclemens•1h ago•0 comments

TaxCalcBench: Evaluating Frontier Models on the Tax Calculation Task

https://arxiv.org/abs/2507.16126
5•handfuloflight•1h ago•0 comments

Did you get lucky or unlucky?

https://antithesis.com/blog/2025/findability/
2•wwilson•1h ago•0 comments

First Ever Continuously Operating Quantum Computer

https://www.thecrimson.com/article/2025/10/2/quantum-computing-breakthrough/
1•oldfuture•1h ago•0 comments

Show HN: VO3 – AI video generator powered by Google Veo 3.1

https://vo3-1ai.com
2•derek39576•1h ago•0 comments

Beijing's anger at 'malicious' US move on Chinese tech firms

https://www.cnn.com/2025/09/30/tech/us-export-curbs-expansion-beijing-anger-intl-hnk
4•rguiscard•1h ago•0 comments

Show HN: Open-source sound –> dmx party lighting

https://github.com/davidhughhenrymack/party-parrot
1•edmack•1h ago•0 comments

Free applicatives, the handle pattern, and remote systems

https://exploring-better-ways.bellroy.com/free-applicatives-the-handle-pattern-and-remote-systems...
9•_jackdk_•1h ago•1 comments
Open in hackernews

New Alzheimer's Treatment Clears Plaques from Brains of Mice Within Hours

https://www.sciencealert.com/new-alzheimers-treatment-clears-plaques-from-brains-of-mice-within-hours
46•amichail•3h ago

Comments

jader201•1h ago
> Within hours of the first injection, the animal brains showed a nearly 45 percent reduction in clumps of amyloid-beta plaques, a hallmark of Alzheimer's disease.

> The mice had previously shown signs of cognitive decline, but after all three doses, the animals performed on par with their healthy peers in spatial learning and memory tasks. The benefits lasted at least six months.

1. This is great news… for mice with Alzheimer’s that don’t mind treatments every 6 months.

2. It’s crazy to think about something like this actually curing Alzheimer’s in humans, even if for just 6 months. Even more so if repeated doses have the same effects.

3. As with all of these studies, mice != humans, but it’s nice to have hope.

Side note: the temporary part of #2 makes me think about The Last Days of Ptolemy Grey [1]. It’s hard to fathom having a relative “come back” like that for a short time. Or even permanently.

[1] https://www.imdb.com/title/tt13820498

nharada•1h ago
If this was effective on humans I think most people would accept having treatments 2x a year
copperx•1h ago
One must live a very privileged life to mind a 2x a year inconvenience in exchange for a working brain.

I wouldn't mind 10x a day injections if it keeps Alzheimer's at bay. Actually, I wouldn't mind a continuous IV drip.

bitmasher9•1h ago
I usually consider dialysis to be the point where treatments start to become very limiting. Twice a week, most people feel tied to their dialysis clinic and cannot go far from it.
jader201•53m ago
Of course, but that’s assuming:

1. There aren’t serious side effects that make it more of a tradeoff

2. The price isn’t on the order of 6-7 figures (or possibly less for some)

whycome•1h ago
I don’t know why this isn’t a case where human subjects for the tests aren’t allowed.
jpollock•1h ago
If the disease is severe enough to justify an untested treatment with unknown toxicity they aren't aware enough to grant consent.
harry8•58m ago
True.

But they could give consent in advance.

If this horrific disease progresses to the point where ... I give my consent for ... Subject to final approval from family member/doctor/whatever.

arijun•45m ago
Isn't that what power of attorney already is?
wahnfrieden•1h ago
Human can’t consent in this case but they can feel immense pain and suffering still in ways that failed experimentation could invoke. Which may be worse than further decay and eventual death.
qwertytyyuu•1h ago
This test shows effectiveness, they also need to go through trials to test for safety and unintended side effects
jryb•1h ago
You’re not seeing all the other candidate treatments that made things worse. If it just gives everyone a heart attack immediately the question would be, why didn’t you try this out on mice first?
PaulKeeble•1h ago
So far all the prior Amyloid clearing drugs did not cause recovery in people despite doing so in mice. Its meant a lot of researchers now aren't convinced that the Beta Amyloid is the problem in Alzheimer's. I hope this one ends up differently, its definitely a lot faster and more effective than the others at clearing.
tombert•1h ago
Well that's depressing. My biggest fear, and this isn't a bad setup for a joke, is early-onset Alzheimers. I don't think I'm especially high-risk for it, but I did have a single great-grandfather who got it so technically it does run in my family. It seems so horrible, having your brain sort of deteriorate and

Ideally I never get it, but if I do get I hope it's in like my late 90's, or even better by the time I get it they already have a cure, though the fact this might not work for humans makes me a little sad.

ineedaj0b•50m ago
there’s some interesting treatment in china that seems promising. something about unclogging drains in the neck. friend told me it looked ‘possible’.

the whole western field is 15-20 years behind because some researcher lied about plaque data and everyone spent all their time chasing the lead. I think you’ll see useful therapies in 15-20 years from the west, maybe sooner if all the some ai hype pans out.

or the Chinese thing turns out to work! can’t tell myself. there’s probably an American who will try it at some point and publish a case study. Very tough to judge Chinese papers..

here’s an overview: https://pmc.ncbi.nlm.nih.gov/articles/PMC12121576/

orangecat•8m ago
See https://www.astralcodexten.com/p/in-defense-of-the-amyloid-h... for an IMO compelling argument that amyloid really is the underlying cause. The theory is that amyloid buildup causes misfolded tau proteins which cause the cognitive damage. So reducing amyloid in people already suffering from Alzheimer's doesn't do much because they already have excessive tau; at best it might slow down the progression.