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The Other Leverage in Software and AI

https://tomtunguz.com/the-other-leverage-in-software-and-ai/
1•gmays•1m ago•0 comments

AUR malware scanner written in Rust

https://github.com/Sohimaster/traur
2•sohimaster•3m ago•0 comments

Free FFmpeg API [video]

https://www.youtube.com/watch?v=6RAuSVa4MLI
2•harshalone•3m ago•1 comments

Are AI agents ready for the workplace? A new benchmark raises doubts

https://techcrunch.com/2026/01/22/are-ai-agents-ready-for-the-workplace-a-new-benchmark-raises-do...
2•PaulHoule•8m ago•0 comments

Show HN: AI Watermark and Stego Scanner

https://ulrischa.github.io/AIWatermarkDetector/
1•ulrischa•9m ago•0 comments

Clarity vs. complexity: the invisible work of subtraction

https://www.alexscamp.com/p/clarity-vs-complexity-the-invisible
1•dovhyi•10m ago•0 comments

Solid-State Freezer Needs No Refrigerants

https://spectrum.ieee.org/subzero-elastocaloric-cooling
1•Brajeshwar•10m ago•0 comments

Ask HN: Will LLMs/AI Decrease Human Intelligence and Make Expertise a Commodity?

1•mc-0•12m ago•1 comments

From Zero to Hero: A Brief Introduction to Spring Boot

https://jcob-sikorski.github.io/me/writing/from-zero-to-hello-world-spring-boot
1•jcob_sikorski•12m ago•0 comments

NSA detected phone call between foreign intelligence and person close to Trump

https://www.theguardian.com/us-news/2026/feb/07/nsa-foreign-intelligence-trump-whistleblower
6•c420•12m ago•0 comments

How to Fake a Robotics Result

https://itcanthink.substack.com/p/how-to-fake-a-robotics-result
1•ai_critic•13m ago•0 comments

It's time for the world to boycott the US

https://www.aljazeera.com/opinions/2026/2/5/its-time-for-the-world-to-boycott-the-us
3•HotGarbage•13m ago•0 comments

Show HN: Semantic Search for terminal commands in the Browser (No Back end)

https://jslambda.github.io/tldr-vsearch/
1•jslambda•13m ago•1 comments

The AI CEO Experiment

https://yukicapital.com/blog/the-ai-ceo-experiment/
2•romainsimon•15m ago•0 comments

Speed up responses with fast mode

https://code.claude.com/docs/en/fast-mode
3•surprisetalk•18m ago•0 comments

MS-DOS game copy protection and cracks

https://www.dosdays.co.uk/topics/game_cracks.php
3•TheCraiggers•19m ago•0 comments

Updates on GNU/Hurd progress [video]

https://fosdem.org/2026/schedule/event/7FZXHF-updates_on_gnuhurd_progress_rump_drivers_64bit_smp_...
2•birdculture•20m ago•0 comments

Epstein took a photo of his 2015 dinner with Zuckerberg and Musk

https://xcancel.com/search?f=tweets&q=davenewworld_2%2Fstatus%2F2020128223850316274
9•doener•21m ago•2 comments

MyFlames: View MySQL execution plans as interactive FlameGraphs and BarCharts

https://github.com/vgrippa/myflames
1•tanelpoder•22m ago•0 comments

Show HN: LLM of Babel

https://clairefro.github.io/llm-of-babel/
1•marjipan200•22m ago•0 comments

A modern iperf3 alternative with a live TUI, multi-client server, QUIC support

https://github.com/lance0/xfr
3•tanelpoder•23m ago•0 comments

Famfamfam Silk icons – also with CSS spritesheet

https://github.com/legacy-icons/famfamfam-silk
1•thunderbong•24m ago•0 comments

Apple is the only Big Tech company whose capex declined last quarter

https://sherwood.news/tech/apple-is-the-only-big-tech-company-whose-capex-declined-last-quarter/
2•elsewhen•27m ago•0 comments

Reverse-Engineering Raiders of the Lost Ark for the Atari 2600

https://github.com/joshuanwalker/Raiders2600
2•todsacerdoti•28m ago•0 comments

Show HN: Deterministic NDJSON audit logs – v1.2 update (structural gaps)

https://github.com/yupme-bot/kernel-ndjson-proofs
1•Slaine•32m ago•0 comments

The Greater Copenhagen Region could be your friend's next career move

https://www.greatercphregion.com/friend-recruiter-program
2•mooreds•32m ago•0 comments

Do Not Confirm – Fiction by OpenClaw

https://thedailymolt.substack.com/p/do-not-confirm
1•jamesjyu•33m ago•0 comments

The Analytical Profile of Peas

https://www.fossanalytics.com/en/news-articles/more-industries/the-analytical-profile-of-peas
1•mooreds•33m ago•0 comments

Hallucinations in GPT5 – Can models say "I don't know" (June 2025)

https://jobswithgpt.com/blog/llm-eval-hallucinations-t20-cricket/
1•sp1982•33m ago•0 comments

What AI is good for, according to developers

https://github.blog/ai-and-ml/generative-ai/what-ai-is-actually-good-for-according-to-developers/
1•mooreds•33m ago•0 comments
Open in hackernews

Stanford Medicine scientists tie lupus to a virus nearly all of us carry

https://med.stanford.edu/news/all-news/2025/11/lupus-epstein-barr.html
28•XzetaU8•2mo ago

Comments

randycupertino•2mo ago
I've worked in lupus research and one of the things rheumatologists have told me is they see it frequently triggered by the most stressful events in people's lives. So a divorce, eviction, moving, death of a parent or child.

https://hsph.harvard.edu/news/stress-trauma-lupus/

Fortunately great steps have been taken with diagnosis and awareness (it used to not only be hard to find but very stigmatized, lumped in with psycho-somatic disorders like fibromyalgia, long COVID and chronic lyme).

Personally I think the T-cell immune balance research is promising: https://www.prnewswire.com/news-releases/lra-awards-2025-lup...

as well as PARP inhibitors for precision medicine https://clinicaltrials.gov/study/NCT05966480

Car-T for lupus thus far has been a nothingburger (Cabaletta Bio, Nkarta, Kyverna, etc).

eaurouge•2mo ago
Kyverna claims to have achieved remission in clinical trials. Is that really a nothing burger?

https://lupus.bmj.com/content/11/Suppl_1/A109

randycupertino•2mo ago
I'm not saying Car-T doesn't work for certain diseases, more that it's too complex and too expensive to operationalize and unsustainable to bring to mass-market. It may prove successful as a one-off for individual rich single-payer patients but cell therapy companies fail left and right because they repeatedly can't operationalize the treatment into a sustainable business model. It has promising data and potential for transformational results, sure just too many challenges exist thus far for anyone to demonstrate durability bringing an actual treatment to market without major technological and economic advancements. The infrastructure & manufacturing is too intense, it's just not a scalable business.