What about the amyloid plaques, tau aggregation and neuronal cell death?
rdgthree•3mo ago
These have always felt like symptoms of the problem to me, so perhaps just downstream effects! Definitely not sure, obviously plenty of complexity to this one.
These [clinical trial] failures, combined with the still-compelling reasons to think that amyloid is indeed a major part of the disease, have led to hypotheses that would square all these conflicting findings: perhaps amyloid really is the cause of Alzheimer’s, but not the form of amyloid we’ve been looking at. The real cause could be well upstream, in small soluble oligomers of the protein that are the earlier bad actors in the disease.
robin_reala•3mo ago
Ah, Betteridge’s law of headlines in action again.
bebb•3mo ago
rdgthree•3mo ago
smallerize•3mo ago
These [clinical trial] failures, combined with the still-compelling reasons to think that amyloid is indeed a major part of the disease, have led to hypotheses that would square all these conflicting findings: perhaps amyloid really is the cause of Alzheimer’s, but not the form of amyloid we’ve been looking at. The real cause could be well upstream, in small soluble oligomers of the protein that are the earlier bad actors in the disease.