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Niacin Pathway Gene Linked to Motor Neuron Weakness Diseases

https://www.sciencedaily.com/releases/2025/11/251106003917.htm
1•Noaidi•2h ago

Comments

Noaidi•2h ago
The gene is NAMPT (Nicotinamide phosphoribosyltransferase), which:

"Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway."[1]

[1] https://www.uniprot.org/uniprotkb/P43490/entry

Full paper:

https://www.science.org/doi/10.1126/sciadv.adx2407

Tesla shareholders approve $878B pay plan for Elon Musk

https://www.aljazeera.com/economy/2025/11/6/tesla-shareholders-approve-878bn-pay-plan-for-elon-musk
1•amrrs•31s ago•0 comments

PyTorch Co-Founder Soumith Chintala Departs Meta After 11 Years

https://twitter.com/soumithchintala/status/1986503070734557568
1•bobrenjc93•50s ago•0 comments

Scientists Need a Positive Vision for AI

https://spectrum.ieee.org/responsible-ai
1•hn_acker•1m ago•0 comments

AT&T falsely promised "everyone" a free iPhone, ad-industry board rules

https://arstechnica.com/tech-policy/2025/11/att-falsely-promised-everyone-a-free-iphone-ad-indust...
2•danaris•2m ago•0 comments

Man who threw sandwich at US border agent not guilty of assault

https://www.bbc.com/news/articles/c5ypvv8n1jvo
12•onemoresoop•5m ago•1 comments

Foreign Food Safety Inspections Hit Historic Low After Trump Cuts

https://www.propublica.org/article/foreign-food-safety-inspections-historic-low-fda
1•hn_acker•6m ago•0 comments

Document Chat System

https://document-chat-system.vercel.app
1•watat83•7m ago•1 comments

Dash0: Otel-Native Observability, Simplified

https://www.dash0.com
2•bradhe•8m ago•0 comments

The Hardest-Working Art Thief in History

https://magazine.atavist.com/2025/blue-book-burglar-art-heist
1•gmays•9m ago•0 comments

Tesla Shareholders Approve Elon Musk's $1T Pay Package

https://www.wired.com/story/tesla-shareholders-approve-musk-1-trillion-dollar-pay-package/
2•AndrewDucker•9m ago•1 comments

Elder Futhark Runes in UTF-8 in a CLI Tool Written in Go

https://github.com/DavidCanHelp/Runes
1•DavidCanHelp•11m ago•0 comments

Are you still paying your rent?

https://www.redfin.com/WA/Bellevue/4123-150th-Ave-SE-98006/home/233955
1•dylan_zhou•12m ago•1 comments

OWASP Top:10 2025 RC1

https://owasp.org/Top10/2025/0x00_2025-Introduction/
1•chha•13m ago•0 comments

Ask HN: By now, Why does every person and project not have an AI?

1•1dolinski•14m ago•2 comments

Show HN: Insinuate – tense description party game

https://wilf.live/insinuate/
1•wolfred•20m ago•0 comments

Differentiation and how it could be the reason why reality exists

https://carlo-htgdc.medium.com/the-principle-of-differentiation-and-how-its-the-reason-why-realit...
1•rlili•23m ago•0 comments

Luanti Non-Profit: We've Joined Open Collective Europe

https://blog.luanti.org/2025/11/05/non-profit/
1•bovermyer•26m ago•0 comments

Elon Musk Wins $1T Tesla Payday

https://www.nytimes.com/2025/11/06/business/elon-musk-tesla-pay-vote.html
3•amelius•26m ago•1 comments

Hurrah to the Fallen Comrades

https://blog.osm-ai.net/2025/11/05/hurrah-to-the-fallen-comrades.html
1•osm3000•28m ago•1 comments

DNA and jolts of electricity get people to make optimal antibodies

https://arstechnica.com/science/2025/10/dna-and-jolts-of-electricity-get-people-to-make-optimal-a...
1•PaulHoule•31m ago•0 comments

Game Design Is Simple

https://www.raphkoster.com/2025/11/03/game-design-is-simple-actually/
8•vrnvu•31m ago•2 comments

Copilot leaked information and misrouted to another users

https://docs.cloud.google.com/support/bulletins
2•benjiro•33m ago•1 comments

AI Agent Guides from Google, Anthropic, Microsoft, etc. Released This Week

https://sarthakai.substack.com/p/6-ai-agent-guides-from-google-anthropic
2•sarthakrastogi•33m ago•0 comments

Europeans recognize Zohran Mamdani's policies as 'normal'

https://www.theguardian.com/us-news/2025/nov/06/europe-zohran-mamdani-policies-normal
20•mykowebhn•33m ago•15 comments

US judge approves DOJ decision to drop Boeing criminal case

https://journalrecord.com/2025/11/06/boeing-737-max-criminal-case-dismissed/
1•layer8•33m ago•0 comments

Show HN: Tool2agent – a protocol for LLM tool feedback workflows

https://github.com/tool2agent/tool2agent
2•klntsky•34m ago•0 comments

Azure Cosmos DB and DocumentDB Agenda for Microsoft Ignite 2025

https://devblogs.microsoft.com/cosmosdb/azure-cosmosdb-documentdb-agenda-microsoft-ignite-2025/
1•jaydestro•35m ago•1 comments

YOLO Mode Is How You Build Fast. Auditable Control Is How You Ship Faster

https://securetrajectories.substack.com/p/auditable-control-coding-agents
1•mooreds•35m ago•0 comments

Show HN: I made a Halloween roguelike where you battle to merge a 1000-line PR

https://haystackeditor.com/game
1•akshaysg•35m ago•0 comments

Detection of Covid via sound of cough by machine-learning with 98.5% accuracy

https://www.nature.com/articles/s41598-025-22874-7/figures/1
1•ck2•38m ago•0 comments