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Why there is no official statement from Substack about the data leak

https://techcrunch.com/2026/02/05/substack-confirms-data-breach-affecting-email-addresses-and-pho...
2•witnessme•2m ago•1 comments

Effects of Zepbound on Stool Quality

https://twitter.com/ScottHickle/status/2020150085296775300
1•aloukissas•5m ago•0 comments

Show HN: Seedance 2.0 – The Most Powerful AI Video Generator

https://seedance.ai/
1•bigbromaker•8m ago•0 comments

Ask HN: Do we need "metadata in source code" syntax that LLMs will never delete?

1•andrewstuart•14m ago•1 comments

Pentagon cutting ties w/ "woke" Harvard, ending military training & fellowships

https://www.cbsnews.com/news/pentagon-says-its-cutting-ties-with-woke-harvard-discontinuing-milit...
2•alephnerd•17m ago•1 comments

Can Quantum-Mechanical Description of Physical Reality Be Considered Complete? [pdf]

https://cds.cern.ch/record/405662/files/PhysRev.47.777.pdf
1•northlondoner•17m ago•1 comments

Kessler Syndrome Has Started [video]

https://www.tiktok.com/@cjtrowbridge/video/7602634355160206623
1•pbradv•20m ago•0 comments

Complex Heterodynes Explained

https://tomverbeure.github.io/2026/02/07/Complex-Heterodyne.html
3•hasheddan•20m ago•0 comments

EVs Are a Failed Experiment

https://spectator.org/evs-are-a-failed-experiment/
2•ArtemZ•32m ago•4 comments

MemAlign: Building Better LLM Judges from Human Feedback with Scalable Memory

https://www.databricks.com/blog/memalign-building-better-llm-judges-human-feedback-scalable-memory
1•superchink•32m ago•0 comments

CCC (Claude's C Compiler) on Compiler Explorer

https://godbolt.org/z/asjc13sa6
2•LiamPowell•34m ago•0 comments

Homeland Security Spying on Reddit Users

https://www.kenklippenstein.com/p/homeland-security-spies-on-reddit
3•duxup•37m ago•0 comments

Actors with Tokio (2021)

https://ryhl.io/blog/actors-with-tokio/
1•vinhnx•38m ago•0 comments

Can graph neural networks for biology realistically run on edge devices?

https://doi.org/10.21203/rs.3.rs-8645211/v1
1•swapinvidya•50m ago•1 comments

Deeper into the shareing of one air conditioner for 2 rooms

1•ozzysnaps•52m ago•0 comments

Weatherman introduces fruit-based authentication system to combat deep fakes

https://www.youtube.com/watch?v=5HVbZwJ9gPE
3•savrajsingh•53m ago•0 comments

Why Embedded Models Must Hallucinate: A Boundary Theory (RCC)

http://www.effacermonexistence.com/rcc-hn-1-1
1•formerOpenAI•55m ago•2 comments

A Curated List of ML System Design Case Studies

https://github.com/Engineer1999/A-Curated-List-of-ML-System-Design-Case-Studies
3•tejonutella•59m ago•0 comments

Pony Alpha: New free 200K context model for coding, reasoning and roleplay

https://ponyalpha.pro
1•qzcanoe•1h ago•1 comments

Show HN: Tunbot – Discord bot for temporary Cloudflare tunnels behind CGNAT

https://github.com/Goofygiraffe06/tunbot
2•g1raffe•1h ago•0 comments

Open Problems in Mechanistic Interpretability

https://arxiv.org/abs/2501.16496
2•vinhnx•1h ago•0 comments

Bye Bye Humanity: The Potential AMOC Collapse

https://thatjoescott.com/2026/02/03/bye-bye-humanity-the-potential-amoc-collapse/
3•rolph•1h ago•0 comments

Dexter: Claude-Code-Style Agent for Financial Statements and Valuation

https://github.com/virattt/dexter
1•Lwrless•1h ago•0 comments

Digital Iris [video]

https://www.youtube.com/watch?v=Kg_2MAgS_pE
1•vermilingua•1h ago•0 comments

Essential CDN: The CDN that lets you do more than JavaScript

https://essentialcdn.fluidity.workers.dev/
1•telui•1h ago•1 comments

They Hijacked Our Tech [video]

https://www.youtube.com/watch?v=-nJM5HvnT5k
2•cedel2k1•1h ago•0 comments

Vouch

https://twitter.com/mitchellh/status/2020252149117313349
41•chwtutha•1h ago•6 comments

HRL Labs in Malibu laying off 1/3 of their workforce

https://www.dailynews.com/2026/02/06/hrl-labs-cuts-376-jobs-in-malibu-after-losing-government-work/
4•osnium123•1h ago•1 comments

Show HN: High-performance bidirectional list for React, React Native, and Vue

https://suhaotian.github.io/broad-infinite-list/
2•jeremy_su•1h ago•0 comments

Show HN: I built a Mac screen recorder Recap.Studio

https://recap.studio/
1•fx31xo•1h ago•1 comments
Open in hackernews

Ozempic 2.0 is on the way, and it could be even more transformative

https://www.washingtonpost.com/health/2025/11/27/weight-loss-drugs-ozempic-pills-shots/
10•bookofjoe•2mo ago

Comments

xenospn•2mo ago
“Ozempic 2.0 Odyssey MAX”
bookofjoe•2mo ago
Pro
paulpauper•2mo ago
At this point given the rapid innovation it's rational to stay overweight until the drugs have become optimized,and then endure fewer side effects and faster and more weight loss.
aduwah•2mo ago
This is a bit misguided. If you lose weight too fast, you will have tons of side effects no matter how safe the medication is. Your heart, kidney, pancreas can be stressed with too fast weight loss even without meds. Also you might end up with a lot of loose skin...

Also a new medication will have unknown long term side effects for sure that will surface over time, similar to the current ones.

In my case mounjaro was life changing (for the better). I would say 42kg over 15 months was fast enough already.

cheald•2mo ago
In regards to obesity and fat loss, smooth, consistent weight loss is essentially always preferable to rapid weight loss - both from a whole health standpoint, and from a durability-of-effect standpoint - and sooner is always better than later.

IMO, the ideal way to use these is as an enabler or multiplier for a healthy lifestyle. Using GLP-1-family drugs to enable an unhealthy lifestyle is always going to work out worse for everyone than using them as an adjunct to disciplined diet, regular exercise, and good sleep.

rekabis•2mo ago
https://archive.ph/8OJmG