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The next frontier in weight-loss drugs: one-time gene therapy

https://www.washingtonpost.com/health/2026/01/24/fractyl-glp1-gene-therapy/
1•bookofjoe•1m ago•1 comments

At Age 25, Wikipedia Refuses to Evolve

https://spectrum.ieee.org/wikipedia-at-25
1•asdefghyk•4m ago•2 comments

Show HN: ReviewReact – AI review responses inside Google Maps ($19/mo)

https://reviewreact.com
1•sara_builds•4m ago•0 comments

Why AlphaTensor Failed at 3x3 Matrix Multiplication: The Anchor Barrier

https://zenodo.org/records/18514533
1•DarenWatson•6m ago•0 comments

Ask HN: How much of your token use is fixing the bugs Claude Code causes?

1•laurex•9m ago•0 comments

Show HN: Agents – Sync MCP Configs Across Claude, Cursor, Codex Automatically

https://github.com/amtiYo/agents
1•amtiyo•10m ago•0 comments

Hello

1•otrebladih•11m ago•0 comments

FSD helped save my father's life during a heart attack

https://twitter.com/JJackBrandt/status/2019852423980875794
2•blacktulip•14m ago•0 comments

Show HN: Writtte – Draft and publish articles without reformatting, anywhere

https://writtte.xyz
1•lasgawe•16m ago•0 comments

Portuguese icon (FROM A CAN) makes a simple meal (Canned Fish Files) [video]

https://www.youtube.com/watch?v=e9FUdOfp8ME
1•zeristor•18m ago•0 comments

Brookhaven Lab's RHIC Concludes 25-Year Run with Final Collisions

https://www.hpcwire.com/off-the-wire/brookhaven-labs-rhic-concludes-25-year-run-with-final-collis...
2•gnufx•20m ago•0 comments

Transcribe your aunts post cards with Gemini 3 Pro

https://leserli.ch/ocr/
1•nielstron•24m ago•0 comments

.72% Variance Lance

1•mav5431•25m ago•0 comments

ReKindle – web-based operating system designed specifically for E-ink devices

https://rekindle.ink
1•JSLegendDev•26m ago•0 comments

Encrypt It

https://encryptitalready.org/
1•u1hcw9nx•26m ago•1 comments

NextMatch – 5-minute video speed dating to reduce ghosting

https://nextmatchdating.netlify.app/
1•Halinani8•27m ago•1 comments

Personalizing esketamine treatment in TRD and TRBD

https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1736114
1•PaulHoule•29m ago•0 comments

SpaceKit.xyz – a browser‑native VM for decentralized compute

https://spacekit.xyz
1•astorrivera•29m ago•0 comments

NotebookLM: The AI that only learns from you

https://byandrev.dev/en/blog/what-is-notebooklm
2•byandrev•30m ago•1 comments

Show HN: An open-source starter kit for developing with Postgres and ClickHouse

https://github.com/ClickHouse/postgres-clickhouse-stack
1•saisrirampur•30m ago•0 comments

Game Boy Advance d-pad capacitor measurements

https://gekkio.fi/blog/2026/game-boy-advance-d-pad-capacitor-measurements/
1•todsacerdoti•30m ago•0 comments

South Korean crypto firm accidentally sends $44B in bitcoins to users

https://www.reuters.com/world/asia-pacific/crypto-firm-accidentally-sends-44-billion-bitcoins-use...
2•layer8•31m ago•0 comments

Apache Poison Fountain

https://gist.github.com/jwakely/a511a5cab5eb36d088ecd1659fcee1d5
1•atomic128•33m ago•2 comments

Web.whatsapp.com appears to be having issues syncing and sending messages

http://web.whatsapp.com
1•sabujp•34m ago•2 comments

Google in Your Terminal

https://gogcli.sh/
1•johlo•35m ago•0 comments

Shannon: Claude Code for Pen Testing: #1 on Github today

https://github.com/KeygraphHQ/shannon
1•hendler•35m ago•0 comments

Anthropic: Latest Claude model finds more than 500 vulnerabilities

https://www.scworld.com/news/anthropic-latest-claude-model-finds-more-than-500-vulnerabilities
2•Bender•40m ago•0 comments

Brooklyn cemetery plans human composting option, stirring interest and debate

https://www.cbsnews.com/newyork/news/brooklyn-green-wood-cemetery-human-composting/
1•geox•40m ago•0 comments

Why the 'Strivers' Are Right

https://greyenlightenment.com/2026/02/03/the-strivers-were-right-all-along/
1•paulpauper•41m ago•0 comments

Brain Dumps as a Literary Form

https://davegriffith.substack.com/p/brain-dumps-as-a-literary-form
1•gmays•42m ago•0 comments
Open in hackernews

Nvidia has produced the first Blackwell wafer on US soil

https://www.xda-developers.com/nvidia-produced-first-blackwell-wafer-us-soil/
164•kristianp•3mo ago

Comments

roboror•3mo ago
This is the culmination of years of work, not months, as the article suggests. I prefer the actual press release.
xnx•3mo ago
Official source press release: https://blogs.nvidia.com/blog/tsmc-blackwell-manufacturing/
echelon•3mo ago
This is incredible news!

I never thought this would happen, or that if it did, we'd be a few generations behind.

Now let's onshore or friendshore everything else we need! Rare earths, mid-tier processors, chemical precursors, pharmaceuticals, steel, robotics/mechatronics, solar, drones, ...

Why even stop there? Kill the Jones Act, get back to building naval drones and ships of all kinds, ...

jrk•3mo ago
It is a few generations behind: Blackwell is still on N4, which is an N5 variant. Meanwhile TSMC has been shipping N3 family processes in large volume products (Apple) for more than 2 years already, and is starting to ramp the next major node family (N2) for Apple et al. next year.

NVIDIA has often lagged on process, since they drive such large dies, but having the first major project demo wafer on N4 now is literally 2 generations behind Taiwan.

AlotOfReading•3mo ago
It's a couple process generations behind, but Blackwell is literally nvidia's most current generation. They don't ship N3 until the next generation.

When was the last time current gen, competitive GPUs were fabbed outside Asia?

rsynnott•3mo ago
Can't be _that_ long ago; AMD were still using GlobalFoundries (Germany and New York) for most stuff until 2018 or so IIRC.
AlotOfReading•3mo ago
Forgot about AMD's brief GPU flirtation with glofo. ATI used TSMC. I think it was only Polaris that ever shipped anything from NY. That's admittedly a couple of legendary value cards though.
contrarian1234•3mo ago
If only Kim Il Sung were still alive to hear you
ofrzeta•3mo ago
So "This is the vision of President Trump of reindustrialization" but it's been in the works for "a few short years"?
lucasRW•3mo ago
Yes, the Phoenix fab plant was indeed kickstarted under Trump's first term.
ofrzeta•3mo ago
Thanks for the heads-up.
contrarian1234•3mo ago
Does anyone have any insight on how they make it economically viable?

US salaries are astronomically high compared to the rest of the world. In the tech sector that's doubly so. Everything is incredibly expensive there. Is this basically a small facility to keep some politicians happy?

Or is it used to provide some supply military gear at 50x the price?

Will it get shut down in a few years once everyone forgets about it?

adgjlsfhk1•3mo ago
semi manufacturing is highly automated, and not much of the cost is labor.
alex43578•3mo ago
Intel has a fab a few miles away, and setting aside Intel's challenges, they're producing chips just fine. Semiconductor production is massively automated and the wafers are ludicrously high revenue/margin products. This isn't like using US labor to stitch t-shirts.
rajnathani•3mo ago
> the wafers are ludicrously high revenue/margin products.

Agree except this point, as at least for MCUs which are of US origin and yet cost ~$1 per chip which also includes reel packaging and distribution margins etc.

evrimoztamur•3mo ago
Just print more money, it's a matter of national security. If the US is in a distrustful state, it's a good investment for the government, military or non-military (e.g. global trade getting more expensive for various reasons).
parineum•3mo ago
Salaries aren't a huge part of manufacturing like people think. Once the factory is built, accounting for logistics of shipping and remote management, it's not a huge difference financially.

Getting the factory built, however, takes significantly more time and costs more in both actual dollars but, more importantly, the opportunity cost lost to not producing products in that extra build time.

DanielHB•3mo ago
And they got subsidies to set up the factory I guess?
parineum•3mo ago
Yes.
gambiting•3mo ago
Some hardware any superpower should be able to produce on home soil almost no matter the cost. That's why even Russia keeps domestic fabs making chips at some ancient process node - not to sell them for profit, but to maintain an ability to produce chips for the military and their own economy should things go down as they say.
westpfelia•3mo ago
Well.. considering the mark up for the H100's is like 80 grand. I think there is a little wiggle room.
elcritch•3mo ago
US Workers while costing more do seem are still competitive at expensive high value tasks. There was some reports a year back where the TSMC labs in Arizona while employee costs were higher also had 4% higher yield [1].

I'd wager combining that with US defense contracts for US made chips would be lucrative for NVidia.

1: https://news.ycombinator.com/item?id=41952534

contrarian1234•3mo ago
is it high value? I know a guy working at a fab in Taiwan and he makes peanuts ($2-3K a month?). It's basically a factory job. From what he said it sounded braindead. TSMC is known for overpaying and having PhDs stare at assembly lines though - so I dunno.
razakel•3mo ago
The average salary in Taiwan is about $1,500, though.
contrarian1234•3mo ago
sorry, I should have thought about it a bit more. It's likely closer to 2K than 3K. A professor at Taiwan University makes ~3K. My only other point of reference is another friend's husband who works as an electric engineer at a LED manufacturer - making 2K a month. Minimum wage is $1K. Point being.. they're miserable jobs and the salaries are low low low. I get fabs sound fancy, but I'm not super sure anyone should be stoked these kinds of jobs are "coming back" to the US.
lesuorac•3mo ago
While I am more of the belief that these people are wanting a time with less income equality and conflating that with factory work.

There's going to be a bunch of people wanting any job [1] and more in the coming years. So they'd probably cheer a local walmart as much as a local tsmc.

[1]: https://www.bls.gov/web/empsit/cpseea10.htm

elcritch•3mo ago
I've had a number of friends who worked at Micron in Boise at their semi-fabs. Yes boring work, but the pay was decent. Especially for guys just graduating. I think it was like a 4-10 schedule.
alephnerd•3mo ago
It's high value but low margins work. It played a major role into why Intel began offshoring a large portion of it's fab work abroad back in the 1990s-2000s, and also why TSMC became a player in the space undercutting Japanese, Korean, Singapore, and Malaysian/American (Intel) vendors.

> TSMC is known for overpaying

Never heard that in my life. Underpay sure.

contrarian1234•3mo ago
In Taiwan they are by far the highest paying employer (maybe Google/Microsoft branches here are comparable). The base pay is usually not impressive, but they come with insane bonus packages. They basically hoover up all the top graduates that haven't left abroad.

They're kind of notorious for have overqualified workers. PhDs left monitoring assembly lines or writing accounting software

alephnerd•3mo ago
> In Taiwan

My bad - didn't see the qualifier for Taiwan there.

Yea, TSMC pay is decent by Taiwan standards, but imo that's largely because Taiwan salaries are fairly low even compared to other East Asian nations when factoring CoL.

elcritch•3mo ago
Googling TSMC margin and it looks to be 53%-59% gross margin. That is after they became the leading global fab of course.

No doubt keeping costs low helped them get to that stage. Still that's a crazy margin. I imagine much of it's re-invested.

IMHO, Intel could've kept up but dropped the ball pretty hard. The volume of ARM / cell phone cpus caught them off guard and huge amounts of revunue let TSMC drive forward.

tiahura•3mo ago
What I find weird is that a year ago there were reports in the NYT and elsewhere that TSMC was unable to make the AZ plant work because of lazy / dumb Americans. And then 6 months later, poof, 180, the reports were that they were right on track???
ksec•3mo ago
In terms of Labour, the number one cost of a node is R&D. And that is happening in Taiwan not in US.

And if US could somehow provide lower electricity cost to Fabs, which is the number one cost in production, it will offset a lot of expensive items on the list. The actual labour cost for running the Fab is comparatively small.

cashsterling•3mo ago
Modern high-end fabs have extremely expensive equipment and are highly automated... like they are so automated that people don't actually handle wafers... it is almost all robotic.

Thus, salaries and cost of services do not factor in as heavily as you might think to fab economics.

Data suggests that TSMC's per wafer costs in Arizona are 10-30% higher than Taiwan and that Arizona fab is relatively new. It's economics will probably improve over time, narrowing the margin to 5-15%.

Looking towards the future, power costs and other global supply chain factors could very easily make TSMC's Arizona fab less expensive and more reliable to operate over time. For one, the US is completely energy independent... Taiwan is not.

bfrog•3mo ago
Aren’t TSM fabs in the US little islands of Taiwanese workers? How is this domestic knowledge and manufacturing not exactly?
clayhacks•3mo ago
They are majority Taiwanese employees for now, but I’m sure they’re hiring Americans to grow and backfill. They just wanted to bootstrap the knowledge and wisdom, but over enough time that can be shared and spread among Americans as well
nothercastle•3mo ago
Yeah right like they are just going to let that knowledge go
ggm•3mo ago
The EU was funding fab lines, several levels back up the chain IIRC? The idea being that the chips doing car comms, engine management, cruder FPGA, old ARM cores, can be done fast, and stop supply chain weaknesses for things Europe needs chips in, like cars (and tanks, and UAVs and ...)

I'm not saying tiny lines aren't cool. I'm just saying the idea you can't be successful if you make cruder, older resolution chips is probably wrong: Your printer and your car don't care if the Dice is 10mm not 5mm, and the track lines are 5x wider. MILSPEC stuff probably runs cruder for other reasons. Resiliency? Verilog proofs?

I also have no idea how many dice you get off a single ingot these days. 300mm wide, but how long?

FirmwareBurner•3mo ago
>The EU was funding fab lines, several levels back up the chain IIRC?

Yeah but much larger(16-12nm) and much less profitable nodes than what Taiwan, the US or even Japan and China have now.

> I'm just saying the idea you can't be successful if you make cruder, older resolution chips is probably wrong

Define success. Smallest nodes are bringing in the most profits and every country prefers more profits versus less profits, especially Europe given it's budget deficits and welfare spending.

Larger nodes that aren't very profitable are good for national security but Russia and even North Korea are proof you don't need much domestic semiconductor industry to completely terrorize neighboring countries and level entire cities. WW1-style artillery shells and rifle rounds will do just fine.

ggm•3mo ago
Yes, I think that's true. But I also think from re-establishing a viable VLSI industry on cruder tech, Europe (like China) can move up the food chain into the smaller lines, as the tech beds in. The irony of ASML being a JV with strong European roots, but the VLSI moving to "anywhere but europe" at scale stands out.

I don't buy labour costs. I think it's probably post-VLSI packaging, assembly of devices, and compliance with HAZMAT that made the moves to Asia and Latin America happen. These plants don't use a lot of cheap labour. So wage cost cannot explain the decision.

There are interesting posts going back decades (crufty google doc shares, USENET posts..) talking about what the work culture at TSMC is like, about Intel management. I think VLSI is like cheese making: if you wear the wrong perfume on the wrong day, you destroy the entire output in one go. But that doesn't justify 16 hour days and toxic management.