I am glad glutamate is finally getting its' day in the sun. I have many GRIN2B polymorphisms and I have schizoaffective disorder and fibromyalgia. I am going to start l-serine to see if it helps me.
Thank you, though I am more afraid this will make my positive symptoms worse. I really have no negative symptoms of schizophrenia, which is why I am schizoaffective and not schizophrenic. Glycine seems to activate the glutamate receptors[1] and sarcosine is a by product of glycine and has also been shown to increase mania in patients[2].
What is interesting is that high levels of B6 seemed to help me in the past and it is a cofactor for SHMT1[1] which balances serine and glycine in the folate cycle.
Noaidi•48m ago
https://www.nature.com/articles/s41380-025-03279-4
I am glad glutamate is finally getting its' day in the sun. I have many GRIN2B polymorphisms and I have schizoaffective disorder and fibromyalgia. I am going to start l-serine to see if it helps me.
PaulHoule•38m ago
Noaidi•9m ago
[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC10740625/
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC4356443/
What is interesting is that high levels of B6 seemed to help me in the past and it is a cofactor for SHMT1[1] which balances serine and glycine in the folate cycle.
[1] https://www.uniprot.org/uniprotkb/P34896/entry
On SHMT1 and mood: https://www.sciencedirect.com/science/article/pii/S075333222...