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The Peptide Craze

https://erictopol.substack.com/p/the-peptide-craze
10•gwintrob•2h ago

Comments

zallarak•22m ago
Ah yes, thousands of people benefiting from cheap and effective drugs that can’t be patented because they naturally occur. Of course it doesn’t work. /sarcasm

The medical field has a terrible problem in terms of literature reproducibility and ethics. The beta blocker scandal is a great example.

qgin•10m ago
> The most important column is the last one—there is no evidence from randomized trials in humans that any of these peptides provide the benefits that are advocated. As seen below, two of the peptides have been prohibited by the World Anti-Doping Agency.

Why would WADA ban things for which there is no evidence that they do anything?

nateb2022•3m ago
To be added to the Prohibited List, a substance must meet any two of the following three conditions:

  1. It has the potential to enhance sport performance. (potential -> a theoretical mechanism, even if unproven)
  2. It represents an actual or potential health risk to the athlete.
  3. It violates the spirit of sport.
Most of these peptides haven't passed adequate human safety trials, and their long term side effect profile is unknown. Additionally, an attempt at using anything to gain an unfair advantage violates the spirit of sport, even if the effect is placebo or even negative.

Best way to annotate large parquet LLM logs without full rewrites?

1•platypii•2m ago•0 comments

The Program 2025 annual review: How much money does an audio drama podcast make?

https://programaudioseries.com/the-program-results-7/
1•I-M-S•2m ago•0 comments

ChatGPT Is a Search Engine

https://queryburst.com/blog/how-chatgpt-works/
1•AznHisoka•3m ago•0 comments

Power outage paralyzes Waymo robotaxis when traffic lights go out

https://arstechnica.com/cars/2025/12/power-outage-paralyzes-waymo-robotaxis-when-traffic-lights-g...
1•chirau•3m ago•1 comments

Reducing contrails reduces CO2 effect of air travel 73%, adds only 0.08% to cost [video]

https://www.youtube.com/watch?v=QoOVqQ5sa08
1•CGMthrowaway•8m ago•0 comments

Algorithmic Personalization Causes Inaccurate Generalization and Overconfidence

https://psycnet.apa.org/fulltext/2026-31272-001.html
1•PaulHoule•8m ago•0 comments

Inquiry ongoing after UK government hacked, says minister

https://www.bbc.co.uk/news/articles/cj4qpwprw9vo
1•GaryBluto•8m ago•0 comments

Older Americans Quit Weight-Loss Drugs in Droves

https://www.nytimes.com/2025/12/21/health/older-people-glp1-weight.html
2•bookofjoe•8m ago•1 comments

Samsung Biologics to buy US drug production facility from GSK for $280M

https://www.reuters.com/business/healthcare-pharmaceuticals/samsung-biologics-buy-us-drug-product...
2•randycupertino•9m ago•0 comments

The Fisherman and the Businessman

https://kevquirk.com/blog/the-fisherman-and-the-businessman/
1•0x54MUR41•10m ago•0 comments

A zero-dependency approach to archival, interactive research

https://tjid3.org/tech
1•TimothyMJones•10m ago•1 comments

MacSync Stealer variant finds a way to bypass Apple malware protections

https://9to5mac.com/2025/12/22/macsync-stealer-variant-finds-a-way-to-bypass-apple-malware-protec...
1•zdw•11m ago•0 comments

Intel x86 considered harmful [pdf]

https://blog.invisiblethings.org/papers/2015/x86_harmful.pdf
1•throwoutway•11m ago•0 comments

National Portrait Gallery Buys Rare Photographs of Ada Lovelace for the UK

https://www.ianvisits.co.uk/articles/national-portrait-gallery-saves-rare-photographs-of-ada-love...
2•ianvisits•11m ago•1 comments

Around 1k systems compromised in ransomware attack on Romanian water agency

https://www.theregister.com/2025/12/22/around_1000_systems_compromised_in/
1•GaryBluto•11m ago•0 comments

The Caucasity of Some Folks (and the Art of Self-Governance)

https://open.substack.com/pub/blacklistedsaint/p/the-caucasity-of-some-folks
1•BlacklistedSNT•12m ago•0 comments

Arm stock declines as Qualcomm acquires RISC-V designer Ventana Micro

https://www.techradar.com/pro/arm-sheds-billions-in-market-capitalization-after-qualcomm-hints-at...
1•mikece•13m ago•0 comments

Rockstar workers fired for union Discord membership just want their jobs back

https://www.cbc.ca/news/entertainment/grand-theft-auto-canadian-fired-worker-9.7024478
2•empressplay•13m ago•0 comments

Post Office had deal with Fujitsu to fix Horizon errors 19 years ago

https://www.bbc.co.uk/news/articles/cqlkx6n15ero
1•ndsipa_pomu•15m ago•0 comments

Agents as Labor

https://open.substack.com/pub/gizmohan/p/agents-as-labor
1•iamthedruid•15m ago•1 comments

Elementary OS 8.1 Switches over to Wayland Session by Default

https://www.phoronix.com/news/Elementary-OS-8.1-Released
1•mikece•16m ago•0 comments

Ultrasound Cancer Treatment: Sound Waves Fight Tumors

https://spectrum.ieee.org/ultrasound-cancer-treatment
11•rbanffy•17m ago•1 comments

Claude Colony – Multi-Agent Orchestration for Claude Code

https://github.com/MakingJamie/claude-colony
1•jamiemurphy•17m ago•1 comments

Run Linux desktop on any recent Android phone or tablet

1•Vasant1234•17m ago•2 comments

What can you do with used wind turbine blades?

https://www.rte.ie/brainstorm/2024/0808/1287943-what-can-you-do-with-used-wind-turbine-blades/
1•austinallegro•17m ago•0 comments

Gold and silver hit records as investors hunt for safety

https://www.bbc.com/news/articles/cd74ldr2zryo
2•reconnecting•19m ago•1 comments

Indexing: From Google to Shazam to AI Agents

https://ossa-ma.github.io/blog/on-indexing
1•ossa-ma•20m ago•0 comments

Reachy Mini – A Hugging Face Space by Pollen-Robotics

https://huggingface.co/spaces/pollen-robotics/Reachy_Mini
1•ulrischa•22m ago•0 comments

Exposing Honey's Evil Business Model [video]

https://www.youtube.com/watch?v=wwB3FmbcC88
2•g3eorge•22m ago•0 comments

US 'demolishing its scientific leadership with a wrecking ball'

https://sciencebusiness.net/news/horizon-europe/us-demolishing-its-scientific-leadership-wrecking...
78•xqcgrek2•22m ago•31 comments