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The Future of the Global Open-Source AI Ecosystem: From DeepSeek to AI+

https://huggingface.co/blog/huggingface/one-year-since-the-deepseek-moment-blog-3
1•gmays•28s ago•0 comments

The Evolution of the Interface

https://www.asktog.com/columns/038MacUITrends.html
1•dhruv3006•2m ago•0 comments

Azure: Virtual network routing appliance overview

https://learn.microsoft.com/en-us/azure/virtual-network/virtual-network-routing-appliance-overview
1•mariuz•2m ago•0 comments

Seedance2 – multi-shot AI video generation

https://www.genstory.app/story-template/seedance2-ai-story-generator
1•RyanMu•5m ago•1 comments

Πfs – The Data-Free Filesystem

https://github.com/philipl/pifs
1•ravenical•9m ago•0 comments

Go-busybox: A sandboxable port of busybox for AI agents

https://github.com/rcarmo/go-busybox
1•rcarmo•9m ago•0 comments

Quantization-Aware Distillation for NVFP4 Inference Accuracy Recovery [pdf]

https://research.nvidia.com/labs/nemotron/files/NVFP4-QAD-Report.pdf
1•gmays•10m ago•0 comments

xAI Merger Poses Bigger Threat to OpenAI, Anthropic

https://www.bloomberg.com/news/newsletters/2026-02-03/musk-s-xai-merger-poses-bigger-threat-to-op...
1•andsoitis•10m ago•0 comments

Atlas Airborne (Boston Dynamics and RAI Institute) [video]

https://www.youtube.com/watch?v=UNorxwlZlFk
1•lysace•11m ago•0 comments

Zen Tools

http://postmake.io/zen-list
1•Malfunction92•14m ago•0 comments

Is the Detachment in the Room? – Agents, Cruelty, and Empathy

https://hailey.at/posts/3mear2n7v3k2r
1•carnevalem•14m ago•0 comments

The purpose of Continuous Integration is to fail

https://blog.nix-ci.com/post/2026-02-05_the-purpose-of-ci-is-to-fail
1•zdw•16m ago•0 comments

Apfelstrudel: Live coding music environment with AI agent chat

https://github.com/rcarmo/apfelstrudel
1•rcarmo•17m ago•0 comments

What Is Stoicism?

https://stoacentral.com/guides/what-is-stoicism
3•0xmattf•18m ago•0 comments

What happens when a neighborhood is built around a farm

https://grist.org/cities/what-happens-when-a-neighborhood-is-built-around-a-farm/
1•Brajeshwar•18m ago•0 comments

Every major galaxy is speeding away from the Milky Way, except one

https://www.livescience.com/space/cosmology/every-major-galaxy-is-speeding-away-from-the-milky-wa...
2•Brajeshwar•18m ago•0 comments

Extreme Inequality Presages the Revolt Against It

https://www.noemamag.com/extreme-inequality-presages-the-revolt-against-it/
2•Brajeshwar•18m ago•0 comments

There's no such thing as "tech" (Ten years later)

1•dtjb•19m ago•0 comments

What Really Killed Flash Player: A Six-Year Campaign of Deliberate Platform Work

https://medium.com/@aglaforge/what-really-killed-flash-player-a-six-year-campaign-of-deliberate-p...
1•jbegley•20m ago•0 comments

Ask HN: Anyone orchestrating multiple AI coding agents in parallel?

1•buildingwdavid•21m ago•0 comments

Show HN: Knowledge-Bank

https://github.com/gabrywu-public/knowledge-bank
1•gabrywu•26m ago•0 comments

Show HN: The Codeverse Hub Linux

https://github.com/TheCodeVerseHub/CodeVerseLinuxDistro
3•sinisterMage•28m ago•2 comments

Take a trip to Japan's Dododo Land, the most irritating place on Earth

https://soranews24.com/2026/02/07/take-a-trip-to-japans-dododo-land-the-most-irritating-place-on-...
2•zdw•28m ago•0 comments

British drivers over 70 to face eye tests every three years

https://www.bbc.com/news/articles/c205nxy0p31o
39•bookofjoe•28m ago•13 comments

BookTalk: A Reading Companion That Captures Your Voice

https://github.com/bramses/BookTalk
1•_bramses•29m ago•0 comments

Is AI "good" yet? – tracking HN's sentiment on AI coding

https://www.is-ai-good-yet.com/#home
3•ilyaizen•30m ago•1 comments

Show HN: Amdb – Tree-sitter based memory for AI agents (Rust)

https://github.com/BETAER-08/amdb
1•try_betaer•30m ago•0 comments

OpenClaw Partners with VirusTotal for Skill Security

https://openclaw.ai/blog/virustotal-partnership
2•anhxuan•31m ago•0 comments

Show HN: Seedance 2.0 Release

https://seedancy2.com/
2•funnycoding•31m ago•0 comments

Leisure Suit Larry's Al Lowe on model trains, funny deaths and Disney

https://spillhistorie.no/2026/02/06/interview-with-sierra-veteran-al-lowe/
1•thelok•31m ago•0 comments
Open in hackernews

Stanford Medicine scientists tie lupus to a virus nearly all of us carry

https://med.stanford.edu/news/all-news/2025/11/lupus-epstein-barr.html
28•XzetaU8•2mo ago

Comments

randycupertino•2mo ago
I've worked in lupus research and one of the things rheumatologists have told me is they see it frequently triggered by the most stressful events in people's lives. So a divorce, eviction, moving, death of a parent or child.

https://hsph.harvard.edu/news/stress-trauma-lupus/

Fortunately great steps have been taken with diagnosis and awareness (it used to not only be hard to find but very stigmatized, lumped in with psycho-somatic disorders like fibromyalgia, long COVID and chronic lyme).

Personally I think the T-cell immune balance research is promising: https://www.prnewswire.com/news-releases/lra-awards-2025-lup...

as well as PARP inhibitors for precision medicine https://clinicaltrials.gov/study/NCT05966480

Car-T for lupus thus far has been a nothingburger (Cabaletta Bio, Nkarta, Kyverna, etc).

eaurouge•2mo ago
Kyverna claims to have achieved remission in clinical trials. Is that really a nothing burger?

https://lupus.bmj.com/content/11/Suppl_1/A109

randycupertino•2mo ago
I'm not saying Car-T doesn't work for certain diseases, more that it's too complex and too expensive to operationalize and unsustainable to bring to mass-market. It may prove successful as a one-off for individual rich single-payer patients but cell therapy companies fail left and right because they repeatedly can't operationalize the treatment into a sustainable business model. It has promising data and potential for transformational results, sure just too many challenges exist thus far for anyone to demonstrate durability bringing an actual treatment to market without major technological and economic advancements. The infrastructure & manufacturing is too intense, it's just not a scalable business.