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The next frontier in weight-loss drugs: one-time gene therapy

https://www.washingtonpost.com/health/2026/01/24/fractyl-glp1-gene-therapy/
1•bookofjoe•54s ago•1 comments

At Age 25, Wikipedia Refuses to Evolve

https://spectrum.ieee.org/wikipedia-at-25
1•asdefghyk•3m ago•1 comments

Show HN: ReviewReact – AI review responses inside Google Maps ($19/mo)

https://reviewreact.com
1•sara_builds•4m ago•0 comments

Why AlphaTensor Failed at 3x3 Matrix Multiplication: The Anchor Barrier

https://zenodo.org/records/18514533
1•DarenWatson•5m ago•0 comments

Ask HN: How much of your token use is fixing the bugs Claude Code causes?

1•laurex•8m ago•0 comments

Show HN: Agents – Sync MCP Configs Across Claude, Cursor, Codex Automatically

https://github.com/amtiYo/agents
1•amtiyo•9m ago•0 comments

Hello

1•otrebladih•10m ago•0 comments

FSD helped save my father's life during a heart attack

https://twitter.com/JJackBrandt/status/2019852423980875794
2•blacktulip•13m ago•0 comments

Show HN: Writtte – Draft and publish articles without reformatting, anywhere

https://writtte.xyz
1•lasgawe•15m ago•0 comments

Portuguese icon (FROM A CAN) makes a simple meal (Canned Fish Files) [video]

https://www.youtube.com/watch?v=e9FUdOfp8ME
1•zeristor•17m ago•0 comments

Brookhaven Lab's RHIC Concludes 25-Year Run with Final Collisions

https://www.hpcwire.com/off-the-wire/brookhaven-labs-rhic-concludes-25-year-run-with-final-collis...
2•gnufx•19m ago•0 comments

Transcribe your aunts post cards with Gemini 3 Pro

https://leserli.ch/ocr/
1•nielstron•23m ago•0 comments

.72% Variance Lance

1•mav5431•24m ago•0 comments

ReKindle – web-based operating system designed specifically for E-ink devices

https://rekindle.ink
1•JSLegendDev•25m ago•0 comments

Encrypt It

https://encryptitalready.org/
1•u1hcw9nx•25m ago•1 comments

NextMatch – 5-minute video speed dating to reduce ghosting

https://nextmatchdating.netlify.app/
1•Halinani8•26m ago•1 comments

Personalizing esketamine treatment in TRD and TRBD

https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1736114
1•PaulHoule•28m ago•0 comments

SpaceKit.xyz – a browser‑native VM for decentralized compute

https://spacekit.xyz
1•astorrivera•28m ago•0 comments

NotebookLM: The AI that only learns from you

https://byandrev.dev/en/blog/what-is-notebooklm
2•byandrev•29m ago•1 comments

Show HN: An open-source starter kit for developing with Postgres and ClickHouse

https://github.com/ClickHouse/postgres-clickhouse-stack
1•saisrirampur•29m ago•0 comments

Game Boy Advance d-pad capacitor measurements

https://gekkio.fi/blog/2026/game-boy-advance-d-pad-capacitor-measurements/
1•todsacerdoti•30m ago•0 comments

South Korean crypto firm accidentally sends $44B in bitcoins to users

https://www.reuters.com/world/asia-pacific/crypto-firm-accidentally-sends-44-billion-bitcoins-use...
2•layer8•30m ago•0 comments

Apache Poison Fountain

https://gist.github.com/jwakely/a511a5cab5eb36d088ecd1659fcee1d5
1•atomic128•32m ago•2 comments

Web.whatsapp.com appears to be having issues syncing and sending messages

http://web.whatsapp.com
1•sabujp•33m ago•2 comments

Google in Your Terminal

https://gogcli.sh/
1•johlo•34m ago•0 comments

Shannon: Claude Code for Pen Testing: #1 on Github today

https://github.com/KeygraphHQ/shannon
1•hendler•34m ago•0 comments

Anthropic: Latest Claude model finds more than 500 vulnerabilities

https://www.scworld.com/news/anthropic-latest-claude-model-finds-more-than-500-vulnerabilities
2•Bender•39m ago•0 comments

Brooklyn cemetery plans human composting option, stirring interest and debate

https://www.cbsnews.com/newyork/news/brooklyn-green-wood-cemetery-human-composting/
1•geox•39m ago•0 comments

Why the 'Strivers' Are Right

https://greyenlightenment.com/2026/02/03/the-strivers-were-right-all-along/
1•paulpauper•40m ago•0 comments

Brain Dumps as a Literary Form

https://davegriffith.substack.com/p/brain-dumps-as-a-literary-form
1•gmays•41m ago•0 comments
Open in hackernews

Ask HN: B2B SaaS founders: what are (or have been) your biggest problems?

4•Vaxind•2mo ago
I'm curious to hear from founders working on B2B SaaS. What feels like a constant pain point or bottleneck for you?

Could be distribution, demo scheduling, leads, onboarding, customer success, integrations — whatever consistently gets in the way.

I’m not trying to pitch anything. I’m 18 years old and just want to build a useful service to help SaaS founders.

Really appreciate any input or stories you can share!

Comments

bewal416•2mo ago
Finding a co-founder, plus making those first few hires, is easily the most challenging part. You're going to realize you can't solve every problem, and you'll need help. Finding your team is like finding a life partner- a great one that complements your strengths and weaknesses could set you up for life. The wrong one will result in mismatched effort, finger-pointing, and time spent away from the customer. It's one thing to ask a user to give you $20/mo. It's another thing to ask another human to wake up with you every day and spend their prime working on your vision in opportunity cost of working on something else. It's going to be the most important sell of your life!
mvkel•2mo ago
Work backwards from the customer.

If you want to generate revenue, you'll need to work with b2b saas companies that can afford your product.

That means they're doing (minimum) $500K ARR; a proxy for having some semblance of a team established, and a level of complexity in the business that can no longer be sustained in docs on Google Drive. In other words, when you cross $500K ARR, you need software to keep growing.

In my own experience, the most annoying thing was low qualified lead volume, because b2b isn't trying to sell to the entire world. But the answer isn't yet another marketing automation platform. Our biggest solve for this was analog: attending lots of industry conferences and making a network.