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The next frontier in weight-loss drugs: one-time gene therapy

https://www.washingtonpost.com/health/2026/01/24/fractyl-glp1-gene-therapy/
1•bookofjoe•2m ago•1 comments

At Age 25, Wikipedia Refuses to Evolve

https://spectrum.ieee.org/wikipedia-at-25
1•asdefghyk•5m ago•2 comments

Show HN: ReviewReact – AI review responses inside Google Maps ($19/mo)

https://reviewreact.com
1•sara_builds•5m ago•0 comments

Why AlphaTensor Failed at 3x3 Matrix Multiplication: The Anchor Barrier

https://zenodo.org/records/18514533
1•DarenWatson•6m ago•0 comments

Ask HN: How much of your token use is fixing the bugs Claude Code causes?

1•laurex•10m ago•0 comments

Show HN: Agents – Sync MCP Configs Across Claude, Cursor, Codex Automatically

https://github.com/amtiYo/agents
1•amtiyo•11m ago•0 comments

Hello

1•otrebladih•12m ago•0 comments

FSD helped save my father's life during a heart attack

https://twitter.com/JJackBrandt/status/2019852423980875794
2•blacktulip•15m ago•0 comments

Show HN: Writtte – Draft and publish articles without reformatting, anywhere

https://writtte.xyz
1•lasgawe•17m ago•0 comments

Portuguese icon (FROM A CAN) makes a simple meal (Canned Fish Files) [video]

https://www.youtube.com/watch?v=e9FUdOfp8ME
1•zeristor•18m ago•0 comments

Brookhaven Lab's RHIC Concludes 25-Year Run with Final Collisions

https://www.hpcwire.com/off-the-wire/brookhaven-labs-rhic-concludes-25-year-run-with-final-collis...
2•gnufx•20m ago•0 comments

Transcribe your aunts post cards with Gemini 3 Pro

https://leserli.ch/ocr/
1•nielstron•24m ago•0 comments

.72% Variance Lance

1•mav5431•25m ago•0 comments

ReKindle – web-based operating system designed specifically for E-ink devices

https://rekindle.ink
1•JSLegendDev•27m ago•0 comments

Encrypt It

https://encryptitalready.org/
1•u1hcw9nx•27m ago•1 comments

NextMatch – 5-minute video speed dating to reduce ghosting

https://nextmatchdating.netlify.app/
1•Halinani8•28m ago•1 comments

Personalizing esketamine treatment in TRD and TRBD

https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1736114
1•PaulHoule•29m ago•0 comments

SpaceKit.xyz – a browser‑native VM for decentralized compute

https://spacekit.xyz
1•astorrivera•30m ago•0 comments

NotebookLM: The AI that only learns from you

https://byandrev.dev/en/blog/what-is-notebooklm
2•byandrev•30m ago•1 comments

Show HN: An open-source starter kit for developing with Postgres and ClickHouse

https://github.com/ClickHouse/postgres-clickhouse-stack
1•saisrirampur•31m ago•0 comments

Game Boy Advance d-pad capacitor measurements

https://gekkio.fi/blog/2026/game-boy-advance-d-pad-capacitor-measurements/
1•todsacerdoti•31m ago•0 comments

South Korean crypto firm accidentally sends $44B in bitcoins to users

https://www.reuters.com/world/asia-pacific/crypto-firm-accidentally-sends-44-billion-bitcoins-use...
2•layer8•32m ago•0 comments

Apache Poison Fountain

https://gist.github.com/jwakely/a511a5cab5eb36d088ecd1659fcee1d5
1•atomic128•34m ago•2 comments

Web.whatsapp.com appears to be having issues syncing and sending messages

http://web.whatsapp.com
1•sabujp•34m ago•2 comments

Google in Your Terminal

https://gogcli.sh/
1•johlo•36m ago•0 comments

Shannon: Claude Code for Pen Testing: #1 on Github today

https://github.com/KeygraphHQ/shannon
1•hendler•36m ago•0 comments

Anthropic: Latest Claude model finds more than 500 vulnerabilities

https://www.scworld.com/news/anthropic-latest-claude-model-finds-more-than-500-vulnerabilities
2•Bender•41m ago•0 comments

Brooklyn cemetery plans human composting option, stirring interest and debate

https://www.cbsnews.com/newyork/news/brooklyn-green-wood-cemetery-human-composting/
1•geox•41m ago•0 comments

Why the 'Strivers' Are Right

https://greyenlightenment.com/2026/02/03/the-strivers-were-right-all-along/
1•paulpauper•42m ago•0 comments

Brain Dumps as a Literary Form

https://davegriffith.substack.com/p/brain-dumps-as-a-literary-form
1•gmays•42m ago•0 comments
Open in hackernews

Show HN: Pianolyze – Learn any piano song using AI/ML, right in the browser

https://pianolyze.com/
4•nickplee•3mo ago
Hey HN,

I'm a pianist who's always been obsessed with understanding how great players think through harmony. What voicings are they using? How do they voice lead through changes? What's actually happening under their hands?

Back in 2022, I built Harmonic Analyzer (https://www.youtube.com/watch?v=iNgSgvUmiOs) – a Mac app that used ML to transcribe polyphonic piano recordings. It got some traction, but I never quite finished it. Requiring users to download a Mac app felt like unnecessary friction, and I didn’t want to limit distribution to Mac users.

I just shipped Pianolyze (https://pianolyze.com), a complete rewrite that runs entirely in the browser.

Tech stack:

• ONNX Runtime hosting Bytedance's piano transcription model (https://github.com/qiuqiangkong/piano_transcription_inferenc...) • Web Workers for async transcription, exposed via Comlink • WebGL for piano roll rendering • Web Audio API for playback • IndexedDB for model caching • React + MobX State Tree

Nothing leaves your device. No servers, no uploads, no inference costs.

Try it: Just drag and drop any solo piano recording (MP3, WAV, FLAC, M4A). The model downloads once (~100MB), and then everything runs locally. It works best with solo recordings; accompaniment can confuse the model. Chrome and Safari work best, on desktop.

I'd love feedback on the UX, performance on different hardware, and how well it handles various recordings. Also happy to discuss the technical approach.

Here it is in action, transcribing the great Mulgrew Miller: https://www.youtube.com/watch?v=sWW-Z9_n8Mk

Comments

ksherlock•3mo ago
Interesting. Here's some UI feedback:

There seems to be a thermometer and a waveform display that are half synchronized; clicking in the thermometer moves the cursor in the waveform but clicking in the waveform doesn't adjust the thermometer. This was annoying and confusing.

Also, the thermometer has labels on both ends so it doesn't line up with the cursor in the waveform. Please move the labels to be above the thermometer so everything lines up.

Maybe it's just me but I would find it more intuitive if the current notes were in the middle of the window (rather than at the extreme left). For the most part, the keyboard will be lit up in the middle of the screen. don't make my eyes bounce around.