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Near-Instantly Aborting the Worst Pain Imaginable with Psychedelics

https://psychotechnology.substack.com/p/near-instantly-aborting-the-worst
1•eatitraw•3m ago•0 comments

Show HN: Nginx-defender – realtime abuse blocking for Nginx

https://github.com/Anipaleja/nginx-defender
2•anipaleja•3m ago•0 comments

The Super Sharp Blade

https://netzhansa.com/the-super-sharp-blade/
1•robin_reala•4m ago•0 comments

Smart Homes Are Terrible

https://www.theatlantic.com/ideas/2026/02/smart-homes-technology/685867/
1•tusslewake•6m ago•0 comments

What I haven't figured out

https://macwright.com/2026/01/29/what-i-havent-figured-out
1•stevekrouse•7m ago•0 comments

KPMG pressed its auditor to pass on AI cost savings

https://www.irishtimes.com/business/2026/02/06/kpmg-pressed-its-auditor-to-pass-on-ai-cost-savings/
1•cainxinth•7m ago•0 comments

Open-source Claude skill that optimizes Hinge profiles. Pretty well.

https://twitter.com/b1rdmania/status/2020155122181869666
2•birdmania•7m ago•1 comments

First Proof

https://arxiv.org/abs/2602.05192
2•samasblack•9m ago•1 comments

I squeezed a BERT sentiment analyzer into 1GB RAM on a $5 VPS

https://mohammedeabdelaziz.github.io/articles/trendscope-market-scanner
1•mohammede•10m ago•0 comments

Kagi Translate

https://translate.kagi.com
2•microflash•11m ago•0 comments

Building Interactive C/C++ workflows in Jupyter through Clang-REPL [video]

https://fosdem.org/2026/schedule/event/QX3RPH-building_interactive_cc_workflows_in_jupyter_throug...
1•stabbles•12m ago•0 comments

Tactical tornado is the new default

https://olano.dev/blog/tactical-tornado/
2•facundo_olano•14m ago•0 comments

Full-Circle Test-Driven Firmware Development with OpenClaw

https://blog.adafruit.com/2026/02/07/full-circle-test-driven-firmware-development-with-openclaw/
1•ptorrone•14m ago•0 comments

Automating Myself Out of My Job – Part 2

https://blog.dsa.club/automation-series/automating-myself-out-of-my-job-part-2/
1•funnyfoobar•14m ago•0 comments

Google staff call for firm to cut ties with ICE

https://www.bbc.com/news/articles/cvgjg98vmzjo
38•tartoran•15m ago•3 comments

Dependency Resolution Methods

https://nesbitt.io/2026/02/06/dependency-resolution-methods.html
1•zdw•15m ago•0 comments

Crypto firm apologises for sending Bitcoin users $40B by mistake

https://www.msn.com/en-ie/money/other/crypto-firm-apologises-for-sending-bitcoin-users-40-billion...
1•Someone•16m ago•0 comments

Show HN: iPlotCSV: CSV Data, Visualized Beautifully for Free

https://www.iplotcsv.com/demo
2•maxmoq•17m ago•0 comments

There's no such thing as "tech" (Ten years later)

https://www.anildash.com/2026/02/06/no-such-thing-as-tech/
1•headalgorithm•17m ago•0 comments

List of unproven and disproven cancer treatments

https://en.wikipedia.org/wiki/List_of_unproven_and_disproven_cancer_treatments
1•brightbeige•17m ago•0 comments

Me/CFS: The blind spot in proactive medicine (Open Letter)

https://github.com/debugmeplease/debug-ME
1•debugmeplease•18m ago•1 comments

Ask HN: What are the word games do you play everyday?

1•gogo61•21m ago•1 comments

Show HN: Paper Arena – A social trading feed where only AI agents can post

https://paperinvest.io/arena
1•andrenorman•22m ago•0 comments

TOSTracker – The AI Training Asymmetry

https://tostracker.app/analysis/ai-training
1•tldrthelaw•26m ago•0 comments

The Devil Inside GitHub

https://blog.melashri.net/micro/github-devil/
2•elashri•26m ago•0 comments

Show HN: Distill – Migrate LLM agents from expensive to cheap models

https://github.com/ricardomoratomateos/distill
1•ricardomorato•26m ago•0 comments

Show HN: Sigma Runtime – Maintaining 100% Fact Integrity over 120 LLM Cycles

https://github.com/sigmastratum/documentation/tree/main/sigma-runtime/SR-053
1•teugent•27m ago•0 comments

Make a local open-source AI chatbot with access to Fedora documentation

https://fedoramagazine.org/how-to-make-a-local-open-source-ai-chatbot-who-has-access-to-fedora-do...
1•jadedtuna•28m ago•0 comments

Introduce the Vouch/Denouncement Contribution Model by Mitchellh

https://github.com/ghostty-org/ghostty/pull/10559
1•samtrack2019•29m ago•0 comments

Software Factories and the Agentic Moment

https://factory.strongdm.ai/
1•mellosouls•29m ago•1 comments
Open in hackernews

A Fentanyl Vaccine Is About to Get Its First Major Test

https://www.wired.com/story/a-fentanyl-vaccine-is-about-to-get-its-first-major-test/
6•bookofjoe•1mo ago

Comments

bookofjoe•1mo ago
https://archive.ph/IIVqw
al_borland•1mo ago
I was most interested in how this might impact use of fentanyl in hospital settings, if they can’t reliably know if it will be effective. Are the current systems for tracking vaccine administration good enough to solve for this?
toomuchtodo•1mo ago
Many (all?) states have an immunization registry ("Immunization Information System"); when you’re vaccinated, the provider submits a digital record with your name and date of birth, along with their info and the vaccine info, to the registry. This is programmatically ingested by Epic’s EMR system, if configured, and will even show up in your mobile app and web interface when logged into your health system’s app. So, in some cases, yes.

With that said, for emergencies, one might have an emergency bracelet with this info on it in the event pain management is required unexpectedly. Otherwise, pain might not be managed.

https://www.cdc.gov/iis/contacts-locate-records/index.html

slwvx•1mo ago
my immediate question was whether fentanyl is unique in that a vaccine can be developed for it. From [1] we read "Vaccines for cocaine, methamphetamine, nicotine and others have all been tested in rats and, in some cases, people."

Reading further, [1] says these vaccines have not yet been successful.

[1] https://theconversation.com/a-new-fentanyl-vaccine-looks-pro...