frontpage.
newsnewestaskshowjobs

Made with ♥ by @iamnishanth

Open Source @Github

fp.

Arrows to Arrows, Categories to Queries

https://reasonablypolymorphic.com/blog/arrows-to-arrows/
1•JNRowe•2m ago•0 comments

Dabous Giraffes

https://en.wikipedia.org/wiki/Dabous_Giraffes
1•gametorch•13m ago•0 comments

NTSB – Hull Failure and Implosion of Submersible Titan [pdf]

https://www.ntsb.gov/investigations/AccidentReports/Reports/MIR2536.pdf
1•twalichiewicz•14m ago•0 comments

What Does George Orwell's '1984' Mean in 2024?

https://www.smithsonianmag.com/history/what-does-george-orwells-1984-mean-in-2024-180984468/
14•KnuthIsGod•22m ago•0 comments

KH3: A Frugal Trajectory Indexing System

https://ieeexplore.ieee.org/abstract/document/11104509
1•teleforce•24m ago•0 comments

The State of PHP in 2025

https://blog.jetbrains.com/phpstorm/2025/10/state-of-php-2025/
2•brentroose•24m ago•0 comments

Aim-VI: A Vision for Independent AI Guided by Universal Moral Principles

https://github.com/Bongikk/AIM-VI
2•bongik•29m ago•1 comments

Printing Money: Paxos Mints, Then Burns $300T in PayPal Stablecoins

https://decrypt.co/344463/printing-money-paxos-mints-burns-300-trillion-paypal-stablecoins
1•shscs911•33m ago•0 comments

Computerized Cognitive Training Improved Acetylcholine Transporter Levels

https://games.jmir.org/2025/1/e75161
1•jbotz•35m ago•0 comments

Many developers leave GZDoom due to leader conflicts and fork it into UZDoom

https://www.gamingonlinux.com/2025/10/many-developers-leave-gzdoom-due-to-leader-conflicts-and-fo...
2•MallocVoidstar•40m ago•0 comments

D'Angelo's Genius Was Pure, and Rare

https://www.newyorker.com/culture/postscript/dangelos-genius-was-pure-and-rare
2•tintinnabula•41m ago•0 comments

Nvidia Sued for Scraping YouTube

https://www.404media.co/nvidia-sued-for-scraping-youtube-after-404-media-investigation/
2•JumpCrisscross•41m ago•0 comments

Extracting Physical and Technical Structured Info from Natural Language Document

https://ieeexplore.ieee.org/document/10803712
1•teleforce•45m ago•0 comments

Australian wet rainforests may be switching from absorbing carbon to emitting it

https://www.abc.net.au/news/science/2025-10-16/australian-rainforest-trees-carbon-storage-produce...
3•nreece•46m ago•0 comments

Sanitized SQL

https://ardentperf.com/2025/10/15/sanitized-sql/
2•qianli_cs•46m ago•0 comments

Do we still have the spark gap in our rearview mirror?

https://www.amateurradio.com/do-we-still-have-the-spark-gap-in-our-rearview-mirror/
1•iamhamm•59m ago•0 comments

Ollama Rolls Out Experimental Vulkan Support for AMD and Intel

https://www.phoronix.com/news/ollama-Experimental-Vulkan
3•geerlingguy•1h ago•0 comments

New Relic's compute based pricing creates unpredictable costs

https://signoz.io/blog/new-relic-ccu-pricing-unpredictable-costs/
1•ak_builds•1h ago•0 comments

OpenAI Build Hour: Responses API [video]

https://www.youtube.com/watch?v=hNr5EebepYs
1•handfuloflight•1h ago•0 comments

Household upgrades can meet 100 percent of data center demand growth

https://www.rewiringamerica.org/research/homegrown-energy-report-ai-data-center-demand
4•zekrioca•1h ago•5 comments

Phases of Fitness

https://medium.com/@prashantgupta24/phases-of-fitness-8984c1c06f37
2•prashantgupta24•1h ago•2 comments

Deconstructing Functional Programming (2013)

https://www.infoq.com/presentations/functional-pros-cons/
2•teleforce•1h ago•0 comments

Inside the Trump Administration's Assault on Higher Education

https://www.newyorker.com/magazine/2025/10/20/inside-the-trump-administrations-assault-on-higher-...
6•mitchbob•1h ago•1 comments

Ad-X2: When US Politicians Took on Science

https://www.historytoday.com/archive/history-matters/ad-x2-when-us-politicians-took-science
1•samclemens•1h ago•0 comments

TaxCalcBench: Evaluating Frontier Models on the Tax Calculation Task

https://arxiv.org/abs/2507.16126
8•handfuloflight•1h ago•0 comments

Did you get lucky or unlucky?

https://antithesis.com/blog/2025/findability/
2•wwilson•1h ago•0 comments

First Ever Continuously Operating Quantum Computer

https://www.thecrimson.com/article/2025/10/2/quantum-computing-breakthrough/
1•oldfuture•1h ago•0 comments

Show HN: VO3 – AI video generator powered by Google Veo 3.1

https://vo3-1ai.com
2•derek39576•1h ago•0 comments

Beijing's anger at 'malicious' US move on Chinese tech firms

https://www.cnn.com/2025/09/30/tech/us-export-curbs-expansion-beijing-anger-intl-hnk
4•rguiscard•1h ago•0 comments

Show HN: Open-source sound –> dmx party lighting

https://github.com/davidhughhenrymack/party-parrot
1•edmack•1h ago•0 comments
Open in hackernews

We're losing the war against drug-resistant infections faster than we thought

https://www.npr.org/sections/goats-and-soda/2025/10/15/g-s1-93449/antibiotic-resistance-bacteria
58•pseudolus•3h ago

Comments

like_any_other•1h ago
Another source of antibiotic resistance (which the article forgets to mention) is their routine use in livestock, preventatively and to accelerate growth. I would wager that is the far more significant contributor, since there's simply much more of it - compare the total number of cattle in places where such use is allowed (meaning cattle are exposed to antibiotics for most of their lives), versus the number of people being treated with antibiotics (i.e. a very limited population, for a very limited period):

https://pmc.ncbi.nlm.nih.gov/articles/PMC12029767/

https://pmc.ncbi.nlm.nih.gov/articles/PMC6017557/

chaostheory•1h ago
It’s not a coincidence that many of the antibiotic resistant bacteria tend to pop up in areas where the livestock industry is located.
dwd•1h ago
Something else unmentioned is that 70-80% of hospital acquired infections are related to medical devices that are susceptible to the formation of biofilms where the bacteria create a protective layer that antibiotics can't penetrate.

For example antibiotic resistant urinary tract infections caused by the use of catheters. Effective antibiotics simply don't work when they can't reach the infection.

amatecha•31m ago
Oh, that's messed up. Aren't catheters supposed to be air-tight, sterile and single-use? Or do they reuse them?! >__>
irjustin•1h ago
The whole article talks about tracking and tracking better is helpful I get that but that won't stop it reverse the trend? Even in areas where we have clean data we see the trends.

So what's next?

itsme0000•59m ago
I’m really glad this article acknowledges that better access to antibiotics is probably the best solution to the problem. I’ve actually heard people argue the opposite.

Many people, even doctors will blame patients for creating antibiotics resistant strains. While it’s true that a resistant strain can develop and spread due to an individual’s actions, those strains will gradually lose their resistance once no longer exposed to antibiotics, so it’s probably better have antibiotics be accessible drugs everywhere to prevent any initial spread and just trust people won’t use them chronically for no reason. Though I’d argue lack of access to antibiotics contributes more to the spread of disease then careless patients stuffing down their mouths, it really depends on what type of bacteria it is. Patients with viruses often misdiagnose themselves as needing antibiotics and that’s another reason it’s not over the counter, that builds resistant bacteria, not inside the patient but in the external environment due to excretion in urine etc.

Doctors will often chide patients for not taking the whole bottle of antibiotics once they stop feeling symptoms as if this gives more opportunity for the resistant strain to spread. It’s true it’s probably safer to totally ensure you are free of disease before stopping a medication, but increasing the overall level of antibiotics in the environment boosts resistance in every case. As people on this thread have pointed out the mass use of antibiotics in cattle farming is going to contribute significantly to resistance because it permanently increases the amount of antibiotics in the environment. Other than stopping that not much can be done to prevent this

It’s kind of a non-issue on an individual level as resistant strains lose resistance over relatively short periods time, once no longer exposed to the antibiotic, people just assume if the bacteria evolved an advantageous trait it will never lose that trait even though it’s no longer advantageous once it’s environment returns to normal.

Supermancho•29m ago
> those strains will gradually lose their resistance once no longer exposed to antibiotics,

I've never heard this. Can you cite an example or source for this? How could we be losing if medicine can afford to "wait out" a strain? MRSA's been around 80 years. Call me skeptical.

JumpCrisscross•25m ago
> Can you cite an example or source for this?

“We previously reconstructed a 1,000-year-old remedy containing onion, garlic, wine, and bile salts, known as ‘Bald’s eyesalve’, and showed it had promising antibacterial activity. In this current paper, we have found this bactericidal activity extends to a range of Gram-negative and Gram-positive wound pathogens in planktonic culture and, crucially, that this activity is maintained against Acinetobacter baumannii, Stenotrophomonas maltophilia, Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus pyogenes in a soft-tissue wound biofilm model” [1].

> How could we be losing if medicine can afford to "wait out" a strain?

In general, “mutations that confer larger” resistance “are more costly” in terms of fitness [2].

Absent the selection pressure of a particular antibiotic, the bugs without that resistance generally outcompete the ones weaving chainmail against Tomahawks.

[1] https://www.nature.com/articles/s41598-020-69273-8

[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC4380921/

Dylan16807•13m ago
To prove the claim we need to see that the salve is useful and that it used to be less useful because of resistance. Is that proven somewhere? This just looks like a "new" antibiotic.

And the more important part is losing resistance in a meaningful timeframe, much smaller than 1000 years. Also the relevant genes can't be easy to reactivate.

JumpCrisscross•4m ago
“In this cluster-randomized, crossover trial the effects of two antibiotic rotation strategies, antibiotic mixing and cycling, on the prevalence of [antibiotic-resistant Gram-negative bacteria] in [intensive care units] are determined. Antibiotic mixing aims to create maximum antibiotic heterogeneity, and cycling aims to create maximum antibiotic homogeneity during consecutive periods” [1].

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC4227018/