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UK gov to ban selling show tickets above face price

https://www.bbc.co.uk/news/articles/c77z2l3yzl8o
1•lifeisstillgood•49s ago•0 comments

LANL and Valar Atomics Announce Project Nova Criticality Milestone

https://www.valaratomics.com/docs/Project-Nova
1•beefman•1m ago•0 comments

Is a 100% Discount the Same as "Free"?

https://dylanbeattie.net/2025/11/17/is-a-100-discount-the-same-as-free.html
1•speckx•2m ago•0 comments

MiniMax Mini-Agent Competes with Claude CLI

https://mslinn.com/llm/7997-mini-agent.html
1•mike_slinn•3m ago•0 comments

Track Major Trends in Neuroscience

https://stateofneuroscience.thetransmitter.org/
1•felixbraun•6m ago•0 comments

What Couchbase Taught Me About System Thinking

https://lorbic.com/what-couchbase-taught-me-about-system-thinking/
1•devdp430•8m ago•0 comments

Why the Global Methane Pledge Is Falling Short

https://oilprice.com/The-Environment/Global-Warming/Why-the-Global-Methane-Pledge-Is-Falling-Shor...
1•PaulHoule•8m ago•0 comments

Run ancient Unix on modern hardware

https://github.com/felipenlunkes/run-ancient-unix
1•doener•10m ago•0 comments

Embedded Swift Improvements Coming in Swift 6.3

https://www.swift.org/blog/embedded-swift-improvements-coming-in-swift-6.3/
1•MBCook•14m ago•0 comments

World Map of Human Ideas

https://ideas.zudiay.me/
2•bookofjoe•14m ago•0 comments

Strengthening America's Education System to Secure Our Future

https://www.thefreedomfrequency.org/p/strengthening-americas-education
1•mudil•18m ago•0 comments

'Moment of Resurgence' for Web Browsers, Says Mozilla CEO (video interview)

https://www.bloomberg.com/news/videos/2025-11-17/mozilla-ceo-moment-of-resurgence-for-web-browser...
1•g-b-r•19m ago•1 comments

American Data Centers

https://tech.marksblogg.com/american-data-centers.html
3•marklit•20m ago•0 comments

What Influence Has the BBC Had on History?

https://www.historytoday.com/archive/head-head/what-influence-has-bbc-had-history
1•pepys•21m ago•0 comments

Operational debt is worse than tech debt

https://arnon.dk/operational-debt-is-worse-than-tech-debt/
1•arnon•24m ago•0 comments

Tiny Prolog [video]

https://www.youtube.com/watch?v=KC7A5QPi5Uo&list=PLRBVoLoCYzDML8e9g58f6zb-faG1rMHIJ&index=15
2•lamg•26m ago•0 comments

Show HN: A Interactive Story App

1•easymode•26m ago•0 comments

20 Yrs old who wants to meet new people

1•Daaddo•26m ago•0 comments

Computers Keep Time [video]

https://www.youtube.com/watch?v=VA2wqrZkfmY
1•Noghartt•27m ago•0 comments

The Evolution of Packet Switching – 1978 [pdf]

https://www.ece.ucf.edu/~yuksem/teaching/nae/reading/1978-roberts.pdf
1•rfmoz•28m ago•0 comments

Color Palette Pro

https://colorpalette.pro/
3•admp•31m ago•0 comments

Harvard Has Almost Half a Billion Dollars in Crypto

https://www.wsj.com/livecoverage/stock-market-today-dow-sp-500-nasdaq-11-17-2025/card/harvard-has...
1•breve•32m ago•0 comments

Here to observe: Labs historian reflects on 30 years of transformation at Sandia

https://www.sandia.gov/labnews/2025/11/13/here-to-observe-labs-historian-reflects-on-three-decade...
1•rbanffy•34m ago•0 comments

50 years of weather forecasting at the ECMWF

https://www.nature.com/articles/s41467-025-65837-2
4•wafngar•35m ago•0 comments

Why 'Store Together, Access Together' Matters for Your Database

https://thenewstack.io/why-store-together-access-together-matters-for-your-database/
1•franckpachot•36m ago•0 comments

Time-Warp-Exploit

https://github.com/tattoosonmyskin/time-warp-exploit-white-paper
1•The_Reformer•37m ago•0 comments

BigQuery Table Sampling

https://jameshartig.dev/2025-bigquery-tablesample/
1•fastest963•38m ago•0 comments

DIY hiring methods for a startup in a world complicated by AI

1•hihicoderhi•38m ago•0 comments

Scientists work out how acetaminophen/paracetamol works

https://scitechdaily.com/after-decades-scientists-have-finally-discovered-tylenols-secret-mechanism/
3•Gaishan•39m ago•0 comments

Does your code match your spec?

https://kiro.dev/blog/property-based-testing/
1•alpaylan•40m ago•0 comments
Open in hackernews

Show HN: SynthonGPT – Drug Discovery LLM with 0% Hallucinations

https://synthongpt.mireklzicar.com/
4•mireklzicar•2h ago

Comments

mireklzicar•1h ago
I trained SynthonGPT, a transformer which is trained in the "language" of chemical building blocks and reactions. Those are chosen based on an existing chemical space, so that any valid sequence of reaction and synthon tokens produces a real drug-like molecule you can actually order (or synthesize yourself in one or two steps of synthesis). Thanks to this trick, it has zero hallucinations: in contrast to GPT-5 which often produces invalid or nonexisting structures, as well as previous models (Chemberta, MolGPT etc.).