That is actually legitimately cool; this is the kind of stuff Framework was meant for.

Framework Laptop 16 already supports desktop GPUs through its USB 4.0 ports.

Tests in the wild have shown that the best performance can be gained in combination with the currently wildly popular enclosures with the ASM2464PD chip from ASMedia due to its really great compatibility with AMD chipsets. This chip has been integrated in the AG02 enclosure from Aoostar (which supports USB4, but also supports Oculink) and the UT3G/UT4G enclosures from ADT-Link (which only support USB4):

https://egpu.io/best-egpu-buyers-guide/

You also need a really fast videocard with > 40 Gbps throughput to make Oculink worthwhile, as even a AMD Radeon 9070XT performs nearly the same (and pretty great!) on USB4 as Oculink, through the Aoostar dock, on the Framework 16.