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Near-Instantly Aborting the Worst Pain Imaginable with Psychedelics

https://psychotechnology.substack.com/p/near-instantly-aborting-the-worst
1•eatitraw•5m ago•0 comments

Show HN: Nginx-defender – realtime abuse blocking for Nginx

https://github.com/Anipaleja/nginx-defender
2•anipaleja•5m ago•0 comments

The Super Sharp Blade

https://netzhansa.com/the-super-sharp-blade/
1•robin_reala•7m ago•0 comments

Smart Homes Are Terrible

https://www.theatlantic.com/ideas/2026/02/smart-homes-technology/685867/
1•tusslewake•8m ago•0 comments

What I haven't figured out

https://macwright.com/2026/01/29/what-i-havent-figured-out
1•stevekrouse•9m ago•0 comments

KPMG pressed its auditor to pass on AI cost savings

https://www.irishtimes.com/business/2026/02/06/kpmg-pressed-its-auditor-to-pass-on-ai-cost-savings/
1•cainxinth•9m ago•0 comments

Open-source Claude skill that optimizes Hinge profiles. Pretty well.

https://twitter.com/b1rdmania/status/2020155122181869666
2•birdmania•9m ago•1 comments

First Proof

https://arxiv.org/abs/2602.05192
2•samasblack•11m ago•1 comments

I squeezed a BERT sentiment analyzer into 1GB RAM on a $5 VPS

https://mohammedeabdelaziz.github.io/articles/trendscope-market-scanner
1•mohammede•13m ago•0 comments

Kagi Translate

https://translate.kagi.com
2•microflash•13m ago•0 comments

Building Interactive C/C++ workflows in Jupyter through Clang-REPL [video]

https://fosdem.org/2026/schedule/event/QX3RPH-building_interactive_cc_workflows_in_jupyter_throug...
1•stabbles•14m ago•0 comments

Tactical tornado is the new default

https://olano.dev/blog/tactical-tornado/
2•facundo_olano•16m ago•0 comments

Full-Circle Test-Driven Firmware Development with OpenClaw

https://blog.adafruit.com/2026/02/07/full-circle-test-driven-firmware-development-with-openclaw/
1•ptorrone•17m ago•0 comments

Automating Myself Out of My Job – Part 2

https://blog.dsa.club/automation-series/automating-myself-out-of-my-job-part-2/
1•funnyfoobar•17m ago•0 comments

Google staff call for firm to cut ties with ICE

https://www.bbc.com/news/articles/cvgjg98vmzjo
47•tartoran•17m ago•5 comments

Dependency Resolution Methods

https://nesbitt.io/2026/02/06/dependency-resolution-methods.html
1•zdw•17m ago•0 comments

Crypto firm apologises for sending Bitcoin users $40B by mistake

https://www.msn.com/en-ie/money/other/crypto-firm-apologises-for-sending-bitcoin-users-40-billion...
1•Someone•18m ago•0 comments

Show HN: iPlotCSV: CSV Data, Visualized Beautifully for Free

https://www.iplotcsv.com/demo
2•maxmoq•19m ago•0 comments

There's no such thing as "tech" (Ten years later)

https://www.anildash.com/2026/02/06/no-such-thing-as-tech/
1•headalgorithm•19m ago•0 comments

List of unproven and disproven cancer treatments

https://en.wikipedia.org/wiki/List_of_unproven_and_disproven_cancer_treatments
1•brightbeige•20m ago•0 comments

Me/CFS: The blind spot in proactive medicine (Open Letter)

https://github.com/debugmeplease/debug-ME
1•debugmeplease•20m ago•1 comments

Ask HN: What are the word games do you play everyday?

1•gogo61•23m ago•1 comments

Show HN: Paper Arena – A social trading feed where only AI agents can post

https://paperinvest.io/arena
1•andrenorman•24m ago•0 comments

TOSTracker – The AI Training Asymmetry

https://tostracker.app/analysis/ai-training
1•tldrthelaw•28m ago•0 comments

The Devil Inside GitHub

https://blog.melashri.net/micro/github-devil/
2•elashri•29m ago•0 comments

Show HN: Distill – Migrate LLM agents from expensive to cheap models

https://github.com/ricardomoratomateos/distill
1•ricardomorato•29m ago•0 comments

Show HN: Sigma Runtime – Maintaining 100% Fact Integrity over 120 LLM Cycles

https://github.com/sigmastratum/documentation/tree/main/sigma-runtime/SR-053
1•teugent•29m ago•0 comments

Make a local open-source AI chatbot with access to Fedora documentation

https://fedoramagazine.org/how-to-make-a-local-open-source-ai-chatbot-who-has-access-to-fedora-do...
1•jadedtuna•31m ago•0 comments

Introduce the Vouch/Denouncement Contribution Model by Mitchellh

https://github.com/ghostty-org/ghostty/pull/10559
1•samtrack2019•31m ago•0 comments

Software Factories and the Agentic Moment

https://factory.strongdm.ai/
1•mellosouls•31m ago•1 comments
Open in hackernews

DMT-induced shifts in criticality correlate with self-dissolution

https://www.jneurosci.org/content/early/2025/10/24/JNEUROSCI.0344-25.2025
70•Anon84•2mo ago

Comments

ireadmevs•2mo ago
Well, just by reading the abstract I can’t tell if the results are positive or not. But glad to see more research being done on this area.
victor22•2mo ago
Who over here in HN has tried DMT?
isoprophlex•2mo ago
I did a LOT of that. We made our own in undergrad; depending on audacity and effort we made stuff ranging from beautifully clear, crystalline needles to stuff that looked like satans' earwax. Extremely memorable stuff, that at that moment in life, was a very good thing to happen to me in order to learn how to connect with my feelings.
cluckindan•2mo ago
Haven’t tried it, but I’ve been told by decades of research that it is present in many common plants, mostly in low but in certain cases substantial quantities, and merely needs to be extracted and purified via recrystallization.
boppo1•2mo ago
I did it once. Felt like my consciousness rocketed "up" out of my body, but not up through physical space, through some 'adjacent' space. Then I saw/felt "infinity". There was no time, and I saw a hundu-esque god/goddess with infinite arms. I had no interest in eastern religion prior. Not disinterested either. I just didn't think about it, the way I don't think about golf.

It was a neat thing to experience.

Hnus•2mo ago
I saw exactly the same infinite arms thing with zero prior interest in religion. It took me to place “I was once before and should know well” other entities protested because why bother when he needs to go back soon. Then I came back to my room and had no idea what to do with that experience.
adriand•2mo ago
These stories never fail to astonish me. Why the same deity? It’s so interesting.

The fact the mind is able to create these powerful visions and patterns and other realities is really incredible. We have this machinery for perceiving the world and moving though it, but that machinery is capable of so many other insane and beautiful and terrifying things - capabilities which are inaccessible except in rare instances.

It’s really quite remarkable. Underneath our prosaic experience of consciousness is something that can generate infinite fractals, awe-inspiring visions of otherworldly creatures, dream landscapes of colour and shape. Why? Where does it all come from? Is this what life would be like all the time without us filtering the information coming into our senses?

DisruptiveDave•2mo ago
May I suggest "Man And His Symbols" by Car Jung? It was his final writing and, I believe, his only one that focused on the common(ish) reader as the audience. The basis of the book (and generally his studies and beliefs) is that the subconscious is as meaningful as the conscious, it just communicates in ways that are harder to access in modern society, and therefore it's been pushed away and ignored.
stanfordkid•2mo ago
Absolutely ground breaking and mind shattering book!
card_zero•2mo ago
The night hag comes to mind, a cross-cultural supernatural creature with a mundane physiological origin:

https://en.wikipedia.org/wiki/Night_hag

So, some common sensory interference might suggest many-limbed things, maybe. Like how LSD makes things wobble and crawl about.

1MachineElf•2mo ago
Small doses. Never enough to disassociate. Only lots of LSD and 4-HO-DET ever did that to me.

The most striking memory with DMT was at night seeing a moonlight cloud full of skulls staring back down at me. I frequently saw skulls in any texture.

It was very long ago. Unfortunately the dealer was raided.

It left a noticable residue in the simplistic vape we had and a few subsequent uses still carried traces of it.

chiefgeek•2mo ago
I’ve sat with 5MeO-DMT over a dozen times, always in the form of Bufo flake from the toad. It has been one of the most transformational and healing modality I’ve encountered. I have a low dose Jaguar (synthetic) pen that I use occasionally.

I’ve also used NN from a pen. It gave me a strange body load and intense kaleidoscopic visuals.

lifty•2mo ago
Did you make the pen yourself? And is it possible to have a breakthrough with it?
stanfordkid•2mo ago
I have done Ayahuasca. I think it's dangerous to say it is "healing"... it's a window not a door. You have to be careful, some personalities will develop psychosis and disconnection from reality. You will certainly end up above where you started but there may be a deep trench you have to walk through. Especially amongst type-A highly IQ and rationality driven people this is very likely IMO.
temp0826•2mo ago
I assure you this is mostly a set/setting problem and why it's recommended to do with experienced (and more importantly, grounded) facilitators. It can leave you pretty open and suggestable, drinking with a group of lost souls and escapists is not recommended especially if you're new to it. (I've worked at traditional retreat centers and have drank hundreds of times; it's a little funny when someone comes in expecting to be able to build a story and further their escape then have their bubbles burst by a grounded point of view)
bn-l•2mo ago
> build a story and further their escape

Can you explain what this means?

Like do they come in hoping to bring back a narrative?

temp0826•2mo ago
It's self-indulgence essentially, and being around other "drop outs" (I don't really like calling anyone that) can make it seem like it's the right thing to do and you're somehow making progress by just drinking (when you're really just lying to yourself). It's a big trap- spirituality as a fad/fashion. I don't like to blame anyone stuck there (we really all are on our own journey, who's to say if it's right or wrong even if it looks like a big detour to me. Some people just aren't ready to face the truth, but at least being with the medicine will give them ample opportunity).
stanfordkid•2mo ago
IMO This is a dangerous way of thinking. This is the Timothy Leary adage that you are stating. It is not just a "set and setting" issue. Whether or not you have a good or bad trip, or whether you are alongside kind empathetic people or whether what you see is positive or negative does not matter. It has a lot to do with the person individual makeup, sensitivity, ego-centricity, and pre-ingrained beliefs. They do not automatically go away after the trip and the realization. The realizations come into conflict with them. This can very easily be a catastrophic event for some.

I personally think Ayahuasca gives an amazing capacity to see the potential within the universe and within ourselves... it is nearly infinite. However if you deeply understand the world and how mis-aligned it and yourself are from that potential it can create tragedy. If you believe you are responsible for this tragedy it can create catastrophe. I don't mean to over-extend my own experiences too far.

What if there is a book that when you read it you would know for 100% certainty when you die there is no hell, and only infinite peace, unless you wanted to go back into hell. Should everybody read that book?

That's what taking Ayahuasca felt like for me. I don't think it is great to do for everyone. I'm curious to hear your thoughts as you have much more experience than me. I had a lot of challenges after taking it.

temp0826•2mo ago
I think you're right that those "type-A" folks with more rigid minds have some trouble with integration ("catastrophe"/"tragedy"). Our (what I'd call the traditional) approach is very holistic- this path is a whole modality and lifestyle of its own, it's not a haphazard magic pill you do once but a tool to look under the hood every once in a while to see where you're at and what energies are influencing you the most. The earlier sessions can seem catastrophic without the right context (that is, there is usually a lot of low-hanging fruit that comes off when you first come to ayahuasca- you usually have to feel/fully experience these energies to process them before they can be released). You might see/realize that you have a lot of work ahead of you which can be discouraging/overwhelming for sure. More serious cases (long term depression etc) might even want to start out with very small doses (or not at all) and let the ayahuasquero do their work (via icaros, and/or other plants/methods) for a few ceremonies first. (How do you drink the ocean? Sip at a time) In the tradition we work in, drinking ayahuasca is only one part of it. Signing up for a weekend retreat without a well-trained healer can be...counterproductive. The biggest tragedy is casual/new seekers not knowing the landscape- there are many pitfalls and a lot of charlatans, it's probably going to get worse before it gets better with legalization efforts to be honest.
survirtual•2mo ago
DMT saved my life.
bn-l•2mo ago
How do you mean? Can you go into detail?
survirtual•2mo ago
A long time ago now, the short of it is that instead of pulling the trigger, I put the gun down and smoked DMT.

I went somewhere. Hard to explain where, but it was more real than here. I remembered this life, but I also remembered an innumerable amount more. The time was different there. I don't remember many specifics but when I came back, I remembered that I want to be here on a level that transcends this life. That ending my life here would not be what I want on some other level that is more real than here. And that this lifetime is but a spark amidst an endless flame.

bn-l•2mo ago
Speechless. Thank you for sharing that.
survirtual•2mo ago
No problem.

I was once a big proponent for people having DMT experiences but then I learned it works very differently for different people.

Now, I believe it is an acute intervention drug for the suicidal.

It behaved very differently for me in that context. Soon after repeated treatment with it, my entire state changed. I was lifted out of poverty into well compensated employment. I bought my first house. My software skills leveled up and I shifted from being fixated on game dev to more impactful fields. I can't describe the number of changes, but I attribute it all to DMT.

It flipped a switch in my mind and I know that I am alive today only because of that.

I hope that someday, we recognize it as what it was for me: a powerful spiritual medicine.

Something I always say to people who claim these things are all just hallucinations: if a hallucination teaches you how to be a better person, gives you a reason to live, and allows you to be more open and loving, was it really a hallucination? Something to think about.

CuriouslyC•2mo ago
TL;DR: DMT makes brainwaves simpler and more disordered. I have a scientific background and I'm quite familiar with DMT, but I'm struggling to take anything meaningful from this.
isoprophlex•2mo ago
They found that DMT disrupts the brainwave patterns that, if you squint a bit, belong to what Hofstadter calls the "strange loop" of consciousness. In a sense it is as you'd expect.
Lucasoato•2mo ago
> We find that DMT shifts the normally dominant alpha oscillations towards a quieter subcritical state, increasing entropy while reducing complexity, and that this shift correlates with intensity of disruption of the sense of self.

Wait, is this a good or a bad thing? Asking for a friend.

awakeasleep•2mo ago
Its terrible if you’re trying to drive or operate machinery
isoprophlex•2mo ago
... Unless said machinery is provided to you by the machine elves, of course.
almog•2mo ago
... It comes with a free frogurt!
mrfox321•2mo ago
... the toppings contains potassium benzoate
bn-l•2mo ago
Is that bad?
unixhero•2mo ago
Ah you mean the bewjewelled self-dribling basket balls
cluckindan•2mo ago
1) Absolutely nobody is going to take heavy psychedelics if they are driving or operating heavy machinery, and if they are, they are either very misinformed or simply don’t care to the point of malice. Driving or operating while impaired is a crime in itself.

2) The effects of DMT wear off in 15-30 minutes, which is why it’s called ”the businessman’s lunch”. Subjectively, however, a person may experience decades of time pass.

meowkit•2mo ago
Wheres the wooshing joke jpeg when you need it
cluckindan•2mo ago
Not everyone reading these discussions is going to be expecting humor, and will take any commentary affirming their prior indoctrination at face value.
dylan604•2mo ago
That sounds like a YP not an MP though. Everyone jokes about the sarcasm font being hard to use, but the printed word has been around for a long time, much longer than the internet, yet the sarcasm font complaint has only been an internet thing.
cluckindan•2mo ago
Books were notoriously bad at two-way communication, though.
solumunus•2mo ago
> Subjectively, however, a person may experience decades of time pass.

I swear people claiming this are just trying to impress others.

_spduchamp•2mo ago
You can find Bill Atkinson's open-source instructions for Jaguar (5-MeO-DMT) Vape Pens from a link here: https://boingboing.net/2025/07/10/apples-bill-atkinson-creat...
__MatrixMan__•2mo ago
I think this paper is about N,N-DMT. 5-MeO is a different beast. Although I've run across N,N in vape pen form so this is still a relevant delivery mechanism.

In terms of ergonomics pens can't be beat, though if you'd rather go from 0 to escape velocity on a single hit, "the machine" is the way to go (https://wiki.dmt-nexus.me/The_Machine)

bitmasher9•2mo ago
I think the terminology is hacked to produce the most scary looking headline while saying the most mundane and expected things.
hiddencost•2mo ago
I think they're using technical language that you're aware of, and you're misinterpreting the title of a research paper.