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In the Beginning Was the Command Line

https://web.stanford.edu/class/cs81n/command.txt
1•wseqyrku•1m ago•0 comments

Portugal updates cybercrime law to exempt security researchers

https://www.bleepingcomputer.com/news/security/portugal-updates-cybercrime-law-to-exempt-security...
1•N19PEDL2•4m ago•0 comments

Optimizing Iceberg Compaction: Why We Built an Embedded Engine in Rust

https://risingwave.com/blog/implementing-iceberg-compaction-rust/
1•WavyPeng•5m ago•0 comments

Geoffrey Hinton says Google is 'beginning to overtake' OpenAI

https://www.businessinsider.com/ai-godfather-geoffrey-hinton-google-overtaking-openai-2025-12
1•djhu9•6m ago•0 comments

Zuck#: A programming language for connecting the world. And harvesting it

https://jayzalowitz.github.io/zucksharp/
1•kf•8m ago•0 comments

Show HN: Dograh – an OSS Vapi alternative to quickly build and test voice agents

https://github.com/dograh-hq/dograh
1•a6kme•10m ago•1 comments

Curated SRE/DevOps/Cloud Job Board

https://sshcareers.com/
1•sajokrit•14m ago•0 comments

You Gotta Push If You Wanna Pull

https://www.morling.dev/blog/you-gotta-push-if-you-wanna-pull/
1•ingve•16m ago•0 comments

Knuth 2025 Christmas lecture: Adventures with Knight's Tours [video]

https://www.youtube.com/watch?v=MKiRte-tnMY
2•fs123•19m ago•0 comments

Ask HN: Smart Glasses with a Decent Camera?

1•brcmthrowaway•20m ago•0 comments

Show HN: Detect employee skill gaps and develop training plans

https://semis.reispar.com
1•Mcjulie•27m ago•0 comments

Adding Unpack Syntax to RCL

https://ruudvanasseldonk.com/2025/adding-unpack-to-rcl
3•todsacerdoti•29m ago•0 comments

Applets Are Officially Gone, but Java in the Browser Is Better

https://frequal.com/java/AppletsGoneButJavaInTheBrowserBetterThanEver.html
18•pjmlp•29m ago•8 comments

Can an English Fish Merchant Turn a Profit in Asia's Largest Market? [video]

https://www.youtube.com/watch?v=PqAf1qRcixc
1•tosh•29m ago•0 comments

The AI-Fication of Cyberthreats

https://www.trendmicro.com/vinfo/gb/security/research-and-analysis/predictions/the-ai-fication-of...
2•runningmike•30m ago•0 comments

GitHub Actions Has a Package Manager, and It Might Be the Worst

https://nesbitt.io/2025/12/06/github-actions-package-manager.html
2•robin_reala•30m ago•0 comments

Why Startups Die

https://www.techfounderstack.com/p/why-startups-die
3•makle•41m ago•0 comments

Show HN: Weather mini – Trip forecasts powered by Apple Intelligence

https://weathermini.app
1•kailuo•43m ago•0 comments

From Azure Functions to FreeBSD

https://jmmv.dev/2025/12/from-azure-functions-to-freebsd.html
1•todsacerdoti•43m ago•0 comments

Guidance: A cheat code for diffusion models

https://sander.ai/2022/05/26/guidance.html
2•tesserato•44m ago•0 comments

App that turns sermon notes to daily devotionals

https://apps.apple.com/us/app/serma/id6745926259
1•roosells•47m ago•1 comments

Closer Look at the Birthday Paradox [video]

https://www.youtube.com/watch?v=OUQVhnuTMVU
1•duck•48m ago•0 comments

European commission X ad account has been terminated

https://twitter.com/nikitabier/status/1997450541275005041
1•teekert•48m ago•0 comments

Show HN: Bugmail – the easiest way to catch and fix production bugs

https://www.bugmail.site/
2•bumpymark•50m ago•0 comments

Show HN: Pocket PMO – Quick free PMO oversight

https://pocketpmo.com/
1•iamasuperuser•50m ago•0 comments

Starmer's Electoral Posturing

https://rodgercuddington.substack.com/p/starmers-electoral-posturing
2•freespirt•51m ago•1 comments

Show HN: GffutilsAI, an agent to analyze genomic files

https://www.biorxiv.org/content/10.64898/2025.12.02.690645v1
1•sbassi•51m ago•0 comments

Drunk Driving – Grand Rapids Dip

https://en.wikipedia.org/wiki/Drunk_driving
1•thunderbong•52m ago•1 comments

The Collapse of Trust in AI Assistants

https://zenodo.org/records/17837188
6•businessmate•54m ago•1 comments

When software becomes fast food

https://world.hey.com/joaoqalves/when-software-becomes-fast-food-23147c9b
2•kiyanwang•58m ago•0 comments
Open in hackernews

Show HN: GffutilsAI, an agent to analyze genomic files

https://www.biorxiv.org/content/10.64898/2025.12.02.690645v1
1•sbassi•51m ago
I've been working on an agent to interact with genomics files (GFF) without coding. It uses the gffutils Python library and Biopython in the backend to ensure deterministic results for coordinate searches and gene lookups.

You can use any model through Ollama (local) or connect to major LLM providers (bring your own API key). It is currently in a PoC state, but fully functional. I would appreciate any feedback or suggestions!